Category: 123-11-5

Recommanded Product: 4-Methoxybenzaldehyde. Authors Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS in FUTURE SCI LTD published article about in [Chu, Po-Chen] China Med Univ, Dept Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen] China Med Univ, Grad Inst Cosmeceut, Taichung 40402, Taiwan; [Chu, Po-Chen; Chang, Chih-Shiang] China Med Univ, Drug Dev Ctr, Taichung 40402, Taiwan; [Wu, Yu-Chieh; Chen, Chien-Yu; Hung, Yu-Syuan; Chang, Chih-Shiang] China Med Univ, Sch Pharm, Coll Pharm, Taichung 40402, Taiwan in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Aim: Tumor cells adapt to hypoxic microenvironments by releasing the key transcription factor HIF-1 alpha, which promotes angiogenesis, glycolytic phenotype, metastasis and erythropoiesis, allowing proliferation amid low oxygen levels. Therefore, therapeutic targeting of HIF-1 alpha represents a viable strategy for cancer therapy. Methods & Results: The authors synthesized a series of novel tetrahydroquinazoline derivatives in six steps and demonstrated that their development had a unique ability to suppress HIF-1 alpha expression through proteasomal degradation. Conclusion: Among these compounds, CDMP-TQZ (8bf) exhibited the highest antiproliferative potency in human cancer cells, in part through downregulation of HIF-1 alpha.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chu, PC; Wu, YC; Chen, CY; Hung, YS; Chang, CS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Synthesis and antitumor activity of sacroflavonoside published in 2021. SDS of cas: 123-11-5, Reprint Addresses Wang, QH (corresponding author), Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

Sacroflavonoside, a new derivative of diphenylethene, was isolated from Artemisia sacrorum, which have been found to possess the inhibitory effect on the proliferation of gastric carcinoma cells (MKN-45) in vitro in our previous studies. With anisaldehyde (SM-A) as starting material, the sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization. The structure of sacroflavonoside was established by 1 D (H-1 NMR and C-13 NMR) and 2 D-NMR (HSQC and HMBC) spectral analysis. The antitumor activity and potential mechanism against MKN-45 cells of sacroflavonoside were evaluated in vitro. The results showed that sacroflavonoside could significantly induce MKN-45 cells apoptosis and autophagy by increasing the expression of Bax, Caspase-3, Beclin1 and LC3-II proteins and decreasing the expression of Bcl-2 protein at low micromole level. This investigation provided a valuable lead structure for the development of antitumor drugs. [GRAPHICS] .

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wang, QH; Xin, Y; Pa, B; He, X; Bao, WQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 123-11-5. Authors Becerra, D; Rojas, H; Castillo, JC in MDPI published article about in [Becerra, Diana; Rojas, Hugo; Castillo, Juan-Carlos] Univ Pedag & Tecnol Colombia, Escuela Ciencias Quim, Fac Ciencias, Ave Cent Norte 39-115, Tunja 150003, Colombia in 2021, Cited 27. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

We reported an efficient one-pot two-step synthesis of 3-(tert-butyl)-N-(4-methoxybenzyl)-1-methyl-1H-pyrazol-5-amine 3 in good yield by a solvent-free condensation/reduction reaction sequence starting from 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and p-methoxybenzaldehyde 2. The one-pot reductive amination proceeded by the formation in situ of the N-(5-pyrazolyl)imine 4 as key synthetic intermediate of other valuable pyrazole derivatives. This methodology is distinguished by its operational easiness, short reaction time, isolation and purification of the aldimine intermediate is not required. The structure of the synthesized N-heterocyclic amine 3 was fully characterized by FTIR-ATR, 1D and 2D NMR experiments, EIMS, and elemental analysis.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Becerra, D; Rojas, H; Castillo, JC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Zeimyte, S; Stoncius, S in [Zeimyte, Simona] Vilnius Univ, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania; [Stoncius, Sigitas] Ctr Phys Sci & Technol, Dept Organ Chem, Akademijos 7, LT-08412 Vilnius, Lithuania published Chiral bipyridine-annulated bicyclo[3.3.1]nonane N-oxide organocatalysts for stereoselective allylation and hydrosilylation reactions in 2021.0, Cited 61.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

The synthesis of chiral C-2-symmetric bis(bipyridine N,N’-dioxide) and bis(bipyridine N-monooxide) derivatives featuring bipyridine-annulated bicyclo[3.3.1 ]nonane framework is reported. The new Lewis basic bipyridine N,N’-dioxides exhibited good catalytic activity in the asymmetric allylation of aldehydes with allyltrichlorosilane, furnishing corresponding homoallylic alcohols in up to 75% ee. Reduction of ketimines and beta-enamino esters with trichlorosilane catalyzed by bipyridine N,N’-dioxides proceeded in high yields but modest enantioselectivity (38-54% ee); good levels of asymmetric induction (up to 73% ee) were attained in the reduction of alpha-imino esters at room temperature. (C) 2020 Elsevier Ltd. All rights reserved.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zeimyte, S; Stoncius, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wu, RP; Gao, K in ROYAL SOC CHEMISTRY published article about in [Wu, Rongpei; Gao, Ke] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan, Hubei, Peoples R China in 2021.0, Cited 44.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly efficient B(C6F5)(3)-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective beta-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)(3) could activate water to promote the protonation and reduction of enamines.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wu, RP; Gao, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Mitsui, A; Nagao, K; Ohmiya, H in WILEY-V C H VERLAG GMBH published article about in [Mitsui, Atsuhisa; Nagao, Kazunori; Ohmiya, Hirohisa] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan; [Ohmiya, Hirohisa] PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan in 2021.0, Cited 59.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of alpha-hydroxy ketones by electrophile-electrophile cross-coupling.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mitsui, A; Nagao, K; Ohmiya, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV in SPRINGER published article about in [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Thi, Phuong Hoang; Tuan, Anh Nguyen; Mai, Ha Hoang; Ha, Thanh Nguyen; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Mai, Ha Hoang; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Le, Tuan Anh] Vietnam Natl Univ Hanoi, Univ Sci, Fac Chem, 334 Nguyen Trai, Hanoi 100000, Vietnam in 2021.0, Cited 37.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component reaction starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and various aromatic aldehydes has been described. This multicomponent domino reaction proceeded through the Knoevenagel condensation, Michael addition, deprotonation, and 1,3-H shift steps. Five of the synthesized compounds displayed good cytotoxic activity against two human cancer cell lines, KB and HepG2, with half maximal inhibitory concentration values in a range of 4-20 mu M.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Authors Zhou, YJ; Wang, XS; Chen, Y; Yuan, BB in WILEY published article about in [Zhou, Yajun; Wang, Xuesong; Chen, Yan] Jilin Univ, Coll Food Sci & Engn, Changchun, Peoples R China; [Yuan, Bingbing] Jilin Ginseng Res Inst, Changchun 130000, Peoples R China in 2021, Cited 30. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The effects of different paprikas on the sensory properties and the physicochemical properties of spiced beef were studied. Headspace solid phase microextraction and gas chromatography-mass spectrometry were used to identify the flavor substances in the samples. The results showed that the protein and fat content of the samples with paprika were higher compared to the blank group, which were 24.10-25.60 g/100 g and 3.40-3.70 g/100g, respectively. The scores of flavor and color in the blank group were 6.50 and 6.56, respectively, which were lower than the paprikas treatment group. Among the five paprika treatment groups, the color and taste scores of the samples treated with qixing paprika were higher, which were 8.00 and 8.07, respectively. A total of 145 volatile flavor substances were detected, compared with the control group, there were more volatile flavor substances in the paprika additive groups, indicated that paprika additive could enrich the flavor of spiced beef. Practical applications Paprika not only has a unique flavor, but also has good antioxidant properties. Spiced beef is popular among consumers. However, the surface color of the product is easy to change due to oxidation, which affects the color of the product, resulting in a decline in product sales and economic losses to the enterprise. In addition, the protein and fat of the product will be lost due to oxidation during processing. Therefore, the effects of different paprika on the color, nutritional value, and volatile flavors of spiced beef were studied. The purpose was to slow down the oxidation of products, improve the color of products, retain the nutritional value, and reduce the loss of enterprises by adding different capsicum. In addition, the volatile flavor of products will directly affect the sensory evaluation of consumers, so it is very important to understand the influence of pepper on volatile flavor compounds and consumption preference for volatile components.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhou, YJ; Wang, XS; Chen, Y; Yuan, BB or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about C-GLYCOSYLIDENE DERIVATIVES; RAMBERG-BACKLUND REACTION; PROTECTED SUGAR LACTONES; EFFICIENT SYNTHESIS; ENOL ETHERS; STEREOCONTROLLED SYNTHESIS; DEHYDROQUINATE SYNTHASE; CONVENIENT SYNTHESIS; SUBSTRATE-ANALOGS; FACILE SYNTHESIS, Saw an article supported by the JST CREST Grant, Japan [JPMJCR18S1]; Koshiyama Research Grant. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Oka, N; Mori, A; Suzuki, K; Ando, K. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Name: 4-Methoxybenzaldehyde

One-pot Julia olefination using ribofuranosyl sulfones is described. The alpha-anomers of the ribofuranosyl sulfones were synthesized with complete alpha-selectivity via the glycosylation of heteroarylthiols using ribofuranosyl iodides as glycosyl donors and the subsequent oxidation of the resulting heteroaryl 1-thioribofuranosides with magnesium monoperphthalate (MMPP). The Julia olefination of the alpha-ribofuranosyl sulfones with aldehydes proceeded smoothly in one pot to afford the thermodynamically less stable (E)-exo-glycals with modest-to-excellent stereoselectivity (up to E/Z = 94:6) under the optimized conditions. The E selectivity was especially high for aromatic aldehydes. In contrast, the (Z)-exo-glycal was obtained as the main product with low stereoselectivity when the corresponding beta-ribofuranosyl sulfone was used (E/Z = 41:59). The remarkable impact of the anomeric configuration of the ribofuranosyl sulfones on the stereoselectivity of the Julia olefination has been rationalized using density functional theory (DFT) calculations. The protected ribose moiety of the resulting exo-glycals induced completely a-selective cyclopropanation on the exocyclic carbon-carbon double bond via the Simmons-Smith-Furukawa reaction. The 2-cyanoethyl group was found to be useful for the protection of the exo-glycals, as it could be removed without affecting the exocyclic C=C bond.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Oka, N; Mori, A; Suzuki, K; Ando, K or concate me.. Name: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Recently I am researching about CARBON-DIOXIDE; LIGANDS; REDUCTION; CHEMISTRY; IRON; PCP; CONVENIENT; REACTIVITY, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21571052, U1804253, 21771057]. Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Chang, JR; Fang, F; Tu, CH; Zhang, J; Ma, NN; Chen, XNA. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A series of bis(phosphinite) (POCOP) pincer ligated nickel complexes, [2,6-(tBu(2)PO)(2)C6H3]NiX (X = SH, 1; SCH2Ph, 2; SPh, 3; NCS, 4; N-3, 5), were used to catalyse the hydrosilylation of aldehydes. It was found that both complexes 1 and 2 are active in catalysing the hydrosilylation of aldehydes with phenylsilane and complex 1 is comparatively more active. The expected alcohols were isolated in good to excellent yields after basic hydrolysis of the resultant hydrosilylation products. However, no reaction was observed when complex 3 or 4 or 5 was used as the catalyst. The results are consistent with complexes 1 and 2 serving as catalyst precursors, which generate the corresponding nickel hydride complex [2,6-(tBu(2)PO)(2)C6H3]NiH in situ, and the nickel hydride complex is the active species that catalyses this hydrosilylation process. The in situ generation of the nickel hydride species was supported by both experimental results and DFT calculation.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chang, JR; Fang, F; Tu, CH; Zhang, J; Ma, NN; Chen, XNA or concate me.. Recommanded Product: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles