Category: 120-72-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120-72-9,1H-Indole,as a common compound, the synthetic route is as follows.

To a solution of indole (10.021 g, 85 mmol) in diethyl ether (150 mL) was added oxalyl chloride (11.0 mL, 16.3 g, 0.13 mol) dropwise over 10 minutes and the yellow suspension was allowed to stir for a further 30 minutes at room temperature. Saturated aqueous sodium bicarbonate (20 mL) was then added with caution and the biphasic mixture was stirred for 16 hours. The product was then collected using vacuum filtration, washed with diethyl ether and dried overnight at 40 C to give a yellow solid (14.167 g, 88%): m.p. 193-196 C; (Lit. 210 C decomp.)47; numax/cm-1(KBr) 3549, 3195, 1719, 1611, 1268; deltaH(300 MHz, DMSO-d6) 7.26 [1H, ddd,J9.1, 7.1, 1.7, C(5)-H], 7.29 [1H, ddd,J9.3, 7.1, 1.9, C(6)-H], 7.52-7.58 [1H, m, C(7)-H], 8.14-8.20 [1H, m, C(4)-H], 8.42 [1H, d,J3.3, C(2)-H], 12.36 (1H, bs, N-H); m/z (ESI+) = 190.3 [(M+H)+100%]., 120-72-9

The synthetic route of 120-72-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Winfield, Hannah J.; Cahill, Michael M.; O’Shea, Kevin D.; Pierce, Larry T.; Robert, Thomas; Ruchaud, Sandrine; Bach, Stephane; Marchand, Pascal; McCarthy, Florence O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4209 – 4224;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

120-72-9, 1H-Indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of lH-indole (0.38 g, 3.244 mmol) in DMF (15 ml) was added TFAA (0.451 ml, 3.244 mmol) at room temperature. The reaction was stirred at 40 C for 2 hr. The mixture was poured into sodium bicarbonate solution (400 mL). The precipitate was filtered and washed with H20. The solid was dissolved in EtOAc and purified by silica gel column chromatography to give the title compound (650 mg). LCMS m/z = 214.2 [M+H]+; NMR (400 MHz, CD3OD) delta ppm 7.28-7.37 (m, 2H), 7.49-7.56 (m, 1H), 8.20-8.24 (m, 1H), 8.25-8.29 (m, 1H)., 120-72-9

120-72-9 1H-Indole 798, aindole-building-block compound, is more and more widely used in various fields.

Reference£º
Patent; ARENA PHARMACEUTICALS, INC.; SEMPLE, Graeme; BEHAN, Dominic P.; FEICHTINGER, Konrad; GLICKLICH, Alan; GROTTICK, Andrew J.; KAM, Maria Matilde Sanchez; KASEM, Michelle; LEHMANN, Juerg; REN, Albert S.; SCHRADER, Thomas O.; SHANAHAN, William R.; WONG, Amy Siu-Ting; ZHU, Xiuwen; WO2015/66344; (2015); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles