Category: 120-14-9

Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M in WILEY-V C H VERLAG GMBH published article about in [Peshkov, Anatoly A.; Bakulina, Olga; Dar’in, Dmitry; Kantin, Grigory; Bannykh, Anton; Krasavin, Mikhail] St Petersburg State Univ, Dept Nat Prod Chem, Inst Chem, 26 Univ Skyi Prospekt, Peterhof 198504, Russia; [Peshkov, Vsevolod A.] Nazarbayev Univ, Dept Chem, Sch Sci & Humanities, Nur Sultan 010000, Kazakhstan; [Krasavin, Mikhail] Immanuel Kant Baltic Fed Univ, Kaliningrad 236041, Russia; [Bannykh, Anton] Univ Jyvaskyla, Dept Chem, Survontie 9B, Jyvaskyla 40014, Finland in 2021.0, Cited 27.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A practical straightforward synthesis of medicinally important NH-delta-lactams through the three-component Castagnoli-Cushman reaction of 3-arylglutaconic anhydrides with carbonyl compound and ammonium acetate has been developed. The scope of the protocol has been thoroughly explored paying particular attention to the carbonyl component using wide array of aliphatic and aromatic aldehydes as well as rarely involved cyclic and acyclic ketones. Synthetic potential of prepared compounds was demonstrated by a series of post-modifications, including unexpected isomerization.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Peshkov, AA; Bakulina, O; Dar’in, D; Kantin, G; Bannykh, A; Peshkov, VA; Krasavin, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Torabi, M; Yarie, M; Zolfigol, MA; Rouhani, S; Azizi, S; Olomola, TO; Maaza, M; Msagati, TAM in ROYAL SOC CHEMISTRY published article about ONE-POT; MAGNETIC NANOPARTICLES; CLAISEN REARRANGEMENT; DERIVATIVES; EFFICIENT; GLYCALS; DRUGS; DECONTAMINATION; HETEROCYCLES; ANTICANCER in [Torabi, Morteza; Yarie, Meysam; Zolfigol, Mohammad Ali] Buali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran; [Rouhani, Shamila; Msagati, Titus A. M.] Univ South Africa, Coll Sci Engn & Technol, Inst Nanotechnol & Water Sustainabil iNanoWS, ZA-1709 Johannesburg, South Africa; [Azizi, Shohreh; Maaza, Malik] Univ South Africa, Coll Grad Studies, UNESCO UNISA Africa Chair Nanosci & Nanotech, POB 392, Pretoria, South Africa; [Azizi, Shohreh] iThemba LABS Natl Res Fdn, Nanosci African Network NANOAFNET, 1 Old Faure Rd,POB 722, ZA-7129 Western Cape, South Africa; [Olomola, Temitope O.] Obafemi Awolowo Univ, Dept Chem, Ife 220005, Nigeria; [Msagati, Titus A. M.] Nelson Mandela African Inst Sci & Technol, Sch Life Sci & Bioengn, POB 447, Arusha, Tanzania in 2021, Cited 96. Quality Control of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

In the present study, we reported the synthesis of a novel quinoline-based dendrimer-like ionic liquid. After characterization of the mentioned ionic liquid with suitable techniques such as Fourier transform infrared spectroscopy (FT-IR), energy dispersive X-ray spectroscopy (EDX), elemental mapping, thermogravimetric analysis (TGA) and derivative thermogravimetry (DTG), its catalytic performance was investigated in the synthesis of new pyridines with sulfonamide moiety via a cooperative vinylogous anomeric-based oxidation mechanism under mild reaction conditions. All target molecules were achieved in short reaction times and high yields.

Quality Control of 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Torabi, M; Yarie, M; Zolfigol, MA; Rouhani, S; Azizi, S; Olomola, TO; Maaza, M; Msagati, TAM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and biological assessment of new selective COX-2 inhibitors including methyl sulfonyl moiety WOS:000600418500058 published article about ORAL DRUGLIKENESS; PREDICTION; DERIVATIVES; SOLUBILITY; DISCOVERY in [Saglik, Begum Nurpelin; Osmaniye, Derya; Levent, Serkan; Cevik, Ulviye Acar; Ozkay, Yusuf; Kaplancikli, Zafer Asim] Anadolu Univ, Fac Pharm, Dept Pharmaceut Chem, TR-26470 Eskisehir, Turkey; [Saglik, Begum Nurpelin; Osmaniye, Derya; Levent, Serkan; Cevik, Ulviye Acar; Ozkay, Yusuf] Anadolu Univ, Fac Pharm, Doping & Narcot Cpds Anal Lab, TR-26470 Eskisehir, Turkey; [Cavusoglu, Betul Kaya] Zonguldak Bulent Ecevit Univ, Fac Pharm, Dept Pharmaceut Chem, TR-67600 Zonguldak, Turkey in 2021, Cited 44. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Nonsteroidal anti-inflammatory drugs (NSAIDs) cause peptic lesions in the gastrointestinal mucosa by inhibiting the cyclooxygenase-1 (COX-1) enzyme. Selective COX-2 inhibition causes decreased side effects over current NSAIDs. Therefore, the studies about selective inhibition of COX-2 enzyme are very important for new drug development. The design, synthesis and biological activity evaluation of novel derivatives bearing thiazolylhydrazine-methyl sulfonyl moiety as selective COX-2 inhibitors were aimed in this paper. The structures of synthesized compounds were assigned using different spectroscopic techniques such as H-1 NMR, C-13 NMR and HRMS. In addition, the estimation of ADME parameters for all compounds was carried out using in silico process. The evaluation of in vitro COX-1/COX-2 enzyme inhibition was applied according to the fluorometric method. According to the enzyme inhibition results, synthesized compounds showed the selectivity against COX-2 enzyme inhibition as expected. Compounds 3a, 3e, 3f, 3g, 3i and 3j demonstrated significant COX-2 inhibition potencies. Among them, compound 3a was found to be the most effective derivative with an IC50 value of 0.140 +/- 0.006 mM. Moreover, it was seen that compound 3a displayed a more potent inhibition profile at least 12-fold than nimesulide (IC50 = 1.684 +/- 0.079 mu M), while it showed inhibitory activity at a similar rate of celecoxib (IC50 = 0.132 +/- 0.005 mu M). Molecular modelling studies aided in the understanding of the interaction modes between this compound and COX-2 enzyme. It was found that compound 3a had a significant binding property. In addition, the selectivity of obtained derivatives on COX-2 enzyme could be explained and discussed by molecular docking studies. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Saglik, BN; Osmaniye, D; Levent, S; Cevik, UA; Cavusoglu, BK; Ozkay, Y; Kaplancikli, ZA or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. I found the field of Chemistry very interesting. Saw the article Synthesis, and biological screening of chloropyrazine conjugated benzothiazepine derivatives as potential antimicrobial, antitubercular and cytotoxic agents published in 2021.0, Reprint Addresses Shaik, AB (corresponding author), Jawaharlal Nehru Technol Univ, Vignan Pharm Coll, Dept Pharmaceut Chem, Vadlamudi 522213, Andhra Pradesh, India.; Bhandare, RR (corresponding author), Ajman Univ, Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, POB 346, Ajman, U Arab Emirates.; Rahman, MM (corresponding author), Univ East London, Sch Hlth Sports & Biosci, Med Res Grp, Stratford Campus,Water Lane, London E15 4LZ, England.; Bhandare, RR (corresponding author), Ajman Univ, Ctr Med & Bioallied Hlth Sci Res, Ajman, U Arab Emirates.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

A series of twenty new chloropyrazine conjugated benzothiazepines (22-41) have been synthesized with 58%-95% yields. The compounds were characterized by using different spectroscopic techniques including FT-IR, H-1 NMR, C-13 NMR spectroscopy and mass spectrometry. The synthesized compounds (22-41) and their precursor chalcones (2-21) were evaluated for antitubercular and cytotoxic activities. Additionally, compounds 22-41 were also tested for antimicrobial activity. Among the chalcone series (2-21), compounds 7 and 14 showed significant antitubercular activities (MICs 25.51 and 23.89 mu M, respectively), whereas among benzothiazepines (22-41), compounds 27 and 34 displayed significant antimicrobial (MICs 38.02 mu M, 19.01 mu M) and antitubercular (MIC 18.10 mu M) activities. Compounds 7 and 41 displayed cytotoxic activities with IC50 of 46.03 +/- 1 and 35.10 +/- 2 mu M respectively. All the compounds were evaluated for cytotoxic activity on normal human liver cell lines (L02) and found to be relatively less selective towards this cell line. The most active compounds identified through this study could be considered as potential leads for the development of drugs with possible antimicrobial, antitubercular, and cytotoxic activities. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Shaik, AB; Bhandare, RR; Nissankararao, S; Lokesh, BVS; Shahanaaz, S; Rahman, MM or concate me.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C9H10O3. Authors Reihani, N; Kiyani, H in BENTHAM SCIENCE PUBL LTD published article about in [Reihani, Neda; Kiyani, Hamzeh] Damghan Univ, Sch Chem, POB 36716-41167, Damghan, Iran; [Kiyani, Hamzeh] Shahrekord Univ, Fac Sci, Dept Chem, Shahrekord, Iran in 2021.0, Cited 67.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient synthesis of 4-arylidene-3-alkylisoxazole-5(4H)-ones has been implemented via the three-component cyclocondensation of aryl(heteroaryl)aldehydes with hydroxylamine hydrochloride and beta-ketoesters. The potassium 2,5-dioxoimidazolidin-1-ide has been introduced as the new organocatalyst to facilitate this heterocyclization. In the current process, three starting materials, including substituted benzaldehydes/heterocyclic aromatic aldehydes, hydroxylamine hydrochloride, and ethyl acetoacetate/propyl acetoacetate/butyryl acetoacetate have been successfully used to synthesize the number of substituted isoxazole-5-(4H)-ones in good to high yields in ethylene glycol as a green reaction medium at 80 degrees C. The low catalyst loading is also a main advantage over some reported catalysts.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Reihani, N; Kiyani, H or concate me.. Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2021.0 ORG LETT published article about ENANTIOSELECTIVE CONSTRUCTION; VINYLETHYLENE CARBONATES; NAZAROV CYCLIZATION; BOND; DESYMMETRIZATION; HETEROCYCLES; REACTIVITY; ALCOHOL; CENTERS; SYSTEM in [Yang, Biwei; Zuo, Linhong; Chang, Xiaowei; Liu, Teng; Cui, Manying; Liu, Yang; Sun, Haiyu; Chen, Weipeng; Guo, Wusheng] Xi An Jiao Tong Univ, Frontier Inst Sci & Technol FIST, Xian 710045, Peoples R China in 2021.0, Cited 71.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

A decarboxylative protocol has been developed toward a range of carbocycles. The key success is based on the use of a batch of newly designed cyclic carbonates as substrates that can provide carbon-carbon zwitterion intermediate under palladium catalysis. The kinetics of the reactions are controllable toward either strained seven- or thermodynamically more favored five-membered carbocycles. The release of this chemistry will shed light on the synthesis of complex and valuable cyclic structures.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Yang, BW; Zuo, LH; Chang, XW; Liu, T; Cui, MY; Liu, Y; Sun, HY; Chen, WP; Guo, WS or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Engineering; Materials Science very interesting. Saw the article A novel method of temporary solidification and extraction of underwater fragile relics in their original state published in 2021.0. COA of Formula: C9H10O3, Reprint Addresses Zhang, BJ (corresponding author), Zhejiang Univ, Dept Cultural Heritage & Museol, Hangzhou 310028, Peoples R China.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Fragile cultural relics at underwater archaeological sites are difficult to preserve in situ over long time periods due to the effects of a complex and constantly changing surrounding environment. Thus, extracting the relics from water and preserving them in a controllable environment is of primary importance. In this paper, the technology of temporary reinforcement and extraction of underwater fragile relics with veratraldehyde followed by a process of secondary temporary reinforcement using polyethylene glycol (PEG) was studied. After investigating the melting temperature and permeability of PEGs with different molecular weights, we found that PEG-3000 is an excellent candidate as the secondary reinforcing agent for the extracted relics. In the laboratory, combined with veratraldehyde and polypropylene-fiber cloth as temporary underwater strengthening materials, and selected dispersed beaded jewelry and a broken three-dimensional crock as our research subject, we carried out an entire retrieval process-temporary stabilization and secondary temporary reinforcement, to systematically evaluate the technological aspects of safely excavating fragile underwater relics in the original state. After being extracted from water and subjected to secondary temporary reinforcement using PEG-3000, the beaded jewelry and broken crock retained their underwater shape and arrangement completely. The use of secondary reinforcing agent prevents the removal process of veratraldehyde and enclosed sediment from affecting the state of the relics.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chen, XQ; Zhang, BJ; Zhang, ZG or concate me.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines WOS:000651228800015 published article about GROWTH-FACTOR RECEPTOR; BIOLOGICAL EVALUATION in [Aziz, Marian W.; Elgendy, Adel A.] Misr Int Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt; [Kamal, Aliaa M.; Mohamed, Khaled O.] Cairo Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Cairo, Egypt; [Kamal, Aliaa M.] October Univ Modern Sci & Arts MSA, Fac Pharm, Dept Pharmaceut Chem, Giza, Egypt in 2021.0, Cited 43.0. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

New acetamide (IV a-e) and 1,3-thiazolidinone derivatives (VII a-e) were designed, synthesized and assessed for their cytotoxic activity against MCF-7 and A549 cell lines along with their lead compounds (erlotinib and gefitinib). The newly designed compounds were prepared according to the adopted procedures in schemes 1 and 2 from their quinazolinone parents. 3D QSAR pharmacophore and docking molecular modeling protocols were conducted using Discovery Studio program, beside a full biological assay for these compounds. The cytotoxicity evaluation demonstrated that compounds IVb, IVc, VIIa, VIIb, VIId exhibited potent cytotoxic activities against both MCF-7 and A549 cell lines. Moreover, the molecular modeling studies corroborated to the affinity of the compounds towards EGFR. Consequently, these five compounds were then screened for their EGFR inhibition and evaluated as well for their toxicity to normal cells, which revealed that the acetamide derivative IVc and the thiazolidinone derivative VIIa were the most potent and least toxic. DNA flow cytometry analysis was conducted for compounds IVc and VIIa, which indicated that they both induced arrest at G2/M phase of the cell cycle.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Aziz, MW; Kamal, AM; Mohamed, KO; Elgendy, AA or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Recently I am researching about HYBRID MAGNETIC NANOCATALYST; ONE-POT; SILICA NANOPARTICLES; GREEN; PROTOCOL, Saw an article supported by the . Published in SPRINGER in NEW YORK ,Authors: Keshavarz, M; Mamaghani, M; Dekamin, MG; Nikpassand, M. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

A heterogeneous organic-inorganic hybrid durable nanocatalyst gamma-Al2O3@Silane-TMG was prepared by covalently functionalization of nano-gamma-Al2O3 through anchored 3-chloropropyl- trimethoxysilane with 1,1,3,3-tetramethylguanidine (TMG). The structure of the catalyst was characterized by various techniques including FT-IR, XRD, SEM, EDX and TGA analyses. The synthesized nanocatalyst was successfully used in an efficient and green four-component synthesis of pyrazolopyranopyrimidine derivatives using ethyl acetoacetate, hydrazine hydrate, arylaldehydes and barbituric acid (or thiobarbituric acid) in H2O at 40 oC. This practical method produced the desired products at reduced reaction times (10-25 min) and high to excellent yields (85-98%). The main advantages of this practical method are the use of heterogeneous basic nanocatalyst, simple work-up procedure with no need to chromatographic purification, affording highly selective conversion and recyclability of the catalyst which could be used in 5 cycles with only a small decrease in its activity. [GRAPHICS] .

Recommanded Product: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Keshavarz, M; Mamaghani, M; Dekamin, MG; Nikpassand, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C9H10O3. Nefisath, P; Dasappa, JP; Haripriya, B; Chopra, D; Venugopala, KN; Deb, PK; Gleiser, RM; Mohanlall, V; Maharaj, R; Shashiprabha; Poojary, V in [Nefisath, P.; Shashiprabha; Poojary, Vishwanatha] Sri Dharmasthala Manjunatheshwara Coll Autonomous, Post Grad Dept Chem, Ujire 574240, India; [Nefisath, P.; Dasappa, Jagadeesh Prasad] Mangalore Univ, Dept Chem, Mangalagangothri, Karnataka, India; [Haripriya, B.; Chopra, Deepak] Indian Inst Sci Educ & Res Bhopal, Dept Chem, Bhopal By Pass Rd, Bhopal 462066, Madhya Pradesh, India; [Venugopala, Katharigatta N.] King Faisal Univ, Coll Clin Pharm, Dept Pharmaceut Sci, Al Hasa 31982, Saudi Arabia; [Venugopala, Katharigatta N.; Mohanlall, Viresh] Durban Univ Technol, Dept Biotechnol & Food Technol, ZA-4001 Durban, South Africa; [Deb, Pran Kishore] Philadelphia Univ, Fac Pharm, Dept Pharmaceut Sci, POB 1, Amman 19392, Jordan; [Gleiser, Raquel M.] UNC, CONICET, IMBIV, CREAN, Av Valparaiso S-N, Cordoba, Argentina; [Gleiser, Raquel M.] Univ Nacl Cordoba, FCEFyN, Av Velez Sarsfield 299, RA-5000 Cordoba, Argentina; [Maharaj, Rajendra] South African Med Res Council, Off Malaria Res Unit, ZA-4091 Durban, South Africa published Synthesis, structural elucidation and larvicidal activity of novel arylhydrazones in 2021.0, Cited 63.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

The present study focuses on a series of novel hydrazones of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carbohydrazide (5a-l) for their larvicidal activity against Anopheles arabiensis. The synthesis of the title compounds was achieved by the conventional reflux method, and structures of the novel compounds were ascertained by FT-IR, NMR (H-1&C-13), LC-MS, and elemental analysis. Compound (5l) was studied by single crystal X-ray diffraction for intra and intermolecular interactions. Title compounds (E)-2-(3-cyano-4-isobutoxyphenyl)-N’-(4-fluoro-3-phenoxybenzylidene)-4-methylthiazole-5-carbohydrazide (5a) and (E)-N’-(4-Chlorobenzylidene)-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carbohydrazide (5g) emerged as promising larvicidal agents against Anopheles arabiensis. (C) 2021 Elsevier B.V. All rights reserved.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Nefisath, P; Dasappa, JP; Haripriya, B; Chopra, D; Venugopala, KN; Deb, PK; Gleiser, RM; Mohanlall, V; Maharaj, R; Shashiprabha; Poojary, V or concate me.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles