Category: 100-83-4

Authors Ocak, H; Ozerol, EA; Celikel, FC; Okutan, M; Eran, BB in SPRINGER INTERNATIONAL PUBLISHING AG published article about SHAPED LIQUID-CRYSTALS; CARBOXYL CONNECTING GROUPS; SMECTIC-A PHASE; HOMOLOGOUS SERIES; LATERAL SUBSTITUENTS; MESOPHASE BEHAVIOR; LINKAGE GROUPS; POLAR ORDER; TRANSITION; MOLECULES in [Ocak, Hale; Celikel, Fulya Cagla; Eran, Belkiz Bilgin] Yildiz Tech Univ, Dept Chem, TR-34220 Istanbul, Turkey; [Ozerol, Esma Ahlatcioglu] Yildiz Tech Univ, Dept Bioengn, TR-34220 Istanbul, Turkey; [Okutan, Mustafa] Yildiz Tech Univ, Dept Phys, TR-34220 Istanbul, Turkey in 2020.0, Cited 51.0. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

The synthesis, mesomorphic and dielectric investigation of new unsymmetrical bent-core mesogens derived from 3-hydroxybenzoic acid central core with linked two rodlike units carrying (S)-3,7-dimethyloctyloxy group and an n-alkyloxy chain at both terminals are presented. The liquid crystalline properties of the new unsymmetrical bent-core materials have been investigated by polarizing optical microscopy and differential scanning calorimetry. New compounds with the reversed ester linking unit exhibit a monotropic or enantiotropic columnar mesophase at lower temperatures as compared to analogs with a straight chain depending on the presence of the branched (S)-3,7-dimethyloctyloxy terminal chain. Dielectric measurements for one of the bent-core mesogens, 3-[[4-[[4-(octyloxy)benzoyl]oxy]benzoyl]oxy]benzoic acid 4-[[4-((S)-3,7-dimethyloctyloxy)phenoxy]carbonyl]phenyl ester (OBDPE), have been carried out on the angular frequency range from 25.12 to 50265k rad/s at different temperatures. Thanks to dielectric measurements, real and imaginary dielectric constant, conductivity mechanism and dielectric relaxation mechanism of OBDPE were obtained. [GRAPHICS] .

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Ocak, H; Ozerol, EA; Celikel, FC; Okutan, M; Eran, BB or concate me.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 100-83-4. Recently I am researching about DRUG DISCOVERY; HEME-BINDING; DESIGN; MALARIA; ANTIBACTERIAL; ANALOGS; BEARING; 1,3,4-OXADIAZOLE; DOCKING; THIAZOLE, Saw an article supported by the Alexandria University-Research Enhancement Program (ALEXREP)Alexandria University [HLTH-13, BASIC-13]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Bekhit, AA; Saudi, MN; Hassan, AMM; Fahmy, SM; Ibrahim, TM; Ghareeb, D; El-Seidy, AM; Nasralla, SN; Bekhit, AEA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

New 1,3,4-trisubstituted pyrazole derivatives were synthesized and evaluated for their antiplasmodial activity. Compounds 4b, 4c, 7a and 7d were the most potent antiplasmodial agents against P. berghei with percent of suppression ranging from 90 to 100%. They were also screened for their in vitro antimalarial activity against the chloroquine resistant strain P. faldparum, (RKL9). Compound 4c displayed the highest in vitro antimalarial activity; 13-fold higher than standard chloroquine phosphate. Molecular docking of the most active compounds against the wildtype and quadruple mutant pf DHFR-TS structures rationalized the in vitro antimalarial activity. Furthermore, these compounds exhibited reasonable in silico drug-likeness and pharmacokinetic properties. Toxicity studies of the most active compounds revealed that all tested compounds were non-toxic and well-tolerated up to 150 mg/kg via oral route and 75 mg/kg via parentral route. According to RBC hemolysis assay, it was found that compound 7a was the most potent anti-inflammatory and least toxic derivative with IC50 value 71-fold higher than IC50 value related to the antimalarial activity. Moreover, cytotoxicity assessment revealed that compound 4c was the least toxic derivative with IC50 value 70000-fold higher than IC50 value related to the antimalarial activity. (C) 2018 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Bekhit, AA; Saudi, MN; Hassan, AMM; Fahmy, SM; Ibrahim, TM; Ghareeb, D; El-Seidy, AM; Nasralla, SN; Bekhit, AEA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-Hydroxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Synthesis, antimicrobial, anticancer and QSAR studies of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substituted phenylaminoethanones published in 2019.0, Reprint Addresses Narasimhan, B (corresponding author), Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

A series of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diaze pin-1-yl]-2-substituted phenylaminoethanones (1-17) was synthesized and evaluated in vitro for its antimicrobial and anticancer activities. Results of antimicrobial screening indicated that 1-[4-[4-C hloro-phenyl)-2-[(3-nitro-phenylazo)-methyl]-benzo[b][1,4]diazepin-1-yl]-2-(2-methyl-5-nitro-phenyl amino)-ethanone (16) and 1-[4-(3,4-dimethoxy-phenyl)-2-[(4-nitro-phenylazo)-methyl]-benzo [b][1,4]diazepin-1-yl]-2-(3-nitrophenylamino)-ethanone (17) were found to be the most effective antimicrobial agents. The anticancer screening results indicated that 1-[4-(4-dimethylaminophenyl)-2-(p-tolylazo-methyl)-benzo[b][1,4]diazepin-1-yl]-2-phenyl aminoethanone (1, IC50 = 1.42 mu M/mL against HCT 116 cancer cell lines) was the most potent anticancer agent and was more potent than 5-FU. The results of QSAR studies demonstrated the importance of topological parameters, Kier’s alpha first order shape index (kappa alpha(1)) and valence zero order molecular connectivity index ((0)chi(v)) in describing antimicrobial activity, LUMO and kappa alpha(2) in describing anticancer activity of 1-[4-(substituted phenyl)-2-(substituted phenyl azomethyl)-benzo[b]-[1,4]diazepin-1-yl]-2-substitu ted phenylaminoethanones. (C) 2015 The Authors. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Verma, D; Kumar, P; Narasimhan, B; Ramasamy, K; Mani, V; Mishra, RK; Majeed, AA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Beatty, JW; Lindsey, EA; Thomas-Tran, R; Debien, L; Mandal, D; Jeffrey, JL; Tran, AT; Fournier, J; Jacob, SD; Yan, XL; Drew, SL; Ginn, E; Chen, A; Pham, AT; Zhao, SR; Jin, LX; Young, SW; Walker, NP; Leleti, MR; Moschutz, S; Strater, N; Powers, JP; Lawson, KV in AMER CHEMICAL SOC published article about ECTO-5′-NUCLEOTIDASE; INSIGHTS; 5-NUCLEOTIDASE; EXPRESSION; ANTI-CD73; ADENOSINE; THERAPY; CD39 in [Beatty, Joel W.; Lindsey, Erick A.; Thomas-Tran, Rhiannon; Debien, Laurent; Mandal, Debashis; Jeffrey, Jenna L.; Tran, Anh T.; Fournier, Jeremy; Jacob, Steven D.; Yan, Xuelei; Drew, Samuel L.; Ginn, Elaine; Chen, Ada; Pham, Amber T.; Zhao, Sharon; Jin, Lixia; Young, Stephen W.; Walker, Nigel P.; Leleti, Manmohan Reddy; Powers, Jay P.; Lawson, Kenneth, V] Arcus Biosci Inc, Hayward, CA 94545 USA; [Moschuetz, Susanne; Straeter, Norbert] Univ Leipzig, Ctr Biotechnol & Biomed, Inst Bioanalyt Chem, D-04103 Leipzig, Germany in 2020.0, Cited 32.0. Product Details of 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

CD73 is an extracellular mediator of purinergic signaling. When upregulated in the tumor microenvironment, CD73 has been implicated in the inhibition of immune function through overproduction of adenosine. Traditional efforts to inhibit CD73 have involved antibody therapy or the development of small molecules, the most potent of which mimic the acidic and ionizable structure of the enzyme’s natural substrate, adenosine 5′-monophosphate (AMP). Here, we report the systematic discovery of a novel class of non-nucleotide CD73 inhibitors that are more potent than all other nonphosphonate inhibitor classes reported to date. These efforts have culminated in the discovery of 4(-{5-[4-fluoro-1-(2H-indazol-6-yl)-1H-1,2,3-benzotriazol-6-yl]-1H-pyrazol-1-yl}methyl)benzonitrile (73, IC50 = 12 nM) and 4-({5[4-4-chloro-1-(2H-indazol-6-yl)-1H-1,2,3-benzotriazol-6-yl]-1H-pyrazol-1-yl}methyl)benzonitrile (74, IC50 = 19 nM). Cocrystallization of 74 with human CD73 demonstrates a competitive binding mode. These compounds show promise for the improvement of drug-like character via the attenuation of the acidity and low membrane permeability inherent to known nucleoside inhibitors of CD73.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Beatty, JW; Lindsey, EA; Thomas-Tran, R; Debien, L; Mandal, D; Jeffrey, JL; Tran, AT; Fournier, J; Jacob, SD; Yan, XL; Drew, SL; Ginn, E; Chen, A; Pham, AT; Zhao, SR; Jin, LX; Young, SW; Walker, NP; Leleti, MR; Moschutz, S; Strater, N; Powers, JP; Lawson, KV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ONE-POT SYNTHESIS; SOLVENT PROMOTED ADDITION; EFFICIENT SYNTHESIS; QUINAZOLIN-4(3H)-ONES; DERIVATIVES; CONVENIENT; OXIDE, Saw an article supported by the University of Newcastle Postgraduate Research Scholarship (UNPRS); Australian Research Council (ARC Discovery Project)Australian Research Council [DP180101781]; Australian Cancer Research Foundation; Ramaciotti Foundation. HPLC of Formula: C7H6O2. Published in CSIRO PUBLISHING in CLAYTON ,Authors: O’Brien, NS; McCluskey, A. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

An elegantly simple, facile, and robust approach to a scaffold of biological importance, 2,3-dihydroquinazolin-4(1H)-ones, is reported. A catalytic 1% SnCl2/microwave-mediated approach afforded access to pure material, collected by cooling and filtration after 20-min microwave irradiation at 120 degrees C. Atotal of 41 analogues were prepared in isolated yields of 17-99 %. This process was highly tolerant of aliphatic, aromatic, heterocyclic, and acyclic aldehydes, but furan, pyrrole, and thiophene aldehyde reactivity correlated with propensity towards electrophilic addition and/or Diels-Alder addition. As a result, thiophene afforded high yields (80 %) whereas pyrrole carboxaldehyde failed to react. With simple cinnamaldehydes, and in the SbCl3-mediated reaction, and with alpha,beta-unsaturated aldehydes the equivalent quinazolin-4(3H)-ones, and not the 2,3-dihydroquinazolin-4(1H)-ones, was favoured.

HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact O’Brien, NS; McCluskey, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHENOLIC METABOLITES; MASS-SPECTROMETRY; HUMAN PLASMA; MEAT INTAKE; BIOMARKER; IDENTIFICATION; POLYPHENOLS; CONSUMPTION; BIOAVAILABILITY; QUANTIFICATION, Saw an article supported by the Spanish Ministry of Economy and Competitiveness (MINECO) [PCIN-2015-238]; (FEDER Program from the European Union); Generalitat de Catalunya’s Agency AGAUR [2017 SGR 1546]; EIT Health Project COOK2HEALTH; Juan de la Cierva program from MINECO [FJCI-2015-26590]; Biotechnology and Biological Sciences Research Council (BBSRC)UK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/R012512/1, BBS/E/F/000PR10343, BBS/E/F/000PR10346]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gonzalez-Dominguez, R; Urpi-Sarda, M; Jauregui, O; Needs, PW; Kroon, PA; Andres-Lacueva, C. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Name: 3-Hydroxybenzaldehyde

Accurate dietary assessment is a challenge in nutritional research, needing powerful and robust tools for reliable measurement of food intake biomarkers. In this work, we have developed a novel quantitative dietary fingerprinting (QDF) approach, which enables for the first time the simultaneous quantitation of about 350 urinary food-derived metabolites, including (poly)phenolic aglycones, phase II metabolites, and microbial-transformed compounds, as well as other compounds (e.g., glucosinolates, amino acid derivatives, methylxanthines, alkaloids, and markers of alcohol and tobacco consumption). This method was fully validated for 220 metabolites, yielding good linearity, high sensitivity and precision, accurate recovery rates, and negligible matrix effects. Furthermore, 127 additional phase II metabolites were also included in this method after identification in urines collected from acute dietary interventions with various foods. Thus, this metabolomic approach represents one-step further toward precision nutrition and the objective of improving the accurateness and comprehensiveness in the assessment of dietary patterns and lifestyles.

Name: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Gonzalez-Dominguez, R; Urpi-Sarda, M; Jauregui, O; Needs, PW; Kroon, PA; Andres-Lacueva, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Pedrood, K; Sherafati, M; Mohammadi-Khanaposhtani, M; Asgari, MS; Hosseini, S; Rastegar, H; Larijani, B; Mahdavi, M; Taslimi, P; Erden, Y; Gunay, S; Gulcin, I in ELSEVIER published article about in [Pedrood, Keyvan; Sherafati, Maedeh; Larijani, Bagher; Mahdavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran; [Mohammadi-Khanaposhtani, Maryam] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran; [Asgari, Mohammad Sadegh] Iran Univ Sci & Technol, Dept Chem, Tehran, Iran; [Hosseini, Samanesadat] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmaceut Chem, Tehran, Iran; [Rastegar, Hossein] MOHE, Cosmet Prod Res Ctr, Iranian Food & Drug Adm, Tehran, Iran; [Taslimi, Parham] Bartin Univ, Fac Sci, Dept Biotechnol, TR-74100 Bartin, Turkey; [Erden, Yavuz; Gunay, Sevilay] Bartin Univ, Fac Sci, Dept Mol Biol & Genet, TR-74100 Bartin, Turkey; [Gulcin, Ilhami] Ataturk Univ, Fac Sci, Dept Chem, TR-25240 Erzurum, Turkey in 2021, Cited 100. SDS of cas: 100-83-4. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

In this study, novel quinazolinone derivatives 7a-n were synthesized and evaluated against metabolic enzymes including alpha-glycosidase, acetylcholinesterase, butyrylcholinesterase, human carbonic anhydrase I, and II. These compounds exhibited high inhibitory activities in comparison to used standard inhibitors with K-i values in the range of 19.28-135.88 nM for alpha-glycosidase (K-i value for standard inhibitor = 187.71 nM), 0.68-23.01 nM for acetylcholinesterase (K-i value for standard inhibitor = 53.31 nM), 1.01-29.56 nM for butyrylcholinesterase (K-i value for standard inhibitor = 58.16 nM), 10.25-126.05 nM for human carbonic anhydrase I (K-i value for standard inhibitor = 248.18 nM), and 13.46-178.35 nM for human carbonic anhydrase II (K-i value for standard inhibitor = 323.72). Furthermore, the most potent compounds against each enzyme were selected in order to evaluate interaction modes of these compounds in the active site of the target enzyme. Cytotoxicity assay of the title compounds 7a-n against cancer cell lines MCF-7 and LNCaP demonstrated that these compounds do not show significant cytotoxic effects. (C) 2020 Published by Elsevier B.V.

SDS of cas: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Pedrood, K; Sherafati, M; Mohammadi-Khanaposhtani, M; Asgari, MS; Hosseini, S; Rastegar, H; Larijani, B; Mahdavi, M; Taslimi, P; Erden, Y; Gunay, S; Gulcin, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 100-83-4. In 2020.0 EUR J MED CHEM published article about OXIDOREDUCTASE 1 NQO1; DT-DIAPHORASE; OXIDATIVE STRESS; CANCER; CYTOTOXICITY; EXPRESSION; SENSITIVITY; METABOLISM; APOPTOSIS; REDUCTASE in [Wu, Li-Qiang; Liu, Zhao-Peng] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, Jinan 250012, Peoples R China; [Wu, Li-Qiang; Ma, Xin; Zhang, Chong] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China in 2020.0, Cited 44.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed anti-tumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of beta-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. In cellular mechanistic studies, the representative compound 3o triggered ROS generation depending on the NQO1 dose, and induce HepG2 cell apoptosis by the generated oxidative stress. In HepG2 xenografts mouse model, at the dose of 20 mg/kg, 3o remarkably suppressed the tumor growth without affecting the animal weights. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wu, LQ; Ma, X; Zhang, C; Liu, ZP or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Continuous Flow Preparation of (Hetero)benzylic Lithiums via Iodine-Lithium Exchange Reaction under Barbier Conditions WOS:000562077400036 published article about DTBB-CATALYZED LITHIATION; BENZYLIC CHLORIDES; ALCOHOLS; THIOLS in [Weidmann, Niels; Harenberg, Johannes H.; Knochel, Paul] Ludwig Maximilians Univ Munchen, Dept Chem, D-81377 Munich, Germany in 2020.0, Cited 49.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Recommanded Product: 100-83-4

Herein we report the generation of benzylic lithiums via an iodine-lithium exchange reaction on benzylic iodides performed in continuous flow using tBuLi as the exchange reagent. The resulting benzylic lithium species are trapped in situ by carbonyl electrophiles under Barbier conditions, resulting in benzylic secondary and tertiary alcohols. This flow procedure further allows the generation of highly reactive heterobenzylic lithium compounds, which are difficult to generate under batch conditions. A general scale-up was possible without further optimization.

Recommanded Product: 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Weidmann, N; Harenberg, JH; Knochel, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalyst free sequential one-pot reaction for the synthesis of 3-indole propanoates/propanoic acid/propanamides as antituberculosis agents WOS:000603439600001 published article about ASYMMETRIC MICHAEL ADDITION; FRIEDEL-CRAFTS ALKYLATION; MELDRUMS ACID; EASY ACCESS; INDOLES; DERIVATIVES; APOPTOSIS; PYRIDINE; ALPHA; ENANTIOSELECTIVITY in [Rajeev, Narasimhamurthy; Sharath Kumar, Kothanahally S.; Bommegowda, Yadaganahalli K.; Sadashiva, Marilinganadoddi P.] Univ Mysore, Dept Studies Chem, Mysuru 570006, India; [Rangappa, Kanchugarakoppal S.] Univ Mysore, Inst Excellence, Mysuru 570006, India in 2021.0, Cited 51.0. Computed Properties of C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A highly efficient catalyst free one pot four component synthesis of highly functionalized three-substituted indole derivatives has been reported. Thus, sequential catalyst free condensation of readily available aldehydes with Meldrum’s acid followed by Michael addition of indole resulting three carbon component condensed product and concurrent decarboxylation by the nucleophilic attack of ethanol/water/amines affords three-indole propanoates/propanoic acid/propanamides in affordable yields. Further, synthesized compounds and standard drugs were evaluated against Mycobacterium tuberculosis H37Rv strain by Alamar blue assay method. Majority of the compounds exhibited the superior activity and specifically compound 4d has MIC 1.6 mu g/ml, which is better than the reference drugs used.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Rajeev, N; Kumar, KSS; Bommegowda, YK; Rangappa, KS; Sadashiva, MP or concate me.. Computed Properties of C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles