Category: 120-14-9

An article Atom-Economic Synthesis of Highly Functionalized Bridged Ring Systems Initiated by Ring Expansion of Indene-1,3-dione WOS:000649101400062 published article about DIELS-ALDER REACTION; CYCLOADDITION REACTIONS; FACILE SYNTHESIS; BOND ACTIVATION; TROPONES; ALKALOIDS; INSERTION in [Mu, Yuanyang; Yao, Qiyi; Yin, Liqiang; Fu, Siyi; Wang, Mengdan; Yuan, Yang; Li, Yanzhong] East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China; [Kong, Lingkai] Linyi Univ, Sch Chem & Chem Engn, Linyi 276000, Shandong, Peoples R China in 2021.0, Cited 60.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Application In Synthesis of 3,4-Dimethoxybenzaldehyde

An atom economic procedure for the regioselective synthesis of bridged seven-membered-ring compounds from simple reactants such as ynones and indene-1,3-dione has been developed. This process was realized through the one-pot reactions of ring-expansion of indene-1,3-dione with alkynyl ketones and successive formal [4+2] cycloaddition. The Michael addition reaction is the key for the regioselectivity of the formal [4+2] cycloaddition.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Mu, YY; Yao, QY; Yin, LQ; Fu, SY; Wang, MD; Yuan, Y; Kong, LK; Li, YZ or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population WOS:000626516000003 published article about ASSOCIATION in [Tian, Xue; Zuo, Yingting; Zhang, Licheng; Luo, Yanxia] Capital Med Univ, Sch Publ Hlth, Dept Epidmiol & Hlth Stat, 10 Xitoutiao, Beijing 100069, Peoples R China; [Tian, Xue; Zuo, Yingting; Zhang, Licheng; Luo, Yanxia] Beijing Municipal Key Lab Clin Epidmiol, Beijing, Peoples R China; [Wang, Anxin] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China; [Wang, Anxin] Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; [Chen, Shuohua; Wu, Shouling] North China Univ Sci & Technol, Kailuan Hosp, Dept Cardiol, 57 Xinhua East Rd, Tangshan 063000, Peoples R China in 2021.0, Cited 37.0. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Background Evidence on longitudinal variability of serum uric acid (SUA) and risk of all-cause mortality in the general population is limited, as many prior studies focused on a single measurement of SUA. Methods A total of 53,956 participants in the Kailuan study who underwent three health examinations during 2006 to 2010 were enrolled. Variability of SUA was measured using the coefficient of variation (primary index), standard deviation, average real variability, and variability independent of the mean. Cox proportional hazard regressions were used to calculate the hazard ratio (HR) and 95% confidence interval (CI) for the association of variability of SUA with subsequent risk of all-cause mortality, considering its magnitude and the direction and across different baseline SUA categories. Results Over a median follow-up of 7.04 years, 2728 participants died. The highest variability of SUA was associated with an increased risk of all-cause mortality, the HR was 1.33 (95% CI, 1.20-1.49) compared with the lowest variability. In this group, both a large fall (HR, 1.28; 95% CI, 1.14-1.44) and rise (HR, 1.18; 95% 1.05-1.32) in SUA were related to risk of all-cause mortality. These associations were similar across different baseline SUA categories. Consistent results were observed in alternative measures of SUA variability. Moreover, individuals with higher variability in SUA were more related to common risk factors than those with stable SUA. Conclusions Higher variability in SUA was independently associated with the risk of all-cause mortality irrespective of baseline SUA and direction of variability in the general population.

HPLC of Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Tian, X; Wang, AX; Zuo, YT; Chen, SH; Zhang, LC; Wu, SL; Luo, YX or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Akhmadiev, NS; Mescheryakova, ES; Akhmetova, VR; Ibragimov, AG in [Akhmadiev, Nail S.; Mescheryakova, Ekaterina S.; Akhmetova, Vnira R.; Ibragimov, Askhat G.] Russian Acad Sci, Inst Petrochem & Catalysis, 141 Praspekt Octyabrya, Ufa 450075, Russia published Metal-free multicomponent synthesis of novel macrocyclic tetrathiadienes with cyano and amino groups in 2021.0, Cited 37.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

The first synthesis of 5,12-diamino-7,14-bis(aryl)-1,4,8,11-tetrathiacyclotetradeca-5,12-diene-6,13-dicarbonitriles was performed as a multicomponent macroheterocyclization of malononitrile, aryl aldehydes, and 1,2-ethanedithiol in the presence of a catalytic amount of triethylamine in ethanol. The structures of the obtained macroheterocycles were confirmed by spectral methods, X-ray diffraction, and MALDI TOF mass spectrometry.

Welcome to talk about 120-14-9, If you have any questions, you can contact Akhmadiev, NS; Mescheryakova, ES; Akhmetova, VR; Ibragimov, AG or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Shaik, AB; Bhandare, RR; Nissankararao, S; Lokesh, BVS; Shahanaaz, S; Rahman, MM in [Shaik, Afzal B.] Jawaharlal Nehru Technol Univ, Vignan Pharm Coll, Dept Pharmaceut Chem, Vadlamudi 522213, Andhra Pradesh, India; [Bhandare, Richie R.] Ajman Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, POB 346, Ajman, U Arab Emirates; [Lokesh, Bontha Venkata Subrahmanya] UCSI Univ, Fac Pharmaceut Sci, Kuala Lumpur, Malaysia; [Shahanaaz, Shaik] Victoria Coll Pharm, Dept Pharmaceut Chem, Nallapadu 522001, Andhra Pradesh, India; [Rahman, M. Mukhlesur] Univ East London, Sch Hlth Sports & Biosci, Med Res Grp, Stratford Campus,Water Lane, London E15 4LZ, England; [Bhandare, Richie R.] Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates published Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents in 2021.0, Cited 65.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

A series of twenty new chloropyrazine conjugated benzothiazepines (22-41) have been synthesized with 58%-95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, H-1 NMR, C-13 NMR spectroscopy and mass spectrometry. The synthesized compounds (22-41) and their precursor chalcones (2-21) were evaluated for antitubercular and cytotoxic activities. Additionally, compounds 22-41 were also tested for antimicrobial activity. Among the chalcone series (2-21), compounds 7 and 14 showed significant antitubercular activities (MICs 25.51 and 23.89 mu M, respectively), whereas among benzothiazepines (22-41), compounds 27 and 34 displayed significant antimicrobial (MICs 38.02 mu M, 19.01 mu M) and antitubercular (MIC 18.10 mu M) activities. Compounds 7 and 41 displayed cytotoxic activities with IC50 of 46.03 +/- 1 and 35.10 +/- 2 mu M respectively. All the compounds were evaluated for cytotoxic activity on normal human liver cell lines (L02) and found to be relatively less selective towards this cell line. The most active compounds identified through this study could be considered as potential leads for the development of drugs with possible antimicrobial, antitubercular, and cytotoxic activities. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Lokesh, BVS; Shahanaaz, S; Rahman, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL in [Cheng, Xi-Chuang; Qin, Zhao; Yang, Qiao-Li; Liu, Hua-Min; Wang, Xue-De; Liu, Yu-Lan] Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou 450001, Henan, Peoples R China published Sequential Extraction of Organosolv Lignin from Chinese Quince Fruit: Structural Features and Antioxidant Activities of the Obtained Fractions in 2021.0, Cited 33.0. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Lignin from the Chinese quince (Chaenomeles sinensis) fruit offers a promising source of natural antioxidant for industrial applications. However, the utilization of Chinese quince fruit lignin is restricted by its inhomogeneous nature. Accordingly, Chinese quince fruit lignin was sequentially fractionated with organic solvents of increasing dissolving capacity to prepare homogeneous lignin fractions. The GPC (gel permeation chromatography) results showed that the molecular weights of lignin fractions increased from dichloromethane fraction to dioxane/water fraction. The five lignin fractions were also compared with respect to yield, carbohydrate content, thermal stability, inter-unit linkages, S/G ratios, and phenolic OH content. Among the five fractions, the ethyl acetate fraction showed a lower proportion of p-o-tv linkages (48.4%), the highest thermal stability, the highest phenolic OH content (2.8 mmol/g), and the highest DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging index and reducing power. The high antioxidant performance of the ethyl acetate fraction implies that it can be used as a natural antioxidant. This study shows that sequential solvent fractionation of lignin can produce homogeneous fractions with enhanced antioxidant performance. In addition, it demonstrates that Chinese quince fruits are a potentially valuable natural resource.

Welcome to talk about 120-14-9, If you have any questions, you can contact Cheng, XC; Qin, Z; Yang, QL; Liu, HM; Wang, XD; Liu, YL or send Email.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. I found the field of Chemistry very interesting. Saw the article Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids published in 2021.0, Reprint Addresses Gill, C (corresponding author), Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

An operationally simple, one-pot multicomponent reaction has been developed for the assembly of pyrido[2,3-d]pyrimidine and pyrazolo[3,4-b]pyridine derivatives (4a-4am) in excellent yields (92-94%) with high purity. The reactions were easy to perform simply by mixing of electron-rich amino heterocycles (including aminouracils and aminopyrazoles), aldehyde, and acyl acetonitrile in the presence of [Et3NH][HSO4] under solvent-free conditions. The remarkable feature of the present approach is that the ionic liquid possesses dual solvent-catalytic engineering capability. Results of this study revealed that 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60 degrees C is the best reaction parameter for the construction of fused pyridine and pyrimidine derivatives in excellent yields. The present methodology showed good results under gram-scale conditions, thereby indicating its applicability in industrial as well as academic settings in the near future.

Welcome to talk about 120-14-9, If you have any questions, you can contact Jadhav, C; Nipate, A; Chate, A; Gill, C or send Email.. Product Details of 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Patil, VS; Yadavalli, SR; Merugu, R; Swamy, SJ; Devunuri, N in TAYLOR & FRANCIS INC published article about DERIVATIVES; MELANOMA; DESIGN in [Patil, Vikas S.; Yadavalli, Subba Rao; Devunuri, Nagaraju] Vignans Fdn Sci Technol & Res VFSTR Deemed Univ, Div Chem, Dept Sci & Humanities, Guntur 522213, Andhra Pradesh, India; [Merugu, Ramchander] Mahatma Gandhi Univ, Dept Bio Chem, Nalgonda, India; [Swamy, S. J.] Kakatiya Univ, Dept Chem, Warangal, Andhra Pradesh, India in 2021.0, Cited 31.0. Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient one-pot two-step synthesis of substituted-triazolo[4,3-a]quinoxalin-4(5H)-one has been developed. The 3-hydrazineylquinoxalin-2(1H)-one reacts with respective aldehyde to afford the individual hydrazineylidene intermediate which undergoes oxidative cyclization in the presence of ferric chloride hexahydrate (FeCl3.6H(2)O) to affords various substituted- triazolo[4,3-a]quinoxalin-4(5H)-one in good to excellent yields.

Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 CHEM BIOL DRUG DES published article about CANDIDA-ALBICANS; PYRIDINIUM DYES; RESISTANCE; COMBINATION; DERIVATIVES; AZOLES; AGENTS; PATHOGENICITY; FLUCONAZOLE; MECHANISMS in [Vaitkiene, Simona; Kuliesiene, Neringa; Sakalauskaite, Sandra; Daugelavicius, Rimantas] Vytautas Magnus Univ, Dept Biochem, Kaunas, Lithuania; [Bekere, Laura; Krasnova, Laura; Vigante, Brigita; Duburs, Gunars] Latvian Inst Organ Synth, Riga, Latvia in 2021.0, Cited 39.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Application In Synthesis of 3,4-Dimethoxybenzaldehyde

We synthesized a set of 13 new and earlier described styrylpyridinium compounds (N-alkyl styrylpyridinium salts with bromide or tosylate anions) in order to evaluate antifungal activity againstC. albicanscells, to assay the possible synergism with fluconazole, and to estimate cytotoxicity to mammalian cells. All compounds were synthesized according to a well-known two-step procedure involving alkylation of gamma-picoline with appropriate alkyl bromide and further condensation with substituted benzaldehyde. Compounds with longN-alkyl chains(C18H37-C20H41) had no antifungal activity against the cells of all testedC. albicansstrains. Other styrylpyridinium compounds were able to inhibit yeast growth at the concentrations of 0.06-16 mu g/ml. At fungicidal concentrations, the compound with the CN- group was least toxic to mammalian cells, showed the most effective synergism with fluconazole, and only slightly inhibited the respiration ofC. albicans. The compound with the 4 ‘-diethylamino group exhibited the strongest fungicidal properties and effectively blocked the respiration ofC. albicanscells. However, toxicity to mammalian cells was also high. Summarizing, the results of our study indicate that styrylpyridinium compounds are promising candidates in the development of new antifungal drugs.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. Authors Kaur, R; Kumar, R; Dogra, N; Kumar, A; Yadav, AK; Kumar, M in FUTURE SCI LTD published article about in [Kaur, Ramandeep; Yadav, Ashok Kumar; Kumar, Manoj] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India; [Kumar, Rajnish] Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Dogra, Nilambra; Kumar, Ashok] Panjab Univ, Ctr Syst Biol & Bioinformat, Chandigarh 160014, India in 2021, Cited 66. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures. Materials & methods: Biological evaluation, cytotoxicity assessment, molecular docking, binding free energy calculations and molecular dynamics studies were performed for hybrids. Results: The most potent inhibitor A-10 (IC50 = 24.73 +/- 0.93 mu M) was competitive in manner and observed as non-cytotoxic. A-10 possessed higher efficacy than the standard drug (acarbose) during in vivo biological testing. Conclusion: The enzyme inhibitory potential and safety profile of synthetic molecules was recognized after in vitro, in vivo, in silico and cytotoxicity studies. Further structural optimization of A-10 can offer potential hit molecules suitable for future investigations.

SDS of cas: 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Kaur, R; Kumar, R; Dogra, N; Kumar, A; Yadav, AK; Kumar, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Authors Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Polaquini, Carlos R.; Marques, Beatriz C.; Ayusso, Gabriela M.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Morao, Luana G.; Cavalca, Lucia B.; Ferreira, Henrique] Sao Paulo State Univ Unesp, Inst Biosci, Dept Biochem & Microbiol, BR-13050690 Rio Claro, SP, Brazil; [Sardi, Janaina C. O.; Rosalen, Pedro L.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Campinas, SP, Brazil; [Sardi, Janaina C. O.] Fed Univ Mato Grosso do Sul Ufms, Sch Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS, Brazil; [Campos, Debora L.; Silva, Isabel C.; Pavan, Fernando R.] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Biol Sci, BR-14800903 Araraquara, SP, Brazil; [Cavalca, Lucia B.; Scheffers, Dirk-Jan] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen, Netherlands; [Rosalen, Pedro L.] Fed Univ Alfenas Unifal, Sch Dent, BR-37130000 Alfenas, MG, Brazil in 2021, Cited 75. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have been shown to overcome these barriers. We synthesized and investigated the antibacterial activity of a series of unsymmetrical MACs derived from acetone against Mycobacterium tuberculosis and Gram-negative and Gram-positive species. Phenolic MACs 4, 6 and 8 showed a broad spectrum and potent activity, mainly against M. tuberculosis, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), with MIC (minimum inhibitory concentration) values ranging from 0.9 to 15.6 mu g/mL. The investigation regarding toxicity on human lung cells (MRC-5 and A549 lines) revealed MAC 4 was more selective than MACs 6 and 8, with SI (selectivity index) values ranging from 5.4 to 15.6. In addition, MAC 4 did not demonstrate genotoxic effects on A549 cells and it was more stable than CUR in phosphate buffer (pH 7.4) for 24 h at 37 degrees C. Fluorescence and phase contrast microscopies indicated that MAC 4 has the ability to disrupt the divisome of Bacillus subtilis without damaging its cytoplasmic membrane. However, biochemical investigations demonstrated that MAC 4 did not affect the GTPase activity of B. subtilis FtsZ, which is the main constituent of the bacterial divisome. These results corroborated that MAC 4 is a promising antitubercular and antibacterial agent.

Welcome to talk about 120-14-9, If you have any questions, you can contact Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO or send Email.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles