Category: 120-14-9

COA of Formula: C9H10O3. Authors Nayak, SS; Wadhawa, GC; Shivankar, VS; Patil, DD; Sonawale, MC; Mirgane, NA in ELSEVIER published article about in [Nayak, Shubhada S.; Wadhawa, Gurumeet C.] Karmaveer Bhaurao Patil Coll, Rayat Shikshan Sansthas, Vashi Sect 15 A Navi, Mumbai 400703, Maharashtra, India; [Shivankar, Vitthal S.] Chhatrapati Shivaji Coll, Rayat Shikshan Sansthas, Satara, Maharashtra, India; [Patil, Dinanath D.] SMBT Coll Sangamner, Sangamner 422605, MH, India; [Sonawale, Maryappa C.] Veer Wajekar ASC Coll, Raigad, MH, India; [Mirgane, Nitin A.] SIES Coll ASC, Dept Chem, Mumbai, Maharashtra, India in 2021.0, Cited 54.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The nanoscience is emerging field of the science and technology. In nanoscience research synthesizing green nanoparticles using green protocols are very good, effective technique, quite safe and ecofriendly technique compared to the conventional chemical and physical methods. These are used in the various field of science. These are used in the catalysis. Theses green and bio-based route for the preparation of the nanoparticles has good attention in the organic synthesis. These nano catalysts used for synthesis of heterocyclic compound. Imidazole and their derivatives are widely used. The imidazole and its derivatives are very important heterocyclic compounds. They have very good biological and pharmaceutical activity. In this we have prepared plant assisted tin oxide nanoparticles from the leaves of Ceropegia jainii plant by the green methods. The synthesized nanoparticles are characterized by various methods of analysis. These synthesized plants assisted nanoparticles are used for the synthesis of the heterocycles. We have developed the simple and highly efficient three component such as benzil, aromatic aldehyde and ammonium acetate under the microwave irradiation without any solvent. This reaction gives the 2,4,5-triarylimidazole derivatives with good yield and purity. This method is very simple and cost effective. Nano catalyst are green and recyclable with very less reaction time. (C) 2020 Elsevier Ltd. All rights reserved.

COA of Formula: C9H10O3. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Nayak, SS; Wadhawa, GC; Shivankar, VS; Patil, DD; Sonawale, MC; Mirgane, NA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Authors Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P in MDPI published article about in [Pitucha, Monika; Drozd, Monika] Med Univ Lublin, Fac Pharm, Independent Radiopharm Unit, PL-20093 Lublin, Poland; [Korga-Plewko, Agnieszka; Kubik, Joanna; Humeniuk, Ewelina; Adamczuk, Grzegorz] Med Univ Lublin, Fac Pharm, Independent Med Biol Unit, PL-20093 Lublin, Poland; [Czylkowska, Agnieszka; Rogalewicz, Bartlomiej] Lodz Univ Technol, Fac Chem, Inst Gen & Ecol Chem, Zeromskiego 116, PL-90924 Lodz, Poland; [Iwan, Magdalena] Med Univ Lublin, Fac Pharm, Chair & Dept Toxicol, PL-20093 Lublin, Poland; [Karczmarzyk, Zbigniew; Wysocki, Waldemar; Bartnik, Paulina] Siedlce Univ Nat Sci & Humanities, Fac Sci, 3 Maja 54, PL-08110 Siedlce, Poland; [Fornal, Emilia] Med Univ Lublin, Fac Med, Chair & Dept Pathophysiol, PL-20090 Lublin, Poland in 2021.0, Cited 50.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

A series of thiosemicarbazone derivatives was prepared and their anti-tumor activity in vitro was tested. The X-ray investigation performed for compounds T2, T3 and T5 confirmed the synthesis pathway and assumed molecular structures of analyzed thiosemicarbazones. The conformational preferences of the thiosemicarbazone system were characterized using theoretical calculations by AM1 method. Selected compounds were converted into complexes of Cu (II) ions. The effect of complexing on anti-tumor activity has been investigated. The copper(II) complexes, with Schiff bases T1, T10, T12, T13, and T16 have been synthesized and characterized by chemical and elemental analysis, FTIR spectroscopy and TGA method. Thermal properties of coordination compounds were studied using TG-DTG techniques under dry air atmosphere. G361, A375, and SK-MEL-28 human melanoma cells and BJ human normal fibroblast cells were treated with tested compounds and their cytotoxicity was evaluated with MTT test. The compounds with the most promising anti-tumour activity were then selected and their cytotoxicity was verified with cell cycle analysis and apoptosis/necrosis detection. Additionally, DNA damages in the form of a basic sites presence and the expression of oxidative stress and DNA damage response genes were evaluated. The obtained results indicate that complexation of thiosemicarbazone derivatives with Cu (II) ions improves their antitumor activity against melanoma cells. The observed cytotoxic effect is associated with DNA damage and G2/M phase of cell cycle arrest as well as disorders of the antioxidant enzymes expression.

Application In Synthesis of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Pitucha, M; Korga-Plewko, A; Czylkowska, A; Rogalewicz, B; Drozd, M; Iwan, M; Kubik, J; Humeniuk, E; Adamczuk, G; Karczmarzyk, Z; Fornal, E; Wysocki, W; Bartnik, P or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Newmultitargetdirectedbenzimidazole-2-thiol-basedheterocycles as prospectiveanti-radicalandanti-Alzheimer’s agents WOS:000566827500001 published article about 2-MERCAPTO BENZIMIDAZOLE; INHIBITORS; DOCKING in [Latif, Abdul; Bibi, Samina; Ali, Sardar; Ammara, Ammara; Ahmad, Manzoor; Ali, Mumtaz] Univ Malakand, Dept Chem, Chakdara, Khyber Pakhtunk, Pakistan; [Khan, Ajmal; Al-Harrasi, Ahmed] Univ Nizwa, UoN Chair Omans Med Plants & Marine Nat Prod, Nizwa, Oman; [Ullah, Farhat] Univ Malakand, Dept Pharm, Chakdara, Khyber Pakhtunk, Pakistan in 2021, Cited 19. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9. Product Details of 120-14-9

A series of new heterocycles (4-18) was synthesized by the structural modification of benzimidazole-2-thiol (BT, 2-MBI). The structures of the synthesized compounds were confirmed with the help of high-resolution mass spectrometry (HRMS) and(1)HNMR spectroscopy. High inhibitions of the oxidants such as ABTS and DPPH were observed for compounds9[IC50(s) = 167.4 mu M (ABTS), 139.5 mu M (DPPH)],10[IC50(s) = 186.5 mu M (ABTS), 155.4 mu M (DPPH)],11[IC50(s) = 286.1 mu M (ABTS), 189.1 mu M (DPPH)],12[IC50(s) = 310.8 mu M (ABTS), 162.2 mu M (DPPH)],14[IC50(s) = 281.3 mu M (ABTS), 205.7 mu M (DPPH)],15[IC50(s) = 284.1 mu M (ABTS), 177.3 mu M (DPPH)], and16[IC50(s) = 344.7 mu M (ABTS), 270.2 mu M (DPPH)] as compared with Ascorbic acid [IC50(s) = 340.9 mu M (ABTS), 164.3 mu M (DPPH)]. The anti-Alzheimer’s activity was performed in vitro against cholinesterase enzymes (AChE, BChE). Compound11was able to show significant inhibitions [IC50(s) = 121.2 mu M (AChE), 38.3 mu M (BChE)] as against that of galantamine [IC50(s) = 139.4 mu M (AChE), 40.3 mu M (BChE)]. Compound14was found as a very good inhibitor of butyrylcholinesterase (IC50= 35.4 mu M) as compared with standard galantamine. Molecular docking was further performed to investigate the mechanism of anticholinesterase activity.

Product Details of 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Latif, A; Bibi, S; Ali, S; Ammara, A; Ahmad, M; Khan, A; Al-Harrasi, A; Ullah, F; Ali, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Li, YX; Li, XQ; Li, XW; Shi, DY in ROYAL SOC CHEMISTRY published article about in [Li, Yuxiu; Li, Xiangqian; Li, Xiaowei; Shi, Dayong] Shandong Univ, State Key Lab Microbial Technol, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China; [Li, Yuxiu; Li, Xiangqian; Li, Xiaowei; Shi, Dayong] Shandong Univ, Marine Biotechnol Res Ctr, 72 Binhai Rd, Qingdao 266237, Shandong, Peoples R China; [Shi, Dayong] Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, 168 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China in 2021.0, Cited 60.0. Application In Synthesis of 3,4-Dimethoxybenzaldehyde. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Regioselective synthesis of alpha-fluoro-beta-arylalkenyl sulfides has been established with gem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselective Z -> E isomerization was achieved under green light irradiation in the absence of a photoinitiator.

Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C9H10O3

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CRYSTAL-STRUCTURES, Saw an article supported by the Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [112T746]; Hacettepe University Scientific Research Projects Coordination UnitHacettepe University [012D06301001, 1527]; Hacettepe University Technology Transfer CenterHacettepe University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Salgin-Goksen, U; Telli, G; Erikci, A; Dedecengiz, E; Tel, BC; Kaynak, FB; Yelekci, K; Ucar, G; Gokhan-Kelekci, N. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde. Recommanded Product: 3,4-Dimethoxybenzaldehyde

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N’-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolinone-3-yl)-acetohydrazide skeleton were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of the molecular docking for hydrazone derivatives supported the in vitro results. Five compounds, 6 (0.008 mu M, Selectivity Index (SI): 9.70 x 10(-4)), 7 (0.009 mu M, SI: 4.55 x 10(-5)), 14 (0.001 mu M, SI: 8.00 x 10(-4)), 21 (0.009 mu M, SI: 1.37 x 10(-5)), and 42 (0.010 mu M, SI: 5.40 x 10(-6)), exhibiting the highest inhibition and selectivity toward hMAO-A and nontoxic to hepatocytes were assessed for antidepressant activity as acute and subchronic in mice. All of these five compounds showed significant antidepressant activity with subchronic administration consistent with the increase in the brain serotonin levels and the compounds crossed the blood-brain barrier according to parallel artificial membrane permeation assay. Compounds 14, 21, and 42 exhibited an ex vivo MAO-A profile, which is highly consistent with the in vitro data.

COA of Formula: C9H10O3. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2021 TETRAHEDRON published article about PHOTOCHROMIC DIARYLETHENES; PHOTOINDUCED REARRANGEMENT; PHOTOCYCLIZATION; 2-VINYLBIPHENYL; CONDENSATION; ARYLGLYOXALS; REACTIVITY; MEMORIES in [Lichitsky, Boris, V; Karibov, Turan T.; Melekhina, Valeriya G.; Komogortsev, Andrey N.; Fakhrutdinov, Artem N.; Minyaev, Mikhail E.; Krayushkin, Michail M.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Leninsky Pr 47, Moscow 119991, Russia in 2021, Cited 45. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

At the first time, we elaborated the method of synthesis of naphtho[1,2-b]benzofurans based on photoinduced reaction of acrylonitriles containing 2-arylbenzofuran fragment as part of 1,3,5-hexatriene system. The considered reaction proceeds via initial 6 pi-electrocyclization followed by [1,9]-H sigmatropic shift and final oxidative aromatization of central benzene ring. It was shown that 5,6-dihydronaphtho[1,2-b]benzofurans are key intermediates of studied process. The structures of obtained 5,6-dihydronaphtho[1,2- b]benzofuran and one of the target naphtho[1,2-b]benzofurans were confirmed by X-ray diffraction. (C) 2021 Elsevier Ltd. All rights reserved.

Category: indole-building-block. About 3,4-Dimethoxybenzaldehyde, If you have any questions, you can contact Lichitsky, BV; Karibov, TT; Melekhina, VG; Komogortsev, AN; Fakhrutdinov, AN; Minyaev, ME; Krayushkin, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 120-14-9. Recently I am researching about ALPHA-LIPOIC ACID; NF-KAPPA-B; INDUCED NEPHROTOXICITY; INDUCED HEPATOTOXICITY; OXIDATIVE STRESS; STAT3; ANTIOXIDANT; DESIGN; INTERLEUKIN-6; CYTOKINES, Saw an article supported by the Deanship of Scientific Research at King Saud UniversityKing Saud University [RGP-193]. Published in NATURE RESEARCH in BERLIN ,Authors: Razak, S; Afsar, T; Bibi, N; Abulmeaty, M; Qamar, W; Almajwal, A; Inam, A; Al Disi, D; Shabbir, M; Bhat, MA. The CAS is 120-14-9. Through research, I have a further understanding and discovery of 3,4-Dimethoxybenzaldehyde

Cisplatin is an efficient anticancer drug against various types of cancers however, its usage involves side effects. We investigated the mechanisms of action of indole derivative, 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N’-[(E)-(3-nitrophenyl) methylidene] acetohydrazide (MMINA) against anticancer drug (cisplatin) induced organ damage using a rodent model. MMINA treatment reversed Cisplatin-induced NO and malondialdehyde (MDA) augmentation while boosted the activity of glutathione peroxidase (GPx), and superoxide dismutase (SOD). The animals were divided into five groups (n=7). Group1: Control (Normal) group, Group 2: DMSO group, Group 3: cisplatin group, Group 4: cisplatin+MMINA group, Group 5: MMINA group. MMINA treatment normalized plasma levels of biochemical enzymes. We observed a significant decrease in CD4(+)COX-2, STAT3, and TNF-alpha cell population in whole blood after MMINA dosage. MMINA downregulated the expression of various signal transduction pathways regulating the genes involved in inflammation i.e. NF-kappa B, STAT-3, IL-1, COX-2, iNOS, and TNF-alpha. The protein expression of these regulatory factors was also downregulated in the liver, kidney, heart, and brain. In silico docking and dynamic simulations data were in agreement with the experimental findings. The physiochemical properties of MMINA predicted it as a good drug-like molecule and its mechanism of action is predictably through inhibition of ROS and inflammation.

Welcome to talk about 120-14-9, If you have any questions, you can contact Razak, S; Afsar, T; Bibi, N; Abulmeaty, M; Qamar, W; Almajwal, A; Inam, A; Al Disi, D; Shabbir, M; Bhat, MA or send Email.. SDS of cas: 120-14-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R in [Vaitkiene, Simona; Kuliesiene, Neringa; Sakalauskaite, Sandra; Daugelavicius, Rimantas] Vytautas Magnus Univ, Dept Biochem, Kaunas, Lithuania; [Bekere, Laura; Krasnova, Laura; Vigante, Brigita; Duburs, Gunars] Latvian Inst Organ Synth, Riga, Latvia published Antifungal activity of styrylpyridinium compounds againstCandida albicans in 2021.0, Cited 39.0. COA of Formula: C9H10O3. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.

We synthesized a set of 13 new and earlier described styrylpyridinium compounds (N-alkyl styrylpyridinium salts with bromide or tosylate anions) in order to evaluate antifungal activity againstC. albicanscells, to assay the possible synergism with fluconazole, and to estimate cytotoxicity to mammalian cells. All compounds were synthesized according to a well-known two-step procedure involving alkylation of gamma-picoline with appropriate alkyl bromide and further condensation with substituted benzaldehyde. Compounds with longN-alkyl chains(C18H37-C20H41) had no antifungal activity against the cells of all testedC. albicansstrains. Other styrylpyridinium compounds were able to inhibit yeast growth at the concentrations of 0.06-16 mu g/ml. At fungicidal concentrations, the compound with the CN- group was least toxic to mammalian cells, showed the most effective synergism with fluconazole, and only slightly inhibited the respiration ofC. albicans. The compound with the 4 ‘-diethylamino group exhibited the strongest fungicidal properties and effectively blocked the respiration ofC. albicanscells. However, toxicity to mammalian cells was also high. Summarizing, the results of our study indicate that styrylpyridinium compounds are promising candidates in the development of new antifungal drugs.

COA of Formula: C9H10O3. Welcome to talk about 120-14-9, If you have any questions, you can contact Vaitkiene, S; Kuliesiene, N; Sakalauskaite, S; Bekere, L; Krasnova, L; Vigante, B; Duburs, G; Daugelavicius, R or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-14-9. Authors Pottie, E; Kupriyanova, OV; Shevyrin, VA; Stove, CP in AMER CHEMICAL SOC published article about in [Pottie, Eline; Stove, Christophe P.] Univ Ghent, Fac Pharmaceut Sci, Dept Bioanal, Lab Toxicol, B-9000 Ghent, Belgium; [Kupriyanova, Olga, V] Kazan Volga Reg Fed Univ, Inst Fundamental Med & Biol, Kazan 420008, Russia; [Kupriyanova, Olga, V] Kazan State Med Univ, Kazan 420012, Russia; [Shevyrin, Vadim A.] Ural Fed Univ, Inst Chem & Technol, Ekaterinburg 620002, Russia in 2021.0, Cited 30.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

Serotonergic psychedelics, substances exerting their pharmacological action through activation of the serotonin 2A receptor (5-HT2AR), have continuously comprised a substantial fraction of the over 1000 reported New Psychoactive Substances (NPS) so far. Within this category, N-benzyl derived phenethylamines, such as NBOMes and NBFs, have shown to be of particular relevance. As these substances remain incompletely characterized, this study aimed at synthesizing positional isomers of 25H-NBF, with two methoxy groups placed on different positions of the phenyl group of the phenethylamine moiety. These isomers were then functionally characterized in an in vitro bioassay monitoring the recruitment of beta-arrestin 2 to the 5HT(2A)R through luminescent readout via the NanoBiT technology. The obtained results provide insight into the optimal substitution pattern of the phenyl group of the phenethylamine moiety of N-benzyl derived substances, a feature so far mostly explored in the phenethylamines underived at the N-position. In the employed bioassay, the most potent substances were 24H-NBF (EC50 value of 158 nM), 26H-NBF (397 nM), and 25H-NBF (448 nM), with 23H-NBF, 35H-NBF, and 34H-NBF yielding mu M EC50 values. A similar ranking was obtained for the compounds’ efficacy: taking as a reference LSD (lysergic acid diethylamide), 24H-, 26H-, and 25H-NBF had an efficacy of 106-107%, followed by 23H-NBF (96.1%), 34H-NBF (75.2%), and 35H-NBF (58.9%). The stronger activity of 24H-, 25H-, and 26H-NBF emphasizes the important role of the methoxy group at position 2 of the phenethylamine moiety for the in vitro functionality of NBF substances.

Product Details of 120-14-9. Welcome to talk about 120-14-9, If you have any questions, you can contact Pottie, E; Kupriyanova, OV; Shevyrin, VA; Stove, CP or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Obregon-Mendoza, MA; Arias-Olguin, II; Meza-Morales, W; Alvarez-Ricardo, Y; Chavez, MI; Toscano, RA; Cassani, J; Enriquez, RG in MDPI published article about in [Obregon-Mendoza, Marco A.; Arias-Olguin, Imilla I.; Meza-Morales, William; Alvarez-Ricardo, Yair; Isabel Chavez, Maria; Toscano, Ruben A.; Enriquez, Raul G.] Univ Nacl Autonoma Mexico, Inst Quim, Ciudad Univ, Mexico City Cdmx 04510, Mexico; [Cassani, Julia] Univ Autonoma Metropolitana, Dept Sistemas Biol, Unidad Xochimilco, Ciudad De Mexico 04960, Mexico in 2021.0, Cited 32.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9

The expected (E)-but-3-en-2-ones compounds I and II (half curcuminoids) were obtained by the Claisen-Schmidt reaction between aldehydes 3,4-dimethoxybenzaldehyde or 4-nitrobenzaldehyde with acetone. Concomitantly, 3-methylcyclohex-2-enones compounds III and IV arose from an unexpected reaction of but-3-en-2-ones in the cascade reaction of a Michael-type addition of a second molecule of acetone followed by Robinson annulation under strong basic conditions. Both enones exhibit the (E)-configuration, compound I displays s-trans conformation, whereas compound II exhibits conformational disorder as solid solution of s-cis and s-trans conformations. The related 3-methylcyclohex-2-enones exhibit envelope conformation. Compound III constitutes an example of the rarest case of racemic solid solution (pseudoracemate), where a lack of chiral discrimination with respect to the two enantiomers leads to an enantiomeric disorder of a racemic mixture with different occupancies at the reference site. Due to the lack of strong hydrogen-bond donors in all compounds, the crystal packing is mainly stabilized by weak intermolecular C-H center dot center dot center dot O interactions between the molecules. The present work provides a new perspective on the search for by-products normally overlooked in Claisen-Schmidt condensations.

Category: indole-building-block. Bye, fridends, I hope you can learn more about C9H10O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles