Category: 100-83-4

An article A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism WOS:000507146000010 published article about STREPTOCOCCUS-MUTANS; INSPIRED ANALOGS; DENTAL-CARIES; MAGNOLOL; BIOFILM in [Ochoa, Cristian; Nowlan, Marcus; Kozlowski, Marisa C.] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, 231 South 34th St, Philadelphia, PA 19104 USA; [Solinski, Amy E.; Dekarske, Madeline M.; Wuest, William M.] Emory Univ, Dept Chem, 1515 Dickey Dr, Atlanta, GA 30322 USA; [Solinski, Amy E.; Dekarske, Madeline M.; Wuest, William M.] Emory Univ, Emory Antibiot Resistance Ctr, 1515 Dickey Dr, Atlanta, GA 30322 USA in 2020.0, Cited 29.0. HPLC of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ochoa, C; Solinski, AE; Nowlan, M; Dekarske, MM; Wuest, WM; Kozlowski, MC or concate me.. HPLC of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. In 2021.0 SYNTHESIS-STUTTGART published article about ONE-POT SYNTHESIS; WACKER-TYPE OXIDATION; CATALYZED OXIDATION; ARYLBORONIC ACIDS; ENDOPHYTIC FUNGUS; PRACTICAL METHOD; BOND FORMATION; COPPER; TBHP; ALKENES in [Chang, Meng-Yang; Lai, Kai-Xiang; Chen, Kuan-Ting] Kaohsiung Med Univ, Dept Med & Appl Chem, 100 Shin Chuan 1st Rd, Kaohsiung 80708, Taiwan; [Chang, Meng-Yang] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 80708, Taiwan in 2021.0, Cited 73.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A concise route for the (BuO2H)-Bu-t/Cu(acac)(2)-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o-allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chang, MY; Lai, KX; Chen, KT or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ONE-POT SYNTHESIS; WACKER-TYPE OXIDATION; CATALYZED OXIDATION; ARYLBORONIC ACIDS; ENDOPHYTIC FUNGUS; PRACTICAL METHOD; BOND FORMATION; COPPER; TBHP; ALKENES, Saw an article supported by the Ministry of Science and Technology of the Republic of ChinaMinistry of Science and Technology, China [MOST 109-2113-M-037-014-MY3]. SDS of cas: 100-83-4. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Chang, MY; Lai, KX; Chen, KT. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A concise route for the (BuO2H)-Bu-t/Cu(acac)(2)-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o-allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Chang, MY; Lai, KX; Chen, KT or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Rapid and green synthesis of 4H-benzo[b]pyrans using triethanolamine as an efficient homogeneous catalyst under ambient conditions published in 2020.0. Product Details of 100-83-4, Reprint Addresses Moradi, L (corresponding author), Univ Kashan, Dept Organ Chem, Fac Chem, POB 8731753153, Kashan, Iran.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

4H-benzo[b]pyrans were obtained rapidly in high yields using triethanolamine as an efficient, eco-friendly and low-cost basic catalyst. One-pot three-component condensation reaction of a series of aldehydes, malononitrile and 1,3-diketones was performed at room temperature. All the products were obtained in high-to-excellent yields and characterized in detail. Green, rapid and mild process, very short reaction times (1-12 min) and simple workup are some of the advantages of this method.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Rahnamafa, R; Moradi, L; Khoobi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about H BOND ACTIVATION; SUBSTITUTED ANTHRAQUINONES; MERGING PHOTOREDOX; DERIVATIVES; ACID; CYCLIZATION; ARYL; ANTHRACYCLINE; BIOSYNTHESIS; ARYLATION, Saw an article supported by the Department of Science and Technology-Science and Engineering Research Board (DST-SERB), New Delhi [SB/S1/OC-39/2014]; MHRD. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Suchand, B; Satyanarayana, G. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A bis-acylation strategy to access functionalized anthraquinones via one-pot relay process, is presented. The first acylation was feasible under [Pd]-catalyzed intermolecular direct acylation reaction, while, the second acylation was accomplished by using intramolecular Friedel-Crafts acylation. Notably, benchtop aldehydes have been utilized as non-toxic acylation agents in the key [Pd]-catalyzed acylation.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Suchand, B; Satyanarayana, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and biological evaluation of benzamide derivatives as novel NTCP inhibitors that induce apoptosis in HepG2 cells WOS:000485100200021 published article about HEPATOCELLULAR-CARCINOMA; HEPATITIS-B; BOSENTAN; CANCER; RISK in [Zhao, Shuangmei; Zhen, Yongqi; Fu, Leilei; Gao, Feng; Zhou, Xianli; Huang, Shuai; Zhang, Lan] Southwest Jiaotong Univ, Sch Life Sci & Engn, 111 North Second Ring Rd, Chengdu 610031, Sichuan, Peoples R China in 2019.0, Cited 22.0. Name: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Sodium taurocholate cotransport polypeptide (NTCP) plays an important role in the development of hepatitis and acts as a switch to allow hepatitis virus to enter hepatic cells. As the entry receptor protein of hepatitis virus, NTCP is also an effective target for the treatment of hepatocellular carcinoma. Herein, twenty-five benzamide analogues were synthesized based on the virtual screening design and their anti-proliferative activities against HepG2 cells were evaluated in vitro. Compound 35 was found to be promising, with an IC50 value of 2.8 mu M. The apoptosis induced by 35 was characterized by the regulation of markers, including an increase in Box, cleaved-caspase 3, and cleaved-PARP proteins, and a decrease in Bcl-2 protein. Molecular docking and molecular dynamics (MD) simulation confirmed that compound 35 can bind tightly to NTCP. Western blot analysis also showed that NTCP was inhibited. Altogether, these results indicate that compound 35 acts as a novel NTCP inhibitor to induce apoptosis in HepG2 cells.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhao, SM; Zhen, YQ; Fu, LL; Gao, F; Zhou, XL; Huang, S; Zhang, L or concate me.. Name: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PROCESS WINDOWS; CHEMISTRY; REACTORS; LIQUID; SAFE, Saw an article supported by the Spanish MINECO [RTI2018-095588-B-I00]; European Regional Development Fund/European Social Fund, Investing in your future; FUSP-CEU [PC17/17]; Fundacion San Pablo-CEU. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde

A new synthesis of treprostinil is described using a plug flow reactor in two of the key steps. First, a Claisen rearrangement reaction is described in scaled flow at multigram amounts. Yields and selectivity of this step are sharply improved compared to those from previous syntheses. Second, the key Pauson-Khand reaction in flow is described under catalytic conditions with 5 mol% of cobalt carbonyl and only 3 equiv. of CO. Scaling up of this reaction safely ensures a good yield of an advanced intermediate which is transformed into treprostinil in three steps. Other improvements are the introduction of the carboxymethyl chain into the phenol from the beginning to reduce the protection-deprotection steps. The synthesis is completed in 14% global yield after 12 linear steps from (S)-epichlorhydrin.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Garcia-Lacuna, J; Dominguez, G; Blanco-Urgoiti, J; Perez-Castells, J or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL in [Li, Zhiwei; Xu, Le; Zhu, Liangyu; Zhao, Yanfang; Liu, Yajing; Hou, Yunlei] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Tao; Yin, Bixi; Hou, Yunlei] Yangtze River Pharmaceut Grp Pharmaceut Co Ltd, 1 South Yangtze River Rd, Taizhou 225321, Jiangsu, Peoples R China published Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors in 2020.0, Cited 21.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A series of novel pteridinone derivatives possessing a hydrazone moiety were designed, synthesized and evaluated for their biological activity. Most of the synthesized compounds demonstrated moderate to excellent activity against A549, HCT116 and PC-3 cancer cell lines. In particular, compound L-19 exhibited the most potent antiproliferative effects on three cell lines with IC50 values of 3.23 mu M, 4.36 mu M and 8.20 mu M, respectively. In kinase assays, the compound L-19 also showed potent inhibition activity toward PLK1 with % inhibition values of 75.1. Further mechanism studies revealed that compound L-19 significantly inhibited proliferation of HCT-116 cell lines, induced a great decrease in mitochondrial membrane potential resulting in apoptosis of cancer cells, inhibited the migration of tumor cells, and arrested G1 phase of HCT116 cells.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Li, ZW; Xu, L; Zhu, LY; Zhao, YF; Hu, T; Yin, BX; Liu, YJ; Hou, YL or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C-H Di- and Trifluoromethoxylation WOS:000572121300001 published article about ALPHA-FLUORINATED ETHERS; LASER FLASH-PHOTOLYSIS; TRANSITION-METAL-FREE; ELECTROCHEMICAL OXIDATION; PHOTOREDOX CATALYSIS; ALCOHOL OXIDATION; NITROXYL RADICALS; ELECTRON-TRANSFER; EFFICIENT; CHEMISTRY in [Lee, Johnny W.; Lim, Sanghyun; Ngai, Ming-Yu] SUNY Stony Brook, Dept Chem, Stony Brook, NY 11794 USA; [Lee, Johnny W.; Lim, Sanghyun; Ngai, Ming-Yu] SUNY Stony Brook, Inst Chem Biol & Drug Discovery, Stony Brook, NY 11794 USA; [Maienshein, Daniel N.; Liu, Peng] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA in 2020.0, Cited 120.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

Applications of TEMPO(.)catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO(+)redox catalytic cycle. Mechanistic studies also suggest that Li(2)CO(3)plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO(.)catalysis.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Lee, JW; Lim, S; Maienshein, DN; Liu, P; Ngai, MY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives WOS:000502686300016 published article about NUCLEOPHILIC-SUBSTITUTION REACTIONS; CELL-CYCLE ARREST; DNA-BINDING; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; THIOREDOXIN REDUCTASE; INTERACTION MECHANISM; SPECTRAL PROPERTIES; COPPER(II) COMPLEX; ANTITUMOR-ACTIVITY in [Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui] Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China; [Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2020.0, Cited 90.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4

Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O’-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O’-dkt is beta-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination method that involves spontaneous formation of the corresponding diketonate scaffold. The obtained palladium(II) complexes have been characterized by NMR spectroscopy, ESI-mass spectrometry as well as elemental analysis. The cytotoxicity analysis indicates that most of the obtained palladium(II) complexes show promising growth inhibition in three human cancer cell lines. Flow cytometry analysis shows complex 3e could promote intracellular reactive oxygen species (ROS) accumulation and lead cancer cell death. And the suppression of ROS accumulation and the rescue of cell viability in HeLa cells by N-acetyl-L-cysteine (NAC) suggest the possible link between the increase in ROS generation and cytotoxicity of complex 3e. Flow cytometry analysis also reveal that complex 3e cause cell cycle arrest in the G2/M phase and collapse of the mitochondrial membrane potential, promote the generation of ROS and lead to tumor cell apoptosis. The interactions of complex Be with calf thymus DNA (CT-DNA) have been evaluated by UV-Vis spectroscopy, fluorescence quenching experiments and viscosity measurements, which reveal that the complex interact with CT-DNA through minor groove binding and/or electrostatic interactions. Further, the results of fluorescence titration and site marker competitive experiment on bovine serum albumin (BSA) suggest that complex 3e can quench the fluorescence of BSA via a static quenching process and bind to BSA in Sudlow’s site II.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wei, XN; Yang, YX; Ge, JF; Lin, X; Liu, DD; Wang, SX; Zhang, JC; Zhou, GQ; Li, SH or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles