With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.108438-43-3,Methyl 1-methyl-1H-indole-3-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 3 Preparation of 1-methyl-3-indoloylguanidine hydrochloride The reaction was carried out in a manner similar to Example 1 except for using 1.00 g (5.29 mmol) of methyl 1-methyl-3-indolecarboxylate, 5.05 g (52.9 mmol) of guanidine hydrochloride and 50 ml of a methanol solution of 2.85 g (52.9 mmol) of sodium methoxide. Thus 0.48 g (35.9%) of 1-methyl-3-indoloylguanidine hydrochloride was obtained. M.P.: 252-253 C. 1H NMR (DMSO-d6) delta: 3.91 (3H, s), 7.25-7.37 (2H, m), 7.58-7.61 (1H, m), 8.15 (1H, dd, J=1.3, 6.6 Hz), 8.3 (2H, br-s), 8.6 (2H, br-s), 8.78 (1H, s), 11.8 (1H, br-s)., 108438-43-3
The synthetic route of 108438-43-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sumitomo Pharmaceutical Co., Ltd.; US6169107; (2001); A;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles