Category: 123-11-5

Product Details of 123-11-5. Authors Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS in FUTURE SCI LTD published article about in [Chu, Po-Chen] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen] China Med Univ, Grad Inst Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen; Chang, Chih-Shiang] China Med Univ, Drug Dev Ctr, Taichung 40402, Taiwan; [Wu, Yu-Chieh; Chen, Chien-Yu; Hung, Yu-Syuan; Chang, Chih-Shiang] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1 alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels. Therefore, therapeutic targeting of HIF-1 alpha represents a viable strategy for cancer therapy. Methods & Results: The authors synthesized a series of novel tetrahydroquinazoline derivatives in six steps and demonstrated that their development had a unique ability to suppress HIF-1 alpha expression through proteasomal degradation. Conclusion: Among these compounds, CDMP-TQZ (8bf) exhibited the highest antiproliferative potency in human cancer cells, in part through downregulation of HIF-1 alpha.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS or concate me.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zenkov, IS; Abel, AS; Averin, AD; Butov, GM; Beletskaya, IP in [Zenkov, I. S.; Abel, A. S.; Averin, A. D.; Beletskaya, I. P.] Lomonosov Moscow State Univ, Dept Chem, 3 Build,1 Leninskie Gory, Moscow 119991, Russia; [Averin, A. D.; Beletskaya, I. P.] Russian Acad Sci, Frumkin Inst Phys Chem & Electrochem, 4 Build,31 Leninsky Prosp, Moscow 119991, Russia; [Butov, G. M.] Volgograd State Tech Univ, Volzhsky Polytech Inst Branch, 42a Ul Engelsa, Volzhskii 404121, Russia published Phosphine-catalyzed [3+2] cycloaddition of Morita-Baylis-Hillman carbonates to isothiocyanates in the synthesis of adamantane-containing trisubstituted aminothiophenes in 2021, Cited 33. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

An addition of the Morita-Baylis-Hillman (MBH) carbonates to adamantane-containing isothiocyanates was studied. The MBH carbonates react with 1-(4-isothiocyanatophenyl)-adamantane in the presence of triphenylphosphine to give 5-aryl-substituted adamantane-containing 2-amino-4-methoxycarbonylthiophenes in 31-59% yields, while 1- and 2-isothio-cyanatoadamantanes were found unreactive in this reaction.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zenkov, IS; Abel, AS; Averin, AD; Butov, GM; Beletskaya, IP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Sustainable Aldehyde Oxidations in Continuous Flow Using in Situ-Generated Performic Acid WOS:000644738000005 published article about FREE AEROBIC OXIDATION; CARBOXYLIC-ACIDS; 2,5-FURANDICARBOXYLIC ACID; SELECTIVE OXIDATION; HYDROGEN-PEROXIDE; PRIMARY ALCOHOLS; PERACETIC-ACID; CHEMISTRY; CATALYSIS; KINETICS in [Prieschl, Michael; Otvos, Sandor B.; Kappe, C. Oliver] Res Ctr Pharmaceut Engn GmbH RCPE, Ctr Continuous Flow Synth & Proc CCFLOW, A-8010 Graz, Austria; [Prieschl, Michael; Otvos, Sandor B.; Kappe, C. Oliver] Karl Franzens Univ Graz, Inst Chem, NAWI Graz, A-8010 Graz, Austria in 2021, Cited 58. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The oxidation of aldehydes is one of the most prevalent methods for the synthesis of a diverse range of carboxylic acids. We herein present a performic acid generator and its application for aldehyde oxidations under continuous flow conditions. Low molecular weight performic acid, an environmentally benign and inexpensive oxidant, was readily formed in situ from formic acid and hydrogen peroxide. The safety hazards typically encountered when manipulating this potentially explosive reagent were eliminated, while at the same time a clean and efficient access to valuable carboxylic acids was ensured. By taking advantage of concentrated or even neat aldehyde streams, the amount of organic solvents utilized, and thus waste formation, was successfully minimized as demonstrated by E-factors in the range of 5-18. The process proved applicable for a wide range of aromatic as well as aliphatic aldehydes, while its synthetic utility and stability were corroborated by scale-out experiments leading to multigram-scale syntheses.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Prieschl, M; Otvos, SB; Kappe, CO or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase WOS:000661282500043 published article about VIRUS; ZANAMIVIR; EPIDEMIOLOGY; DERIVATIVES; RESISTANCE in [Zhao, Hongqian; Jiang, Siyuan; Ye, Zhifan; Zhu, Hongxi; Meng, Peipei; Wang, Kuanglei; Tian, Yongshou] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Key Lab Struct Based Drug Design & Discovery, Minist Educ, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Baichun] Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Zhang, Huicong] Shenyang Pharmaceut Univ, Wuya Coll Innovat, 103 Wenhua Rd, Shenyang 110016, Peoples R China; [Hu, Yanmei; Wang, Jun] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA in 2021, Cited 41. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Neuraminidase (NA) inhibitors play a prime role in treating influenza. However, a variety of viruses containing mutant NAs have developed severe drug resistance towards NA inhibitors, so it is of crucial significance to solve this problem. Encouraged by urea-containing compound 12 disclosed by our lab, we designed a series of oseltamivir derivatives bearing hydrazide fragment for targeting the 150 cavity. Among the synthesized compounds, compound 17a showed 8.77-fold, 4.12-fold, 203-fold and 6.23-fold more potent activity than oseltamivir carboxylate against NAs from H5N1, H1N1, H5N1-H274Y, H1N1-H274Y, respectively. Meanwhile, the best compound 17a exhibited satisfactory metabolic stability in vitro. This study offers an important reference for the structural optimization of oseltamivir aiming at potent inhibition against H274Y mutant of NAs. (C) 2021 Elsevier Masson SAS. All rights reserved.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhao, HQ; Jiang, SY; Ye, ZF; Zhu, HX; Hu, BC; Meng, PP; Hu, YM; Zhang, HC; Wang, KL; Wang, J; Tian, YS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zhou, YJ; Wang, XS; Chen, Y; Yuan, BB in WILEY published article about in [Zhou, Yajun; Wang, Xuesong; Chen, Yan] Jilin Univ, Coll Food Sci & Engn, Changchun, Peoples R China; [Yuan, Bingbing] Jilin Ginseng Res Inst, Changchun 130000, Peoples R China in 2021, Cited 30. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The effects of different paprikas on the sensory properties and the physicochemical properties of spiced beef were studied. Headspace solid phase microextraction and gas chromatography-mass spectrometry were used to identify the flavor substances in the samples. The results showed that the protein and fat content of the samples with paprika were higher compared to the blank group, which were 24.10-25.60 g/100 g and 3.40-3.70 g/100g, respectively. The scores of flavor and color in the blank group were 6.50 and 6.56, respectively, which were lower than the paprikas treatment group. Among the five paprika treatment groups, the color and taste scores of the samples treated with qixing paprika were higher, which were 8.00 and 8.07, respectively. A total of 145 volatile flavor substances were detected, compared with the control group, there were more volatile flavor substances in the paprika additive groups, indicated that paprika additive could enrich the flavor of spiced beef. Practical applications Paprika not only has a unique flavor, but also has good antioxidant properties. Spiced beef is popular among consumers. However, the surface color of the product is easy to change due to oxidation, which affects the color of the product, resulting in a decline in product sales and economic losses to the enterprise. In addition, the protein and fat of the product will be lost due to oxidation during processing. Therefore, the effects of different paprika on the color, nutritional value, and volatile flavors of spiced beef were studied. The purpose was to slow down the oxidation of products, improve the color of products, retain the nutritional value, and reduce the loss of enterprises by adding different capsicum. In addition, the volatile flavor of products will directly affect the sensory evaluation of consumers, so it is very important to understand the influence of pepper on volatile flavor compounds and consumption preference for volatile components.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhou, YJ; Wang, XS; Chen, Y; Yuan, BB or concate me.. Application In Synthesis of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Hsu, MH; Kapoor, M; Pradhan, TK; Tse, MH; Chen, HY; Yan, MJ; Cheng, T; Lin, YC; Hsieh, CY; Liu, KY; Han, CC in GEORG THIEME VERLAG KG published article about in [Hsu, Ming-Hua; Tse, Man-Him; Chen, Hsin-Ya; Yan, Man-Jun; Cheng, Tsen; Lin, Yu-Cheng] Natl Changhua Univ Educ, Dept Chem, Changhua 50007, Taiwan; [Kapoor, Mohit] Chitkara Univ, Inst Engn & Technol, Rajpura 140401, Punjab, India; [Pradhan, Tapan Kumar] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Pradhan, Tapan Kumar] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Hsieh, Cheng-Ying; Liu, Ker-Yin; Han, Chien-Chung] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan in 2021.0, Cited 43.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A sustainable and time economic approach has been developed for the synthesis of polysubstituted pyrroles using copper iodide as a catalyst. The reaction proceeded through imine formation followed by cyclization with alkyne-Cu intermediate, which was supported by control experiments studies. The newly formed substituted pyrroles were obtained in excellent yields with high regioselectivity under mild conditions.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Hsu, MH; Kapoor, M; Pradhan, TK; Tse, MH; Chen, HY; Yan, MJ; Cheng, T; Lin, YC; Hsieh, CY; Liu, KY; Han, CC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ONE-POT SYNTHESIS; CONVENIENT SYNTHESIS; PYRAN DERIVATIVES; HETEROPOLY ACIDS; NIFE2O4; LIQUID, Saw an article supported by the . Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Ataie, F; Davoodnia, A; Khojastehnezhad, A. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Name: 4-Methoxybenzaldehyde

In this study, a graphene oxide (GO) functionalized organic-inorganic hybrid was prepared by covalently immobilization of organic (3-aminopropyltrimethoxysilane) and inorganic (H3PMo12O40) groups on the basal plane of GO. Structure of catalyst was characterized with different analysis such as FT-IR, SEM, TEM, EDS, WDX, XRD, and TGA. All analyses approve the successful covalently immobilization of organic and inorganic parts on the GO. The activity of catalyst has been tested for the synthesis of tetrahydrobenzo[b]pyran derivatives under solvent-free condition in short reaction time and good to excellent yields. [GRAPHICS] .

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ataie, F; Davoodnia, A; Khojastehnezhad, A or concate me.. Name: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about RUTHENIUM(II) POLYPYRIDYL COMPLEXES; COPPER(I) COMPLEXES; IN-VITRO; CATALYTIC-PROPERTIES; OXIDATIVE STRESS; HIGHLY EFFICIENT; CU(I) COMPLEXES; CANCER-CELLS; PHOTOSENSITIZERS; SERIES, Saw an article supported by the Science and Engineering Research Board [EMR/2016/007955]. Published in WILEY in HOBOKEN ,Authors: Pathaw, L; Khamrang, T; Selvakumaran, B; Murali, M; Prakash, PA; Jaabir, MSM; Velusamy, M. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

Copper(I) complexes of the types [Cu(N-N)(PPh3)(2)]NO3(LC41-LC44) and [Cu(N-N)(PPh3)(NO3)] (LC45) carrying 3-substituted 1-pyridine-2-ylimidazo[1,5-a]pyridine (N-N) derivatives and triphenylphosphine (PPh3) ligands have been prepared. The synthesized copper(I)-phosphine complexes were fully characterized by NMR, IR, ESI-MS and UV-visible spectroscopy as well as by cyclic voltammetry. Selected structures such as LC42, LC43 and LC45 were additionally analysed by single-crystal X-ray method, which show that copper(I) centre adopts a highly distorted tetrahedral geometry. The(1)H and(13)C NMR spectral data of the complexes throw light on the nature of metal-ligand bonding. They display d pi-pi* metal-to-ligand charge transfer (MLCT) transition and show quasireversible Cu-I/Cu(II)metal oxidation. Among the copper(I)-phosphine complexes, LC41-LC44 exhibit moderate cytotoxicity (IC50: 24 h, 67-74 mu M; 48 h, 58-70 mu M) against human lung epithelial adenocarcinoma A549 cells, whereas LC45 displays the best activity (IC50: 24 h, 42 mu M; 48 h, 34 mu M) for A549 cancer cell line, which is better than that of the commercial antitumor drug cisplatin. All the complexes also displayed excellent selectivity by being relatively inactive against the human lung epithelial L132 normal cell line with selectivity index (SI) values ranging from 3.4 to 7.4. The complexes block cell cycle progression of A549 cells in G(0)/G(1)phase. FACSVerse analyses are suggestive of reactive oxygen species (ROS) generation and apoptotic cell death induced by the LC41, LC43 and LC45. The induction of apoptosis in A549 cells was shown by Annexin V with propidium iodide (PI) and 4 ‘,6-diamidino-2-phenylindole (DAPI) staining methods and established the ability of LC41, LC43 and LC45 to accumulate in the cell nuclei.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Pathaw, L; Khamrang, T; Selvakumaran, B; Murali, M; Prakash, PA; Jaabir, MSM; Velusamy, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ando, K; Watanabe, H; Zhu, XX in AMER CHEMICAL SOC published article about ALPHA,BETA-UNSATURATED ALDEHYDES; STEREOSELECTIVE-SYNTHESIS; 2-CARBON HOMOLOGATION; KETONES; DERIVATIVES; ALCOHOLS in [Ando, Kaori; Watanabe, Haruka; Zhu, Xiaoxian] Gifu Univ, Fac Engn, Dept Chem & Biomol Sci, Gifu 5011193, Japan in 2021.0, Cited 40.0. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

(E)-alpha,beta-Unsaturated aldehydes were synthesized by the Julia-Kocienski reaction of 2,2-dimethoxyethyl 1-phenyl-1H-tetrazol-5-yl (PT) sulfone 3 with various aldehydes, followed by acid hydrolysis. The reaction could be carried out in one pot, and various (E)-alpha,beta-unsaturated aldehydes were obtained in a short time and with high yields.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ando, K; Watanabe, H; Zhu, XX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Demidov, MR; Osyanin, VA; Osipov, DV; Klimochkin, YN in [Demidov, Maxim R.; Osyanin, Vitaly A.; Osipov, Dmitry, V; Klimochkin, Yuri N.] Samara State Tech Univ, Samara 443100, Russia published Three-Component Condensation of Pyridinium Ylides, beta-Ketonitriles, and Aldehydes with Divergent Regioselectivity: Synthesis of 4,5-Dihydrofuran-3-and 2H-Pyran-5-carbonitriles in 2021.0, Cited 41.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A library of trans-4,5-dihydrofuran-3-carbonitriles was synthesized in a diastereoselective manner in good yields by the three-component reaction of beta-ketonitriles, carbonyl- and semistabilized pyridinium ylide precursors, and aldehydes in the presence of piperidine. This one-pot transformation generates two C-C and one C-O bond and proceeds through a cascade Knoevenagel condensation, a Michael addition, and intramolecular S(N)2 cyclization. Formation of cyclopropanecarbonitrile derivatives, which in some cases were obtained as major products, was found to be a competing reaction. The use of arylglyoxals changes regioselectivity and leads to 2-hydroxy-2H-pyran-5-carbonitriles.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Demidov, MR; Osyanin, VA; Osipov, DV; Klimochkin, YN or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles