Category: 120-72-9

Yildiz, Halit; Tokalioglu, Serife; Soykan, Cengiz published an article in 2021. The article was titled 《Preparation of polyacrylonitrile/polyindole conducting polymer composite and its use for solid phase extraction of copper in a certified reference material》, and you may find the article in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy.Application In Synthesis of 1H-Indole The information in the text is summarized as follows:

A polyacrylonitrile/polyindole (PAN/PIN) [50, 50] conducting polymer composite was chem. synthesized using FeCl3 as an oxidizing agent in chloroform solution and nitrogen atm. at 10°C. The formation of the composite was supported by Fourier transform IR spectroscopy. The morphol. properties of the composite were investigated by at. force microscopy and SEM. The thermal properties of the composite were examined by using thermogravimetric analyses. It was found that the composite had good thermal stability. The conducting polymer composite was used for the first time as an adsorbent for solid phase extraction of Cu (II). The optimum pH was found to be 7. The adsorption and elution shaking times were 5 and 15 min, resp. The elution was done with 5 mL of 2 mol L-1 HNO3. The accuracy of the developed method was confirmed by analyzing certified reference material (TMDA-70.2 Lake Water). In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 1H-IndoleIn 2019 ,《An insight into the medicinal perspective of synthetic analogs of indole: A review》 appeared in European Journal of Medicinal Chemistry. The author of the article were Thanikachalam, Punniyakoti Veeraveedu; Maurya, Rahul Kumar; Garg, Vishali; Monga, Vikramdeep. The article conveys some information:

A review. Heterocycles occupy a salient place in chem. due to their wide range of activity in the fields of drug design, photochem., agrochems., dyes, and so on. Amongst all, indole scaffold is considered as one of the most promising heterocycles found in natural and synthetic sources and has been shown to possess various biol. activity, including anti-inflammatory, anti-HIV, antitubercular, antimalarial, anticonvulsant, antidiabetic, antihypertensive, analgesics, antidepressant, anticancer, antioxidant, antifungal, and antimicrobial, etc. All the reported indole mols. bind to multiple receptors with high affinity, thus expedite the research on the development of novel biol. active compounds through the various approach. In this review, we aimed to highlight synthetic and medicinal perspective on the development of indole-based analogs. In addition, structural activity relationship (SAR) study to correlate for their biol. activity also discussed. In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9Quality Control of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Cu2O-incorporated MAF-6-derived highly porous carbons for the adsorptive denitrogenation of liquid fuel》 was published in Chemical Engineering Journal (Amsterdam, Netherlands) in 2020. These research results belong to Khan, Nazmul Abedin; Shin, Subin; Hwa Jhung, Sung. Formula: C8H7N The article mentions the following:

Metal-organic framework (MOF)-derived carbons (MDCs) with remarkable porosity were synthesized through pyrolysis of a MOF (metal-azolate framework-6 or MAF-6) in the presence of KOH activating agent. Further, Cu2O particles were synthesized under a mild condition within the MDCs. The Cu2O/MDCs showed very efficient adsorptions of both quinoline (454 mg/g) and indole (435 mg/g) from liquid fuel. Or, the Cu2O/MDC resulted in increase of quinoline and indole adsorption, by around 213% and 243%, resp., compared with simple MDC, prepared without KOH. Addnl., the new adsorbent showed around 5-6 times efficiency in removal of such adsorbates to that of conventional activated carbon. The maximum adsorption capacities (Qm) of the studied adsorbent for quinoline and indole also stand at the first and second positions, resp., among the carbon-based adsorbents reported so far. Moreover, compared with other studied adsorbents, the Cu2O-incorporated MDCs had a good selectivity towards both adsorbates, especially during the adsorptions in the presence of toluene as a co-solvent. The remarkable adsorptions with Cu2O/MDC were explained by the π-complexation and huge porosity. In addition, the adsorbents could be regenerated for several cycles via a simple solvent wash. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Formula: C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies》 was written by Al-Warhi, Tarfah; Abo-Ashour, Mahmoud F.; Almahli, Hadia; Alotaibi, Ohoud J.; Al-Sanea, Mohammad M.; Al-Ansary, Ghada H.; Ahmed, Hanaa Y.; Elaasser, Mahmoud M.; Eldehna, Wagdy M.; Abdel-Aziz, Hatem A.. Synthetic Route of C8H7N And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020. The article conveys some information:

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates is here designed and synthesized with the prime aim to develop more efficient isatin-based antitumor candidates. Utilizing the SAR outputs from the previous study, our design here is based on appending four alkyl groups with different length (Et and n-propyl), bulkiness (iso-propyl) and unsaturation (allyl) on N-1 of indole motif, with subsequent conjugation with different N-unsubstituted isatin moieties to furnish the target conjugates. As planned, the adopted strategy achieved a substantial improvement in the growth inhibitory profile for the target conjugates in comparison to the reported lead . The best results were obtained with N-propylindole -5-methylisatin hybrid which displayed broad spectrum anti-proliferative action with efficient sub-panel GI50 (MG-MID) range from 1.33 to 4.23 μM, and promising full-panel GI50 (MG-MID) equals 3.10 μM, at the NCI five-dose assay. Also, hybrid was able to provoke cell cycle disturbance and apoptosis in breast T-47D cells as evidenced by the DNA flow cytometry and Annexin V-FITC/PI assays. Furthermore, hybrid exhibited good inhibitory action against cell cycle regulator CDK2 protein kinase and the anti-apoptotic Bcl-2 protein (IC50= 0.85 ± 0.03 and 0.46 ± 0.02 μM, resp.). Interestingly, mol. docking for hybrid in CDK2 and Bcl-2 active sites unveiled that N-Pr group is involved in significant hydrophobic interactions. Taken together, the results suggested conjugate as a promising lead for further development and optimization as an efficient antitumor drug. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Synthetic Route of C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Tripodal molecular propellers perturb microtubule dynamics: indole acts as a blade and plays a crucial role in anticancer activity》 was written by Barman, Surajit; Das, Gaurav; Mondal, Prasenjit; Pradhan, Krishnangsu; Jana, Batakrishna; Bhunia, Debmalya; Saha, Abhijit; Kar, Chirantan; Ghosh, Surajit. Application In Synthesis of 1H-IndoleThis research focused ontripodal mol microtubule dynamics indole anticancer activity. The article conveys some information:

An indole-rich tripodal microtubule inhibitor is designed, which binds at the DCVJ site of tubulin and inhibits its polymerization It causes apoptotic death of cancer cells without affecting normal cells and inhibits the growth of tumors. Finally, STD-NMR and TR-NOESY experiments reveal that the indole appendages play a crucial role in interacting with tubulin. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-blockIn 2020 ,《On the possibility of direct triplet state excitation of indole》 appeared in Journal of Photochemistry and Photobiology, B: Biology. The author of the article were Chavez, Jose; Ceresa, Luca; Kitchner, Emma; Kimball, Joseph; Shtoyko, Tanya; Fudala, Rafal; Borejdo, Julian; Gryczynski, Zygmunt; Gryczynski, Ignacy. The article conveys some information:

We studied the luminescence properties of indole in poly (vinyl alc.) (PVA) film. The indole mols. are effectively immobilized in this polymer film and display both fluorescence and phosphorescence emission at room temperature We noticed that the phosphorescence of indole in PVA film can be effectively excited at a longer wavelength than its typical singlet to triplet population route involving intersystem crossing. The maximum of the phosphorescence excitation is about 410 nm which corresponds to the energy of indole triplet state. Interestingly, the phosphorescence anisotropy excited with the longer wavelength (405 nm) is pos. and reaches a value of about 0.25 in contrast to the phosphorescence anisotropy excited within the indole singlet absorption spectrum (290 nm), which is neg. Very different temperature dependences have been observed for fluorescence and phosphorescence of indole in PVA film. While fluorescence depends minimally, the phosphorescence decreases with temperature dramatically. The fluorescence lifetime was measured to be a single component 4.78 ns while the intensity weighted average phosphorescence lifetime with 290 nm and 405 nm excitations were 6.57 and 5.62 ms, resp. We believe that the possibility of the excitation of indole phosphorescence in the blue region of visible light and its high anisotropy opens a new avenue for future protein studies. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Category: indole-building-block)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 120-72-9In 2019 ,《Enhanced anaerobic biodegradation efficiency and mechanism of quinoline, pyridine, and indole in coal gasification wastewater》 appeared in Chemical Engineering Journal (Amsterdam, Netherlands). The author of the article were Shi, Jingxin; Xu, Chunyan; Han, Yuxing; Han, Hongjun. The article conveys some information:

Anaerobic bottle experiments were operated in parallel for 160 consecutive days for raw (R1), Polyurethane (R2), and Fe3O4@Cu/Polyurethane (R3) biodegradation of selected nitrogen-heterocyclic (NHCs) in coal gasification wastewater. The addition of Fe3O4@Cu/Polyurethane absolutely had an enhancement of microorganism for the degradation of NHCs. The results of GC-MS showed that the first step of anaerobic degradation of NHCs was the opening of nitrogen heterocyclic ring, the second step was the release of ammonia nitrogen and the opening of benzene ring. In R3, direct interspecies electron transfer (DIET) guided by Fe3O4@Cu could realize the rapid transfer of electrons and avoid the accumulation of electrons in the degradation of the NHCs. Furthermore, acute toxicity anal. showed that under the enhancement of Fe3O4@Cu/Polyurethane, the selected NHCs was degraded effectively and the toxic inhibition of selected NHCs on living organisms decreased effectively. Finally, high-throughput 16S rRNA pyrosequencing showed that the dominant strains were dispersed more balanced with the assist of Fe3O4@Cu/Polyurethane. In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Product Details of 120-72-9) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Product Details of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Indole: A Promising Scavenging Agent for Methylglyoxal and Related Carbonyls in Tryptophan Containing Maillard Model Systems》 was written by Ghassem Zadeh, Raheleh; Yaylayan, Varoujan. HPLC of Formula: 120-72-9This research focused ontryptophan Maillard model indole methylglyoxal carbonyl scavenging; carbonyl scavengers; formaldehyde; indole; methylglyoxal; phenylacetaldehyde and PhIP; tryptophan. The article conveys some information:

In situ generation of efficient carbonyl trapping agents from amino acids during food processing can be considered a useful approach to control the accumulation of harmful Maillard reaction products in food. Tryptophan is one such amino acid that can be used to generate carbonyl trapping agents. Indole, the main thermal degradation product of tryptophan, is known to react with simple aldehydes through electrophilic aromatic substitution type reactions mainly at carbon positions 2 and 3 in addition to the ring nitrogen. The ability of indole to scavenge three moles of reactive aldehydes per mol of indole such as formaldehyde, methylglyoxal, and phenylacetaldehyde was investigated using model systems containing tryptophan or indole. The model systems were either (a) heated in an aqueous solution in stainless steel reactors at specified time and temperatures and analyzed by qTOF-MS/MS or (b) directly pyrolyzed and analyzed by GC/MS using isotope labeling technique. Unlike the other aldehydes, the initial alc. formed with phenylacetaldehyde was able to dehydrate and form an stable conjugated system with the indole. In general, indole was able to capture three moles of paraformaldehyde, three moles of methylglyoxal and three moles of phenylacetaldehyde and suppress the formation of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) generated in a model system. After reading the article, we found that the author used 1H-Indole(cas: 120-72-9HPLC of Formula: 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.HPLC of Formula: 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles