Category: 120-14-9

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT in [Al-Ahmed, Zehbah Ali] King Khalid Univ, Coll Art & Sci Dhahran Aljounb, Abha, Saudi Arabia; [Habib, Ibrahim H. I.; Abdelhameed, Reda M.; El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Giza 12311, Egypt; [Khattab, Reham R.; Abu Bieh, Moursi H.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Giza, Egypt; [El-Naggar, Mohamed] Univ Sharjah, Dept Chem, Fac Sci, Sharjah, U Arab Emirates; [Pisarevd, Sergey A.] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka, Russia; [Voronkov, Andrey] Digital Bio Pharm Ltd, 145-157 St John St, London EC1V 4PW, England published Synthesis, spectrophotometric, voltammetric, and density functional theory studies of tetrahydro[3,2-b]indolocarbazoles for sensing small molecules in 2021.0, Cited 39.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Absorption spectra of tetrahydro[3,2-b]indolocarbazoles (THICZs) with respective molecular property and alkyl substituents have been prerecorded in diverse solvents in the scope between 200 and 600 nm for very fewer times in the literary study. The photo-physical behavior of liquified THICZs belonging to the existence surroundings. The solvatochromic behaviors of THICZs and solvent substance physical phenomenon can be analyzed by implementation of linear solvating energy state conception. Compound 4 shows excellent properties for sensing small molecules. The electrochemical behavior of some THICZs was investigated at carbon paste electrode where two electrode reactions were involved, irreversible oxidation-one electron transfer and quasi-reversible redox reactions forming phenolic followed by quinolone moiety electro active species. The density functional theory which means calculated molecular orbital energies (B3LYP/6-31G) and HOMO-LUMO gap/space for some presented indolocarbazoles have been performed.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, Synthesis, and Anticancer Screening for Repurposed Pyrazolo[3,4-d]pyrimidine Derivatives on Four Mammalian Cancer Cell Lines WOS:000655074500001 published article about SERUM; INHIBITION; MECHANISMS; CELECOXIB; ANTITUMOR in [Othman, Eman M.; Dandekar, Thomas] Univ Wurzburg, Bioctr, Dept Bioinformat, D-97074 Wurzburg, Germany; [Othman, Eman M.; Bekhit, Amany A.] Minia Univ, Fac Pharm, Dept Biochem, Al Minya 61519, Egypt; [Anany, Mohamed A.] Univ Hosp Wuerzburg, Dept Internal Med 2, Div Mol Internal Med, D-97080 Wurzburg, Germany; [Anany, Mohamed A.] Natl Res Ctr, Dept Microbial Biotechnol, Div Genet Engn & Biotechnol, Giza 12622, Egypt; [Ragab, Hanan M.] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21500, Egypt; [Wahid, Ahmed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Biochem, Alexandria 21500, Egypt in 2021.0, Cited 44.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Name: 3,4-Dimethoxybenzaldehyde

The present study reports the synthesis of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to mono-, di-, and trimethoxy benzylidene moieties through hydrazine linkages. First, in silico docking experiments of the synthesized compounds against Bax, Bcl-2, Caspase-3, Ki67, p21, and p53 were performed in a trial to rationalize the observed cytotoxic activity for the tested compounds. The anticancer activity of these compounds was evaluated in vitro against Caco-2, A549, HT1080, and Hela cell lines. Results revealed that two (5 and 7) of the three synthesized compounds (5, 6, and 7) showed high cytotoxic activity against all tested cell lines with IC50 values in the micro molar concentration. Our in vitro results show that there is no significant apoptotic effect for the treatment with the experimental compounds on the viability of cells against A549 cells. Ki67 expression was found to decrease significantly following the treatment of cells with the most promising candidate: drug 7. The overall results indicate that these pyrazolopyrimidine derivatives possess anticancer activity at varying doses. The suggested mechanism of action involves the inhibition of the proliferation of cancer cells.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Authors Zhou, LC; Shi, XM; Yin, HH; Huang, Y; Wang, R; Ma, L in WILEY-V C H VERLAG GMBH published article about in [Zhou, Licheng; Shi, Ximeng; Yin, Huanhuan; Huang, Yi; Wang, Rui; Ma, Lei] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2021, Cited 36. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The complex pathogenesis of Alzheimer’s disease (AD) has become a major obstacle in its therapy. One hopeful approach is to develop multifuntional ligands. Here, a total of 23 compounds based on nobiletin structure were designed and synthesized. The neuroprotective activities were evaluated for their antioxidant, anti-inflammatory and anti-A beta(42) (Amyloid beta-protein 42) neurotoxicity properties by MTT assays. The results demonstrated compound A12 was the most promising derivative against inflammatory (14.6 +/- 0.6 %) and cell damages induced by hydrogen peroxide (47.2 +/- 1.1 %), oxygen glucose deprivation (36.2 +/- 1.1 %) and A beta(42) (40.7 +/- 2.1 %). Molecular docking study revealed A12 formed a greater area of interactions with A beta(42) to prevent it from acquiring a beta sheet conformation for aggregation. Structure-activity relationships revealed the introduction of hydroxyl on ring B and aurone skeleton with a five-membered ring C could be benefit to increase their neuroprotective activities. In summary, A12 might represent a promising multifunctional neuroprotective agent against AD.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Zhang, XY; Dou, PH; Lu, WY; You, Y; Zhao, JQ; Wang, ZH; Yuan, WC in ROYAL SOC CHEMISTRY published article about in [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya; You, Yong; Zhao, Jian-Qiang; Wang, Zhen-Hua; Yuan, Wei-Cheng] Chengdu Univ, Inst Adv Study, Chengdu 610106, Peoples R China; [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya] Chinese Acad Sci, Chengdu Inst Organ Chem, Natl Engn Res Ctr Chiral Drugs, Chengdu 610041, Peoples R China; [Zhang, Xia-Yan; Dou, Pei-Hao; Lu, Wen-Ya] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2021.0, Cited 38.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

By taking advantage of benzylidene succinimides as a new class of 3C synthons, a highly diastereo- and enantioselective tandem Mannich reaction/transamidation has been established by reacting them with cyclic trifluoromethyl N-acyl ketimines. Using a Cinchona alkaloid-derived squaramide as the catalyst, the tandem reaction proceeded smoothly under mild conditions and afforded a range of F3C-containing chiral polycyclic dihydroquinazolinones with excellent results (up to 99% yield, all cases >20 : 1 dr, up to 99% ee).

Category: indole-building-block. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. In 2021 EUR J MED CHEM published article about ALZHEIMERS-DISEASE; A-BETA; CHEMICAL-SYNTHESIS; DESIGN; ABAD/17-BETA-HSD10; IDENTIFICATION; OPTIMIZATION; DERIVATIVES; CHEMISTRY; PEPTIDE in [Boutin, Sophie; Maltais, Rene; Roy, Jenny; Poirier, Donald] CHU Quebec, Res Ctr, Lab Med Chem, Endocrinol & Nephrol Unit, Quebec City, PQ, Canada; [Boutin, Sophie; Poirier, Donald] Univ Laval, Fac Med, Dept Mol Med, Quebec City, PQ, Canada in 2021, Cited 47. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

17beta-Hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is the only mitochondrial member of 17 beta-HSD family. This enzyme can oxidize estradiol (E2) into estrone (E1), thus reducing concentration of this neuroprotective steroid. Since 17 beta-HSD10 possesses properties that suggest a possible role in Alzheimer’s disease, its inhibition appears to be a therapeutic strategy. After we identified the androsterone (ADT) derivative 1 as a first steroidal inhibitor of 17 beta-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17 beta-HSD3 and to optimize the inhibitory potency. From six D-ring derivatives of 1 (17-C = O), two compounds (17 beta-H/17 alpha-OH and 17 beta-OH/17aC CH) were more metabolically stable and did not inhibit the 17 beta-HSD3. Moreover, solid phase synthesis was used to extend the molecular diversity on the 3b-piperazinylmethyl group of the steroid base core. Eight over 120 new derivatives were more potent inhibitors than 1 for the transformation of E2 to E1, with the 4-(4-trifluoromethyl-3-methoxybenzyl)piperazin-1-ylmethyl-ADT (D-3,7) being 16 times more potent (IC50 = 0.14 mM). Finally, D-ring modification of D-3,7 provided 17 beta-OH/17 alpha-C CH derivative 25 and 17 beta-H/17 alpha-OH derivative 26, which were more potent inhibitor than 1 (1.8 and 2.4 times, respectively). (C) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 120-14-9, If you have any questions, you can contact Boutin, S; Maltais, R; Roy, J; Poirier, D or send Email.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Pottie, E; Kupriyanova, OV; Shevyrin, VA; Stove, CP in AMER CHEMICAL SOC published article about in [Pottie, Eline; Stove, Christophe P.] Univ Ghent, Fac Pharmaceut Sci, Dept Bioanal, Lab Toxicol, B-9000 Ghent, Belgium; [Kupriyanova, Olga, V] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, Kazan 420008, Russia; [Kupriyanova, Olga, V] Kazan State Med Univ, Kazan 420012, Russia; [Shevyrin, Vadim A.] Ural Fed Univ, Inst Chem & Technol, Ekaterinburg 620002, Russia in 2021.0, Cited 30.0. Product Details of 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Serotonergic psychedelics, substances exerting their pharmacological action through activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a substantial fraction of the over 1000 reported New Psychoactive Substances (NPS) so far. Within this category, N-benzyl derived phenethylamines, such as NBOMes and NBFs, have shown to be of particular relevance. As these substances remain incompletely characterized, this study aimed at synthesizing positional isomers of 25H-NBF, with two methoxy groups placed on different positions of the phenyl group of the phenethylamine moiety. These isomers were then functionally characterized in an in vitro bioassay monitoring the recruitment of beta-arrestin 2 to the 5HT(2A)R through luminescent readout via the NanoBiT technology. The obtained results provide insight into the optimal substitution pattern of the phenyl group of the phenethylamine moiety of N-benzyl derived substances, a feature so far mostly explored in the phenethylamines underived at the N-position. In the employed bioassay, the most potent substances were 24H-NBF (EC50 value of 158 nM), 26H-NBF (397 nM), and 25H-NBF (448 nM), with 23H-NBF, 35H-NBF, and 34H-NBF yielding mu M EC50 values. A similar ranking was obtained for the compounds’ efficacy: taking as a reference LSD (lysergic acid diethylamide), 24H-, 26H-, and 25H-NBF had an efficacy of 106-107%, followed by 23H-NBF (96.1%), 34H-NBF (75.2%), and 35H-NBF (58.9%). The stronger activity of 24H-, 25H-, and 26H-NBF emphasizes the important role of the methoxy group at position 2 of the phenethylamine moiety for the in vitro functionality of NBF substances.

Product Details of 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Malasala, Satyaveni; Akunuri, Ravikumar; Madhavi, Y., V; Nanduri, Srinivas] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, Telangana, India; [Ahmad, Md Naiyaz; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India; [Ahmad, Md Naiyaz; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] AcSIR, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2021.0, Cited 58.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Owing to the rapid rise in antibiotic resistance, infectious diseases have become serious threat to public health. There is an urgent need to develop new antimicrobial agents with diverse chemical structures and novel mechanisms of action to overcome the resistance. In recent years, Quinazoline-benzimidazole hybrids have emerged as a new class of antimicrobial agents active against S. aureus and M. tuberculosis. In the current study, we designed and synthesized fifteen new Quinazoline-benzimidazole hybrids and evaluated them for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine potent antibacterial agents 8a, 8b, 8c, 8d, 8f, 8g, 8h, 8i and 10c with MICs in the range of 4-64 mu g/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clinical isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC50 = 40->= 200 mu g/mL) and demonstrated a favourable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives have emerged as promising antimicrobial agents for the treatment of MDR-S. aureus and Mycobacterial infections. (C) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. In 2021 ACS CATAL published article about TO-HEAD DIMERIZATION; NONAROMATIC CATECHOL BIOISOSTERES; AZA-CLAISEN REARRANGEMENT; TERMINAL ARYL ALKYNES; CONJUGATED ENYNES; SELECTIVE DIMERIZATION; CATALYZED DIMERIZATION; PALLADIUM COMPLEXES; TAIL DIMERIZATION; PALLADACYCLE in [Pfeffer, Camilla; Wannenmacher, Nick; Frey, Wolfgang; Peters, Rene] Univ Stuttgart, Inst Organ Chem, D-70569 Stuttgart, Germany in 2021, Cited 69. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Enynes are important motifs in bioactive compounds. They can be synthesized by alkyne-alkyne couplings for which a number of mechanisms have been suggested depending on catalyst type and dominant product isomers. Regarding bimetallic pathways, hydrometalations and anti-carbopalladations have been discussed to account for the formation of geminally substituted and (Z)-configured enynes, respectively. Here we report a bimetallic alkyne-alkyne coupling that yields (E)-configured enynes. An unusual type of acetylide Pd bridging was found in putative catalytic intermediates which is arguably responsible for the regio- and stereochemical reaction outcome. Mechanistic studies suggest that a double mu-kappa:eta(2) acetylide bridging enables a bimetallic syn-carbometalation. Interestingly, depending on the reaction conditions, it is also possible to form the geminal regioisomer as major product with the same catalyst. This regiodivergent outcome is explained by bi-versus monometallic reaction pathways.

Welcome to talk about 120-14-9, If you have any questions, you can contact Pfeffer, C; Wannenmacher, N; Frey, W; Peters, R or send Email.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M in WILEY-V C H VERLAG GMBH published article about in [Peshkov, Anatoly A.; Bakulina, Olga; Dar’in, Dmitry; Kantin, Grigory; Bannykh, Anton; Krasavin, Mikhail] St Petersburg State Univ, Dept Nat Prod Chem, Inst Chem, 26 Univ Skyi Prospekt, Peterhof 198504, Russia; [Peshkov, Vsevolod A.] Nazarbayev Univ, Dept Chem, Sch Sci & Humanities, Nur Sultan 010000, Kazakhstan; [Krasavin, Mikhail] Immanuel Kant Baltic Fed Univ, Kaliningrad 236041, Russia; [Bannykh, Anton] Univ Jyvaskyla, Dept Chem, Survontie 9B, Jyvaskyla 40014, Finland in 2021.0, Cited 27.0. Safety of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A practical straightforward synthesis of medicinally important NH-delta-lactams through the three-component Castagnoli-Cushman reaction of 3-arylglutaconic anhydrides with carbonyl compound and ammonium acetate has been developed. The scope of the protocol has been thoroughly explored paying particular attention to the carbonyl component using wide array of aliphatic and aromatic aldehydes as well as rarely involved cyclic and acyclic ketones. Synthetic potential of prepared compounds was demonstrated by a series of post-modifications, including unexpected isomerization.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M or concate me.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors El-Helw, EAE; Morsy, ARI; Hashem, AI in WILEY published article about in [El-Helw, Eman A. E.; Hashem, Ahmed I.] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt; [Morsy, Alaa R. I.] Agr Res Ctr, Cent Lab Evaluat Vet Biol CLEVB, Cairo, Egypt in 2021.0, Cited 38.0. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The hydrazide obtained from furan-2(3H)-one integrated with a quinolin-2(1H)-one core reported previously by our research group was utilized as a building block synthon to obtain some pyrrolone, pyridazinone, oxadiazole, and triazole derivatives through treating with some carbon electrophilic reagents, for example, chloroacetyl chloride, benzoyl chloride, acetic anhydride, carbon disulfide, 3,4-dimethoxybenzaldehyde, and 2-oxoquinolin-3-carbaldehyde to achieve the target heterocycles. The newly synthesized compounds were evaluated as immunomodulator against highly pathogenic avian influenza virus (H5N8). The compounds 1, 11, and 17 displayed the highest potency (100% protection).

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact El-Helw, EAE; Morsy, ARI; Hashem, AI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles