Category: 120-14-9

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Authors Kaur, R; Kumar, R; Dogra, N; Kumar, A; Yadav, AK; Kumar, M in FUTURE SCI LTD published article about in [Kaur, Ramandeep; Yadav, Ashok Kumar; Kumar, Manoj] Panjab Univ, Univ Inst Pharmaceut Sci, Chandigarh 160014, India; [Kumar, Rajnish] Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Dogra, Nilambra; Kumar, Ashok] Panjab Univ, Ctr Syst Biol & Bioinformat, Chandigarh 160014, India in 2021, Cited 66. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Aim: Keeping in view the side effects associated with clinically used alpha-glucosidase inhibitors, novel thiazolidinedione-isatin hybrids were synthesized and evaluated by in vitro, in vivo and in silico procedures. Materials & methods: Biological evaluation, cytotoxicity assessment, molecular docking, binding free energy calculations and molecular dynamics studies were performed for hybrids. Results: The most potent inhibitor A-10 (IC50 = 24.73 +/- 0.93 mu M) was competitive in manner and observed as non-cytotoxic. A-10 possessed higher efficacy than the standard drug (acarbose) during in vivo biological testing. Conclusion: The enzyme inhibitory potential and safety profile of synthetic molecules was recognized after in vitro, in vivo, in silico and cytotoxicity studies. Further structural optimization of A-10 can offer potential hit molecules suitable for future investigations.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kaur, R; Kumar, R; Dogra, N; Kumar, A; Yadav, AK; Kumar, M or concate me.. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Awasthi, A; Yadav, P; Tiwari, DK in ROYAL SOC CHEMISTRY published article about in [Awasthi, Annapurna; Yadav, Pushpendra; Tiwari, Dharmendra Kumar] Ctr Biomed Res CBMR, Mol Synth & Drug Discovery Unit, SGPGIMS Campus,Raibareli Rd, Lucknow 226014, Uttar Pradesh, India; [Awasthi, Annapurna; Yadav, Pushpendra] Banaras Hindu Univ, Inst Sci, Dept Chem, Varanasi 221005, Uttar Pradesh, India in 2021.0, Cited 63.0. HPLC of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An efficient, general, and practical route for highly diastereoselective synthesis of aza-spirocyclic pyrazolones from easily available alpha-amino acids, aldehydes, and alkylidene pyrazolones by means of a decarboxylative annulation process is reported. This high-yielding reaction proceeds through a [3+2]-cycloaddition reaction between alkylidene pyrazolones and a nonstabilized azomethine ylide generated in situ. This method provides easy and smooth access to a variety of highly functionalized aza-spirocyclic pyrazolones in excellent yields (up to 96%). The obtained spiro-pyrazolones comprise four contiguous stereogenic centers including a quaternary carbon center.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Awasthi, A; Yadav, P; Tiwari, DK or concate me.. HPLC of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3,4-Dimethoxybenzaldehyde. Authors Kaur, N; Singh, P; Banerjee, P in WILEY-V C H VERLAG GMBH published article about in [Kaur, Navpreet; Singh, Priyanka; Banerjee, Prabal] Indian Inst Technol Ropar, Dept Chem, Rupnagar 140001, Punjab, India in 2021.0, Cited 78.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Herein, we report an efficient protocol for the synthesis of spiro-imidazolidinone-cyclohexadienones from p-quinone methides (p-QMs) and dialkyloxy ureas under mild conditions. The strategy follows a two-step process involving an initial vinylogous conjugate addition of urea derivatives to p-QMs, followed by oxidative dearomative cyclization of open-chain product to the projected spiro-imidazolidinones. This protocol exhibits good functional group tolerance and provides a straightforward method to access spiro-imidazolidinone-cyclohexadienones. In follow-up chemistry, we have shown the debenzylation of spiroimidazolidinones to give N-hydroxycyclic ureas.

Recommanded Product: 3,4-Dimethoxybenzaldehyde. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Kaur, N; Singh, P; Banerjee, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Design, synthesis and application of spiro[4.5]cyclohexadienones via one-pot sequential p-hydroxybenzylation/oxidative dearomatization published in 2021.0. Formula: C9H10O3, Reprint Addresses Chegondi, R (corresponding author), CSIR Indian Inst Chem Technol CSIR IICT, Dept Organ Synth & Proc Chem, Hyderabad 500007, Andhra Pradesh, India.; Chegondi, R (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

One-pot sequential p-hydroxybenzylation/oxidative dearomatization/spiroannulation has been designed for the efficient construction of tetrahydrofuran containing spiro-cyclohexadienones. This reaction proceeds through the p-hydroxybenzylation of 1,3-diketones with p-hydroxybenzyl alcohol via quinone methide formation followed by oxidative dearomatization/spiroannulation with suitable alcohols. The Friedel-Crafts alkylation of spiro[4.5]cyclohexadienones with indoles provided a broad array of highly diastereoselective C-3 alkylated spirocycles and cyclohepta[b]indoles depending upon the ring size of the fused cyclic ketones.

Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Patil, VB; Nanubolu, JB; Chegondi, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C9H10O3. Authors Chupakhin, EG; Kantin, P; Dar’in, DV; Krasavin, M in ELSEVIER published article about in [Chupakhin, Evgeny G.; Kantin, P.; Dar’in, Dmitry V.; Krasavin, Mikhail] St Petersburg State Univ, Inst Chem, St Petersburg 199034, Russia; [Chupakhin, Evgeny G.; Krasavin, Mikhail] Immanuel Kant Balt Fed Univ, Kaliningrad 236016, Russia in 2021.0, Cited 15.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A practically convenient synthesis of (E)-3-arylidene-4diazopyrrolidine-2,5-diones from N-substituted maleimides via the Wittig reaction and the Regitz diazo transfer has been developed. In all 26 cases studied, only one chromatographic purification was required with no need for aqueous workup, which makes this protocol amenable to producing the emerging class of diazo compounds in parallel format.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Chupakhin, EG; Kantin, P; Dar’in, DV; Krasavin, M or concate me.. Computed Properties of C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-14-9. Authors Honari, M; Sanaeishoar, H; Kiasat, AR; Mohammadi, MK in SPRINGER published article about in [Honari, Mehran; Sanaeishoar, Haleh; Kiasat, Ali Reza; Mohammadi, Mohammad Kazem] Islamic Azad Univ, Dept Chem, Ahvaz Branch, Ahvaz, Iran; [Kiasat, Ali Reza] Shahid Chamran Univ Ahvaz, Collage Sci, Dept Chem, Ahvaz, Iran in 2021.0, Cited 38.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A simple and efficient method for the synthesis of pyrazolopyranopyrimidines under solvent-free has been developed. The one-pot multicomponent condensation of arylaldehydes with hydrazine hydrate, ethyl acetoacetate and barbituric acid in the vicinity of a mesoporous basic nanomagnetic catalyst, namely DBU immobilized on Fe3O4@nSiO(2)@mSiO(2) was synthesized in remarkably high yields and in short reaction times. Significantly, this catalyst can be easily separated from the reaction media by applying an external magnet, and can be reused for several cycles. [GRAPHICS] .

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Honari, M; Sanaeishoar, H; Kiasat, AR; Mohammadi, MK or concate me.. Recommanded Product: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3,4-Dimethoxybenzaldehyde. Authors Nayak, A; Saxena, H; Bathula, C; Kumar, T; Bhattacharjee, S; Sen, S; Gupta, A in BMC published article about in [Nayak, Akshaykumar; Saxena, Himani; Gupta, Ashish] Shiv Nadar Univ, Epigenet & Human Dis Lab, Dept Life Sci, NH-91, Tehsil Dadri 201314, Greater Noida, India; [Bathula, Chandramohan; Sen, Subhabrata] Shiv Nadar Univ, Dept Chem, Dept Life Sci, Tehsil Dadri 201314, Greater Noida, India; [Kumar, Tarkeshwar; Bhattacharjee, Souvik] Jawaharlal Nehru Univ, Special Ctr Mol Med, New Delhi, India in 2021.0, Cited 43.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

BackgroundDespite numerous efforts to eradicate the disease, malaria continues to remain one of the most dangerous infectious diseases plaguing the world. In the absence of any effective vaccines and with emerging drug resistance in the parasite against the majority of anti-malarial drugs, the search for new drugs is urgently needed for effective malaria treatment.MethodsThe goal of the present study was to examine the compound library, based on indoles generated through diversity-oriented synthesis belonging to four different architecture, i.e., 1-aryltetrahydro/dihydro-beta -carbolines and piperidine/pyrrolidine-fused indole derivatives, for their in vitro anti-plasmodial activity. Trifluoroacetic acid catalyzed transformation involving tryptamine and various aldehydes/ketones provided the library.ResultsAmong all the compounds screened, 1-aryltetrahydro-beta -carbolines 2 and 3 displayed significant anti-plasmodial activity against both the artemisinin-sensitive and artemisinin-resistant strain of Plasmodium falciparum. It was observed that these compounds inhibited the overall parasite growth in intra-erythrocytic developmental cycle (IDC) via reactive oxygen species-mediated parasitic death and thus could be potential anti-malarial compounds.ConclusionOverall the compounds 2 and 3 identified in this study shows promising anti-plasmodial activity that can kill both artemisinin-sensitive and artemisinin-resistant strains of P. falciparum.

About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Nayak, A; Saxena, H; Bathula, C; Kumar, T; Bhattacharjee, S; Sen, S; Gupta, A or concate me.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C9H10O3. Authors Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Polaquini, Carlos R.; Marques, Beatriz C.; Ayusso, Gabriela M.; Regasini, Luis O.] Sao Paulo State Univ Unesp, Inst Biosci Humanities & Exact Sci, Dept Chem & Environm Sci, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil; [Morao, Luana G.; Cavalca, Lucia B.; Ferreira, Henrique] Sao Paulo State Univ Unesp, Inst Biosci, Dept Biochem & Microbiol, BR-13050690 Rio Claro, SP, Brazil; [Sardi, Janaina C. O.; Rosalen, Pedro L.] Univ Campinas Unicamp, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Campinas, SP, Brazil; [Sardi, Janaina C. O.] Fed Univ Mato Grosso do Sul Ufms, Sch Pharmaceut Sci Food & Nutr, BR-79070900 Campo Grande, MS, Brazil; [Campos, Debora L.; Silva, Isabel C.; Pavan, Fernando R.] Sao Paulo State Univ Unesp, Sch Pharmaceut Sci, Dept Biol Sci, BR-14800903 Araraquara, SP, Brazil; [Cavalca, Lucia B.; Scheffers, Dirk-Jan] Univ Groningen, Groningen Biomol Sci & Biotechnol Inst, Dept Mol Microbiol, NL-9747 AG Groningen, Netherlands; [Rosalen, Pedro L.] Fed Univ Alfenas Unifal, Sch Dent, BR-37130000 Alfenas, MG, Brazil in 2021, Cited 75. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Curcumin (CUR) is a symmetrical dicarbonyl compound with antibacterial activity. On the other hand, pharmacokinetic and chemical stability limitations hinder its therapeutic application. Monocarbonyl analogs of curcumin (MACs) have been shown to overcome these barriers. We synthesized and investigated the antibacterial activity of a series of unsymmetrical MACs derived from acetone against Mycobacterium tuberculosis and Gram-negative and Gram-positive species. Phenolic MACs 4, 6 and 8 showed a broad spectrum and potent activity, mainly against M. tuberculosis, Acinetobacter baumannii and methicillin-resistant Staphylococcus aureus (MRSA), with MIC (minimum inhibitory concentration) values ranging from 0.9 to 15.6 mu g/mL. The investigation regarding toxicity on human lung cells (MRC-5 and A549 lines) revealed MAC 4 was more selective than MACs 6 and 8, with SI (selectivity index) values ranging from 5.4 to 15.6. In addition, MAC 4 did not demonstrate genotoxic effects on A549 cells and it was more stable than CUR in phosphate buffer (pH 7.4) for 24 h at 37 degrees C. Fluorescence and phase contrast microscopies indicated that MAC 4 has the ability to disrupt the divisome of Bacillus subtilis without damaging its cytoplasmic membrane. However, biochemical investigations demonstrated that MAC 4 did not affect the GTPase activity of B. subtilis FtsZ, which is the main constituent of the bacterial divisome. These results corroborated that MAC 4 is a promising antitubercular and antibacterial agent.

Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Polaquini, CR; Marques, BC; Ayusso, GM; Morao, LG; Sardi, JCO; Campos, DL; Silva, IC; Cavalca, LB; Scheffers, DJ; Rosalen, PL; Pavan, FR; Ferreira, H; Regasini, LO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 J MOL STRUCT published article about CHAGAS-DISEASE; BENZNIDAZOLE; POSACONAZOLE; CHALLENGES; COMPLEXES; DESIGN in [da Silva, Aline Alves; Valle, Marcelo Siqueira] Univ Fed Sao Joao Del Rei, Dept Ciencias Nat, BR-36301160 Sao Joao Del Rei, MG, Brazil; [Maia, Pedro Ivo da Silva] Univ Fed Triangulo Mineiro, Dept Quim, BR-38025440 Uberaba, MG, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque; de Albuquerque, Sergio] Univ Sao Paulo, USP, FCFRP, Ave Cafes S-N, BR-14040903 Ribeirao Preto, SP, Brazil; [Lopes, Carla Duque] Ctr Univ Estacio Ribeirao Preto, Abraao Issa Halach St 980, BR-14096160 Ribeirao Preto, SP, Brazil in 2021, Cited 28. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

Chagas disease is a neglected disease, being one of the leading causes of death from infectious diseases. In view of the severity of this pathology, this work describes the synthesis of new thiosemicarbazones derived from chalcones and dibenzalacetones as potential drugs for the treatment of this disease. The structures of all compounds were elucidated by infrared (IR) and nuclear magnetic resonance (H-1 and C-13 NMR) spectroscopies. The chalcone derived thiosemicarbazones 10-14 were tested against the intracellular amastigote form of the protozoan Trypanosoma cruzi and had their cytotoxicity assessed using LLC-MK2 cells. The compound 10 (IC50 = 12.25 mu M) presented the best activity when compared with the standard drug benznidazole (IC50 = 5.64 mu M). (C) 2021 Elsevier B.V. All rights reserved.

Product Details of 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact da Silva, AA; Maia, PID; Lopes, CD; de Albuquerque, S; Valle, MS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Malasala, Satyaveni; Akunuri, Ravikumar; Madhavi, Y., V; Nanduri, Srinivas] Natl Inst Pharmaceut Educ & Res NIPER, Dept Med Chem, Hyderabad 500037, Telangana, India; [Ahmad, Md Naiyaz; Shukla, Manjulika; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India; [Ahmad, Md Naiyaz; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] AcSIR, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2021.0, Cited 58.0. Computed Properties of C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Owing to the rapid rise in antibiotic resistance, infectious diseases have become serious threat to public health. There is an urgent need to develop new antimicrobial agents with diverse chemical structures and novel mechanisms of action to overcome the resistance. In recent years, Quinazoline-benzimidazole hybrids have emerged as a new class of antimicrobial agents active against S. aureus and M. tuberculosis. In the current study, we designed and synthesized fifteen new Quinazoline-benzimidazole hybrids and evaluated them for their antimicrobial activity against S. aureus ATCC 29213 and M. tuberculosis H37Rv. These studies led to the identification of nine potent antibacterial agents 8a, 8b, 8c, 8d, 8f, 8g, 8h, 8i and 10c with MICs in the range of 4-64 mu g/mL. Further, these selected compounds were found to possess potent antibacterial potential against a panel of drug-resistant clinical isolates which include methicillin and vancomycin-resistant S. aureus. The selected compounds were found to be less toxic to Vero cells (CC50 = 40->= 200 mu g/mL) and demonstrated a favourable selectivity index. Based on the encouraging results obtained these new benzimidazol-2-yl quinazoline derivatives have emerged as promising antimicrobial agents for the treatment of MDR-S. aureus and Mycobacterial infections. (C) 2020 Elsevier Masson SAS. All rights reserved.

Computed Properties of C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Malasala, S; Ahmad, MN; Akunuri, R; Shukla, M; Kaul, G; Dasgupta, A; Madhavi, YV; Chopra, S; Nanduri, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles