Category: 1008-89-5

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Deliberately Losing Control of C-H Activation Processes in the Design of Small-Molecule-Fragment Arrays Targeting Peroxisomal Metabolism.Quality Control of 2-Phenylpyridine.

1-Biphenylylpyrrolidones,and 2-biphenylyl- and 2-terphenylylpyridines were prepared by photochem. arylation of 1-arylpyrrolidones and 2-arylpyridines with arenediazonium tetrafluoroborates. Combined photochem. arylation, “”nuisance effect”” (SNAr) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination Reactions were deliberately allowed to run “”out of control”” in terms of selectivity; for example the ortho-arylation of 2-phenylpyridine gave five products resulting from mono- and bisarylations combined with SNAr processes. As a result, a number of crystallog. hits against NUDT7, a key peroxisomal CoA ester hydrolase, have been identified.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Mitochondrial targeted rhodium(III) complexes: Synthesis, characterized and antitumor mechanism investigation, the main research direction is rhodium phenylpyridine imidazophenanthrolinyldiphenylaniline complex preparation anticancer phosphorescence lifetime; Apoptosis; Mitochondrial; ROS; Rhodium complexes.Recommanded Product: 1008-89-5.

Recently, rhodium complexes have received intensive attentions due to their tunable chem. and biol. properties as well as attractive antitumor activity. In this work, two imidazole triphenylamino rhodium complexes [Rh(ppy)2L1]PF6 (Rh1) and [Rh(ppy)2L2]PF6 (Rh2) (ppy = 2-phenylpyridine, L1 = 4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline, L2 = N-(4-(1H-imidazo[4,5-f][1,10]phenanthrolin-2-yl)phenyl)-4-methyl-N-(p-tolyl)aniline) have been synthesized and characterized. Both complexes display stronger anticancer activity against a various of cancer cells than cisplatin and they can effectively localize to mitochondria. Further mechanism studies show that Rh1 induce caspase-dependent apoptosis through mitochondrial damage, down-regulate the expression of B-cell lymphoma-2 (Bcl-2)/Bcl2-associated x (Bax) and reactive oxygen species (ROS) elevation. Our work provides a strategy for the construction of highly effective anticancer agents targeting mitochondrial metabolism through rational modification of rhodium complexes.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Khan, Danish; Parveen, Iram; Shaily; Sharma, Saurabh published the article 《Design, Synthesis and Characterization of Aurone Based α,β-unsaturated Carbonyl-Amino Ligands and their Application in Microwave Assisted Suzuki, Heck and Buchwald Reactions》. Keywords: diaryl aminomethylenebenzofuranone preparation; arylboronic acid aryl bromide palladium catalyst Suzuki Miyaura coupling; biaryl preparation; bromobenzene alkene palladium catalyst microwave assisted Mizoroki Heck reaction; phenyl alkene preparation; bromobenzoic acid aniline palladium catalyst microwave Buchwald Hartwig reaction; phenylamino benzoic acid preparation.They researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).SDS of cas: 1008-89-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1008-89-5) here.

A new series of phosphine-free aurone-based α,β-unsaturated carbonyl-amino bidentate ligands I [R1 = 2-furanyl, Ph, 3-4-dimethoxyphenyl, etc.; R2 = Ph, 3-nitrophenyl, 1-naphthyl, etc.] were synthesized and characterized via different anal. techniques such as IR, 1H-NMR, 13C-NMR and mass spectrometry. Moreover, the structure of ligand I [R1 = 2-furanyl; R2 = 2-nitrophenyl] was also characterized by single-crystal X-ray diffraction. The synthesized ligands I with the PdCl2 salt showed excellent catalytic activity in the Suzuki-Miyaura, Mizoroki-Heck and Buchwald-Hartwig reactions. A broad range of substrates including heterocycles, chalcones and sterically hindered coupling partners were well tolerated in the developed protocol. Addnl., the metal complex formed in the catalytic cycle was characterized by 1H-NMR spectroscopy and mass spectrometry.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation, published in 2021-04-11, which mentions a compound: 1008-89-5, mainly applied to dipyrrinato iridium complex preparation antimicrobial photodynamic inactivation therapy; crystal structure dipyrrinato iridium complex antimicrobial photodynamic inactivation therapy; mol structure dipyrrinato iridium complex; dipyrromethane oxidation chloroanil reagent; (dipyrrinato)iridium(III) complexes; antimicrobial photodynamic inactivation; dipyrrins; glycosylation; photodynamic therapy, Application of 1008-89-5.

The generation of bio-targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo-)therapy. A synthetic strategy is presented in which chelating dipyrrin moieties were used to enhance the known photoactivity of Ir(III) metal complexes. Formed complexes can thus be functionalized in a facile manner with a range of targeting groups at their chem. active reaction sites. Dipyrrins with N- and O-substituents afforded (dipy)iridium(III) complexes via complexation with the resp. Cp*-Ir(III) and ppy-Ir(III) precursors (dipy = dipyrrinato, Cp* = pentamethyl-η5-cyclopentadienyl, ppy = 2-phenylpyridyl). Similarly, electron-deficient [Ir(III)(dipy)(ppy)2] complexes could be used for post-functionalization, forming alkenyl, alkynyl and glyco-appended Ir(III) complexes. The phototoxic activity of these complexes was assessed in cellular and bacterial assays with and without light; the [Ir(III)(Cl)(Cp*)(dipy)] complexes and the glyco-substituted Ir(III) complexes showing particular promise as photomedicine candidates. Representative crystal structures of the complexes are also presented.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Importance of Two-Electron Processes in Fe-Catalyzed Aryl-(hetero)aryl Cross-Couplings: Evidence of Fe0/Fe(II) Couple Implication, published in 2021-10-11, which mentions a compound: 1008-89-5, mainly applied to iron catalyzed aryl heteroaryl halide coupling reaction Grignard reagent; biaryl preparation; kinetics coupling reaction Grignard reagent aryl halide iron catalyst, Related Products of 1008-89-5.

Two drastically distinct mechanisms can be involved in aryl-(hetero)aryl Fe-mediated cross-couplings between Grignard reagents and organic halides, depending on the nature of the latter. (Hetero)aryl electrophiles, which easily undergo 1-electron reduction, can be involved in a Fe(II)/Fe(III) coupling sequence featuring an in situ generated organoiron(II) species, akin to their aliphatic analogs. However, less easily reduced substrates can be activated by transient Fe0 species formed by the reduction of the precatalyst. In this case, the coupling mechanism relies on two-electron elementary steps involving the Fe0/Fe(II) redox couple and proceeds by an oxidative addition/reductive elimination sequence. Hammett anal. shows that both those elementary steps are faster for electrophiles substituted by electron-withdrawing groups. The two mechanisms discussed herein can be involved concomitantly for electrophiles displaying an average oxidative power. Attesting to the feasibility of the aforementioned bielectronic mechanism, high-spin organoiron(II) intermediates formed by two-electron oxidative addition onto (hetero)aryl halides in catalytically relevant conditions were also characterized for the 1st time. Those results are sustained by paramagnetic 1H NMR, kinetics monitoring, and d. functional theory (DFT) calculations

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called A Mild Method for Electrochemical Reduction of Heterocyclic N-Oxides, published in 2020-06-01, which mentions a compound: 1008-89-5, Name is 2-Phenylpyridine, Molecular C11H9N, Safety of 2-Phenylpyridine.

Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chem. or enzymic methods. In this work, we report on an expedient protocol for electrochem. reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring. Thus, e.g., 2-phenylpyridine N-oxide → 2-phenylpyridine (89% isolated) by carring out the reaction in an undivided electrochem. cell with two graphite electrodes in 1:1 MeCN/water mixture using LiBF4 as supporting electrolyte.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1008-89-5, is researched, Molecular C11H9N, about Visible-light- and bromide-mediated photoredox Minisci alkylation of N-heteroarenes with ester acetates, the main research direction is ethyl heteroarene preparation; heteroarene ethyl acetate photoredox Minisci alkylation photocatalyst.Computed Properties of C11H9N.

A visible-light-induced photoredox Minisci alkylation reaction of N-heteroarenes such as 7-chloro-2-methylquinoline with Et acetate has been reported. Et acetate was used for the first time as an alkylation reagent with reduced toxicity. Hence, 4-quinazolinones I [R = H, Cl, Et, (2-methoxyethyl)oxidanyl; R1 = H, F, Cl, Br, (2-methoxyethyl)oxidanyl], quinolines such as 7-chloro-2-methylquinoline, and pyridines such as 4-phenylpyridine and 2-phenylpyridine reacted smoothly in the current reaction system. Mechanistic studies indicate that LiBr plays a key role to dramatically improve the efficiency of the reaction by the mediation of hydrogen atom transfer.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C11H9N. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Emission Intensity Enhancement for Iridium(III) Complex in Dimethyl Sulfoxide under Photoirradiation. Author is Hattori, Shingo; Hirata, Shuntaro; Shinozaki, Kazuteru.

We found emission intensity enhancement for fac-Ir(ppy)3 (ppy = 2-(2′-phenyl)pyridine) in aerated DMSO during photoirradiation for the first time. This phenomenon was concluded to be responsible for the consumption of 3O2 dissolved in DMSO through di-Me sulfone production by photosensitized reaction using fac-Ir(ppy)3. A 3O2 adduct of DMSO mol. was detected by UV absorption measurement and theor. calculation We proposed a mechanism for the emission enhancement reaction including 1,3O2 mols. and 1,3O2-DMSO adducts and validated it through a simulation of emission intensity change using an ordinary differential equation solver.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Electric Literature of C11H9N. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Phenylpyridine, is researched, Molecular C11H9N, CAS is 1008-89-5, about Synthesis, characterization and theoretical studies of a series of Iridium(III) heteroleptic complexes with Schiff base ligands. Author is Pradhan, Kahnu Charan; Barik, Sahadev; Singh, Bimal Chandra; Mohapatra, Priyabrat; Kisan, Hemanta Kumar; Pal, Satyanarayan.

A series of Iridium(III) complexes of general formula [Ir(ppy)2(L)]0/+ (ppy = 2-Ph pyridine, L = Schiff base) were synthesized from the dichloro bridged dimeric starting material, [(ppy)2Ir(μ-Cl)2Ir(ppy)2]. Three Schiff bases used as ligand were obtained from condensation of 2-aminophenol with benzaldehyde (L1), salicylaldehyde with 2-aminopyridine (L2) and pyridine 2-aldehyde with 2-aminopyridine (L3). All the complexes were characterized by IR, 1H NMR, electronic absorption spectroscopy and cyclic voltammetry studies. Mol. structure of two of these complexes were determined by single crystal x-ray structure anal. Complexes displayed several weak absorptions in visible region in the range of 401-499 nm. TDDFT calculations on complexes revealed the ligand orbital dominance in both HOMO and LUMO orbitals and subsequent ligand centered transitions were observed in absorption spectra.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Moon, Yonghoon; Lee, Wooseok; Hong, Sungwoo researched the compound: 2-Phenylpyridine( cas:1008-89-5 ).Name: 2-Phenylpyridine.They published the article 《Visible-Light-Enabled Ortho-Selective Aminopyridylation of Alkenes with N-Aminopyridinium Ylides》 about this compound( cas:1008-89-5 ) in Journal of the American Chemical Society. Keywords: blue LED ortho selective aminopyridylation alkene aminopyridinium ylide. We’ll tell you more about this compound (cas:1008-89-5).

By utilizing an underexplored reactivity mode of N-aminopyridinium ylides, we developed the visible-light-induced ortho-selective aminopyridylation of alkenes via radical-mediated 1,3-dipolar cycloaddition The photocatalyzed single-electron oxidation of N-aminopyridinium ylides generates the corresponding radical cations that enable previously inaccessible 1,3-cycloaddition with a broader range of alkene substrates. The resulting cycloaddition adducts rapidly undergo subsequent homolytic cleavage of the N-N bond, conferring a substantial thermodn. driving force to yield various β-aminoethylpyridines. Remarkably, amino and pyridyl groups can be installed into both activated and unactivated alkenes with modular control of ortho-selectivity and 1,2-syn-diastereoselectivity under metal-free and mild conditions. Combined exptl. and computational studies are conducted to clarify the detailed reaction mechanism and the origins of site selectivity and diastereoselectivity.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles