Category: 120-14-9

Authors Awasthi, A; Yadav, P; Tiwari, DK in ROYAL SOC CHEMISTRY published article about in [Awasthi, Annapurna; Yadav, Pushpendra; Tiwari, Dharmendra Kumar] Ctr Biomed Res CBMR, Mol Synth & Drug Discovery Unit, SGPGIMS Campus,Raibareli Rd, Lucknow 226014, Uttar Pradesh, India; [Awasthi, Annapurna; Yadav, Pushpendra] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 63.0. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available alpha-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This high-yielding reaction proceeds through a [3+2]-cycloaddition reaction between alkylidene pyrazolones and a nonstabilized azomethine ylide generated in situ. This method provides easy and smooth access to a variety of highly functionalized aza-spirocyclic pyrazolones in excellent yields (up to 96%). The obtained spiro-pyrazolones comprise four contiguous stereogenic centers including a quaternary carbon center.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Awasthi, A; Yadav, P; Tiwari, DK or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ALZHEIMERS-DISEASE; A-BETA; CHEMICAL-SYNTHESIS; DESIGN; ABAD/17-BETA-HSD10; IDENTIFICATION; OPTIMIZATION; DERIVATIVES; CHEMISTRY; PEPTIDE, Saw an article supported by the Merck Sharpe & Dome e Faculte de medecine (Universite Laval); Mitacs Inc (Montreal, QC, Canada); foundation of CHU de Quebec (Endocrinology and Nephrology Unit); Faculty of Medicine of Universite Laval. Category: indole-building-block. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Boutin, S; Maltais, R; Roy, J; Poirier, D. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

17beta-Hydroxysteroid dehydrogenase type 10 (17 beta-HSD10) is the only mitochondrial member of 17 beta-HSD family. This enzyme can oxidize estradiol (E2) into estrone (E1), thus reducing concentration of this neuroprotective steroid. Since 17 beta-HSD10 possesses properties that suggest a possible role in Alzheimer’s disease, its inhibition appears to be a therapeutic strategy. After we identified the androsterone (ADT) derivative 1 as a first steroidal inhibitor of 17 beta-HSD10, new analogs were synthesized to increase the metabolic stability, to improve the selectivity of inhibition over 17 beta-HSD3 and to optimize the inhibitory potency. From six D-ring derivatives of 1 (17-C = O), two compounds (17 beta-H/17 alpha-OH and 17 beta-OH/17aC CH) were more metabolically stable and did not inhibit the 17 beta-HSD3. Moreover, solid phase synthesis was used to extend the molecular diversity on the 3b-piperazinylmethyl group of the steroid base core. Eight over 120 new derivatives were more potent inhibitors than 1 for the transformation of E2 to E1, with the 4-(4-trifluoromethyl-3-methoxybenzyl)piperazin-1-ylmethyl-ADT (D-3,7) being 16 times more potent (IC50 = 0.14 mM). Finally, D-ring modification of D-3,7 provided 17 beta-OH/17 alpha-C CH derivative 25 and 17 beta-H/17 alpha-OH derivative 26, which were more potent inhibitor than 1 (1.8 and 2.4 times, respectively). (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Boutin, S; Maltais, R; Roy, J; Poirier, D or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalyst-free visible-light induced synthesis of nitrogen- and oxygen-containing heterocycles from 1,3-diketones WOS:000604195100001 published article about ONE-POT SYNTHESIS; POLYHYDROQUINOLINE DERIVATIVES; ORGANIC-SYNTHESIS; CHEMISTRY in [Chen, Lu; Lin, Zhenyuan; Zhang, Xuefang; Tan, Leshi; Zhang, Min; Li, Yibiao] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen, Peoples R China in 2021.0, Cited 40.0. Computed Properties of C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The synthesis of nitrogen- and oxygen-containing heterocycles has found many applications in the preparation of biomedical intermediates, yet actual synthetic procedures display limitations such as high-loading catalysts, harsh reaction conditions and tedious preparation of heterogeneous catalysts. Alternatively, photocatalysis allows to access functional products with minimum synthetic procedures and waste generation. Here, we present an efficient, simple, green protocol for the synthesis of N- and O-containing six-membered-ring compounds under mild conditions under visible blue light. Various aldehydes and 1,3-diketones can be reacted to afford eight series of corresponding 1,4-dihydropyridines and 4H-benzo[b]pyrans. This protocol has some merits such as the use of abundant and sustainable aqueous ethanol as solvent, short reaction time (within 60 min), no need of catalyst and broad functional group tolerance to afford 81 different series of target molecules in 75-96% yield under mild conditions.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chen, L; Lin, ZY; Zhang, XF; Tan, LS; Zhang, M; Li, YB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. Authors Zhou, LC; Shi, XM; Yin, HH; Huang, Y; Wang, R; Ma, L in WILEY-V C H VERLAG GMBH published article about in [Zhou, Licheng; Shi, Ximeng; Yin, Huanhuan; Huang, Yi; Wang, Rui; Ma, Lei] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China in 2021, Cited 36. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The complex pathogenesis of Alzheimer’s disease (AD) has become a major obstacle in its therapy. One hopeful approach is to develop multifuntional ligands. Here, a total of 23 compounds based on nobiletin structure were designed and synthesized. The neuroprotective activities were evaluated for their antioxidant, anti-inflammatory and anti-A beta(42) (Amyloid beta-protein 42) neurotoxicity properties by MTT assays. The results demonstrated compound A12 was the most promising derivative against inflammatory (14.6 +/- 0.6 %) and cell damages induced by hydrogen peroxide (47.2 +/- 1.1 %), oxygen glucose deprivation (36.2 +/- 1.1 %) and A beta(42) (40.7 +/- 2.1 %). Molecular docking study revealed A12 formed a greater area of interactions with A beta(42) to prevent it from acquiring a beta sheet conformation for aggregation. Structure-activity relationships revealed the introduction of hydroxyl on ring B and aurone skeleton with a five-membered ring C could be benefit to increase their neuroprotective activities. In summary, A12 might represent a promising multifunctional neuroprotective agent against AD.

Safety of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Zhou, LC; Shi, XM; Yin, HH; Huang, Y; Wang, R; Ma, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Redox-Neutral Cobalt(III)-Catalyzed C-H Activation/Annulation of alpha,beta-Unsaturated Oxime Ether with Alkyne: One-Step Access to Multisubstituted Pyridine WOS:000606840200088 published article about EFFICIENT SYNTHESIS; 3+2 ANNULATION; ACTIVATION; ENAMIDES; ISOQUINOLINES; IMINES; ROUTE; METAL in [Mohanty, Smruti Ranjan; Pati, Bedadyuti Vedvyas; Banjare, Shyam Kumar; Das Adhikari, Gopal Krushna; Ravikumar, Ponneri Chandrababu] Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, HBNI, Khurja 752050, Odisha, India in 2021.0, Cited 43.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Recommanded Product: 120-14-9

A redox neutral Co(III)-catalyzed annulation of alpha,beta-unsaturated oxime ether with alkyne has been reported. Multisubstituted pyridines were synthesized in good yields without the use of any heavy metal oxidants. The developed methodology tolerates a variety of functional groups. Notably, this transformation has been applied to the late-stage modification of the bioactive molecule dehydropregnenolone.

Recommanded Product: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Mohanty, SR; Pati, BV; Banjare, SK; Das Adhikari, GK; Ravikumar, PC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT in WILEY published article about DERIVATIVES; OXIDATION; SPECTRA; INDOLE in [Al-Ahmed, Zehbah Ali] King Khalid Univ, Coll Art & Sci Dhahran Aljounb, Abha, Saudi Arabia; [Habib, Ibrahim H. I.; Abdelhameed, Reda M.; El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Giza 12311, Egypt; [Khattab, Reham R.; Abu Bieh, Moursi H.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Giza, Egypt; [El-Naggar, Mohamed] Univ Sharjah, Dept Chem, Fac Sci, Sharjah, U Arab Emirates; [Pisarevd, Sergey A.] Russian Acad Sci, Inst Physiol Act Cpds, Chernogolovka, Russia; [Voronkov, Andrey] Digital Bio Pharm Ltd, 145-157 St John St, London EC1V 4PW, England in 2021.0, Cited 39.0. Name: 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Absorption spectra of tetrahydro[3,2-b]indolocarbazoles (THICZs) with respective molecular property and alkyl substituents have been prerecorded in diverse solvents in the scope between 200 and 600 nm for very fewer times in the literary study. The photo-physical behavior of liquified THICZs belonging to the existence surroundings. The solvatochromic behaviors of THICZs and solvent substance physical phenomenon can be analyzed by implementation of linear solvating energy state conception. Compound 4 shows excellent properties for sensing small molecules. The electrochemical behavior of some THICZs was investigated at carbon paste electrode where two electrode reactions were involved, irreversible oxidation-one electron transfer and quasi-reversible redox reactions forming phenolic followed by quinolone moiety electro active species. The density functional theory which means calculated molecular orbital energies (B3LYP/6-31G) and HOMO-LUMO gap/space for some presented indolocarbazoles have been performed.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Al-Ahmed, ZA; Habib, IHI; Khattab, RR; Abdelhameed, RM; El-Naggar, M; Abu Bieh, MH; Pisarevd, SA; Voronkov, A; El Sayed, MT or concate me.. Name: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Recently I am researching about LACTIM-LACTAM TAUTOMERISM; PHOTOPHYSICAL PROPERTIES; SUBSTITUTED IMIDAZOLES; SPECTROSCOPIC APPROACH; ANTIFUNGAL AGENTS; IONIC LIQUIDS; GREEN; OXIDATION; HYDROGEN; SYSTEM, Saw an article supported by the . Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

A rapid practical process has been developed for synthesis of 2,4,5-trisubstituted-imidazoles in excellent yields up to 95% from readily available starting materials. In this CuI catalyzed synthesis, trisubstituted imidazoles were afforded in short reaction times, wherein the substrate scope is well explored with benzoin as well as benzil reacting with different aldehydes in the presence of ammonium acetate as the nitrogen source.

Recommanded Product: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kadu, VD; Mali, GA; Khadul, SP; Kothe, GJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Wang, Bin; Wang, Li-Ren; Liu, Lu-Lu; Wang, Wei; Zheng, Da-Jun; Deng, Yu-Shan; Yang, Yu-Shun; Xu, Chen; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China in 2021.0, Cited 44.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In this work, a series of diaryl benzo[b][1,4]thiazepine derivatives D1-D36 were synthesized and screened as tubulin polymerization inhibitors with anti-tumor potency. They were designed by introducing the seven member ring benzothiazepine as the linker for CA-4 modification for the first time. Among them, the hit compound D8 showed potential on inhibiting the growth of several cancer cell lines (IC50 values: 1.48 mu M for HeLa, 1.47 mu M for MCF-7, 1.52 mu M for HT29 and 1.94 mu M for A549), being comparable with the positive controls Colchicine and CA-4P. The calculated IC50 value of D8 as an tubulin polymerization inhibitor was 1.20 mu M. The results of the flow cytometry assay revealed that D8 could induce the mitotic catastrophe and the death of living cancer cells. D8 also indicated the anti-vascular activity. The possible binding pattern was implied by docking simulation, inferring the possibility of introducing interactions with the nearby tubulin chain. Since the novel structural trial has been conducted with preliminary discussion, this work might stimulate new ideas in further modification of tubulin-related anti-cancer agents and therapeutic approaches.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Wang, B; Wang, LR; Liu, LL; Wang, W; Man, RJ; Zheng, DJ; Deng, YS; Yang, YS; Xu, C; Zhu, HL or concate me.. Quality Control of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-alpha inhibitory activity published in 2021. HPLC of Formula: C9H10O3, Reprint Addresses Abd El-Karim, SS (corresponding author), Natl Res Ctr, Dept Therapeut Chem, Cairo 12622, Egypt.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

A new set of derivatives bearing pyrazole-methylenehydrazono-thiazolidinone scaffold 4-23 was designed, synthesized and confirmed by different spectroscopic means and elemental analyses. In-vivo anti-inflammatory and ulcerogenic evaluation was performed for all the newly synthesized derivatives using indomethacin, celecoxib and diclofenac as standard drugs. The compounds 5, 10, 15, 17, 21, 22 appeared to be the most promising candidates producing rapid onset and long duration of anti-inflammatory activity as well as promising GIT safety profile. Furthermore, analgesic evaluation revealed that the compounds 5, 10, 15 and 22 produced potent and long acting analgesia accompanied with significant inhibition of the inflammatory cytokine TNF-alpha level in comparison with the standard drugs. Molecular docking study of the latter derivatives was also carried out to rationalize their binding affinities and their modes of interactions with the active site of TNF-alpha.

HPLC of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Abd El-Karim, SS; Mohamed, HS; Abdelhameed, MF; Amr, AE; Almehizia, AA; Nossier, ES or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. In 2021.0 EUR J ORG CHEM published article about STEREOSELECTIVE-SYNTHESIS; CRAFTS CYCLIZATION; NATURAL-PRODUCTS; EPICALYXIN-F; SCH 900229; DERIVATIVES; SCAFFOLDS; TETRAHYDROPYRANS; CONSTRUCTION; HETEROCYCLES in [Satteyyanaidu, Vallabhareddy; Chandrashekhar, Rapelli; Reddy, B. V. Subba] CSIR, Indian Inst Chem Technol, Fluoro & Agrochem, Hyderabad 500007, India; [Satteyyanaidu, Vallabhareddy; Chandrashekhar, Rapelli; Reddy, B. V. Subba] Acad Sci & Innovat Res AcSIR, New Delhi 110025, India; [Lalli, Claudia] Univ Rennes, CNRS, ISCR UMR 6226, F-35000 Rennes, France in 2021.0, Cited 53.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

We propose the synthesis of biologically relevant hexahydro-1H-pyrano[3,4-c]chromenes, via a tandem Prins/Friedels-Crafts process, catalyzed by BF3.Et2O, starting from (E)- and (Z)-5-phenoxypent-3-en-1-ol. The diastereoselectivity of the process is controlled by the geometry of the homoallylic alcohol. We also point out that the Prins product can be obtained in high yields and good diastereoselectivity when the reaction is promoted by AlCl3 as Lewis acid in the presence of an external nucleophile.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Satteyyanaidu, V; Chandrashekhar, R; Reddy, BVS; Lalli, C or concate me.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles