120-72-9 | - Page 2 of 11 - Indole Building Blocks

Chen, Shuyou’s team published research in ACS Catalysis in 2019 | CAS: 120-72-9

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 1H-Indole

Reference of 1H-IndoleIn 2019 ,《C2/C4 Regioselective Heteroarylation of Indoles by Tuning C-H Metalation Modes》 appeared in ACS Catalysis. The author of the article were Chen, Shuyou; Zhang, Min; Su, Rongchuan; Chen, Xingyu; Feng, Boya; Yang, Yudong; You, Jingsong. The article conveys some information:

The development of a rational strategy to achieve the complete regioselectivity and the capability to switch regioselectivity is an appealing, yet challenging, puzzle in transition-metal-catalyzed oxidative Ar-H/Ar-H cross-coupling. Disclosed herein is an iridium-catalyzed C2/C4 regioselective C-H heteroarylation of indoles with the help of a pivaloyl group at the C3 position. The judicious choice of the catalytic systems allows the C2-heteroarylation of indole via a concerted metalation-deprotonation (CMD) process and the C4-heteroarylation via a trimol. electrophilic substitution (SE3) pathway. The oxidants Cu(OAc)2·H2O and Ag2O are demonstrated to play a vital role in the C2/C4 regioselectivity. In this Article, a heteroaryl-Ir(III)-heteroaryl complex prior to reductive elimination is successfully isolated and characterized, which represents the first example of capturing the bis(hetero)aryl metallic intermediate in oxidative Ar-H/Ar-H cross-coupling. The regiodivergent heteroarylation of indoles developed herein provides an opportunity to rapidly assemble diverse C4- and C2-heteroarylated indoles. The experimental part of the paper was very detailed, including the reaction process of 1H-Indole(cas: 120-72-9Reference of 1H-Indole)

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dhuguru, Jyothi’s team published research in Molecules in 2020 | CAS: 120-72-9

Application of 120-72-9In 2020 ,《Role of indole scaffolds as pharmacophores in the development of anti-lung cancer agents》 appeared in Molecules. The author of the article were Dhuguru, Jyothi; Skouta, Rachid. The article conveys some information:

A review. Lung cancer is the leading cause of death in men and women worldwide, affecting millions of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is more common than small cell lung cancer (SCLC). Besides surgery and radiotherapy, chemotherapy is the most important method of treatment for lung cancer. Indole scaffold is considered one of the most privileged scaffolds in heterocyclic chem. Indole may serve as an effective probe for the development of new drug candidates against challenging diseases, including lung cancer. In this review, we will focus on discussing the existing indole based pharmacophores in the clin. and pre-clin. stages of development against lung cancer, along with the synthesis of some of the selected anti-lung cancer drugs. Moreover, the basic mechanism of action underlying indole based anti-lung cancer treatment, such as protein kinase inhibition, histone deacetylase inhibition, DNA topoisomerase inhibition, and tubulin inhibition will also be discussed. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)

Somboonna, Naraporn’s team published research in mBio in 2019 | CAS: 120-72-9

In 2019,mBio included an article by Somboonna, Naraporn; Ziklo, Noa; Ferrin, Thomas E.; Suh, Jung Hyuk; Dean, Deborah. Application In Synthesis of 1H-Indole. The article was titled 《Clinical persistence of Chlamydia trachomatis sexually transmitted strains involves novel mutations in the functional αββα tetramer of the tryptophan synthase operon》. The information in the text is summarized as follows:

We examined serial urogenital samples from a woman who had recurrent Ct infections over 4 years despite antibiotic treatment. The Ct isolates from each infection episode were genome sequenced and analyzed for phenotypic, structural, and functional characteristics. Each isolate displayed an altered αββα structure, could not synthesize tryptophan from indole, and had significantly lower trpBA expression but higher intracellular tryptophan levels compared with those of reference Ct strain F/IC-Cal3. Our data indicate that emergent mutations in the tryptophan operon, which were previously thought to be restricted only to ocular Ct strains, likely resulted in in vivo persistence in the described patient and represents a novel host-pathogen adaptive strategy for survival. IMPORTANCE:Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterium with more than 131 million cases occurring annually worldwide. Here, we discovered that the genomes of serial isolates from a woman with recurrent, treated Ct STIs over many years were identical with a novel synthase mutation. Our findings indicate an emerging adaptive host-pathogen evolutionary strategy for survival in the urogenital tract that will prompt the field to further explore chlamydial persistence, evaluate the genetics of mutant Ct strains and fitness within the host, and their implications for disease pathogenesis. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

Kumar, Alok’s team published research in ACS Sensors in 2020 | CAS: 120-72-9

《Ultrafast detection and discrimination of methanol gas using a polyindole-embedded substrate integrated waveguide microwave sensor》 was written by Kumar, Alok; Wang, Cong; Meng, Fan-Yi; Jiang, Cheng-Peng; Yan, Guo-Feng; Zhao, Meng; Jing, Chang-Qiang; Wang, Lei. COA of Formula: C8H7N And the article was included in ACS Sensors in 2020. The article conveys some information:

The fast and sensitive detection of methanol gas using cost-effective sensors in the industry is a significant issue to be addressed. Herein, a polyindole (PIn)-deposited substrate integrated waveguide (SIW) has been introduced to perform quant. and qual. methanol gas sensing with quick response and recovery time at room temperature First, PIn is synthesized and deposited in the microwell etched at the intensified elec. field region of the microwave-based cavity resonator, which gives a sensing response through variation of PIn’s high-frequency conductivity and dielec. property caused by the adsorption and desorption of methanol gas. Second, an enhanced filling factor and high Q factor have been attained using the proposed microwell etched SIW structure, which exhibits high sensitivity in terms of frequency shift (3.33 kHz/ppm), amplitude shift (0.005 dB/ppm), bandwidth broadening (3.66 kHz/ppm), and loaded Q factor (10.60 Q value/ppm). Third, the gas measurement results reveal excellent long-term stability with a relative standard deviation (RSD) of 0.02% for 7 days, excellent repeatability with an RSD of 0.004%, and desired response and recovery time of 95 and 120 s, resp. The results indicate that the proposed microwave sensor has great potential to achieve high sensitivity and fast response toward methanol gas mols. at room temperature In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9COA of Formula: C8H7N)

Kim, Taegwan’s team published research in Molecules in 2022 | CAS: 120-72-9

Application of 120-72-9In 2022 ,《Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries》 appeared in Molecules. The author of the article were Kim, Taegwan; Ha, Min Woo; Kim, Jonghoon. The article conveys some information:

A review. Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-mol. libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-mol. libraries. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)

Ruiz-Ruiz, Susana’s team published research in Aging Cell in 2020 | CAS: 120-72-9

《Functional microbiome deficits associated with ageing: Chronological age threshold》 was written by Ruiz-Ruiz, Susana; Sanchez-Carrillo, Sergio; Ciordia, Sergio; Mena, Maria C.; Mendez-Garcia, Celia; Rojo, David; Bargiela, Rafael; Zubeldia-Varela, Elisa; Martinez-Martinez, Monica; Barbas, Coral; Ferrer, Manuel; Moya, Andres. Related Products of 120-72-9 And the article was included in Aging Cell in 2020. The article conveys some information:

Composition of the gut microbiota changes during aging, but questions remain about whether age is also associated with deficits in microbiome function and whether these changes occur sharply or progressively. The ability to define these deficits in populations of different ages may help determine a chronol. age threshold at which deficits occur and subsequently identify innovative dietary strategies for active and healthy aging. Here, active gut microbiota and associated metabolic functions were evaluated using shotgun proteomics in three well-defined age groups consisting of 30 healthy volunteers, namely, ten infants, ten adults and ten elderly individuals. Samples from each volunteer at intervals of up to 6 mo (n = 83 samples) were used for validation. Aging gradually increases the diversity of gut bacteria that actively synthesize proteins, that is by 1.4-fold from infants to elderly individuals. An anal. of functional deficits consistently identifies a relationship between tryptophan and indole metabolism and aging (p < 2.8e-8). Indeed, the synthesis of proteins involved in tryptophan and indole production and the fecal concentrations of these metabolites are directly correlated (r2 > .987) and progressively decrease with age (r2 > .948). An age threshold for a 50% decrease is observed ca. 11-31 years old, and a greater than 90% reduction is observed from the ages of 34-54 years. Based on recent investigations linking tryptophan with abundance of indole and other “”healthy”” longevity mols. and on the results from this small cohort study, dietary interventions aimed at manipulating tryptophan deficits since a relatively “”young”” age of 34 and, particularly, in the elderly are recommended. The experimental part of the paper was very detailed, including the reaction process of 1H-Indole(cas: 120-72-9Related Products of 120-72-9)

Wu, Zhiqiang’s team published research in Green Chemistry in 2019 | CAS: 120-72-9

In 2019,Green Chemistry included an article by Wu, Zhiqiang; Wang, Gang; Yuan, Shuo; Wu, Dan; Liu, Wanyi; Ma, Baojun; Bi, Shuxian; Zhan, Haijuan; Chen, Xiaoyan. SDS of cas: 120-72-9. The article was titled 《Synthesis of bis(indolyl)methanes under dry grinding conditions, promoted by a Lewis acid-surfactant-SiO2-combined nanocatalyst》. The information in the text is summarized as follows:

An in situ developed Lewis acid-surfactant-SiO2-combined (LASSC) nanocatalyst was used, for the first time, as a green and effective promoting medium for the electrophilic activation of aldehydes RCHO (R = 4-nitrophenyl, 2,4-dichlorophenyl, 3,4-dihydroxyphenyl, etc.) under solvent-free and dry grinding conditions. The advantages of using the LASSC nanocatalyst include avoiding the generation of wastewater containing sodium dodecyl sulfate and the use of toxic reagents, excellent reusability of the catalyst, and obtaining a high yield of bis(indolyl)methanes I (R1 = 6-NO2, 2-Me, 3-Me, etc.). In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9SDS of cas: 120-72-9)

Chen, Xiaohua’s team published research in Food Chemistry in 2019 | CAS: 120-72-9

In 2019,Food Chemistry included an article by Chen, Xiaohua; Chen, Dejing; Jiang, Hai; Sun, Haiyan; Zhang, Chen; Zhao, Hua; Li, Xinsheng; Yan, Fei; Chen, Chen; Xu, Zhimin. Electric Literature of C8H7N. The article was titled 《Aroma characterization of Hanzhong black tea (Camellia sinensis) using solid phase extraction coupled with gas chromatography-mass spectrometry and olfactometry and sensory analysis》. The information in the text is summarized as follows:

The unique aroma of the Hanzhong black tea is due to the special location of the harvesting place and specific manufacturing processes. In this study, a solid phase extraction method (SPE) as sample preparation tool was combined with gas chromatog. (GC) as separation technique and several detection systems such as mass spectrometry (MS), flame ionization (FID) and olfactometry (O), which, together with sensorial anal. were used to characterize aroma compounds in Hanzhong black tea infusion. Seventy three aroma compounds were identified and quantified in the tea infusion by the GC-MS and GC-FID methods, resp. Among them, odor perceptions of 24 compounds were characterized by the GC-O anal. It was found that linalool oxide I, II and III, E,E-2,4-nonadienal, 4,5-dimethyl-3-hydroxy-2,5-dihydrofuran-2-one, 1-octen-3-one, E,Z-2,6-nonadienal, bis(2-methyl-3-furyl) disulfide had higher odor activity value in the tea infusion and offered floral, fatty, and caramel, mushroom, cucumber, and cooked beef -like odors, resp. Overall, floral and mushroom and caramel -like odors significantly dominated in the Hanzhong black tea infusion.1H-Indole(cas: 120-72-9Electric Literature of C8H7N) was used in this study.

Feng, Zhihui’s team published research in Food Chemistry in 2019 | CAS: 120-72-9

Safety of 1H-IndoleIn 2019 ,《Tea aroma formation from six model manufacturing processes》 was published in Food Chemistry. The article was written by Feng, Zhihui; Li, Yifan; Li, Ming; Wang, Yijun; Zhang, Liang; Wan, Xiaochun; Yang, Xiaogen. The article contains the following contents:

Tea aroma is determined by the nature of the plant, the production processes, and many other factors influencing its formation and release. The objective of this study was to investigate the impact of manufacturing processes on the aroma composition of tea. Fresh tea leaves from the same cultivar and growing area were selected for producing the six types of tea: green, white, yellow, oolong, black, and dark teas. Comprehensive anal. by gas chromatog. mass spectrometry (GC/MS) was performed for the volatiles of tea infusion, prepared by solid-phase microextraction (SPME), solid-phase extraction (SPE), and solvent assisted flavor evaporation (SAFE). A total of 168 volatile compounds were identified. Black tea has the highest volatile concentration of 710 μg/g, while green tea has the lowest concentration of 20 μg/g. Significantly affected by these processes, tea aroma mols. are formed mainly from four precursor groups: carotenoids, fatty acids, glycosides, and amino acids/sugars. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Safety of 1H-Indole)

Dong, Fangcong’s team published research in Gut Microbes in 2020 | CAS: 120-72-9

Reference of 1H-IndoleIn 2020 ,《The aryl hydrocarbon receptor as a mediator of host-microbiota interplay》 appeared in Gut Microbes. The author of the article were Dong, Fangcong; Perdew, Gary H.. The article conveys some information:

A review. Increasing evidence suggests a significant role for microbiota dependent metabolites and co-metabolites, acting as aryl hydrocarbon receptor (AHR) ligands, to facilitate bidirectional communication between the host and the microbiota and thus modulate physiol. Such communication is particularly evident within the gastrointestinal tract. Through binding to or activating the AHR, these metabolites play fundamental roles in various physiol. processes and likely contribute to the maintenance of intestinal homeostasis. In recent years, tryptophan metabolites were screened to identify physiol. relevant AHR ligands or activators. The discovery of specific microbiota-derived indole-based metabolites as AHR ligands may provide insight concerning how these metabolites affect interactions between gut microbiota and host intestinal homeostasis and how this relates to chronic GI disease and overall health. A greater understanding of the mechanisms that modulate the production of such metabolites and associated AHR activity may be utilized to effectively treat inflammatory diseases and promote human health. Here, we review microbiota-derived AHR ligands generated from tryptophan that modulate host-gut microbiota interactions and discuss possible intervention strategies for potential therapies in the future. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Reference of 1H-Indole)