Category: 123-11-5

An article Synthesis, structural, molecular docking and spectroscopic studies of (E)-N’-(4-methoxybenzylidene)-5-methyl-1H-pyrazole-3-carbohydrazide WOS:000595273300002 published article about CRYSTAL-STRUCTURE; AB-INITIO; BIOLOGICAL EVALUATION; DFT CALCULATIONS; SCHIFF-BASES; FORCE-FIELDS; FT-RAMAN; ANTIOXIDANT; IR; DERIVATIVES in [Karrouchi, Khalid; El Karbane, Miloud] Mohammed V Univ, Fac Med & Pharm, Lab Analyt Chem & Bromatol, Rabat, Morocco; [Brandan, Silvia A.] Univ Nacl Tucuman, Fac Bioquim Quim & Farm, Inst Quim Inorgan, Catedra Quim Gen, Ayacucho 471, RA-4000 San Miguel De Tucuman, Argentina; [Sert, Yusuf] Yozgat Bozok Univ, Sci & Art Fac, Sorgun Vocat Sch, Dept Phys, Yozgat, Turkey; [Radi, Smaail] Mohammed I Univ, Fac Sci, Dept Chem, Lab Appl Chem & Environm LCAE, Oujda 60000, Morocco; [Ferbinteanu, Marilena] Univ Bucharest, Fac Chem, Inorgan Chem Dept, Dumbrava Rosie 23, Bucharest 020462, Romania; [Garcia, Yann] Catholic Univ Louvain, Inst Condensed Matter & Nanosci, Mol Chem Mat & Catalysis IMCN MOST, Pl L Pasteur 1, B-1348 Louvain La Neuve, Belgium; [Ansar, M’hammed] Mohammed V Univ, Fac Med & Pharm, Lab Med Chem, Rabat, Morocco in 2021, Cited 73. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

(E)-N’-4-methoxybenzylidene-5-methyl-1H-pyrazole-3-carbohydrazide (E-MBPC) has been synthesized and characterized by FT-IR, H-1 & C-13 NMR and ESI-MS spectroscopic methods. The (E)-configuration of hydrazonoic group was confirmed by single-crystal X-ray diffraction. Theoretical structures of E-MBPC in both gas phase and aqueous solution have been optimized by using hybrid B3LYP/6-311++G** calculations. Calculations in solution have shown that dipole moment increases from 7.97 D in the gas phase to 13.68 D in solution with solvation energy of -131.34 kJ/mol. Atomic charges have evidenced that the protonation of E-MBPC in solution could occur only in the N28 atom because those charges on this atom show negative values. Mapped MEP surfaces show that the nucleophilic sites is located on the O21 and N28 atoms including the N16 atom while the electrophilic sites are observed on the N24-H27 and N18-H19 bonds. NBO calculations support the high stability of E-MBPC in solution while frontier orbitals studies suggest low reactivity of E-MBPC in both media, as compared with the (E)-N’-(4-(dimethylamino)benzylidene)-5-methyl-1H-pyrazole-3-carbohydrazide derivative. The vibrational assignments of 93 vibration modes expected for E-MBPC were reported together with the corresponding force fields and force constants in both media. The predicted Raman and Ultraviolet-visible spectra were also reported for E-MBPC at the same level of theory. Good correlations were obtained between the predicted H-1- and C-13 NMR spectra and the corresponding experimental ones. In addition, molecular docking studies between the title ligand and 4AMJ protein were performed. Docking results revealed that the title compound can be designed as a potential anti-diabetic agent. (C) 2020 Elsevier B.V. All rights reserved.

Welcome to talk about 123-11-5, If you have any questions, you can contact Karrouchi, K; Brandan, SA; Sert, Y; El Karbane, M; Radi, S; Ferbinteanu, M; Garcia, Y; Ansar, M or send Email.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Maitusong, J; Aimila, A; Zhang, JP; Mahinur, B; Maiwulanjiang, M; Aisa, HA in [Maitusong, Jumai; Aimila, Aoken; Zhang, Junping; Mahinur, Bakri; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, State Key Lab Basis Xinjiang Indigenous Med Plant, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China; [Maitusong, Jumai; Aimila, Aoken; Zhang, Junping; Mahinur, Bakri; Maiwulanjiang, Maitinuer; Aisa, Haji Akber] Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China; [Maitusong, Jumai; Aimila, Aoken] Univ Chinese Acad Sci, Beijing, Peoples R China; [Maitusong, Jumai] Coll Xinjiang Uyghur Med, Hotan, Peoples R China published Process optimization for the supercritical carbon dioxide extraction of Foeniculum vulgare Mill. seeds aromatic extract with respect to yield and trans-anethole contents using Box-Behnken design in 2021.0, Cited 30.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Fennel (seeds of Foeniculum vulgare Mill.) is the widely used aromatic and medicinal plant throughout the world. In this research, supercritical carbon dioxide (SC-CO2) extraction was carried out to extract the aromatic extract from F vulgare seeds under various operating conditions, and aromatic extract samples were characterized for properties such as yield and trans-anethole content. A three-level Box-Behnken design from response surface method was applied to optimize the extraction parameters such as pressure, temperature, and extraction time with an aim to obtain high yield and rich trans-anethole content. The optimum extraction conditions were found to be 177 bar, 40 degrees C and 68 min where the predicted oil yield and trans-anethole contents were found to be 3.798% and 95 mg/g, respectively. Under the optimum conditions, the experimental oil yield was 3.85%, and the content of trans-anethole was 94 mg/g. The results were very close to the values predicted by the model. At the same time, the chemical compositions of the oils from two different extraction methods, hydrodistillation and SC-CO2, were compared. The chemical constituents of oils from two different extraction methods found to be the same, and they showed slight difference in terms of the quantity of the main chemicals. Antibacterial and antioxidant effects of the oils obtained by the two extraction methods were compared, and they showed similar effects.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in subcritical EtOH WOS:000671550500009 published article about ONE-POT SYNTHESIS; HANTZSCH 1,4-DIHYDROPYRIDINES; OXIDATIVE DEALKYLATION; MICROWAVE IRRADIATION; SOLVENT; CATALYST; CHEMISTRY; ETHANOL; ABSENCE; SERIES in [Ersatir, Mehmet; Giray, Elife Sultan] Cukurova Univ, Arts & Sci Fac, Dept Chem, TR-01330 Adana, Turkey; [Turk, Murat] Cukurova Univ, Vocat Sch Ceyhan, Dept Property Protect & Secur, Adana, Turkey in 2021, Cited 41. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

Welcome to talk about 123-11-5, If you have any questions, you can contact Ersatir, M; Turk, M; Giray, ES or send Email.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kohli, S; Rathee, G; Hooda, S; Chandra, R in [Kohli, Sahil; Rathee, Garima; Chandra, Ramesh] Univ Delhi, Dept Chem, Drug Discovery & Dev Lab, Delhi 110007, India; [Kohli, Sahil; Hooda, Sunita] Univ Delhi, Acharya Narendra Dev Coll, Dept Chem, Delhi 110019, India published Al2O3/CuI/PANI nanocomposite catalyzed green synthesis of biologically active 2-substituted benzimidazole derivatives in 2021.0, Cited 66.0. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

This work is generally focused on the synthesis of an efficient, reusable and novel heterogeneous Al2O3/CuI/PANI nanocatalyst, which has been well synthesized by a simple self-assembly approach where aniline is oxidized into PANI and aniline in the presence of KI also acts as a reductant. The nanocatalyst was well characterized by XRD, FTIR, SEM, EDX, TEM, BET and XPS techniques. In this study, the fabricated material was employed for the catalytic one-pot synthesis of 2-substituted benzimidazoles via condensation between o-phenylenediamine and aldehydes in ethanol as a green solvent. The present method is facile and offers several advantages such as high % yield, less reaction time, and no use of additive/bases. Also, the catalyst showed better values of green metrics including low E-factor: 0.17, high reaction mass efficiency: 85.34%, high carbon efficiency: 94%, and high process mass intensity: 1.17.

Welcome to talk about 123-11-5, If you have any questions, you can contact Kohli, S; Rathee, G; Hooda, S; Chandra, R or send Email.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. Authors Moosavi-Zare, AR; Rezaei-Gohar, M; Tavasoli, M; Goudarziafshar, H in SPRINGER published article about in [Moosavi-Zare, Ahmad Reza; Goudarziafshar, Hamid] Hamedan Univ Technol, Dept Chem Engn, Hamadan 65155, Hamadan, Iran; [Rezaei-Gohar, Mohammad; Tavasoli, Mahsa] Sayyed Jamaleddin Asadabadi Univ, Asadabad 6541861841, Iran in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

4-Carboxy-1-sulfopyridin-1-ium monozinc(II) trichloride {[4CSPy]ZnCl3} as a new acidic catalyst was designed and tested on the synthesis of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidative aromatization. The structure of [4CSPy]ZnCl3 was studied by various analyses such as Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (H-1 NMR and C-13 NMR), energy-dispersive X-ray spectroscopy, thermal gravimetric analysis, differential thermal gravimetric analysis and mass spectroscopy (MS). [GRAPHICS] .

COA of Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Chemoselective synthesis of fully substituted pyrroles via a one-pot four-component isocyanide-based reaction WOS:000637889600001 published article about ASSISTED ONE-POT; MULTICOMPONENT SYNTHESIS; ULTRASOUND; WATER; NANOPARTICLES; DERIVATIVES; SCAFFOLDS; CHEMISTRY; PYRAZOLE; DESIGN in [Nazeri, Mohammad Taghi; Shaabani, Ahmad; Notash, Behrouz] Shahid Beheshti Univ, Fac Chem, GC, POB 19396-4716, Tehran, Iran; [Shaabani, Ahmad] RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia in 2021, Cited 74. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

Small-ring heterocycles comprising pyrrole and pyrazole are well known for their rich biological properties. In this article, an efficient green sonochemical approach was designed for the synthesis of novel, fully substituted pyrroles connected to pyrazole scaffolds via a one-pot, four-component isocyanide-based sequential reaction. This reaction was carried out using various 5-amino-pyrazoles, aldehydes, dialkyl acetylenedicarboxylates and isocyanides for the synthesis of fully functionalized pyrroles with high chemoselectivity in the presence of a catalytic amount of PTSA center dot H2O, in good to excellent yields under ultrasound irradiation. This waste-free (-H2O) reaction exhibited a high atom economy and step economy via creating four new bonds, including two C-N and two C-C bonds, and the formation of two five-member heterocycles which are connected in a single operation. The mechanism of this four-component domino process involved sequential imination-dipolar cyclization-[1,5]-H shift reactions. The synthesized compounds possess interesting fluorescence features, and the bioactive scaffolds might attract great interest in the fields of clinical diagnostics and biomedical research in the future.

Welcome to talk about 123-11-5, If you have any questions, you can contact Nazeri, MT; Shaabani, A; Notash, B or send Email.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. I found the field of Chemistry very interesting. Saw the article Green synthesis of benzochromenopyrimidines in the presence of MWCNTs@SiO2/MSA as a new and effective solid acid catalyst under microwave irradiation published in 2021, Reprint Addresses Moradi, L (corresponding author), Univ Kashan, Fac Chem, Dept Organ Chem, POB 8731753153, Kashan, Iran.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde.

A new and green synthesis of benzochromenopyrimidine derivatives is efficiently catalyzed by supported meglumine sulfonic acid on multiwalled carbon nanotube surfaces (MWCNTs@SiO2/MSA). Preparation of catalyst was performed through a simple and convenient method and characterized using FTIR, FESEM, TGA and EDX techniques. This recyclable catalyst provided a green and soft strategy to solvent-free synthesis of benzochromenopyrimidine derivatives under microwave irradiation. Presented protocol is a safe, eco-friendly and convenient method for the synthesis of benzochromenopyrimidines in high to excellent yields using a new high efficient solid acid catalyst. (C) 2021 Published by Elsevier B.V.

SDS of cas: 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact Ahmadi, M; Moradi, L; Sadeghzadeh, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about EPITHELIAL-MESENCHYMAL TRANSITION; ANTICONVULSANT ACTIVITIES; BIOLOGICAL EVALUATION; CANCER; ANTIBACTERIAL; PROLIFERATION; INHIBITION; APOPTOSIS; POTENT, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81960626, 82060628]; Doctoral Research Startup Foundation of Yanbian University [602020087]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Shang, FF; Wang, JY; Xu, Q; Deng, H; Guo, HY; Jin, XJ; Li, XT; Shen, QK; Quan, ZS. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2

Four series of hypoxia-inducible factor-1 alpha (HIF-1 alpha) functioning derivatives stemming from modifications to the C-29 carboxyl group of celastrol were designed and synthesized, and their anticancer activities were evaluated. To address the structure and activity relationship of each derivative, extensive structural changes were made. HRE luciferase reporter assay demonstrated that 12 modified compounds showed superior HIF-1 alpha inhibitory activity. Among them, compound C6 exhibited the best features: firstly, the strongest HIF-1 alpha inhibitory activity (IC50 = 0.05 mu M, 5-fold higher than that of celastrol); secondly, lower cytotoxicity (22-fold lower, C6-16.85 mu M vs celastrol-0.76 mu M). Thus, the safety factor of C6 was about 112 times higher than that of celastrol. Western blot assay indicated that C6 may inhibit the expression of HIF-1 alpha protein in cells. Additionally, C6 hindered tumor cell cloning, migration and induced cell apoptosis. It is worth mentioning that in the mouse tumor xenograft model, C6 (10 mg/kg) displayed good antitumor activity in vivo, showing a better inhibition rate (74.03%) than the reference compound 5-fluorouracil (inhibition rate, 59.58%). However, the celastrol treatment group experienced collective death after four doses of the drug. Moreover, C6 minimally affected the mouse weight, indicating that its application in vivo has little toxic effect. H&E staining experiments show that it could also exacerbate the degree of tumor cell damage. The results of water solubility experiment show that the solubility of C6 is increased by 1.36 times than that of celastrol. In conclusion, C6 is a promising antitumor agent through HIF-1 alpha pathway. (C) 2021 Elsevier Masson SAS. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Shang, FF; Wang, JY; Xu, Q; Deng, H; Guo, HY; Jin, XJ; Li, XT; Shen, QK; Quan, ZS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Authors Yang, C; Zhao, ZN; Zou, YF; Ma, SY; Qi, J; Liu, DY in TAYLOR & FRANCIS LTD published article about in [Yang, Cong; Zhao, Zhinan; Ma, Shuangyu; Liu, Dengyong] Bohai Univ, Coll Food Sci & Technol, Natl & Local Joint Engn Res Ctr Storage Proc & Sa, Jinzhou, Peoples R China; [Zou, Yufeng] Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing, Peoples R China; [Zou, Yufeng; Liu, Dengyong] Jiangsu Collaborat Innovat Ctr Meat Prod & Proc Q, Nanjing, Peoples R China; [Qi, Jun] Anhui Agr Univ, Sch Tea & Food Sci & Technol, Hefei, Peoples R China in 2021.0, Cited 0.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

This study was intended to characterize six types of commercial smoked chicken products in China by using gas chromatography-mass spectrometry (GC-MS), odor-activity values (OAVs), and sensory evaluation. Results demonstrated that a total of 89 components were identi?ed in all samples, and 34 were considered as odor-active compounds because their OAVs were greater than one. Liaocheng Chicken that smoked with fruit tree sawdust had more phenols, which contributed to the smoky aroma. Jinshan and Goubangzi Chicken that smoked with sugar had more furans which contributed the overall odor with sweety and caramel aroma. Zhuozishan and Laoting Chicken that smoked with sugar and wood chips had similar flavor and volatile compounds. Tengqiao Chicken that smoked with sugar, tea and rice had significant difference with other chicken in smoky, bittern and caramel aroma (P< .05). The diversity of these smoked chicken flavors was mainly due to the cooking culture differences. Recommanded Product: 123-11-5. Welcome to talk about 123-11-5, If you have any questions, you can contact Yang, C; Zhao, ZN; Zou, YF; Ma, SY; Qi, J; Liu, DY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about AMINO-ACIDS; RENIN INHIBITORS; DESIGN; ANALOGS; POTENT; DIFLUOROSTATONE; PEPTIDES; AMIDES; ANION, Saw an article supported by the Natural Sciences and Engineering Research Council of Canada (NSERC)Natural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2017-04233]. Quality Control of 4-Methoxybenzaldehyde. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Soley, J; Taylor, SD. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

The synthesis of beta-hydroxy-alpha,alpha-difluorosulfona-mides was achieved by reacting difluoromethanesulfonamides with KHMDS in the presence of an aldehyde or ketone. The reaction exhibited a dramatic counterion effect with KHMDS or NaHMDS usually giving excellent yields in minutes, while lithium bases gave little or no product. Excellent yields and high diastereomeric ratios were achieved with N-alpha-benzyl-N-alpha-phenylfluorenyl (PhF)-protected chiral amino aldehydes derived from amino acids. Following deprotection, a beta-hydroxy-alpha,alpha-sulfonamide reacted under peptide coupling and Mitsunobu conditions to furnish a peptidomimetic in an excellent overall yield.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Soley, J; Taylor, SD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles