120-72-9 | - Page 4 of 11 - Indole Building Blocks

Zarkan, Ashraf’s team published research in Trends in Microbiology in 2020 | CAS: 120-72-9

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 120-72-9

Application of 120-72-9In 2020 ,《Local and Universal Action: The Paradoxes of Indole Signalling in Bacteria》 appeared in Trends in Microbiology. The author of the article were Zarkan, Ashraf; Liu, Junyan; Matuszewska, Marta; Gaimster, Hannah; Summers, David K.. The article conveys some information:

A review. Indole is a signaling mol. produced by many bacterial species and involved in intraspecies, interspecies, and interkingdom signaling. Despite the increasing volume of research published in this area, many aspects of indole signaling remain enigmatic. There is disagreement over the mechanism of indole import and export and no clearly defined target through which its effects are exerted. Progress is hindered further by the confused and sometimes contradictory body of indole research literature. We explore the reasons behind this lack of consistency and speculate whether the discovery of a new, pulse mode of indole signaling, together with a move away from the idea of a conventional protein target, might help to overcome these problems and enable the field to move forward. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Application of 120-72-9)

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhou, Wei’s team published research in Journal of Natural Products in 2022 | CAS: 120-72-9

Zhou, Wei; Vergis, John; Mahmud, Taifo published an article in 2022. The article was titled 《EDB Gene Cluster-Dependent Indole Production Is Responsible for the Ability of Pseudomonas fluorescens NZI7 to Repel Grazing by Caenorhabditis elegans》, and you may find the article in Journal of Natural Products.Product Details of 120-72-9 The information in the text is summarized as follows:

The “”EDB”” (from “”edible””) gene cluster, a variant of the ebo cluster of genes found in many bacteria and algae, allows Pseudomonas fluorescens NZI7 (referred to here as “”NZI7″”) to repel grazing by the nematode Caenorhabditis elegans. The mechanism underlying this phenotype is unknown. Here we report that the EDB cluster is involved in the conversion of tryptophan to (1H-indol-3-yl)-oxoacetamide, indole 3-aldehyde, and other indole-derived compounds Inactivation of the EDB genes in NZI7 resulted in mutants that lack the ability to excrete indole-derived compounds as well as the ability to repel C. elegans. Heterologous expression of the NZI7 EDB cluster in E. coli cultivated in minimal M9 medium containing 2 mM L-tryptophan also released indole derivatives including tryptophol, 3-(hydroxyacetyl)indole, colletotryptin E, and two new dimeric indoles. Expression of the NZI7 EDB cluster in E. coli, cultured in minimal M9 medium and lacking tryptophan, did not produce detectable levels of indole derivatives Both (1H-indol-3-yl)-oxoacetamide and indole 3-aldehyde showed repellent activity against C. elegans, revealing the mechanism underlying the ability of P. fluorescens NZI7 to repel grazing by C. elegans. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Product Details of 120-72-9)

Yang, Jie’s team published research in Food Research International in 2021 | CAS: 120-72-9

Yang, Jie; Zhou, Xiaochen; Wu, Shuhua; Gu, Dachuan; Zeng, Lanting; Yang, Ziyin published an article in 2021. The article was titled 《Involvement of DNA methylation in regulating the accumulation of the aroma compound indole in tea (Camellia sinensis) leaves during postharvest processing》, and you may find the article in Food Research International.SDS of cas: 120-72-9 The information in the text is summarized as follows:

The manufacturing process of tea (Camellia sinensis), especially oolong tea, involves multiple postharvest stresses. These stresses can induce the formation and accumulation of many important aroma compounds, such as indole-a key floral aroma contributor of oolong tea. However, little is known about the regulation mechanisms of aroma compound formation, especially epigenetic regulation. DNA methylation is an important epigenetic modification. Changes in the DNA methylation levels of promoter sequences can regulate gene expression under stress conditions. In this study, the differences in DNA methylation levels and histone 3 lysine 9 dimethylation levels of indole key biosynthetic gene (tryptophan synthase β-subunit 2, CsTSB2) were detected between untreated and continuous wounding treatment tea leaves. The results show that the DNA methylation levels affect the ability of the basic helix-loop-helix family transcription factor CsMYC2a to bind to the promoter of CsTSB2. Analyses of the transcript levels of DNA methyltransferases during oolong tea processing screened out candidate genes involved in the regulation of secondary metabolite product biosynthesis/accumulation. The results suggest that the domains rearranged methyltransferase 3, a DNA methyltransferase, is involved in the DNA methylation regulation of indole formation during the oolong tea manufacturing process. This is the first report on the involvement of DNA methylation in the regulation of aroma compound formation in tea leaves exposed to postharvest stresses. The experimental part of the paper was very detailed, including the reaction process of 1H-Indole(cas: 120-72-9SDS of cas: 120-72-9)

Wang, Tianmin’s team published research in Nature Chemical Biology in 2020 | CAS: 120-72-9

《Dynamics of transcription-translation coordination tune bacterial indole signaling》 was published in Nature Chemical Biology in 2020. These research results belong to Wang, Tianmin; Zheng, Xiang; Ji, Haonan; Wang, Ting-Liang; Xing, Xin-Hui; Zhang, Chong. Recommanded Product: 120-72-9 The article mentions the following:

Indole signaling is an important cross-species communication pathway in the mammalian gut. In bacteria, upon induction by tryptophan, the mol. sensor (tnaC) controls indole biosynthesis by precisely coordinating dynamics of the corresponding macromol. machineries during its transcription and translation. The authors’ understanding of this regulatory program is still limited owing to its rapid dynamic nature. To address this shortcoming, the authors adopted a massively parallel profiling method to quantify the responses of 1450 synthetic tnaC variants in the presence of three concentrations of tryptophan in living bacterial cells. The resultant dataset enabled the authors to comprehensively probe the key intermediate states of macromol. machineries during the transcription and translation of tnaC. The authors also used modeling to provide a systems-level understanding of how these critical states collectively shape the output of this regulatory program quant. A similar methodol. will likely apply to other poorly understood dynamics-dependent cis-regulatory elements. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9)

Zheng, Jing’s team published research in FEMS Microbiology Letters in 2019 | CAS: 120-72-9

The author of 《Pantoea agglomerans YS19 poly(A) polymerase I gene possesses the indole-sensing sequence in the promoter region》 were Zheng, Jing; Liu, Qi; Xia, Yifan; Bai, Lijuan; Feng, Yongjun. And the article was published in FEMS Microbiology Letters in 2019. Product Details of 120-72-9 The author mentioned the following in the article:

Pantoea agglomerans YS19 is a predominant diazotrophic endophyte with multiple growth-promoting effects on its host plant that was isolated from rice. Indole is confirmed to induce many changes of physiol. and biochem. characteristics in bacteria. Although YS19 cannot produce indole, it can sense indole in the environment and be regulated by indole. Here, using gfp as a reporter gene, we constructed a series of recombinant plasmids containing the promoter region of the poly(A) polymerase I gene (pcnB) fused with gfp, and compared the green fluorescence intensity at different concentrations of exogenous indole by a flow cytometer. In this research, we confirmed that exogenous indole significantly inhibited the expression of pcnB by its promoter; the regulation sequence sensitive to indole in the promoter region of the pcnB gene (In-pcnB) was between -129 and -88 bp. In-pcnB is widely distributed and strictly conserved in the same genus. These results suggest novel roles of In-pcnB in P. agglomerans YS19, showing its special relation to the indole regulatory pathway. After reading the article, we found that the author used 1H-Indole(cas: 120-72-9Product Details of 120-72-9)

Wani, Tanveer A.’s team published research in Bioorganic Chemistry in 2019 | CAS: 120-72-9

The author of 《Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin》 were Wani, Tanveer A.; Bakheit, Ahmed H.; Zargar, Seema; Bhat, Mashooq A.; Al-Majed, Abdulrahman A.. And the article was published in Bioorganic Chemistry in 2019. Recommanded Product: 120-72-9 The author mentioned the following in the article:

The indole derivative 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N’-[(E)-(3-nitrophenyl) methylidene]acetohydrazide (IND) was synthesized for its therapeutic potential to inhibit cyclooxygenase (COX)-II. Binding if IND to bovine serum albumin (BSA) was investigated was because most drugs bind to serum albumin in-vivo. Fluorescence, UV-vis spectrophotometry and mol. modeling methodologies were employed for studying the interaction mechanism. The intrinsic fluorescence of BSA was quenched by BSA and the quenching mechanism involved was static quenching. The binding constants between IND and BSA at the three studied temperatures (298, 301 and 306 K) were 1.09 × 105, 4.36 × 104 and 1.23 × 104 L mol-1 resp. The most likely site for binding IND to BSA was Site I (subdomain IIA). The anal. of thermodn. parameter revealed the involvement of hydrogen bonding and van der Waals forces in the IND-BSA interaction. Synchronous fluorescence spectroscopic (SFS) and UV-vis spectrophotometric studies suggested conformational change in BSA mol. post interaction to IND. Mol. docking and the exptl. results corroborated one another. The study can prove as an insight for future IND drug development.1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9) was used in this study.

Kumari, Archana’s team published research in Bioorganic Chemistry in 2019 | CAS: 120-72-9

Name: 1H-IndoleIn 2019 ,《Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives》 appeared in Bioorganic Chemistry. The author of the article were Kumari, Archana; Singh, Rajesh K.. The article conveys some information:

A review. Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic compound with wide ranges of pharmacol. activities due to different mechanisms of action. It is an superlative moiety in drug discovery with the sole property of resembling different structures of the protein. Plenty of research has been taking place in recent years to synthesize and explore the various therapeutic prospectives of this moiety. This review summarizes some of the recent effective chem. synthesis (2014-2018) for indole ring. This review also emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogs accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years. The precise features with motives and framework of each research topic is introduced for helping the medicinal chemists to understand the perspective of the context in a better way. This review will definitely offer the platform for researchers to strategically design diverse novel indole derivatives having different promising pharmacol. activities with reduced toxicity and side effects. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Name: 1H-Indole)

Mullins, Terry’s team published research in Nature Communications in 2022 | CAS: 120-72-9

In 2022,Mullins, Terry; Karamatskos, Evangelos T.; Wiese, Joss; Onvlee, Jolijn; Rouzee, Arnaud; Yachmenev, Andrey; Trippel, Sebastian; Kuepper, Jochen published an article in Nature Communications. The title of the article was 《Picosecond pulse-shaping for strong three-dimensional field-free alignment of generic asymmetric-top molecules》.Formula: C8H7N The author mentioned the following in the article:

Fixing mols. in space is a crucial step for the imaging of mol. structure and dynamics. Here, we demonstrate three-dimensional (3D) field-free alignment of the prototypical asym. top mol. indole using elliptically polarized, shaped, off-resonant laser pulses. A truncated laser pulse is produced using a combination of extreme linear chirping and controlled phase and amplitude shaping using a spatial-light-modulator (SLM) based pulse shaper of a broadband laser pulse. The angular confinement is detected through velocity-map imaging of H+ and C2+ fragments resulting from strong-field ionization and Coulomb explosion of the aligned mols. by intense femtosecond laser pulses. The achieved three-dimensional alignment is characterized by comparing the result of ion-velocity-map measurements for different alignment directions and for different times during and after the alignment laser pulse to accurate computational results. The achieved strong three-dimensional field-free alignment of cos2δ = 0.89 demonstrates the feasibility of both, strong three-dimensional alignment of generic complex mols. and its quant. characterization.1H-Indole(cas: 120-72-9Formula: C8H7N) was used in this study.

Shi, Jingxin’s team published research in Bioresource Technology in 2019 | CAS: 120-72-9

Reference of 1H-IndoleIn 2019 ,《Enhanced biodegradation of coal gasification wastewater with anaerobic biofilm on polyurethane (PU), powdered activated carbon (PAC), and biochar》 appeared in Bioresource Technology. The author of the article were Shi, Jingxin; Han, Yuxing; Xu, Chunyan; Han, Hongjun. The article conveys some information:

The primary objective was to explore the feasibility of anaerobic biofilm on polyurethane (PU), powd. activated carbon (PAC), and biochar in strengthening anaerobic degradation of phenolic compounds and selected nitrogen heterocyclic compounds (NHCs) in coal gasification wastewater (CGW). When total phenols (TPh) was less than 300 mg/L, PAC-based biofilm was more efficient. Whereas, when the TPh concentration was more than 450 mg/L, PU-based biofilm performed the optimal degradation efficiency. Furthermore, microbial community structure anal. showed that PAC and biochar had little effect on the microbial community structure after 120 days of operation, while the addition of PU could lead to the enrichment of Giesbergeria, Caldisericum, Thauera, Methanolinea, and Methanoregula. The experimental part of the paper was very detailed, including the reaction process of 1H-Indole(cas: 120-72-9Reference of 1H-Indole)

Naaz, Fatima’s team published research in Future Medicinal Chemistry in 2021 | CAS: 120-72-9

Application of 120-72-9In 2021 ,《Indole derivatives (2010-2020) as versatile tubulin inhibitors: synthesis and structure-activity relationships》 appeared in Future Medicinal Chemistry. The author of the article were Naaz, Fatima; Neha, Kumari; Haider, Rafi Md; Shafi, Syed. The article conveys some information:

A review. Tubulin inhibitors are conjugates that interfere with the dynamic equilibrium of the polymerization and depolymerization of microtubules. Among all the reported conjugates, indole moiety is one of the most significant classes for the development of new drug candidates for cancer therapy. Due to their presence in a wide range of natural as well as synthetic antitubulin agents, indole has become a versatile scaffold in research, and various synthetic and semisynthetic indole-based antitubulin agents have been identified and reported. The present article focuses on the reported indole-based tubulin inhibitors of synthetic origin from last the decade. Synthesis, structure-activity relationships and biol. activities of synthetic indole derivatives along with brief updates on their antitubulin activity are presented. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)