Category: 123-11-5

An article Hydrotalcites as catalyst in suitable multicomponent synthesis of uracil derivatives WOS:000662269700006 published article about ONE-POT SYNTHESIS; BIGINELLI-TYPE REACTION; MG-AL HYDROTALCITES; SOLVENT-FREE; HETEROGENEOUS CATALYSTS; EFFICIENT SYNTHESIS; IONIC LIQUID; SOLID BASE; MECHANISM; CONDENSATION in [Nope, Eliana; Sathicq, Angel G.; Romanelli, Gustavo] Univ Nacl La Plata, Ctr Invest & Desarrollo Ciencias Aplicadas Dr Jor, CONICET, CINDECA,CCT La Plata,CIC,PBA, Calle 47 257,B1900AJK, La Plata, Argentina; [Martinez, Jose J.; Rojas, Hugo] Univ Pedag & Tecnol Colombia UPTC, Fac Ciencias, Escuela Ciencias Quim, Ave Cent Norte, Tunja, Boyaca, Colombia; [Romanelli, Gustavo] Univ Nacl La Plata, Fac Ciencias Agr & Forestales, Catedra Quim Organ, Ctr Invest Sanidad Vegetal CISaV, Calles 60 & 119 S-N,B1904AAN, La Plata, Argentina in 2021.0, Cited 61.0. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Uracil compounds participate in a wide range of biological activities; however, reports on their synthesis using heterogeneous catalysts are scarce. In this work, the multicomponent synthesis of uracil derivatives assisted by layered double hydroxides (LDH) was studied under green chemistry conditions. The incorporation of Ni2+ or Co2+ was successfully performed by co-precipitation method. The yields to uracil derivatives are associated with the presence of weak basic sites and a better interaction of the reagents when the reaction is carried out in solvent-free conditions. The reaction pathway involves the formation of an enone between benzaldehyde and ethyl cyanoacetate, and subsequent reaction with urea, which is assisted by the presence of a basic catalyst. The scope of this synthesis is illustrated with nine examples.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nope, E; Sathicq, AG; Martinez, JJ; Rojas, H; Romanelli, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Authors Nagy, MI; Darwish, KM; Kishk, SM; Tantawy, MA; Nasr, AM; Qushawy, M; Swidan, SA; Mostafa, SM; Salama, I in MDPI published article about in [Nagy, Manar, I; Darwish, Khaled M.; Kishk, Safaa M.; Mostafa, Samia M.; Salama, Ismail] Suez Canal Univ, Fac Pharm, Dept Med Chem, Ismailia 41522, Egypt; [Tantawy, Mohamed A.] Natl Res Ctr, Hormones Dept, Med Res Div, Giza 12622, Egypt; [Nasr, Ali M.] Port Said Univ, Fac Pharm, Dept Pharmaceut, Port Said 42526, Egypt; [Nasr, Ali M.; Qushawy, Mona] Sinai Univ, Fac Pharm, Dept Pharmaceut, Alarish 45511, North Sinai, Egypt; [Qushawy, Mona] Univ Tabuk, Fac Pharm, Dept Pharmaceut, Tabuk 71491, Saudi Arabia; [Swidan, Shady A.] British Univ Egypt, Fac Pharm, Dept Pharmaceut, Cairo 11837, Egypt; [Swidan, Shady A.] British Univ Egypt, Fac Pharm, Ctr Drug Res & Dev CDRD, Cairo 11837, Egypt in 2021.0, Cited 90.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Cancer is a multifactorial disease necessitating identification of novel targets for its treatment. Inhibition of Bcl-2 for triggered pro-apoptotic signaling is considered a promising strategy for cancer treatment. Within the current work, we aimed to design and synthesize a new series of benzimidazole- and indole-based derivatives as inhibitors of Bcl-2 protein. The market pan-Bcl-2 inhibitor, obatoclax, was the lead framework compound for adopted structural modifications. The obatoclax’s pyrrolylmethine linker was replaced with straight alkylamine or carboxyhydrazine methylene linkers providing the new compounds. This strategy permitted improved structural flexibility of synthesized compounds adopting favored maneuvers for better fitting at the Bcl-2 major hydrophobic pocket. Anti-cancer activity of the synthesized compounds was further investigated through MTT-cytotoxic assay, cell cycle analysis, RT-PCR, ELISA and DNA fragmentation. Cytotoxic results showed compounds 8a, 8b and 8c with promising cytotoxicity against MDA-MB-231/breast cancer cells (IC50 = 12.69 +/- 0.84 to 12.83 +/- 3.50 mu M), while 8a and 8c depicted noticeable activities against A549/lung adenocarcinoma cells (IC50 = 23.05 +/- 1.45 and 11.63 +/- 2.57 mu M, respectively). The signaling Bcl-2 inhibition pathway was confirmed by molecular docking where significant docking energies and interactions with key Bcl-2 pocket residues were depicted. Moreover, the top active compound, 8b, showed significant upregulated expression levels of pro-apoptotic/anti-apoptotic of genes; Bax, Bcl-2, caspase-3, -8, and -9 through RT-PCR assay. Improving the compound’s pharmaceutical profile was undertaken by introducing 8b within drug-solid/lipid nanoparticle formulation prepared by hot melting homogenization technique and evaluated for encapsulation efficiency, particle size, and zeta potential. Significant improvement was seen at the compound’s cytotoxic activity. In conclusion, 8b is introduced as a promising anti-cancer lead candidate that worth future fine-tuned lead optimization and development studies while exploring its potentiality through in-vivo preclinical investigation.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nagy, MI; Darwish, KM; Kishk, SM; Tantawy, MA; Nasr, AM; Qushawy, M; Swidan, SA; Mostafa, SM; Salama, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 TETRAHEDRON LETT published article about AEROBIC OXIDATION; MOLECULAR-OXYGEN; FLAVIN; SULFIDES; AMINES; ORGANOCATALYSTS; THIOLS; AIR in [Zhang, Shiqi; Li, Ling; Zhao, Gang] Sichuan Univ, Sch Chem Engn, Chengdu 610065, Sichuan, Peoples R China; [Li, Guangxun; Tang, Zhuo] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China; [Yi, Dong] Southwest Med Univ, Sch Pharm, Dept Med Chem, Luzhou 646000, Sichuan, Peoples R China in 2021.0, Cited 37.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. SDS of cas: 123-11-5

Given the necessity of sacrificial reductants in various biomimetic aerobic oxygenations, alloxan-catalyzed aerobic redox system for one-pot atom-economic synthesis of sulfinyl-functionalized benzimidazoles was developed by ingeniously binding both the substrate sulfide and sacrificial reductant. This mild and transition-metal-free protocol undergoes two oxidations without additional sacrificial reagents, except for the environmentally benign molecular oxygen. (C) 2020 Elsevier Ltd. All rights reserved.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, SQ; Yi, D; Li, GX; Li, L; Zhao, G; Tang, Z or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sayed, AR; Gomha, SM; Abd El-lateef, HM; Abolibda, TZ in TAYLOR & FRANCIS LTD published article about in [Sayed, Abdelwahed R.; Abd El-lateef, Hany M.] King Faisal Univ, Coll Sci, Dept Chem, Al Hasa, Saudi Arabia; [Sayed, Abdelwahed R.] Beni Suef Univ, Fac Sci, Chem Dept, Bani Suwayf, Egypt; [Gomha, Sobhi M.] Cairo Univ, Fac Sci, Chem Dept, Giza 12613, Egypt; [Gomha, Sobhi M.; Abolibda, Tariq Z.] Islamic Univ Almadinah Almonawara, Fac Sci, Chem Dept, Almadinah Almonawara 42351, Saudi Arabia; [Abd El-lateef, Hany M.] Sohag Univ, Fac Sci, Chem Dept, Sohag, Egypt in 2021, Cited 54. Application In Synthesis of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

L-Proline organocatalyst was investigated as an efficient and environmentally benign catalyst for synthesis of some novel bioactive benzil bis(2-cyano-3-aryl-2-propenoylhydrazone) derivatives from reaction of the benzil bis(cyanoacetylhydrazone) with the respective aldehydes. The reusability of the L-proline was tested and the results revealed that the recovered catalyst can be reused at least three additional times in subsequent reactions without significant decrease in product yield. The current protocol is very efficient as it provides mild reaction, cleaner reaction profiles, effortless work phase with outstanding purity, and with short reaction time, high performance of the desired products. IR, H-1-NMR and MS and alternative methods, whenever available, have verified the chemical structures of the newly prepared compounds. Compared to the Doxorubicin reference drug using the MTT assay, the in vitro growth inhibitory activity of ten new compounds was investigated against the liver carcinoma cell line (HepG-2) and the findings revealed promising activities of six derivatives.

Application In Synthesis of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sayed, AR; Gomha, SM; Abd El-lateef, HM; Abolibda, TZ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2021 POLYCYCL AROMAT COMP published article about ONE-POT SYNTHESIS; SOLVENT-FREE; ANTIMICROBIAL ACTIVITY; EFFICIENT CATALYST; HETEROCYCLIC-COMPOUNDS; ANTIOXIDANT ACTIVITY; ANTICANCER AGENTS; DERIVATIVES; CANCER; COPPER(II) in [Majedi, Soma] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838395, Iran; [Karamian, Roya; Farida, Seyed Flamed Moazzami; Asadbegy, Mostafa] Bu Ali Sina Univ, Fac Sci, Dept Biol, Hamadan, Iran; [Alizadeh, Hojjat] Rooyana Vet Lab, Saqqez, Kurdistan, Iran in 2021, Cited 78. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

3,4,7,8-tetrahydro-3,3-dimethyl-11-aryl-2H-pyridazino[1,2-a]indazole-1,6,9(11H)-triones 5a-j were synthesized by a one-pot cyclocondensation of four components such as succinic anhydride, hydrazine hydrate, benzaldehyde derivatives and dimedone at room temperature through a multi-component reaction and solvent-free condition by using 1-methyl imidazolium trinitromethanide {[HMIM]C(NO2)(3)} as a very effective ionic liquid catalyst. All synthesized compounds which are soluble in DMSO were subjected to antibacterial activity assay against Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, and Bacillus cereus. Results showed that the compounds had antibacterial activity against some bacteria tested. In addition, the antioxidant activity of the compounds was evaluated by DPPH free radical scavenging assay. Our results indicated that most of the compounds had excellent dose-dependent antiradical properties. Based on obtained data, the compounds possessed moderate to excellent bactericidal effect on both Gram-positive and Gram-negative bacteria. Moreover, the compounds 5b and 5g exhibited the most anti-proliferative potencies against MCF-7 (breast carcinoma), A549 (non-small lung carcinoma) and AGS (gastric carcinoma) cell lines.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Majedi, S; Karamian, R; Farida, SFM; Asadbegy, M; Alizadeh, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about AGENTS, Saw an article supported by the Organic Chemistry Department of Chemistry and Chemical Engineering Research Center of Iran, Tehran, Iran. Published in ELSEVIER in AMSTERDAM ,Authors: Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Computed Properties of C8H8O2

In this study, new tri-amides 5a-1 have been synthesized via a one-pot four-component Ugi reaction between repaglinide, aniline derivatives, aldehyde derivatives, and cyclohexyl isocyanide in good yields. These compounds were evaluated against yeast alpha-glucosidase. Obtained in vitro alpha-glucosidase results demonstrated that all the synthesized compounds 5a-1 were more potent than standard inhibitor acarbose. Among them, the most potent compounds were compounds 5j, 5k, and 5h. The kinetic analysis of the most potent compound 5j revealed that this compound is a competitive inhibitor for alpha-glucosidase (K-i = 24 mu M). Furthermore, docking study of the most potent compounds was also performed in the alpha-glucosidase active site to find interaction modes and binding energies of these compounds. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 NEW J CHEM published article about CALCIUM-CHANNEL BLOCKERS; ONE-POT SYNTHESIS; BIGINELLI REACTION; ACID-ESTERS; EFFICIENT; SOLVENT; DERIVATIVES; LIQUID; NITROGEN; WATER in [Li, Yancong; Ma, Jiliang; Liu, Zhendong; Jin, Dongnv; Jiao, Gaojie; Guo, Yanzhu; Wang, Qiang; Zhou, Jinghui; Sun, Runcang] Dalian Polytech Univ, Ctr Lignocellulos Chem & Biomat, Coll Light Ind & Chem Engn, Dalian 116034, Peoples R China in 2021, Cited 52. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Application In Synthesis of 4-Methoxybenzaldehyde

A simple and efficient photocatalytic method for the synthesis of dihydropyrimidinones (DHPMs) and their derivatives via porous ultrathin carbon nitride nanosheets (p-CNNs) without solvents was demonstrated. The yields of 3,4-dihydropyrimidin-2(1H)-ones/thiones and their derivatives were up to 97.0%. Furthermore, the yield of 5-ethoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one in the 10th cycle retained 98.9% of its 1st value. Considering the environmental and economic benefits, this work exhibits various merits including excellent yields, environmental friendliness, inexpensiveness, and avoiding the use of solvents and metal-based photocatalysts. In addition, the excellent performance of the p-CNNs and environmentally benign reaction system have also been checked by the photocatalytic synthesis of 12-phenyl-9,9-dimethyl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-one and 5-phenyl-1(4-methoxyphenyl)-3[(4-methoxy-phenyl)-aminol]-1H-pyrrol-2(5H)-one. This work paves a new way for carrying out a three-component reaction using metal-free photocatalysts under mild reaction conditions.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Li, YC; Ma, JL; Liu, ZD; Jin, D; Jiao, GJ; Guo, YZ; Wang, Q; Zhou, JH; Sun, RC or concate me.. Application In Synthesis of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Koohestani, F; Sadjadi, S; Heravi, M in NATURE RESEARCH published article about in [Koohestani, Fatemeh; Sadjadi, Samahe] Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran; [Heravi, Majid] Alzahra Univ, Sch Phys & Chem, Dept Chem, POB 1993891176, Tehran, Iran in 2021, Cited 35. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Combining the encapsulating capability of cyclodextrin and instinctive features of bentonite clay, a versatile metal free catalyst has been developed that could promote various chemical reactions such as Knoevenagel condensation, synthesis of xanthan and octahydroquinazolinones in aqueous media under ultrasonic irradiation. To prepare the catalyst, bentonite was Cl-functionalized and then reacted with isatin and guanidine successively to furnish amino functionalized bentonite. The latter then reacted with tosylated cyclodextrin. The resultant catalytic composite was characterized via XRD, SEM, EDS, BET, elemental mapping analysis, TGA and FTIR. The catalytic activity tests approved excellent activity of the catalyst as well as broad substrate scope. Notably, the catalyst could be simply recovered and reused for several reaction runs. Moreover, the activity of the composite was superior to that of its components.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Koohestani, F; Sadjadi, S; Heravi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 CHEMSUSCHEM published article about DEPENDENT AMINE OXIDASES; AEROBIC OXIDATION; CATALYTIC MECHANISM; ALCOHOL OXIDATION; TOPA QUINONE; ACTIVE-SITE; COPPER; HYDROGEN; MODEL; PYRIMIDINES in [K. Bains, Amreen; Adhikari, Debashis] Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India; [Ankit, Yadav] Indian Inst Sci Educ & Res IISER Mohali, Dept Earth & Environm Sci, Sas Nagar 140306, Punjab, India in 2021, Cited 42. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. COA of Formula: C8H8O2

A redox-active iminoquinone motif connected with pi-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the molecule was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcohols happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcohols under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinoline and pyrimidine. This organocatalytic approach is very mild (70 degrees C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Bains, AK; Ankit, Y; Adhikari, D or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Tuning the solid-state emission of liquid crystalline nitro-by halogen bonding published in 2021. Quality Control of 4-Methoxybenzaldehyde, Reprint Addresses Giese, M (corresponding author), Univ Duisburg Essen, Organ Chem, Univ Str 7, D-45141 Essen, Germany.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

The first example of halogen-bonded fluorescent liquid crystals based on the interaction of iodofluorobenzene derivatives with nitro-cyanostilbenes is reported. The systematic variation of the fluorination degree and pattern indicates the relevance of the halogen bond strength for the induction of liquid crystalline properties. The modular self-assembly approach enables the efficient tuning of the fluorescence behaviour and mesomorphic properties of the assemblies.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nath, S; Kappelt, A; Spengler, M; Roy, B; Voskuhl, J; Giese, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles