Category: 123-11-5

Safety of 4-Methoxybenzaldehyde. Authors Mohamed, AR; El Kerdawy, AM; George, RF; Georgey, HH; Gawad, NMA in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Mohamed, Abdalla R.] Egyptian Russian Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo 11829, Egypt; [Kerdawy, Ahmed M. El; George, Riham F.; Georgey, Hanan H.; Gawad, Nagwa M. Abdel] Cairo Univ, Dept Pharmaceut Chem, Fac Pharm, Cairo 11562, Egypt; [Kerdawy, Ahmed M. El] New Giza Univ, Dept Pharmaceut Chem, Fac Pharm, Km 22 Cairo Alexandria Desert Rd, Cairo, Egypt; [Georgey, Hanan H.] Heliopolis Univ Sustainable Dev, Dept Pharmaceut Chem, Fac Pharm, Cairo 11777, Egypt in 2021, Cited 90. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aiming to obtain an efficient anti-proliferative activity, structure- and ligand-based drug design approaches were expanded and utilized to design and refine a small compound library. Subsequently, thirty-two 7,8-disubstituted-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione derivatives were selected for synthesis based on the characteristic pharmacophoric features required for PI3K and B-Raf oncogenes inhibition. All the synthesized compounds were evaluated for their in vitro anticancer activity. Compounds 17 and 22c displayed an acceptable potent activity according to the DTP-NCI and were further evaluated in the NCI five doses assay. To validate our design, compounds with the highest mean growth inhibition percent were screened against the target PI3K alpha and B-Raf(V)(600E) to confirm their multi-kinase activity. The tested compounds showed promising multi-kinase activity. Compounds 17 and 22c anticancer effectiveness and multi-kinase activity against PI3K alpha and B-Raf(V)(600E) were consolidated by the inhibition of B-Raf(WT), EGFR and VEGFR-2 with IC50 in the sub-micromolar range. Further investigations on the most potent compounds 17 and 22c were carried out by studying their safety on normal cell line, in silico profiling and predicted ADME characteristics.

Safety of 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4-Methoxybenzaldehyde. In 2021 SYNTHESIS-STUTTGART published article about CARBONYL-COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC ALLYLATION; ALKYL BROMIDES; ACTIVATION; ALCOHOL; REAGENT; HALIDES; DESIGN; IMINES in [Suzuki, Hiroyuki; Yamaguchi, Eiji; Itoh, Akichika] Gifu Pharmaceut Univ, Lab Pharmaceut Synthet Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan in 2021, Cited 68. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Carbonyl allylation reactions constitute an important step in the formation of carbon-carbon reactions, and involve various related reactions that chiefly use allylmetal reagents. This report presents a nickel-catalyzed carbonyl allylation reaction using allyl acetate, which produces homoallyl alcohols in moderate to good yields, as an efficient methodology under reductive coupling conditions.

Welcome to talk about 123-11-5, If you have any questions, you can contact Suzuki, H; Yamaguchi, E; Itoh, A or send Email.. Application In Synthesis of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 123-11-5. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study published in 2021.0, Reprint Addresses Ibrahim, TS (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia.; Mohamed, MFA (corresponding author), Sohag Univ, Fac Pharm, Dept Pharmaceut Chem, Sohag 82524, Egypt.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde.

New antibacterial drugs are urgently needed to tackle the rapid rise in multi-drug resistant bacteria. DNA gyrase is a validated target for the development of new antibacterial drugs. Thus, in the present investigation, a novel series of 1,2,4-oxadiazole-chalcone/oxime (6a-f) and (7a-f) were synthesized and characterized by IR, NMR (1H and 13C) and elemental analyses. The title compounds were evaluated for their in-vitro antimicrobial activity by the modified agar diffusion method as well as their E. coli DNA gyrase inhibitory activity. The minimum inhibitory concentration (MIC) and the structure activity relationships (SARs) were evaluated. Among all, compounds 6a, 6c-e, 7b and 7e were the most potent and proved to possess broad spectrum activity against the tested Gram-positive and Gram-negative organisms. Additionally, compounds 6a (against S. aureus), 6c (against B. subtilis and E. hirae), 6e (against E. hirae), 6f, 7a and 7c (against E. coli) and 7d (against B. subtilis), with MIC value of 3.12 mu M were two-fold more potent than the standard ciprofloxacin (MIC = 6.25 mu M). Mechanistically, compounds 6c, 7c, 7e and 7b had good inhibitory activity against E. coli gyrase with IC50 values of 17.05, 13.4, 16.9, and 19.6 mu M, respectively, in comparison with novobiocin (IC50 = 12.3 mu M) and ciprofloxacin (IC50 = 10.5 mu M). The molecular docking results at DNA gyrase active site revealed that the most potent compounds 6c and 7c have binding mode and docking scores comparable to that of ciprofloxacin and novobiocin suggesting their antibacterial activity via inhibition of DNA gyrase. Finally, the predicted parameters of Lipinski’s rule of five and ADMET analysis showed that 6c and 7c had good drug-likeness and acceptable physicochemical properties. Therefore, the hybridization of the chalcone and oxadiazole moieties could be promising lead as antibacterial candidate which merit further future structural optimizations.

Welcome to talk about 123-11-5, If you have any questions, you can contact Ibrahim, TS; Almalki, AJ; Moustafa, AH; Allam, RM; Abuo-Rahma, GEDA; El Subbagh, HI; Mohamed, MFA or send Email.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about BIOLOGICAL EVALUATION; CHROMOSOME INSTABILITY; TOPOISOMERASE-I; DERIVATIVES; TUBULIN; APOPTOSIS; DEFECTS; CRYSTAL; ANALOGS; VITRO in [Noha, Ryad M.; Ismail, M. Mohsen] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Pharmaceut Organ Chem Dept, POB 77, Giza, Egypt; [Abdelhameid, Mohammed K.; Ismail, M. Mohsen; Salwa, Elmeligie] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Cairo 11561, Egypt; [Mohammed, Manal R.] Natl Ctr Radiat Res & Technol, Dept Radiat Biol, Cairo 11787, Egypt; [Abdelhameid, Mohammed K.] 33 Kasr El Aini St, Cairo, Egypt in 2021, Cited 39. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel series of benzimidazole derivatives with methoxylated aryl groups was designed and synthesized as molecules with potential cytotoxic activity. In vitro cytotoxic activity over HCT-116 cells showed that N-(benzimidazothiazolone)acetamides 11a, 11b and 11c were found to be the most cytotoxic compounds compared camptothecin (CPT). The tested compounds had a dual topoisomerase I-beta (Topo I-beta) and tubulin inhibiting activities when compared to CPT and Podophyllotoxin (Podo) where, compounds l0a, l0b, 11a and 11b exhibited a potent inhibitory activity on Topo I-b enzyme in nano-molar concentration, on the other hand, compounds 12b and 13b exhibited the best inhibitory activity beta-tubulin polymerization. Results of the cell cycle analysis as well as the results of annexin-V on HCT-116 cells showed that benzimidazothiazoles 12b and 13b had a pro-apoptotic activity higher than CPT by 1.33- and 1.30-folds, respectively. Moreover, the concentration of p53, Bax/Bcl-2 ratio and caspase 3/7 increased in compounds l0b, 11b, l2b, 13b, especially, compounds 11b and 13b exhibited an increased level of these mediators than CPT. Finally, compound 11b regulated the radiosensitizing activity of the HCT-116 cells by modulating the chromosomal instability. (c) 2020 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 123-11-5, If you have any questions, you can contact Noha, RM; Abdelhameid, MK; Ismail, MM; Mohammed, MR; Salwa, E or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors El-Emary, TI; Abdel-Mohsen, SA; Mohamed, SA in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about CALCIUM-CHANNEL BLOCKERS; DIHYDROPYRIMIDINE in [El-Emary, Talaat, I; Abdel-Mohsen, Shawkat A.; Mohamed, Shereen A.] Assiut Univ, Fac Sci, Dept Chem, Assiut 71516, Egypt in 2021.0, Cited 27.0. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The synthesis of 5-acetyl-6-methyl-4-(1,3-diphenyl-1H-pyrazol-4-yl)-3,4-dihydropyrmidin-2(1H)-thione was achieved by one-pot three-component synthesis using CaCl2 in refluxing EtOH. The starting compound was utilized to synthesize a new series of 5-pyrazolyl; isoxazolyl; pyrimidinyl derivatives via the synthesized chalcone. Also, fused isoxazolo [5,4-d]pyrimidine and pyrazolo[3,4-d]pyrimidine were obtained by the treatment of 5-acetyl derivative with hydroxyl amine and/ or hydrazine hydrate. Also, the thiosemicarbazide derivative was prepared and utilized to synthesize other new thiazole derivatives. The structures of all compounds have been established on the basis of their analytical and spectral data. All compounds was also evaluated for their antibacterial and antifungal activity against various strains of bacteria and fungi. Also, the anti-inflammatory activity of some of synthesized compounds was evaluated using the carrageenan induced paw oedema test in rats using indomethacin as the reference drug.

Recommanded Product: 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact El-Emary, TI; Abdel-Mohsen, SA; Mohamed, SA or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Mansour, HS; Abd El-wahab, HAA; Ali, AM; Aboul-Fadl, T in ROYAL SOC CHEMISTRY published article about in [Mansour, Hany S.; Abd El-wahab, Hend A. A.; Ali, Ahmed M.; Aboul-Fadl, Tarek] Assiut Univ, Dept Med Chem, Fac Pharm, Assiut, Egypt in 2021.0, Cited 39.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The structure-based design of some CDK2 inhibitors with a 3-(benzylidene)indolin-2-one scaffold as potential anticancer agents was realized. Target compounds were obtained as E/Z mixtures and were resolved to corresponding E- and Z-diastereomers. In silico studies using MOE 2019.01 software revealed better docking on the targeted enzyme for the Z-diastereomer compared to the E-one. A time-dependent kinetic isomerization study was carried out for the inversion of E/Z diastereomers in DMSO-d(6) at room temperature, and were found to obey the first order kinetic reactions. Furthermore, a determination of the kinetic inter-conversion rate order by graphical analysis method and calculation of the rate constant and half-life of this kinetic process were carried out. For the prediction of the stability of the diastereomer(s), a good multiple regression equation was generated between the reaction rates of isomerization and some QM parameters with significant p value.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Microwave-assisted Synthesis of Novel Pyrazole Derivatives and their Biological Evaluation as Anti-Bacterial Agents published in 2021. Recommanded Product: 4-Methoxybenzaldehyde, Reprint Addresses Hatamjafari, F; Pourshamsian, K (corresponding author), Islamic Azad Univ, Dept Chem, Tonekabon Branch, Tonekabon, Iran.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

Aims and Objectives: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, H-1, C-13 NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles were evaluated against three gram-positive bacteria, such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain, and none of them demonstrated antibacterial activity against E. coli.

Welcome to talk about 123-11-5, If you have any questions, you can contact Khodadad, H; Hatamjafari, F; Pourshamsian, K; Sadeghi, B or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 SYNTHESIS-STUTTGART published article about CARBONYL-COMPOUNDS; ENANTIOSELECTIVE SYNTHESIS; NUCLEOPHILIC ALLYLATION; ALKYL BROMIDES; ACTIVATION; ALCOHOL; REAGENT; HALIDES; DESIGN; IMINES in [Suzuki, Hiroyuki; Yamaguchi, Eiji; Itoh, Akichika] Gifu Pharmaceut Univ, Lab Pharmaceut Synthet Chem, 1-25-4 Daigaku Nishi, Gifu 5011196, Japan in 2021, Cited 68. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 4-Methoxybenzaldehyde

Carbonyl allylation reactions constitute an important step in the formation of carbon-carbon reactions, and involve various related reactions that chiefly use allylmetal reagents. This report presents a nickel-catalyzed carbonyl allylation reaction using allyl acetate, which produces homoallyl alcohols in moderate to good yields, as an efficient methodology under reductive coupling conditions.

Recommanded Product: 4-Methoxybenzaldehyde. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Authors Castro, KP; Ito, M in MDPI published article about in [Castro, Kimberly P.; Ito, Michiho] Kyoto Univ, Dept Pharmacognosy, Grad Sch Pharmaceut Sci, Sakyo Ku, 46-29 Yoshida Shimoadachi Cho, Kyoto 6068501, Japan in 2021, Cited 43. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Agarwood is known to have a sedative effect and the less studied volatile aromatic constituents it contains may have contribution to the activity. In this study, two Kyara grade (highest-grade agarwood in Japan) samples were extracted using headspace-solid phase microextraction (HS-SPME) and analyzed through gas chromatography-mass spectrometry (GC-MS). Six low molecular weight aromatic compounds (LACs) and one structurally simple compound (diethylene glycol monoethyl ether) present in the aromas were individually evaluated for inhalational sedative activity in mice through open field test. Doses of 0.0001 g/L to 1 g/L were prepared for each compound and administered to mice (n = 6/dose/compound). Results revealed all compounds decreased spontaneous motor activity at almost all doses. Strongest sedative activity of each compound reduced total spontaneous motor activity by more than half against control, demonstrating their contribution to agarwood aroma and potential as independent sedating agents. Mixtures of compounds using their most effective dose were made and evaluated again for inhalational sedative effect. Interestingly, the combination of all compounds showed no significant effect and even caused stimulation in mice movements. This result suggests antagonistic-like interaction between the compounds, which is probably due to structural similarities. Consequently, it implies the other constituents present in agarwood, along with LACs, are also important to the overall sedative activity.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about (+)-USNIC ACID, Saw an article supported by the Science and Technology Incubator Youth Program [3/2018/H-D-KHCN-VU]. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Nguyen, VK; Sichaem, J; Nguyen, HH; Nguyen, XH; Huynh, TTL; Nguyen, TP; Niamnont, N; Mac, DH; Pham, DD; Chavasiri, W; Nguyen, KPP; Duong, TH. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2

A series of usnic acid benzylidene derivatives (groups I-V) were designed, synthesized and evaluated for their anticancer activity in the search for potentially new anticancer agents. Compounds 1a, 5b, 2b, 2e and 2f exhibited the most potent cytotoxcity against K562 cell line with IC50 values of 10.0 +/- 3.6, 5.6 +/- 0.4, 8.8 +/- 1.0, 4.5 +/- 0.1 and 8.4 +/- 0.4 mu M, respectively. It is noteworthy that compound 2e displayed potent cytotoxicity against K562 cells without any cytotoxic effect on HEK293 normal cell line.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles