120-72-9 | - Page 6 of 11 - Indole Building Blocks

Shavit, Reut’s team published research in Plant Science (Shannon, Ireland) in 2022 | CAS: 120-72-9

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 1H-Indole

《The wheat dioxygenase BX6 is involved in the formation of benzoxazinoids in planta and contributes to plant defense against insect herbivores》 was written by Shavit, Reut; Batyrshina, Zhaniya S.; Yaakov, Beery; Florean, Matilde; Kollner, Tobias G.; Tzin, Vered. Safety of 1H-IndoleThis research focused onwheat dioxygenase benzoxazinoid insect herbivore plant defense; Aphid; Bread wheat; Caterpillar; Durum wheat; Herbivory; Triticum aestivum; Triticum turgidum; Two-spotted spider mite; Virus-induced gene silencing; Wild emmer wheat. The article conveys some information:

Benzoxazinoids are plant specialized metabolites with defense properties, highly abundant in wheat (Triticum), one of the world′s most important crops. The goal of our study was to characterize dioxygenase BX6 genes in tetraploid and hexaploid wheat genotypes and to elucidate their effects on defense against herbivores. Phylogenetic anal. revealed four BX6 genes in the hexaploid wheat T. aestivum, but only one ortholog was found in the tetraploid (T. turgidum) wild emmer wheat and the cultivated durum wheat. Transcriptome sequencing of durum wheat plants, damaged by either aphids or caterpillars, revealed that several BX genes, including TtBX6, were upregulated upon caterpillar feeding, relative to the undamaged control plants. A virus-induced gene silencing approach was used to reduce the expression of BX6 in T. aestivum plants, which exhibited both reduced transcript levels and reduced accumulation of different benzoxazinoids. To elucidate the effect of BX6 on plant defense, bioassays with different herbivores feeding on BX6-silenced leaves were conducted. The results showed that plants with silenced BX6 were more susceptible to aphids and the two-spotted spider mite than the control. Overall, our study indicates that wheat BX6 is involved in benzoxazinoid formation in planta and contributes to plant resistance against insect herbivores. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Safety of 1H-Indole)

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zheng, Mengqi’s team published research in Journal of Hazardous Materials in 2020 | CAS: 120-72-9

《Insights into electroactive biofilms for enhanced phenolic degradation of coal pyrolysis wastewater (CPW) by magnetic activated coke (MAC): Metagenomic analysis in attached biofilm and suspended sludge》 was written by Zheng, Mengqi; Shi, Jingxin; Xu, Chunyan; Han, Yuxing; Zhang, Zhengwen; Han, Hongjun. Product Details of 120-72-9 And the article was included in Journal of Hazardous Materials in 2020. The article conveys some information:

To investigate the role of electroactive biofilms for enhanced phenolic degradation, lignite activated coke (LAC) and MAC were used as carriers in moving-bed biofilm reactor (MBBR) for CPW treatment. In contrast to activated sludge (AS) reactor, the carriers improved degradation performance of MBBR. Although two MBBRs exerted similar degradation capacity with over 92% of COD and 93% phenols removal under the highest phenolics concentration (500 mg/L), the effluent of MAC-based MBBR remained higher biodegradability (BOD5/COD = 0.34 vs 0.18) than that of LAC-based MBBR. Metagenomic anal. revealed that electroactive biofilms determined phenolic degradation of MAC-based MBBR. Primarily, Geobacter (17.33%) started Fe redox cycle on biofilms and developed syntrophy with Syntrophorhabdus (6.47%), which fermented phenols into easily biodegradable substrates. Subsequently, Ignavibacterium (3.38% to 2.52%) and Acidovorax (0.46% to 8.83%) conducted biol. electricity from electroactive biofilms to suspended sludge. They synergized with dominated genus in suspended sludge, Alicycliphilus (19.56%) that accounted for phenolic oxidation and nitrate reduction Consequently, the significantly advantage of Geobater and Syntrophorhabdus was the keystone reason for superior biodegradability maintenance of MAC-based MBBR. In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9Product Details of 120-72-9)

Begum, Bushra’s team published research in Polymers (Basel, Switzerland) in 2021 | CAS: 120-72-9

Begum, Bushra; Bilal, Salma; Shah, Anwar ul Haq Ali; Rose, Philipp published an article in 2021. The article was titled 《Physical, Chemical, and Electrochemical Properties of Redox-Responsive Polybenzopyrrole as Electrode Material for Faradaic Energy Storage》, and you may find the article in Polymers (Basel, Switzerland).Recommanded Product: 1H-Indole The information in the text is summarized as follows:

Polybenzopyrrole (Pbp) is an emerging candidate for electrochem. energy conversion and storage. There is a need to develop synthesis strategies for this class of polymers that can help improve its overall properties and make it as suitable for energy storage applications as other well-studied polymers in this substance class, such as polyaniline and polypyrrole. In this study, by synthesizing Pbp in surfactant-supported acidic medium, we were able to show that the physicochem. and electrochem. properties of Pbp-based electrodes are strongly influenced by the resp. polymerization conditions. Through appropriate optimization of various reaction parameters, a significant enhancement of the thermal stability (up to 549.9°C) and the electrochem. properties could be achieved. A maximum specific capacitance of 166.0 ± 2.0 F g-1 with an excellent cycle stability of 87% after 5000 cycles at a c.d. of 1 A g-1 was achieved. In addition, a particularly high-power d. of 2.75 kW kg-1 was obtained for this polybenzopyrrole, having a gravimetric energy d. of 17 Wh kg-1. The results show that polybenzopyrroles are suitable candidates to compete with other conducting polymers as electrode materials for next-generation Faradaic supercapacitors. In addition, the results of the current study can also be easily applied to other systems and used for adaptations or new syntheses of advanced hybrid/composite Pbp-based electrode materials.1H-Indole(cas: 120-72-9Recommanded Product: 1H-Indole) was used in this study.

Vavra, K.’s team published research in Journal of Molecular Spectroscopy in 2019 | CAS: 120-72-9

The author of 《Rotational spectra of indole in the lowest vibrational states》 were Vavra, K.; Lukova, K.; Kania, P.; Koucky, J.; Urban, S.. And the article was published in Journal of Molecular Spectroscopy in 2019. Synthetic Route of C8H7N The author mentioned the following in the article:

The millimetre- and submillimetre-wave rotational spectra of indole (C8H7N) have been recorded in several frequency regions from 140 to 715 GHz. Nearly 6000 rotational transitions corresponding to the ground and two vibrationally excited states ν42 and ν41 were assigned and analyzed using the A-reduced Hamiltonian. All newly measured transitions were fitted together with the previously published data yielding significantly improved rotational and centrifugal distortion constants Such highly precise mol. parameters could support future searches of the spectral features of indole in the interstellar medium as this mol. is the simplest prototype of polycyclic N-substituted aromatic hydrocarbons (PANHs), the possible sources of unidentified IR emission in the interstellar medium. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Synthetic Route of C8H7N)

Sun, Haoyu’s team published research in Science of the Total Environment in 2019 | CAS: 120-72-9

The author of 《Multiple-species hormetic phenomena induced by indole: A case study on the toxicity of indole to bacteria, algae and human cells》 were Sun, Haoyu; Zheng, Min; Song, Jinyuan; Huang, Shengyou; Pan, Yongzheng; Gong, Ruochong; Lin, Zhifen. And the article was published in Science of the Total Environment in 2019. Safety of 1H-Indole The author mentioned the following in the article:

Hormesis is a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition. Although hormetic phenomena have been reported in broadly ranging biol. areas, there is still no unified mechanism of hormesis. Investigating multiple-species hormesis of one compound and then exploring the possible mechanism may be an effective approach to clarify the reason for the occurrence of hormetic phenomena in a broad range of organisms. In this study, indole was selected as the test chem. due to the broad biol. and hormetic effects of indole compounds The results show that indole induces multiple-species hormetic phenomena in bacteria (Aliivibrio fischeri (A. fischeri), Escherichia coli and Bacillus subtilis), algae (Microcystis aeruginosa and Selenastrum capricornutum), and human cells (human skin fibroblasts and human cervical cancer cells). Through in-depth investigation of the time-dependent hormetic effects of indole, indole derivatives and indole’s structural analogs on the bioluminescence of A. fischeri, indole ring has been identified as the potential key structure that causes indole to act on quorum sensing of A. fischeri to induce hormetic effects on the bioluminescence at lag, logarithmic, and stationary phases. Therefore, the occurrence of multiple-species hormetic phenomena is speculated to be derived from the action of indole on the cell-to-cell communication of organism cells. This paper can not only further confirm the generalizability of hormesis but also provide a reasonable explanation for hormesis, which will benefit the development of hormesis and the risk assessment of environmental pollutants.1H-Indole(cas: 120-72-9Safety of 1H-Indole) was used in this study.

Feng, Tao’s team published research in Applied and Environmental Microbiology in 2019 | CAS: 120-72-9

The author of 《Interspecies and intraspecies signals synergistically regulate Lysobacter enzymogenes twitching motility》 were Feng, Tao; Han, Yong; Li, Bingqing; Li, Zhiqiang; Yu, Yameng; Sun, Qingyang; Li, Xiaoyu; Du, Liangcheng; Zhang, Xiao-Hua; Wang, Yan. And the article was published in Applied and Environmental Microbiology in 2019. Reference of 1H-Indole The author mentioned the following in the article:

The twitching motility of bacteria is closely related to environmental adaptability and pathogenic behaviors. Lysobacter is a good genus in which to study twitching motility because of the complex social activities and distinct movement patterns of its members. Regardless, the mechanism that induces twitching motility is largely unknown. In this study, we found that the interspecies signal indole caused Lysobacter to have irregular, random twitching motility with significantly enhanced speed. Deletion of qseC or qseB from the two-component system for indole signaling perception resulted in the disappearance of rapid, random movements and significantly decreased twitching activity. Indole-induced, rapid, random twitching was achieved through upregulation of expression of gene cluster pilE1-pilY11-pilX1-pilW1-pilV1-fimT1. In addition, under conditions of extremely low bacterial d., individual Lysobacter cells grew and divided in a stable manner in situ without any movement. The intraspecies quorum-sensing signaling factor 13-methyltetradecanoic acid, designated L. enzymogenes diffusible signaling factor (LeDSF), was essential for Lysobacter to produce twitching motility through indirect regulation of gene clusters pilM-pilN-pilO-pilP-pilQ and pilS1-pilR-pilA-pilB-pilC. These results demonstrate that the motility of Lysobacter is induced and regulated by indole and LeDSF, which reveals a novel theory for future studies of the mechanisms of bacterial twitching activities. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Reference of 1H-Indole)

Han, Yu’s team published research in European Journal of Medicinal Chemistry in 2020 | CAS: 120-72-9

Application In Synthesis of 1H-IndoleIn 2020 ,《The importance of indole and azaindole scaffold in the development of antitumor agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Han, Yu; Dong, Wei; Guo, Qunqun; Li, Xiufen; Huang, Longjiang. The article conveys some information:

A review. With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives Combining structure activity relationships and mol. targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

Zhang, Shanshan’s team published research in Journal of Applied Microbiology in 2022 | CAS: 120-72-9

In 2022,Zhang, Shanshan; Yang, Qian; Defoirdt, Tom published an article in Journal of Applied Microbiology. The title of the article was 《Indole decreases the virulence of pathogenic vibrios belonging to the Harveyi clade》.Application In Synthesis of 1H-Indole The author mentioned the following in the article:

Indole is a signaling mol. secreted by over 85 species of bacteria, including several Vibrio species, and it has been reported to affect different bacterial phenotypes such as biofilm formation, motility, and virulence. In this study, we aimed at investigating the inter-strain variability of the effect of indole in 12 different strains belonging to the Harveyi clade of vibrios. Indole reduced the virulence of all strains towards gnotobiotic brine shrimp larvae. The survival rate of brine shrimp larvae challenged with vibrios pretreated with indole was increased by 1.3-fold to 1.8-fold. Addnl., indole significantly decreased the biofilm formation in all of the strains, decreased the swimming motility in eight of the strains, and decreased swarming motility in five of the strains. When cultured in the presence of exogenous indole, the mRNA level of the pirA and pirB toxin genes were down-regulated to 65% and 46%, and to 62% and 55% in the AHPND-causing strains Vibrio parahaemolyticus M0904 and Vibrio campbellii S01, resp. These data indicate that indole has a significant impact on the virulence of different strains belonging to the Harveyi clade of vibrios. Significance and Impact of the Study : Our results suggest that indole signaling is a valid target for the development of novel therapeutics in order to control infections caused by Harveyi clade vibrios in aquaculture.1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole) was used in this study.

Plekan, Oksana’s team published research in Journal of Physical Chemistry A in 2020 | CAS: 120-72-9

《Experimental and Theoretical Photoemission Study of Indole and Its Derivatives in the Gas Phase》 was written by Plekan, Oksana; Sa’adeh, Hanan; Ciavardini, Alessandra; Callegari, Carlo; Cautero, Giuseppe; Dri, Carlo; Di Fraia, Michele; Prince, Kevin C.; Richter, Robert; Sergo, Rudi; Stebel, Luigi; Devetta, Michele; Facciala, Davide; Vozzi, Caterina; Avaldi, Lorenzo; Bolognesi, Paola; Castrovilli, Mattea Carmen; Catone, Daniele; Coreno, Marcello; Zuccaro, Fabio; Bernes, Elisa; Fronzoni, Giovanna; Toffoli, Daniele; Ponzi, Aurora. Application In Synthesis of 1H-Indole And the article was included in Journal of Physical Chemistry A in 2020. The article conveys some information:

The valence and core-level photoelectron spectra of gaseous indole, 2,3-dihydro-7-azaindole, and 3-formylindole have been investigated using VUV and soft X-ray radiation supported by both an ab initio electron propagator and d. functional theory calculations Three methods were used to calculate the outer valence band photoemission spectra: outer valence Green function, partial third order, and renormalized partial third order. While all gave an acceptable description of the valence spectra, the last method yielded very accurate agreement, especially for indole and 3-formylindole. The carbon, nitrogen, and oxygen 1s core-level spectra of these heterocycles were measured and assigned. The double ionization appearance potential for indole has been determined to be 21.8 ± 0.2 eV by C 1s and N 1s Auger photoelectron spectroscopy. Theor. anal. identifies the doubly ionized states as a band consisting of two overlapping singlet states and one triplet state with dominant configurations corresponding to holes in the two uppermost MOs. One of the singlet states and the triplet state can be described as consisting largely of a single configuration, but other doubly ionized states are heavily mixed by configuration interactions. This work provides full assignment of the relative binding energies of the core level features and an anal. of the electronic structure of substituted indoles in comparison with the parent indole. The experimental process involved the reaction of 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

Zhu, Yuqian’s team published research in European Journal of Medicinal Chemistry in 2021 | CAS: 120-72-9

Reference of 1H-IndoleIn 2021 ,《Research progress of indole compounds with potential antidiabetic activity》 appeared in European Journal of Medicinal Chemistry. The author of the article were Zhu, Yuqian; Zhao, Jinran; Luo, Longbiao; Gao, Yang; Bao, He; Li, Pengfei; Zhang, Hailong. The article conveys some information:

A review. New types of antidiabetic agents are continually needed with diabetes becoming the epidemic in the world. Indole alkaloids play an important role in natural products owing to their variable structures and versatile biol. activities like anticonvulsant, anti-inflammatory, antidiabetic, antimicrobial, and anticancer activities, which are a promising source of novel antidiabetic drugs discovery. The synthesized indole derivatives possess similar properties to natural indole alkaloids. In the last two decades, more and more indole derivatives have been designed and synthesized for searching their bioactivities. This present review describes comprehensive structures of indole compounds with the potential antidiabetic activity including natural indole alkaloids and the synthetic indole derivatives based on the structure classification, summarizes their approaches isolated from natural sources or by synthetic methods, and discusses the antidiabetic effects and the mechanisms of action. Furthermore, this review also provides briefly synthetic procedures of some important indole derivatives In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Reference of 1H-Indole) was used in this study.