Category: 123-11-5

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Exploring the ability of dihydropyrimidine-5-carboxamide and 5-benzyl-2,4-diaminopyrimidine-based analogues for the selective inhibition of L. major dihydrofolate reductase published in 2021. Quality Control of 4-Methoxybenzaldehyde, Reprint Addresses Rashid, U (corresponding author), COMSATS Univ Islamabad, Dept Chem, Abbottabad Campus, Abbottabad 22060, Khyber Pakhtunk, Pakistan.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

To tackle leishmaniasis, search for efficient therapeutic drug targets should be pursued. Dihydrofolate reductase (DHFR) is considered as a key target for the treatment of leishmaniasis. In current study, we are interested in the design and synthesis of selective antifolates targeting DHFR from L. major. We focused on the development of new antifolates based on 3,4-dihydropyrimidine-2-one and 5-(3,5-dimethoxybenzyl)pyrimidine-2,4-diamine motif. Structure activity relationship (SAR) studies were performed on 4-phenyl ring of dihydropyrimidine (26-30) template. While for 5-(3,5-dimethoxybenzyl) pyrimidine-2,4-diamine, the impact of different amino acids (valine, tryptophan, phenylalanine, and glutamic acid) and two carbon linkers were explored (52-59). The synthesized compounds were assayed against LmDHFR. Compound 59 with the IC50 value of 0.10 mu M appeared as potent inhibitors of L. major. Selectivity for parasite DHFR over human DHFR was also determined. Derivatives 55-59 demonstrated excellent selectivity for LmDHFR. Highest selectivity for LmDHFR was shown by compounds 56 (SI = 84.5) and 58 (SI = 87.5). Compounds Antileishmanial activity against L. major and L. donovani promastigotes was also performed. To explore the interaction pattern of the synthesized compounds with biological macromolecules, the docking studies were carried out against homology modelled LmDHFR and hDHFR targets. (C) 2020 Elsevier Masson SAS. All rights reserved.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Bibi, M; Qureshi, NA; Sadiq, A; Farooq, U; Hassan, A; Shaheen, N; Asghar, I; Umer, D; Ullah, A; Khan, FA; Salman, M; Bibi, A; Rashid, U or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans WOS:000649672200001 published article about GENERAL REGIOSPECIFIC SYNTHESIS; SQUARIC ACID; SUBSTITUTED QUINONES; PROTECTING-GROUP; REARRANGEMENTS; 4-ALLYLCYCLOBUTENONES; HYDROXYQUINONES; TRANSFORMATION; CHEMISTRY; EXPANSION in [Bennett, Ryan M.; Sun, Wei; Wilson, Dharyl C.; Light, Mark E.; Harrowven, David C.] Univ Southampton, Chem, Southampton SO17 1BJ, Hants, England in 2021.0, Cited 77.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. SDS of cas: 123-11-5

A dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavage via O- to C-lithium transfer. This distinct mode of ring scission gives access to 2-oxobut-3-enamides and tetrasubstituted furans.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Bennett, RM; Sun, W; Wilson, DC; Light, ME; Harrowven, DC or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Xu, D; Wei, MQ; Peng, SR; Mo, HZ; Huang, L; Yao, LS; Hu, LB in ELSEVIER SCI LTD published article about in [Xu, Dan; Wei, Mengqi; Peng, Shurui; Mo, Haizhen; Yao, Lishan; Hu, Liangbin] Shaanxi Univ Sci & Technol, Sch Food & Biol Engn, Xian 710021, Peoples R China; [Huang, Lin] Tianjin Univ Sci & Technol, Tianjin Engn Res Ctr Microbial Metab & Fermentat, Tianjin 300457, Peoples R China in 2021, Cited 37. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The contamination of food with Aspergillus flavus has caused serious economic losses and posed a great threat to human and animal health. Cumin, a condiment and flavoring in many dishes, was showed to have great potential to prevent A. flavus contamination in the present study. By using cumin essential oil (CEO), the occurrence of A. flavus contamination on peanuts was prevented during the storage period even up to 9 months. We further identified cuminaldehyde as the predominant component in CEO with great inhibitory activity to both the growth of A. flavus and aflatoxin B1 (AFB1) biosynthesis. The data showed that the minimum inhibitory concentration (MIC) of cuminaldehyde to conidial growth was 0.64 ?L/mL, and the mycelia exposed to 0.80 ?L/mL cuminaldehyde reduced AFB1 production by more than 99% in comparison to the control. RNA-Seq profiles showed that some genes, involving the synthesis pathway of ergosterol and AFB1, were significantly downregulated in the transcription by cuminaldehyde. Further investigation confirmed a significantly reduced cellular ergosterol content in the presence of cuminaldehyde, and the qRT-RCR results were also in agreement with that by RNA-Seq, indicating down-regulated expressions of those genes involving ergosterol and AFB1 synthesis. Taken together, our study strongly supported cuminaldehyde as a potential agent for the prevention of A. flavus contamination.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Xu, D; Wei, MQ; Peng, SR; Mo, HZ; Huang, L; Yao, LS; Hu, LB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and anticonvulsant evaluation of indoline derivatives of functionalized aryloxadiazole amine and benzothiazole acetamide WOS:000608842900011 published article about DISCOVERY; BINDING in [Nath, Rajarshi; Pathania, Shelly; Grover, Gourav; Akhtar, Md Jawaid] ISF Coll Pharm, Dept Pharmaceut Chem, Ferozpur GT Rd, Moga 142001, Punjab, India; [Yar, M. Shahar] Jamia Hamdard, Sch Pharmaceut Educ & Res, Dept Pharmaceut Chem, New Delhi 110062, India; [Debnath, Biplab] Bharat Technol, Dept Pharm, Howrah 711316, W Bengal, India in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Category: indole-building-block

A series of N-(substituted benzothiazole-2-yl)-2-(2,3 dioxoindolin-1-yl)acetamide (4a-i) and substituted-[3-((5-phenyl-1,3,4-oxadiazole-2-yl)imino)indolene-2-one] (5a-f) were designed, synthesized fulfilling the structural requirement of pharmacophore and evaluated for anticonvulsant activities using maximal electroshock test (MES), subcutaneous pentylenetetrazole (scPTZ) seizures and neurotoxicity by motor impairment model in mice. The most active compound N-(5-chlorobenzo[d]thiazol-2-yl)-2-(2,3-dioxoindolin-1-yl)acetamide (4a) has shown significant anticonvulsant activity against both MES and scPTZ screens and emerged as most effective anticonvulsant compound with median dose of 35.7 mg/kg (MES ED50), 88.15 mg/kg (scPTZ ED50) and toxic dose (TD50) was found to be > 500mg/kg. In silico studies including molecular docking study was carried to establish the molecular interaction of potent compound (4a) in both Na+ channel and GABA(A) receptors. The prediction of pharmacokinetic parameters and distance mapping of compounds were also performed to establish the drug likeness property. (C) 2020 Elsevier B.V. All rights reserved.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nath, R; Yar, MS; Pathania, S; Grover, G; Debnath, B; Akhtar, MJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Enantioselective Stetter Reactions Catalyzed by Bis(amino)cyclopropenylidenes: Important Role for Water as an Additive WOS:000606842300030 published article about ALDEHYDES in [Khalkhali, Mehran Rezazadeh; Wilde, Myron M. D.; Gravel, Michel] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada in 2021.0, Cited 28.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2

The first highly enantioselective intermolecular Stetter reaction using simple enones is reported. A series of novel chiral BAC structures were designed and prepared. They were tested in the Stetter reaction with simple aldehydes and enones. The products were generated in excellent yields and enantioselectivities (up to 94% ee). Surprisingly, a substoichiometric amount of water was crucial to obtain high enantioselectivities. Chiral BACs were also shown to catalyze 1,6-conjugate addition reactions with paraquinone methides enantioselectively.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Khalkhali, MR; Wilde, MMD; Gravel, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Authors Pees, A; Vosjan, MJWD; Vasdev, N; Windhorst, AD; Vugts, DJ in ROYAL SOC CHEMISTRY published article about in [Pees, Anna; Windhorst, Albert D.; Vugts, Danielle J.] Vrije Univ Amsterdam, Amsterdam UMC, Radiol & Nucl Med, Radionuclide Ctr, Boelelaan 1085c, Amsterdam, Netherlands; [Vosjan, Maria J. W. D.] BV Cyclotron VU, Boelelaan 1081, NL-1081 HV Amsterdam, Netherlands; [Vasdev, Neil] Univ Toronto, Ctr Addict & Mental Hlth, Brain Hlth Imaging Ctr, Azrieli Ctr Neuroradiochem, 250 Coll St, Toronto, ON M5T 1R8, Canada; [Vasdev, Neil] Univ Toronto, Dept Psychiat, 250 Coll St, Toronto, ON M5T 1R8, Canada in 2021, Cited 25. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [F-18]Me3SiCF3. [F-18]Me3SiCF3 was synthesized from [F-18]fluoroform with radiochemical yields of 85-95% and radiochemical purities of >95% within 20 minutes. F-18-trifluoromethylated compounds were successfully prepared by reaction of [F-18]Me3SiCF3 with benzaldehydes, acetophenones and benzophenones.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Pees, A; Vosjan, MJWD; Vasdev, N; Windhorst, AD; Vugts, DJ or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. In 2021.0 ORG LETT published article about ALPHA-ALLYLATION; ENANTIOSELECTIVE ALLYLATION; SYNERGISTIC IRIDIUM; UMPOLUNG ALLYLATION; SUBSTITUTIONS; DIASTEREO; ENANTIO; BEARING; DIASTEREOSELECTIVITY; TERTIARY in [Mitra, Sankash; Mukherjee, Santanu] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India in 2021.0, Cited 59.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Compared with the ever-growing list of nonprochiral nucleophiles in Ir-catalyzed asymmetric allylic substitution reactions, prochiral nucleophiles are less studied. We present a new prochiral nucleophile, namely, deconjugated butyrolactam, for Ir-catalyzed asymmetric allylic alkylation (AAA). This reaction provides access to a-allyl deconjugated butyrolactams with a moderate to good dr and an excellent er. This is the first AAA reaction of deconjugated butyrolactams. Allyl transposition through Cope rearrangement appears to proceed stereospecifically to form.-allyl conjugated butyrolactams.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mitra, S; Mukherjee, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2021 ACS CATAL published article about RESONANCE RAMAN; CATALYSIS; AMINATIONS; COMPLEXES; CHEMISTRY; AMIDES; AZIDES in [Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Weyhermueller, Thomas; Werle, Christophe] Max Planck Inst Chem Energy Convers, D-45470 Mulheim, Germany; [Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Werle, Christophe] Ruhr Univ Bochum, D-44801 Bochum, Germany in 2021, Cited 130. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein, we describe an approach centered on an operationally simple iron-based system that, depending on the reaction conditions, selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron’s dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity on the basis of the iron system’s ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system’s molecular environment can supply control over bond activation processes, thus providing easy access to various products from primary building blocks.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chatterjee, B; Jena, S; Chugh, V; Weyhermuller, T; Werle, C or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Oladipo, SD; Yusuf, TL; Zamisa, SJ; Shapi, M; Ajayi, TJ in [Oladipo, Segun D.; Yusuf, Tunde L.; Zamisa, Sizwe J.] Univ KwaZulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa; [Oladipo, Segun D.] Olabisi Onabanjo Univ, Dept Chem Sci, PMB 2002, Ago Iwoye, Nigeria; [Yusuf, Tunde L.] Univ Johannesburg, Dept Chem Sci, POB 17011, ZA-2028 Johannesburg, South Africa; [Shapi, Micheal; Ajayi, Tomilola J.] Mangosuthu Univ Technol, Dept Chem, ZA-4000 Durban, South Africa published Synthesis, crystal structure, Hirshfeld surface analysis and DFT studies of N-(2,6-diisopropylphenyl)-1-(4-methoxyphenyl) methanimine in 2021, Cited 83. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

We report the synthesis of a new Schiffbase(N-(2,6-diisopropylphenyl)-1-(4-methoxyphenyl) methanimine) 1; derived from the condensation of 4-methoxybenzaldehyde and 2,6-diisopropylaniline in 1:1 mole ratio. The compound was elucidated by single-crystal X-ray diffraction, C-13, and H-1, NMR, FTIR, UV-vis spectroscopies. The molecular geometries of the new Schiffbase were investigated using the DFT/B3LYP method using 6-311++G (2d,2p) basis set. The optimized structure of the studied compound is consistent with the finding of the X-ray analysis. In addition, Time-dependent density functional theory (TD-DFT) analysis was applied to shed more light on the manner of the electronic transitions determined in the UV-Vis spectra. Hirshfeld surface analyses for the compound were presented and discussed. The Experimental and theoretical result for geometric and spectroscopic parameters were in good agreement. (C) 2021 Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Oladipo, SD; Yusuf, TL; Zamisa, SJ; Shapi, M; Ajayi, TJ or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Co-MOF/COF nanocomposite: application as a powerful and recoverable catalyst in the Knoevenagel reaction WOS:000558615800001 published article about COVALENT ORGANIC FRAMEWORKS; MIXED MATRIX MEMBRANES; CRYSTALLINE; ENERGY; FABRICATION; ADSORPTION; SEPARATION; POLYIMIDE; DESIGN in [Rahmati, Ensiyeh; Rafiee, Zahra] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran in 2021, Cited 52. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel mesoporous composite was prepared through the hybridization of cobalt-based metal-organic framework (Co-MOF) and covalent organic framework (COF) based on melamine and terephthaldehyde (Co-MOF/COF) and characterized by FT-IR, SEM, XRD, EDS, BET, and STA analyses. The resultant composite was utilized as a robust recoverable catalyst in the condensation of several aldehydes with malononitrile to produce benzylidenemalononitrile derivatives in 62-94% yields under solvent-free conditions at room temperature using 15 mg of the catalyst and 5-60 min of reaction. The examination of catalytic performance of designated Co-MOF/COF exhibited an outstanding activity for the Knoevenagel condensation in a very short time. The recoverability, reusability and durability of Co-MOF/COF have also been investigated under applied conditions.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rahmati, E; Rafiee, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles