Category: 120-14-9

COA of Formula: C9H10O3. I found the field of Physiology; Respiratory System very interesting. Saw the article E-cigarettes and health risks: more to the flavor than just the name published in 2021.0, Reprint Addresses Ween, MP (corresponding author), Royal Adelaide Hosp, Dept Thorac Med, Adelaide, SA, Australia.; Ween, MP (corresponding author), Univ Adelaide, Sch Med, Adelaide, SA, Australia.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde.

The growing interest in regulating flavored E-liquids must incorporate understanding of the flavoring profile of each E-liquid-which flavorings (flavoring chemicals) are present and at what concentrations not just focusing on the flavor on the label. We investigated the flavoring profile of 10 different flavored E-liquids. We assessed bronchial epithelial cell viability and apoptosis, phagocytosis of bacteria and apoptotic cells by macrophages after exposure to E-cigarette vapor extract (EVE). We validated our data in normal human bronchial epithelial cells (NHBE) and alveolar macrophages (AM) from healthy donors. We also assessed cytokine release and validated in the saliva from E-cigarette users. Increased necrosis/apoptosis (16.1-64.5% apoptosis) in 16HBE cells was flavor dependent, and NHBEs showed an increased susceptibility to flavors. In THP-1 differentiated macrophages phagocytosis was also flavor dependent, with AM also showing increased susceptibility to flavors. Further, Banana and Chocolate were shown to reduce surface expression of phagocytic target recognition receptors on alveolar macrophages. Banana and Chocolate increased IL-8 secretion by NHBE, whereas all 4 flavors reduced AM IL-1 beta secretion, which was also reduced in the saliva of E-cigarette users compared with healthy controls. Flavorant profiles of E-liquids varied from simple 2 compound mixtures to complex mixtures containing over a dozen flavorants. E-liquids with high benzene content, complex flavoring profiles, high chemical concentration had the greatest impacts. The Flavorant profile of E-liquids is key to disruption of the airway status quo by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines.

COA of Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article MnO2@Zeolite-Y Nanoporous: Preparation and Application as a High Efficient Catalyst for Multi-Component Synthesis of 4-Arylidene-Isoxazolidinones WOS:000524962800001 published article about ONE-POT SYNTHESIS; 3-COMPONENT SYNTHESIS; GREEN SYNTHESIS; AQUEOUS-MEDIA; 3-METHYL-4-ARYLMETHYLENE-ISOXAZOL-5(4H)-ONES; DERIVATIVES; ZEOLITES; FACILE; ISOXAZOLE-5(4H)-ONES; NANOCATALYST in [Kalhor, Mehdi; Samiei, Sima; Mirshokraie, Seyed Ahmad] Univ Payame Noor, Dept Chem, POB 19395-4697, Tehran, Iran in 2021, Cited 59. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

In this project, nano-MnO2@zeolite-Y (NMOZ) was successfully prepared via hydrothermal technique and its structure was confirmed using FT-IR, XRD, FE-SEM, EDX and BET analyses. MnO2 nanoparticles stabilized on zeolite-NaY were used as nanocatalyst for efficient solventless preparation of 3,4-disubstituted isoxazole-5(4H)-one scaffolds via one-pot three-component reaction of ethyl acetoacetate, hydroxylamine hydrochloride, and aromatic aldehydes at 100 degrees C. One of the advantages of this new method is the non-use of a metal oxidant such as KMnO4 (greener method) and the stabilization of MnO2 to the zeolite-Y surface via ion bonding. This causes the MnO2 not be leached from the zeolite during the processes of nanocatalyst recycling in organic reactions. This simple approach also has promising features as like as safe, inexpensive and recyclable nanocatalyst, solvent-free reaction, short reaction times, high to excellent yields, and easy isolation of the products.

Welcome to talk about 120-14-9, If you have any questions, you can contact Kalhor, M; Samiei, S; Mirshokraie, SA or send Email.. Product Details of 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhang, HC; Liu, Y; Fu, SY; Deng, YL in [Zhang, Haichuan; Fu, Shiyu] South China Univ Technol, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Guangdong, Peoples R China; [Liu, Yang] Guangdong Univ Petrochem Technol, Sch Environm Sci & Engn, Guangdong Prov Key Lab Petrochem Pollut Proc & Co, Maoming 525000, Guangdong, Peoples R China; [Zhang, Haichuan; Deng, Yulin] Georgia Inst Technol, Sch Chem & Biomol Engn, 500 10th St NW, Atlanta, GA 30332 USA; [Zhang, Haichuan; Deng, Yulin] Georgia Inst Technol, RBI Georgia Tech, 500 10th St NW, Atlanta, GA 30332 USA published Selective hydrodeoxygenation of lignin model compound (3,4-dimethoxybenzyl alcohol) by Pd/CNX catalyst in 2021.0, Cited 53.0. Safety of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

Upgrading of lignin derived bio-oil is an essential step for producing sustainable bio-based chemicals and fuel. Taken into account that alpha hydroxyl is the abundant functional group in lignin, high effective and selective catalytic alcoholysis for cleaving the C-alpha-OH linkages would be desirable. However, an in-depth understanding of the reaction mechanisms involved in the cleavage of C-aromatic-C-alpha and C-alpha-O bonds over a novel catalyst is still needed. Herein, we report an efficient liquid-phase hydrogen transfer strategy for the selective hydrodeoxygenation of a non-phenolic lignin model compound, 3,4-dimethoxybenzyl (veratryl) alcohol, under mild conditions. By employing iso-propanol as solvent and H-donor, and palladium nanoparticles immobilized on nitrogen-doped carbon (Pd/CNX) as efficient multifunctional catalyst, veratryl alcohol dehydroxylation exhibited almost 100% conversion along with very high selectivity for 1,2-dimethoxy-benzene (46%) and 3,4-dimethoxytoluene (54%). Compared with other Pd catalysis, the Pd/CNX has excellent catalytic performances and exhibits higher selectivity for 3,4-dimethoxytoluene under incorporation with 1% HCOOH at 220 degrees C. The proportion of Pd (0) significantly increases in Pd/CNX catalyst when introduced into N precursor because of its highly dispersed Pd NPs and preventing the reoxidation of Pd (0). The dehydrogenation reaction occurred through the hydrogen generation of a secondary alcohol. Then, the C-alpha-OH and C-aromatic-C-alpha bonds of veratryl alcohol were selectively cleaved by catalytic transfer hydrogenolysis. The alcoholysis mechanism is supported by dispersion-corrected density functional theory computations. (C) 2020 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Safety of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Exploring the 2 ‘-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents published in 2021.0. Product Details of 120-14-9, Reprint Addresses Detsi, A (corresponding author), Natl Tech Univ Athens, Sch Chem Engn, Dept Chem Sci, Lab Organ Chem, Heroon Polytechniou 9,Zografou Campus, Athens 15780, Greece.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

2 ‘-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) inhibitory activity, the design, synthesis, and bioactivity profile of a series of 2 ‘-hydroxy-chalcones bearing diverse substituents on rings A and B, are presented. Among all the synthesized derivatives, chalcone 4b, bearing two hydroxyl substituents on ring B, was found to possess the best combined activity (82.4% DPPH radical scavenging ability, 82.3% inhibition of lipid peroxidation, and satisfactory LOX inhibition value (IC50 = 70 mu M). Chalcone 3c, possessing a methoxymethylene substituent on ring A, and three methoxy groups on ring B, exhibited the most promising LOX inhibitory activity (IC50 = 45 mu M). A combination of in silico techniques were utilized in an effort to explore the crucial binding characteristics of the most active compound 3c and its analogue 3b, to LOX. A common H-bond interaction pattern, orienting the hydroxyl and carbonyl groups of the aromatic ring A towards Asp768 and Asn128, respectively, was observed. Regarding the analogue 3c, the bulky (-OMOM) group does not seem to participate in a direct binding, but it induces an orientation capable to form H-bonds between the methoxy groups of the aromatic ring B with Trp130 and Gly247.

Welcome to talk about 120-14-9, If you have any questions, you can contact Kostopoulou, I; Tzani, A; Polyzos, NI; Karadendrou, MA; Kritsi, E; Pontiki, E; Liargkova, T; Hadjipavlou-Litina, D; Zoumpoulakis, P; Detsi, A or send Email.. Product Details of 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Electrochemical Arylation of Aldehydes, Ketones, and Alcohols: from Cathodic Reduction to Convergent Paired Electrolysis WOS:000621048400001 published article about C-H FUNCTIONALIZATION; PHOTOREDOX CATALYSIS; CARBONYL-COMPOUNDS; COUPLING REACTIONS; NICKEL CATALYSIS; GRIGNARD; HYDROGEN; HALIDES; IMINES; REAGENTS in [Zhang, Sheng; Li, Lijun; Li, Jingjing; Shi, Jianxue; Xu, Kun; Gao, Wenchao; Zong, Luyi] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Engn Technol Res Ctr Henan Prov Photo & Electroch, Nanyang, Peoples R China; [Li, Guigen; Findlater, Michael] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79423 USA in 2021, Cited 67. Recommanded Product: 120-14-9. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Arylation of carbonyls, one of the most common approaches toward alcohols, has received tremendous attention, as alcohols are important feedstocks and building blocks in organic synthesis. Despite great progress, there is still a great gap to develop an ideal arylation method featuring mild conditions, good functional group tolerance, and readily available starting materials. We now show that electrochemical arylation can fill the gap. By taking advantage of synthetic electrochemistry, commercially available aldehydes (ketones) and benzylic alcohols can be readily arylated to provide a general and scalable access to structurally diverse alcohols (97 examples, >10 gram-scale). More importantly, convergent paired electrolysis, the ideal but challenging electrochemical technology, was employed to transform low-value alcohols into more useful alcohols. Detailed mechanism study suggests that two plausible pathways are involved in the redox neutral alpha-arylation of benzylic alcohols.

Recommanded Product: 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Recently I am researching about TO-HEAD DIMERIZATION; NONAROMATIC CATECHOL BIOISOSTERES; AZA-CLAISEN REARRANGEMENT; TERMINAL ARYL ALKYNES; CONJUGATED ENYNES; SELECTIVE DIMERIZATION; CATALYZED DIMERIZATION; PALLADIUM COMPLEXES; TAIL DIMERIZATION; PALLADACYCLE, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Pfeffer, C; Wannenmacher, N; Frey, W; Peters, R. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Enynes are important motifs in bioactive compounds. They can be synthesized by alkyne-alkyne couplings for which a number of mechanisms have been suggested depending on catalyst type and dominant product isomers. Regarding bimetallic pathways, hydrometalations and anti-carbopalladations have been discussed to account for the formation of geminally substituted and (Z)-configured enynes, respectively. Here we report a bimetallic alkyne-alkyne coupling that yields (E)-configured enynes. An unusual type of acetylide Pd bridging was found in putative catalytic intermediates which is arguably responsible for the regio- and stereochemical reaction outcome. Mechanistic studies suggest that a double mu-kappa:eta(2) acetylide bridging enables a bimetallic syn-carbometalation. Interestingly, depending on the reaction conditions, it is also possible to form the geminal regioisomer as major product with the same catalyst. This regiodivergent outcome is explained by bi-versus monometallic reaction pathways.

Welcome to talk about 120-14-9, If you have any questions, you can contact Pfeffer, C; Wannenmacher, N; Frey, W; Peters, R or send Email.. Application In Synthesis of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article KOH-mediated stereoselective alkylation of 3-bromooxindoles for the synthesis of 3,3 ‘-disubstituted oxindoles with two contiguous all carbon quaternary centres published in 2021.0. Quality Control of 3,4-Dimethoxybenzaldehyde, Reprint Addresses Singh, RP (corresponding author), Indian Inst Technol, Dept Chem, Hauz Khas, New Delhi 110016, India.. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

The stereoselective synthesis of 3,3 ‘-disubstituted oxindoles having all-carbon quaternary stereocenters has been achieved using KOH as a base with an excellent diastereomeric ratio (98 : 2). The practicability of the present methodology has been validated with the synthesis of a series of substrates in good to excellent yields. The aesthetic simplicity, accessibility, and eco-friendly base (KOH) have prompted the broader application of the present methodology in organic synthesis.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Fe3O4@MCM-41@Zn-Arg: as a novel, magnetically recoverable and ecofriendly nanocatalyst for the synthesis of disulfides, sulfoxides and 2,3-dihydroquinazolin-4(1H)-ones WOS:000561334800001 published article about SCHIFF-BASE COMPLEX; SELECTIVE OXIDATION; CHEMOSELECTIVE OXIDATION; EFFICIENT SYNTHESIS; NANOPOROUS MCM-41; MESOPOROUS MCM-41; HIGHLY EFFICIENT; SULFIDES; CATALYST; NANOPARTICLES in [Nikoorazm, Mohsen; Erfani, Zahra] Ilam Univ, Dept Chem, Fac Sci, POB 69315516, Ilam, Iran in 2021.0, Cited 58.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

The direct supporting of Zn-arginine complex on magnetic core-shell nanostructures (Fe3O4@MCM-41@Zn-Arg) was reported as a novel, heterogeneous and excellent nanocatalyst, which applied for the oxidation reaction of sulfides to sulfoxides, oxidative coupling of thiols to their corresponding disulfides and the synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under mild conditions. The structure of the catalyst was studied by X-Ray diffraction, Fourier transform-infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, atomic absorption spectroscopy, and vibrating sample magnetometry techniques. The simple experimental procedure, very good catalytic activity, low cost, and excellent recycling are the noteworthy features of the currently employed heterogeneous catalytic system.

Product Details of 120-14-9. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3,4-Dimethoxybenzaldehyde. Authors Mathioudakis, AG; Ghrew, M; Ustianowski, A; Ahmad, S; Borrow, R; Papavasileiou, LP; Petrakis, D; Bakerly, ND in MDPI published article about in [Mathioudakis, Alexander G.] Univ Manchester, Sch Biol Sci, Div Infect Immun & Resp Med, Manchester M23 9LT, Lancs, England; [Mathioudakis, Alexander G.] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, North West Lung Ctr Wythenshawe Hosp, Manchester M23 9LT, Lancs, England; [Ghrew, Murad; Bakerly, Nawar Diar] Salford Royal Hosp NHS Fdn Trust, Dept Resp Med, Manchester M6 8HD, Lancs, England; [Ghrew, Murad] Salford Royal Hosp NHS Fdn Trust, Dept Intens Care Med, Manchester M6 8HD, Lancs, England; [Ghrew, Murad; Ustianowski, Andrew] Univ Manchester, Sch Biol Sci, Fac Biol Med & Hlth, Manchester M13 9PL, Lancs, England; [Ustianowski, Andrew] North Manchester Gen Hosp, Reg Infect Dis Unit, Manchester M8 5RB, Lancs, England; [Ahmad, Shazaad] Manchester Univ NHS Fdn Trust, Manchester Med Microbiol Partnership, Dept Virol, Manchester M13 9WL, Lancs, England; [Borrow, Ray] Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Royal Infirm, Vaccine Evaluat Unit,Publ Hlth England, Manchester M13 9WL, Lancs, England; [Papavasileiou, Lida Pieretta] Hygeia Hosp, Dept Cardiol, Athens 15123, Greece; [Petrakis, Dimitrios] Petrakis Allergy Care, Allergy Clin, Thessaloniki 55133, Greece; [Bakerly, Nawar Diar] Manchester Metropolitan Univ, Sch Healthcare Sci, Manchester M15 6BH, Lancs, England in 2021.0, Cited 11.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

An online survey was conducted to compare the safety, tolerability and reactogenicity of available COVID-19 vaccines in different recipient groups. This survey was launched in February 2021 and ran for 11 days. Recipients of a first COVID-19 vaccine dose >= 7 days prior to survey completion were eligible. The incidence and severity of vaccination side effects were assessed. The survey was completed by 2002 respondents of whom 26.6% had a prior COVID-19 infection. A prior COVID-19 infection was associated with an increased risk of any side effect (risk ratio 1.08, 95% confidence intervals (1.05-1.11)), fever (2.24 (1.86-2.70)), breathlessness (2.05 (1.28-3.29)), flu-like illness (1.78 (1.51-2.10)), fatigue (1.34 (1.20-1.49)) and local reactions (1.10 (1.06-1.15)). It was also associated with an increased risk of severe side effects leading to hospital care (1.56 (1.14-2.12)). While mRNA vaccines were associated with a higher incidence of any side effect (1.06 (1.01-1.11)) compared with viral vector-based vaccines, these were generally milder (p < 0.001), mostly local reactions. Importantly, mRNA vaccine recipients reported a considerably lower incidence of systemic reactions (RR < 0.6) including anaphylaxis, swelling, flu-like illness, breathlessness and fatigue and of side effects requiring hospital care (0.42 (0.31-0.58)). Our study confirms the findings of recent randomised controlled trials (RCTs) demonstrating that COVID-19 vaccines are generally safe with limited severe side effects. For the first time, our study links prior COVID-19 illness with an increased incidence of vaccination side effects and demonstrates that mRNA vaccines cause milder, less frequent systemic side effects but more local reactions. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Mathioudakis, AG; Ghrew, M; Ustianowski, A; Ahmad, S; Borrow, R; Papavasileiou, LP; Petrakis, D; Bakerly, ND or concate me.. Quality Control of 3,4-Dimethoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. Authors Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P in MDPI published article about in [Pitucha, Monika; Drozd, Monika] Med Univ Lublin, Fac Pharm, Independent Radiopharm Unit, PL-20093 Lublin, Poland; [Korga-Plewko, Agnieszka; Kubik, Joanna; Humeniuk, Ewelina; Adamczuk, Grzegorz] Med Univ Lublin, Fac Pharm, Independent Med Biol Unit, PL-20093 Lublin, Poland; [Czylkowska, Agnieszka; Rogalewicz, Bartlomiej] Lodz Univ Technol, Fac Chem, Inst Gen & Ecol Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Iwan, Magdalena] Med Univ Lublin, Fac Pharm, Chair & Dept Toxicol, PL-20093 Lublin, Poland; [Karczmarzyk, Zbigniew; Wysocki, Waldemar; Bartnik, Paulina] Siedlce Univ Nat Sci & Humanities, Fac Sci, 3 Maja 54, PL-08110 Siedlce, Poland; [Fornal, Emilia] Med Univ Lublin, Fac Med, Chair & Dept Pathophysiol, PL-20090 Lublin, Poland in 2021.0, Cited 50.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A series of thiosemicarbazone derivatives was prepared and their anti-tumor activity in vitro was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the synthesis pathway and assumed molecular structures of analyzed thiosemicarbazones. The conformational preferences of the thiosemicarbazone system were characterized using theoretical calculations by AM1 method. Selected compounds were converted into complexes of Cu (II) ions. The effect of complexing on anti-tumor activity has been investigated. The copper(II) complexes, with Schiff bases T1, T10, T12, T13, and T16 have been synthesized and characterized by chemical and elemental analysis, FTIR spectroscopy and TGA method. Thermal properties of coordination compounds were studied using TG-DTG techniques under dry air atmosphere. G361, A375, and SK-MEL-28 human melanoma cells and BJ human normal fibroblast cells were treated with tested compounds and their cytotoxicity was evaluated with MTT test. The compounds with the most promising anti-tumour activity were then selected and their cytotoxicity was verified with cell cycle analysis and apoptosis/necrosis detection. Additionally, DNA damages in the form of a basic sites presence and the expression of oxidative stress and DNA damage response genes were evaluated. The obtained results indicate that complexation of thiosemicarbazone derivatives with Cu (II) ions improves their antitumor activity against melanoma cells. The observed cytotoxic effect is associated with DNA damage and G2/M phase of cell cycle arrest as well as disorders of the antioxidant enzymes expression.

SDS of cas: 120-14-9. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles