Category: 123-11-5

Kurma, SH; Sridhar, B; Bhimapaka, CR in [Kurma, Siva Hariprasad; Bhimapaka, China Raju] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, India; [Kurma, Siva Hariprasad; Bhimapaka, China Raju] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India; [Sridhar, Balasubramanian] CSIR Indian Inst Chem Technol, Dept Analyt & Struct Chem, Hyderabad 500007, India published Direct Access for the Regio- and Stereoselective Synthesis of N-Alkenylpyrazoles and Chromenopyrazoles in 2021.0, Cited 61.0. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A highly regio- and stereoselective method was developed for the preparation of N-alkenylpyrazoles and chromenopyrazoles by the reaction of N-tosylhydrazones and salicyl N-tosylhydrazones with alkynes under neat conditions in the presence of La(OTf)(3). The present study was found to be efficient and convenient for direct access to N-alkenylpyrazoles and chromenopyrazoles through C-C, C-N, and C-O bond forming reactions. Structure assignment of N-alkenylpyrazole compound 5c was confirmed by X-ray analysis.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kurma, SH; Sridhar, B; Bhimapaka, CR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and Antiproliferative Activity of Novel Hydrazono Thiazolidene and Thiazole Derivatives Bearing Rhodanine Moiety WOS:000662914800023 published article about ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; IN-VITRO; THIOSEMICARBAZONE; INHIBITORS; PYRAZOLE; DESIGN in [Elasasy, M. E. A.; Elnaggar, D. H.; Hafez, N. A. Abdel; Mohamed, A. M.] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt; [Azab, M. E.] Ain Shams Univ, Fac Sci, Chem Dept, Cairo 11566, Egypt; [Amr, A. E.] King Saud Univ, Coll Pharm, Pharmaceut Chem Dept, Drug Explorat & Dev Chair DEDC, Riyadh 11451, Saudi Arabia; [Amr, A. E.] Natl Res Ctr, Organ Chem Dept, Chem Ind Res Div, Cairo 12622, Egypt; [Omran, M. M.] Cairo Univ, Natl Canc Inst, Canc Biol Dept, Pharmacol Unit, Cairo 11796, Egypt in 2021, Cited 31. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

Some new fluoro-heterocyclic compounds containing thiazole and pyridine moities have been synthesized and studied for their antiproliferative activity. Thiazole derivatives have been synthesized by the reaction of alpha-halo carbonyl compounds with thiosemicarbazones. Some pyridine derivatives have been synthesized by the reaction of chalcone with cyanothioacetamide and/or malononitrile. Spectroscopic methods have been used for elucidating molecular structures of the products. Cytotoxic activity of several derivatives has been tested against human breast cancer (MCF-7), human colon cancer (HCT-116) and human liver cancer (Hep-G2) by the SRB method. Most of compounds exhibit mild effect on the tested cell lines. One of thiazolidin-4-one derivatives has been characterized by moderate to strong effect on MCF-7 cell line.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elasasy, MEA; Elnaggar, DH; Hafez, NAA; Azab, ME; Amr, AE; Omran, MM; Mohamed, AM or concate me.. Product Details of 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Maran, BAV; Josmeh, D; Tan, JK; Yong, YS; Shah, MD in MDPI published article about in [Venmathi Maran, Balu Alagar; Josmeh, Dawglas; Shah, Muhammad Dawood] Univ Malaysia Sabah, Borneo Marine Res Inst, Jalan UMS 88450, Kota Kinabalu, Sabah, Malaysia; [Tan, Jen Kit] Univ Kebangsaan Malaysia, Dept Biochem, Med Ctr, Kuala Lumpur 56000, Malaysia; [Yong, Yoong Soon] Xiamen Univ Malaysia, Lab Ctr, Jalan Sunsuria, Bandar Sunsuria 43900, Sepang, Malaysia in 2021.0, Cited 52.0. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Zeylanicobdella arugamensis (Hirudinea), a marine parasitic leech, not only resulted in the mortality of the host fish (Groupers) but also caused economic losses. The current study aimed to elucidate the antiparasitic efficacy of the aqueous extract of the Azadirachta indica leaves against Z. arugamensis and to profile the composition via LC-Q Exactive HF Orbitrap mass spectrometry. Different concentrations (25, 50 and 100 mg/mL) of A. indica extract were prepared and tested on the parasitic leeches. The total mortality of leeches was noticed with an exposure to the A. indica aqueous extract. The average times required for the aqueous extract at concentrations of 25, 50 and 100 mg/mL to kill the leeches were 42.65 +/- 9.20, 11.69 +/- 1.11 and 6.45 +/- 0.45 min, respectively, in a dose-dependent manner. The Orbitrap mass spectrometry analysis indicated the presence of five flavonoids (myricetin 3-O-galactoside, trifolin, isorhamnetin, quercetin and kaempferol), four aromatics (4-methoxy benzaldehyde, scopoletin, indole-3-acrylic acid and 2,4-quinolinediol), three phenolics (p-coumaric acid, ferulic acid and phloretin) and two terpenoids (pulegone and caryophyllene oxide). Thus, our study indicates that A. indica aqueous extract is a good source of metabolites with the potential to act as a biocontrol agent against the marine parasitic leech in aquaculture.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Maran, BAV; Josmeh, D; Tan, JK; Yong, YS; Shah, MD or concate me.. Quality Control of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. In 2021 J CHIN CHEM SOC-TAIP published article about DOMINO REACTIONS; 4-COMPONENT SYNTHESIS; NATURAL-PRODUCTS; EFFICIENT; CATALYST; PHENAZINES; BENZOPHENAZINES; DABCO; BENZO in [Olyaei, Abolfazl; Aghajanzadeh, Atiye; Feizy, Elaheh] Payame Noor Univ PNU, Dept Chem, POB 19395-4697, Tehran, Iran; [Sadeghpour, Mahdieh] Islamic Azad Univ, Dept Chem, Takestan Branch, Takestan, Iran in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A simple and efficient synthesis of novel 6,6 ‘-(arylmethylene)bis(benzo[a]phenazin-5-ol) derivatives has been developed via a sequential one-pot, two-step, pseudo-five-component tandem reaction starting from 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, and aromatic aldehydes in the presence of 2-aminopyridine as co-catalyst and p-TsOH as catalyst at 90 degrees C under solvent-free conditions. This sequential green process offers several advantages, such as operational simplicity, high yield, low cost, easy handling, clean reactions, absence of any tedious work-up, and purification of products by non-chromatographic methods.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Olyaei, A; Aghajanzadeh, A; Feizy, E; Sadeghpour, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Methoxybenzaldehyde. Authors Habibi, D; Shojaei, S; Heydari, S in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Habibi, D.; Shojaei, S.; Heydari, S.] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 6517838683, Hamadan, Iran; [Heydari, S.] Faran Shimi Pharmaceut Co, Dept Res & Dev, Tuyserkan, Iran in 2021.0, Cited 31.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Potassium hydrogen sulfate (KHSO4) and trifluoromethanesulfonic acid (CF3SO3H) were separately used as efficient catalysts for the one-pot three-component synthesis of a series of indazolophthalazinetriones from various aldehydes, dimedone, and 2,3-dihydrophthalazine-1,4-dione at 80 degrees C under solvent-free conditions in good to excellent yields. It was found that trifluoromethanesulfonic acid is a more efficient catalyst than potassium hydrogen sulfate since CF3SO3H is a stronger acid than KHSO4, and the corresponding intermediate will probably be formed at a higher rate and be more stable.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Habibi, D; Shojaei, S; Heydari, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Identification of Potential SARS-CoV-2 Main Protease and Spike Protein Inhibitors from the Genus Aloe: An In Silico Study for Drug Development WOS:000645394300001 published article about VAR NATALENSIS BERGER; CHEMICAL-CONSTITUENTS; SAPONARIA-HAW; TETRAHYDROANTHRACENE DERIVATIVES; STRUCTURE ELUCIDATION; C-GLUCOSYLANTHRONES; CHROMONE COMPONENTS; MOLECULAR-DYNAMICS; ANTIVIRAL ACTIVITY; CALLUS-TISSUE in [Abouelela, Mohamed E.; Assaf, Hamdy K.; Abdelhamid, Reda A.; Elkhyat, Ehab S.] Al Azhar Univ, Fac Pharm, Dept Pharmacognosy, Assiut Branch, Assiut 71524, Egypt; [Sayed, Ahmed M.] Nanda Univ, Fac Pharm, Dept Pharmacognosy, Bani Suwayf 62513, Egypt; [Oszako, Tomasz] Forest Res Inst, Dept Forest Protect, PL-05090 Sekocin Stary, Poland; [Belbahri, Lassaad] Univ Neuchatel, Lab Soil Biol, CH-2000 Neuchatel, Switzerland; [El Zowalaty, Ahmed E.] Univ Gothenburg, Sahlgrenska Ctr Canc Res, Inst Clin Sci, Dept Surg, S-40530 Gothenburg, Sweden; [El Zowalaty, Ahmed E.] Univ Gothenburg, Wallenberg Ctr Mol & Translat Med, S-40530 Gothenburg, Sweden; [Abdelkader, Mohamed Salaheldin A.] Sohag Univ, Fac Pharm, Dept Pharmacognosy, Nasr City 82524, Sohag, Egypt in 2021, Cited 182. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. HPLC of Formula: C8H8O2

Severe acute respiratory syndrome coronavirus (SARS-CoV-2) disease is a global rapidly spreading virus showing very high rates of complications and mortality. Till now, there is no effective specific treatment for the disease. Aloe is a rich source of isolated phytoconstituents that have an enormous range of biological activities. Since there are no available experimental techniques to examine these compounds for antiviral activity against SARS-CoV-2, we employed an in silico approach involving molecular docking, dynamics simulation, and binding free energy calculation using SARS-CoV-2 essential proteins as main protease and spike protein to identify lead compounds from Aloe that may help in novel drug discovery. Results retrieved from docking and molecular dynamics simulation suggested a number of promising inhibitors from Aloe. Root mean square deviation (RMSD) and root mean square fluctuation (RMSF) calculations indicated that compounds 132, 134, and 159 were the best scoring compounds against main protease, while compounds 115, 120, and 131 were the best scoring ones against spike glycoprotein. Compounds 120 and 131 were able to achieve significant stability and binding free energies during molecular dynamics simulation. In addition, the highest scoring compounds were investigated for their pharmacokinetic properties and drug-likeness. The Aloe compounds are promising active phytoconstituents for drug development for SARS-CoV-2.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Abouelela, ME; Assaf, HK; Abdelhamid, RA; Elkhyat, ES; Sayed, AM; Oszako, T; Belbahri, L; El Zowalaty, AE; Abdelkader, MSA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Washio, A; Hosaka, M; Uemura, N; Yoshida, Y; Mino, T; Kasashima, Y; Sakamoto, M in AMER CHEMICAL SOC published article about CHIRAL-SYMMETRY BREAKING; CRYSTALLIZATION; TRANSFORMATION; EMERGENCE in [Washio, Aoi; Hosaka, Momoka; Uemura, Naohiro; Yoshida, Yasushi; Mino, Takashi; Sakamoto, Masami] Chiba Univ, Grad Sch Engn, Dept Appl Chem & Biotechnol, Chiba 2638522, Japan; [Yoshida, Yasushi; Mino, Takashi; Sakamoto, Masami] Chiba Univ, Mol Chiral Res Ctr, Chiba 2638522, Japan; [Kasashima, Yoshio] Chiba Inst Technol, Educ Ctr, Fac Creat Engineeing, Chiba 2750023, Japan in 2021, Cited 37. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The highly enantioselective synthesis of p-anisoin was achieved via the benzoin condensation of a prochiral p-anisaldehyde using achiral NHC catalysts such as vitamin B1. In this reaction, p-anisoin crystallized as a conglomerate, and the deracemization of racemic p-anisoin under basic conditions was efficiently performed by Viedma ripening. Although the handedness of the enantioselective crystallization could not be controlled by spontaneous crystallization, it could be controlled by the coexistence of a catalytic amount of optically active valine. It was clarified that this is due to the asymmetric transformation of p-anisoin with enantiomeric valine in the mother liquor.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Washio, A; Hosaka, M; Uemura, N; Yoshida, Y; Mino, T; Kasashima, Y; Sakamoto, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Pacheco, BS; Da Silva, CC; Da Rosa, BN; Mariotti, KC; Nicolodi, C; Poletti, T; Segatto, NV; Collares, T; Seixas, FK; Paniz, O; Carreno, NLV; Pereira, CMP in SPRINGER INTERNATIONAL PUBLISHING AG published article about in [Pacheco, Bruna S.; Da Silva, Caroline C.; Da Rosa, Bruno N.; Nicolodi, Caroline; Poletti, Tais; Pereira, Claudio M. P.] Univ Fed Pelotas, Lab Lipid & Bioorgan, Bioforens Res Grp, BR-96001970 Pelotas, RS, Brazil; [Mariotti, Kristiane C.] Brazilian Fed Police, Biometr Grp, BR-90610093 Porto Alegre, RS, Brazil; [Segatto, Natalia, V; Collares, Tiago; Seixas, Fabiana K.] Univ Fed Pelotas, Postgrad Program Biotechnol, Res Grp Cellular & Mol Oncol, BR-96001970 Pelotas, RS, Brazil; [Paniz, Oscar; Vilarreal Carreno, Neftali Lenin] Univ Fed Pelotas, Technol Dev Ctr, Mat Sci & Engn, BR-96010000 Pelotas, RS, Brazil in 2021, Cited 30. Safety of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Fingerprint development is one of the most useful techniques in forensic investigation. The powder method is widely used, as it consists of a non-destructive testing. However, some of the powders commonly used are toxic and dangerous to human health. In this sense, monofunctional analogues of curcumin (3a-e) are proposed as novel coloring powders for the development of latent fingerprints. Granulometric and scanning electron microscopy analysis were performed for a better understanding of the interaction between developers and substrates. The best results for the development of fingerprints were obtained with compound (1E,4E)-1,5-di-p-tolylpenta-1,4-dien-3-one (3b). Development with this compound was specific and allowed detection both from male and female donors. Also, in an in vitro experiment, compound 3b presented low cytotoxicity in a mammalian cell line. Based on that, a novel alternative for latent fingerprint developers was proposed.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Pacheco, BS; Da Silva, CC; Da Rosa, BN; Mariotti, KC; Nicolodi, C; Poletti, T; Segatto, NV; Collares, T; Seixas, FK; Paniz, O; Carreno, NLV; Pereira, CMP or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Recently I am researching about ORGANIC-COMPOUNDS; SMOKE CHEMISTRY; PART I; NICOTINE; CARBONYLS; EXPOSURE; INGREDIENTS; ADDITIVES; PRODUCTS; BENZENE, Saw an article supported by the FCT-Fundacao para a Ciencia e a TecnologiaPortuguese Foundation for Science and Technology [UIDB/00674/2020, UIDP/00674/2020]; ARDITI-Agencia Regional para o Desenvolvimento da Investigacao Tecnologia e Inovacao – Centro de Quimica da Madeira – CQM+ (Madeira 14-20 Program) [M1420-01-0145-FEDER-000005]; ARDITI [M1420 -09-5369-FSE-000001]; Madeira Employment Institute (IEM); Fundacao para a Ciencia e TecnologiaPortuguese Foundation for Science and TechnologyEuropean Commission; Madeira 14-2020 program [M14-20 M1420-01-0145-FEDER-000008]. Published in ELSEVIER in AMSTERDAM ,Authors: Berenguer, C; Pereira, JAM; Camara, JS. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

Electronic cigarettes (e-cigarettes) have become popular alternatives to traditional tobacco. Despite this, a comprehensive evaluation of their long-term effects and safety for the consumers and the environment is missing. To contribute to filling this gap, headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME/GC-MS) was employed to establish and compare the volatile fingerprints of traditional tobacco and e-cigarettes. The analysis of traditional tobacco included two popular brands and different parts of the cigarette (solid tobacco, cigarette smoke, cigarette paper and filter). Regarding the e-cigarettes, two e-liquids, with and without nicotine, their main constituents (e-bases) and corresponding vapours, obtained under default vaping (power) conditions, were analysed. A total of 80 volatile organic compounds (VOCs) were identified in traditional tobacco, of which 14 carbonyl compounds, 9 benzene derivatives, 9 ethyl esters and 9 hydrocarbons. Slight differences in the volatile profile of cigarette paper and filter between the two brands were also detected, showing that exogenous components of tobacco influence the flavour and harmfulness perceived by the smokers. In turn, 92 VOCs were identified in e-cigarettes, including 31 ethyl esters, 18 alcohols and 10 hydrocarbons. No VOCs with potentially toxic or harmful effects were identified in the vapour of Do It Yourself (DIY) liquids and Premium samples. Therefore, taking into consideration the volatile compositions obtained for smoking and vaping procedures under normal conditions of operation and using certified e-liquid mixtures, the e-cigarettes analysed seemed to constitute a valid and less harmful alternative to traditional tobacco for smokers, secondhand smokers and the environment.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Berenguer, C; Pereira, JAM; Camara, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Gilanizadeh, M; Zeynizadeh, B in TAYLOR & FRANCIS LTD published article about in [Gilanizadeh, Masumeh; Zeynizadeh, Behzad] Urmia Univ, Fac Chem, Orumiyeh 5756151818, Iran in 2021, Cited 45. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An efficient green method has been developed for the cascade multi-component Hantzsch reaction of acridinediones and biscoumarins using Fe3O4@SiO2@Ni-Zn-Fe layered double hydroxide (LDH). Nano Ni-Zn-Fe LDH immobilized on silica-layered magnetite was synthesized via a simple co-precipitation procedure, and characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM). The nanocatalyst has the usual features of Fe3O4@SiO2 and Ni-Zn-Fe LDH. Moreover, it contains magnetism properties which is related to the presence of magnetite in the nanocatalyst and can be easily separated from the reaction mixture with an external magnetic field. Subsequently, the nanomagnetic-LDH was used to evaluate catalytic activity with the tandem synthesis of acridinedione and biscoumarin derivatives. The mesoporous catalyst showed excellent performance for multi-component reactions between aromatic aldehydes, 4-hydroxycoumarin, and dimedone and ammonium acetate. Acridinediones were provided within 15-35 min in 80-96% yields under solvent-free conditions in 70-80 degrees C and also, biscoumarins were obtained within 1-40 min in 87-95% yields under reflux conditions in water. The present study includes noteworthy advantages of mild reaction conditions, short times of reaction, absence of hazardous and expensive organic solvents and reagents, presence of water as an eco-friendly solvent, using green nanomagnetic-LDH and the ability to recycle the nanocatalyst.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gilanizadeh, M; Zeynizadeh, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles