Category: 123-11-5

An article Royal jelly fatty acids bioprofiling using TLC-MS and digital image analysis coupled with chemometrics and non-parametric regression for discovering efficient biomarkers against melanoma WOS:000655866800004 published article about PRODUCTS; IDENTIFICATION; EFFICACY; PROFILE in [Ibrahim, Reham S.; El-Banna, Alaa A.] Alexandria Univ, Fac Pharm, Dept Pharmacognosy, Alexandria 21521, Egypt in 2021, Cited 37. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A comprehensive approach of untargeted and targeted fatty acid bioprofiling of different royal jelly commercial and pharmaceutical products based on HPTLC-image analysis and melanoma cytotoxic activity together with chemometric analysis was applied in this study for discovering efficient biomarkers. Principal component analysis based on HPTLC-image analysis fingerprints of fatty acid loading plots were used to determine the chemical markers responsible for classification of royal jelly samples into fresh and lyophilized ones. These markers were identified using the HPTLC-MS technique as 8-hydroxyoctanoic acid, 3,10-dihydroxydecanoic acid, 10-hydroxy-2-decenoic acid, decanedioic acid and 10-hydroxydecanoic acid. These discriminating markers were quantified via the HPTLC-imaging technique for targeted profiling using two different methods: parametric and non-parametric regression. The non-parametric regression method exhibited superiority in terms of linearity, accuracy and precision. Biomarkers were determined from the 3D-loading plot of orthogonal projection to latent structures model based on the fatty acid quantitative data together with the melanoma cytotoxic activity data. 10-Hydroxy-2-decenoic acid showed the greatest reduction in melanoma cell viability followed by decanedioic acid then 8-hydroxyoctanoic acid. The present study is considered the first attempt to discriminate fresh and lyophilized royal jelly samples based on their holistic lipidomic profile to discover efficient fatty acid reducing melanoma cell viability.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ibrahim, RS; El-Banna, AA or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Experimental and Computational Studies of Palladium-Catalyzed Spirocyclization via a Narasaka-Heck/C(sp(3) or sp(2))-H Activation Cascade Reaction WOS:000657212800032 published article about C-H ALKYLATION; ARYLATION; FUNCTIONALIZATION; CONSTRUCTION; CYCLIZATION; ALKENES; ARENES in [Wei, Wan-Xu; Wen, Ya-Ting; Li, Ming; Li, Xue-Song; Wang, Cui-Tian; Liu, Hong-Chao; Jiao, Rui-Qiang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China; [Xia, Yu] Xinjiang Univ, Coll Chem, Urumqi Key Lab Green Catalysis & Synth Technol, Urumqi 830046, Peoples R China; [Zhang, Bo-Sheng] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China in 2021, Cited 91. SDS of cas: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The first synthesis of highly strained spirocyclobutane-pyrrolines via a palladium-catalyzed tandem Narasaka-Heck/C(sp(3) or sp(2))-H activation reaction is reported here. The key step in this transformation is the activation of a delta-C-H bond via an in situ generated sigma-alkyl-Pd(II) species to form a five-membered spiro-palladacycle intermediate. The concerted metalation-deprotonation (CMD) process, rate-determining step, and energy barrier of the entire reaction were explored by density functional theory (DFT) calculations. Moreover, a series of control experiments was conducted to probe the rate-determining step and reversibility of the C(sp(3))-H activation step.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wei, WX; Li, YK; Wen, YT; Li, M; Li, XS; Wang, CT; Liu, HC; Xia, Y; Zhang, BS; Jiao, RQ; Liang, YM or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Diastereoselective Rhodium Catalyzed [4+2] Cycloisomerization of Allenes WOS:000641296000014 published article about HIGHLY ENANTIOSELECTIVE APPROACH; CYCLOADDITION; 4C+3C in [Li, Jun; Gilbertson, Scott R.] Univ Houston, Dept Chem, Houston, TX 77204 USA in 2021.0, Cited 18.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. COA of Formula: C8H8O2

A diastereoselective [4 + 2] cycloisomerization of asymmetric allenyl dienes is reported. The asymmetric dienyl allenes are synthesized using the method reported by Ma. These substrates readily undergo diastereoselective intramolecular rhodium catalyzed [4 + 2] cycloisomerization analogous to thermal intramolecular Diels-Alder reactions. Overall, 29 examples are presented with tethers possessing nitrogen, oxygen, and carbon. Diastereoselectivities range from 99:1 to 90:10 in most examples.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Li, J; Gilbertson, SR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Zaiter, J; Hibot, A; Hafid, A; Khouili, M; Neves, CMB; Simoes, MMQ; Neves, MGPMS; Faustino, MAF; Dagci, T; Saso, L; Armagan, G in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Zaiter, Jamila; Hibot, Achraf; Hafid, Abderrafia; Khouili, Mostafa] Univ Sultan Moulay Slimane, Fac Sci & Tech, Lab Chim Organ & Analyt, BP 523, Beni Mellal 23000, Morocco; [Neves, Claudia M. B.; Simoes, Mario M. Q.; Neves, M. Graca P. M. S.; Faustino, M. Amparo F.] Univ Aveiro, Dept Chem, LAQV REQUIMTE, P-3810193 Aveiro, Portugal; [Dagci, Taner] Ege Univ, Fac Med, Dept Physiol, TR-35100 Izmir, Turkey; [Saso, Luciano] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy; [Armagan, Guliz] Ege Univ, Fac Pharm, Dept Biochem, TR-35100 Izmir, Turkey in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell death induced by 1-methyl-4-phenylpyridinium (MPP+). The percentages of neuroprotection by derivatives were found between 21.26% and 52.67% at selected concentrations (10-50 mu M) with compound 4d exerting the best neuroprotective effect. The results show that the studied spiropyrazolones perform important roles in dopaminergic neuroprotection and can be used for potential new therapies in the treatment of neurodegenerative disorders including Parkinson’s disease. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zaiter, J; Hibot, A; Hafid, A; Khouili, M; Neves, CMB; Simoes, MMQ; Neves, MGPMS; Faustino, MAF; Dagci, T; Saso, L; Armagan, G or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. Authors Moghaddam, FM; Goudarzi, M; Dezag, HM in TAYLOR & FRANCIS INC published article about in [Moghaddam, Firouz Matloubi; Goudarzi, Mehri; Dezag, Hamid Mohammadzadeh] Sharif Univ Technol, Dept Chem, Lab Organ Synth & Nat Prod, Azadi St,POB 111559516, Tehran, Iran in 2021, Cited 46. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An efficient and one-pot procedure is described for the synthesis of a variety of derivatives of 1,2-dihydrobenzo[f]chromen-3-ones and 3,4-dihydrochromen-2-ones under solvent-free conditions via a pseudo-four-component domino reaction of acetic anhydride, aryl aldehydes, glycine-based dithiocarbamates, and phenols/naphthols in the presence of l-proline and H-4[Si(W3O10)(4)].xH(2)O as green catalysts. All products were made under the green strategy for the synthesis of corresponding products with excellent yields (up to 94%) and diastereoselectivity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Moghaddam, FM; Goudarzi, M; Dezag, HM or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Temperature Sensing of Thiolate Addition by Phenolate Merocyanine Dyes: Importance of the Quinone Methide Resonance Structure published in 2021. Safety of 4-Methoxybenzaldehyde, Reprint Addresses Manderville, RA (corresponding author), Univ Guelph, Dept Chem, Guelph, ON N1G 2W1, Canada.; Manderville, RA (corresponding author), Univ Guelph, Dept Toxicol, Guelph, ON N1G 2W1, Canada.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

Merocyanine (MC) dyes containing an aromatic donor vinyl linked to a cationic acceptor serve as chemosensors for analyte detection. Their electrophilicity permits anion detection through addition reactions that disrupt dye conjugation. Herein, we demonstrate the temperature influence on thiolate addition to MCs containing the N-methylbenzothiazolium (Btz) acceptor. The zwitterionic phenolate dye (PhOBtz) displays impressive temperature sensitivity to thiolate addition, with the brightly colored phenolate favored upon heating and the colorless thiolate adduct favored upon cooling. In contrast, MC dyes containing neutral donors (PhOMeBtz and PhNMe(2)Btz) display only moderate temperature sensitivity to thiolate capture and release. Extraction of thermodynamic parameters demonstrates a strong enthalpic driving force for thiolate addition to PhOBtz that is absent for PhOMeBtz and PhNMe(2)Btz. Variable temperature H-1 NMR studies demonstrate that PhOBtz adopts the para-quinone methide (p-QM) resonance structure. Thus, thiolate addition to PhOBtz resembles 1,6-conjugate addition to p-QMs which is accompanied by a large increase in the pi-stabilization energy upon adduct formation. Manipulation of PhOBtz electrophilicity by attaching chlorine substituents to the phenolate caused the thiolate adducts to dissipate over time for p-QM regeneration. Our work provides new design ideas for the utility of phenolate MC dyes, given that they are carriers of the p-QM electrophile.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Van Riesen, AJ; Johnson, RE; Al-Abdul-Wahid, MS; Liota, C; Christyanton, A; Manderville, RA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, structure analysis, biological activity and molecular docking studies of some hydrazones derived from 4-aminobenzohydrazide WOS:000600569700030 published article about SCHIFF-BASE; CRYSTAL-STRUCTURES; FT-RAMAN; ANTIMICROBIAL ACTIVITIES; AB-INITIO; DERIVATIVES; ANTIBACTERIAL; COMPLEXES; ACID; DFT in [Senthilkumar, S.; Seralathan, J.] Annamalai Univ, Dept Chem, Chidambaram 608002, Tamil Nadu, India; [Muthukumaran, G.] Krishnasamy Coll Engn & Technol, Dept Chem, Cuddalore 607109, Tamil Nadu, India in 2021, Cited 51. Category: indole-building-block. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

(E)-4-Amino-N’-(substituted benzylidene) benzohydrazides (1-8) were synthesized by condensing 4-aminobenzohydrazide with an appropriate aldehyde in the molar ratio of 1:1 in methanol as solvent. Single crystal X-ray diffraction has been recorded for compound 1. For all the synthesized compounds, FT-IR, H-1 and C-13 NMR spectra have been recorded. Also antibacterial and docking studies have been done for all compounds 1-8. Since for compound 1 only single crystal X-ray analysis has been carried out, its structural characterization have been done in detail, characterisation of remaining compounds 2-8 have been carried out by comparing their FT-IR, H-1 and C-13 NMR spectral data with that of compound 1. Single crystal X-ray analysis of 1 show that the compound exists in E-configuration about azomethine double bond. The crystal state of the compound was stabilised by the hydrogen bond present in the molecule. DFT calculations using the B3LYP/6-311++G method have been carried out for 1 to get the optimized geometry, IR and NMR frequencies, Mulliken charge distribution, molecular electrostatic potential (MEP) and energies of HOMO – LUMO. A good agreement between the DFT predicted and the experimentally measured IR and NMR spectra of 1 was found. Analysis of MEP and Mulliken atomic charges bar diagram of 1, confirms the chemical reactivity and existence of intermolecular hydrogen bonding of the molecule. The result of antibacterial and antifungal activities shows that the compounds 2, 4, 7 and 8 showed good antibacterial activity against the tested bacteria and the compounds 1, 3, 5 and 6 showed good antifungal activities against all the three fungal strains. These results showed that electron donating and electron withdrawing groups play important roles in antibacterial and antifungal activities of the compounds1-8, respectively. Molecular docking studies of compounds 1-8 shows that the various ligand of compounds 1-8 shows glide score values lies between -5.923 to -7.298, among these the compounds 6 and 8 showed excellent glide score values. (C) 2020 Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Senthilkumar, S; Seralathan, J; Muthukumaran, G or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Generation of alpha-Boryl Radicals and Their Conjugate Addition to Enones: Transition-Metal-Free Alkylation of gem-Diborylalkanes WOS:000605575500001 published article about B-ALKYLCATECHOLBORANES; BORONIC ESTERS; PHOTOREDOX; ACTIVATION; REACTIVITY; SECONDARY; KETONES; ACCESS in [Wu, Chaoqiang; Bao, Zhicheng; Dou, Bowen; Wang, Jianbo] Peking Univ, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn, Minist Educ,Coll Chem, Beijing 100871, Peoples R China in 2021.0, Cited 56.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A transition-metal-free method for the alkylation of gem-diborylalkanes with alpha,beta-unsaturated ketones has been developed. It is demonstrated that the alpha-boryl radicals can be generated efficiently from gem-diborylalkanes with the aid of catechol and oxidants. The alpha-boryl radicals formed through such process can be engaged in conjugate addition reaction with alpha,beta-unsaturated ketones. This transformation is a straightforward method for the synthesis of gamma-borylketones.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wu, CQ; Bao, ZC; Dou, BW; Wang, JB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2021 J ORG CHEM published article about ASYMMETRIC 1,3-DIPOLAR CYCLOADDITIONS; MELDRUMS ACID; MULTICOMPONENT SYNTHESIS; AZOMETHINE IMINES; ANNULATION; CHEMISTRY; YLIDES in [Lebrene, Arthur; Martzel, Thomas; Gouriou, Laura; Levacher, Vincent; Oudeyer, Sylvain; Afonso, Carlos; Loutelier-Bourhis, Corinne; Briere, Jean-Francois] Normandie Univ, COBRA, CNRS, INSA Rouen,UNIROUEN, F-76000 Rouen, France; [Sanselme, Morgane] Univ Rouen, Normandie Univ, Lab SMS, EA3233, F-76821 Mont St Aignan, France in 2021, Cited 37. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A straightforward synthesis of original 1,6-diazabicyclo[4.3.0]nonane-2,7-diones was achieved through a DBU-organocatalyzed multicomponent Knoevenagel-aza-Michael-Cyclocondensation reaction which takes advantage of an unprecedented highly regio- and diastereoselective conjugate addition of pyridazinones to alkylidene Meldrum’s acid intermediates. The key reactive intermediates of this complex process were analyzed by means of electrospray ionization mass spectrometry coupled to ion mobility spectrometry, allowing us to validate the proposed mechanism.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Lebrene, A; Martzel, T; Gouriou, L; Sanselme, M; Levacher, V; Oudeyer, S; Afonso, C; Loutelier-Bourhis, C; Briere, JF or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Seralite SRC-120 resin catalyzed synthesis of bis(indolyl)methanes using indoles and low/high boiling point carbonyl compounds under solvent free conditions WOS:000592607300001 published article about FRIEDEL-CRAFTS ALKYLATION; EFFICIENT; 3,3′-DIINDOLYLMETHANE; ALDEHYDES; ACID; DERIVATIVES; INDOLYLMETHANES; ALKALOIDS; BACTERIUM; ACCESS in [Indurthi, Harish K.; Koli, Papita; Sharma, Deepak K.] Banaras Hindu Univ, Dept Pharmaceut Engn & Technol, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India; [Virdi, Reena] Overseas Healthcare Pvt Ltd, Phillaur, India; [Nageswara Rao, Desaboini] Univ Massachusetts, Sch Med, Dept Biochem & Mol Pharmacol, Worcester, MA 01655 USA in 2021, Cited 70. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly inexpensive, and operationally simple seralite SRC-120 (strongly acidic cation exchange resin) catalyzed synthesis of 3,3 ‘-bis(indolyl)methanes (BIMs) from indoles and low/high boiling point carbonyl compounds under solvent-free condition is reported. Synthesis of BIMs with low boiling point carbonyls at room temperature takes prolonged reaction time and give low yields at high temperature. The reported method overcomes these limitations and works remarkably well with low/high boiling point aldehydes/ketones in shorter reaction times (5-10 min) under microwave irradiation conditions and provides moderate to excellent yields (65-94%). Moreover, the recyclability of the catalyst for at least five times without notable loss in activity makes the whole process attractive and green protocol.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Indurthi, HK; Virdi, R; Koli, P; Rao, DN; Sharma, DK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles