Category: 123-11-5

An article Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes WOS:000664252100009 published article about MGI2-MEDIATED RING EXPANSIONS; OXA-MICHAEL REACTION; CYCLOADDITION; LEWIS; ALKYLIDENECYCLOPROPANES; 2-METHYLENEAZIRIDINES; HETEROCYCLES; ANNULATION in [Suzuki, Itaru; Shibata, Ikuya] Osaka Univ, Res Ctr Environm Preservat, 2-4 Yamadaoka, Suita, Osaka 5650871, Japan; [Ogura, Kazuki; Shimazu, Jun-ya; Shibata, Ikuya] Osaka Univ, Dept Appl Chem, Grad Sch Engn, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Formula: C8H8O2

MgX2-catalyzed annulation of methylenecyclopropanes with acyl cyanoalkenes was accomplished to give oxaspiro[2.5]octenes in excellent yields. The reaction proceeded through a rare intramolecular oxa-Michael addition of Mg enolate. The oxaspiro ring was transformed into 4H-pyran at a higher temperature in the presence of MgX2.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Suzuki, I; Ogura, K; Shimazu, J; Shibata, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Vetter, AC; Gilheany, DG; Nikitin, K in AMER CHEMICAL SOC published article about in [Vetter, Anna C.; Gilheany, Declan G.; Nikitin, Kirill] Univ Coll Dublin, Sch Chem, Dublin 4, Ireland in 2021.0, Cited 64.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Despite common perception, the use of strong bases in Wittig chemistry is utterly unnecessary: we report a series of novel ion-pair phosphonium carboxylate reagents which are essentially storable ylides. These reagents are straightforwardly prepared in excellent yields, and their fluxional nature permits clean olefination of a broad range of aldehydes and even hemiacetals.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Vetter, AC; Gilheany, DG; Nikitin, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Saito, A; Adachi, S; Kumagai, N; Shibasaki, M in WILEY-V C H VERLAG GMBH published article about ACETONITRILE in [Saito, Akira; Adachi, Shinya; Kumagai, Naoya; Shibasaki, Masakatsu] Inst Microbial Chem, Shinagawa Ku, 3-14-23 Kamiosaki, Tokyo 1410021, Japan in 2021.0, Cited 52.0. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A direct catalytic asymmetric addition of acetonitrile to aldehydes that realizes over 90 % ee is the ultimate challenge in alkylnitrile addition chemistry. Herein, we report achieving high enantioselectivity by the strategic use of a sterically demanding Ni-II pincer carbene complex, which afforded highly enantioenriched beta-hydroxynitriles. This highly atom-economical process paves the way for exploiting inexpensive acetonitrile as a promising C2 building block in a practical synthetic toolbox for asymmetric catalysis.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Saito, A; Adachi, S; Kumagai, N; Shibasaki, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Authors Xu, MH; Yuan, YH; Liang, DD; Zhang, XM; Zhang, FM; Tu, YQ; Ma, AJ; Zhang, K; Peng, JB in ROYAL SOC CHEMISTRY published article about in [Xu, Ming-Hui; Yuan, Yong-Hai; Liang, Dong-Dong; Zhang, Xiao-Ming; Zhang, Fu-Min; Tu, Yong-Qiang] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Xu, Ming-Hui; Yuan, Yong-Hai; Liang, Dong-Dong; Zhang, Xiao-Ming; Zhang, Fu-Min; Tu, Yong-Qiang] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China; [Tu, Yong-Qiang] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Ma, Ai-Jun; Zhang, Kun; Peng, Jin-Bao] Wuyi Univ, Sch Biotechnol & Hlth Sci, Jiangmen 529020, Peoples R China in 2021.0, Cited 51.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A novel spiro-pyrrolidine (SPD)-derived bifunctional thiourea catalyst has been developed, enabling the development of a stereoselective conjugate addition of furfurals to beta,gamma-unsaturated alpha-ketoesters. The reaction represents an example of asymmetric trienamine catalysis in the benzylic C-H functionalization of 5-benzylfurfurals, and the rigid spirocyclic framework of the catalyst is proven to be essential for a highly enantioselective transformation.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Xu, MH; Yuan, YH; Liang, DD; Zhang, XM; Zhang, FM; Tu, YQ; Ma, AJ; Zhang, K; Peng, JB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Tang, YC; Yang, M; Wang, FF; Hu, X; Wang, G in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Tang, Yucai; Yang, Meng; Wang, Feifei; Hu, Xia; Wang, Gang] Hunan Univ Arts & Sci, Coll Chem & Mat Engn, Hunan Prov Cooperat Innovat Ctr Construct & Dev D, Changde 415000, Peoples R China; [Tang, Yucai] Hunan Prov Key Lab Water Treatment Funct Mat, Changde 415000, Peoples R China; [Tang, Yucai] Hunan Prov Engn Res Ctr Electroplating Wastewater, Changde 415000, Peoples R China in 2021.0, Cited 42.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A facile I2O5 induced radical relay addition/cyclization of activated alkenes with sulfonylhydrazides has been successfully developed, leading to a broad range of sulfonylated benzimidazo[2,1-a]isoquinolin-6 (5H)-ones in moderate to good yields. The protocol has advantages of a metal-, base-, acid-, peroxide-free process, simple operation, and broad functional group tolerance. (C) 2021 Elsevier Ltd. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Tang, YC; Yang, M; Wang, FF; Hu, X; Wang, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Methoxybenzaldehyde. Authors Gomes, LR; Low, JN; Wardell, JL in ELSEVIER published article about in [Gomes, Ligia R.] Univ Fernando Pessoa, FP ENAS Fac Ciencias Saude, Escola Super Saude UFP, Rua Carlos da Maia 296, P-4200150 Porto, Portugal; [Gomes, Ligia R.] Univ Porto, Dept Quim & Bioquim, REQUIMTE, LAQV,Fac Ciencias, Rua Campo Alegre 687, P-4169007 Porto, Portugal; [Low, John N.; Wardell, James L.] Univ Aberdeen, Dept Chem, Meston Walk AB24 3UE, Old Aberdeen, Scotland; [Wardell, James L.] Fundacao Oswaldo Cruz, Inst Tecnol Farmacos & Farmanguinhos, BR-21041250 Rio De Janeiro, RJ, Brazil in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The crystal structures, Hirshfeld surface analysis and PIXEL calculations are reported for (E)-3-(4-methoxyphenyl)-1-(2-hydroxy-5-isoproproxyphenyl)prop-2-en-1-one, 1, and (E)-3-(3-methoxy-4-isopropoxyphenyl)-1-(2-hydroxy-4,6-diisoproproxyphenyl)prop-2-en-1-one, 2. Different sets of C-H…O, C-H…pi, off-set, face-to-face pi…pi and/or C=O…pi intermolecular interactions are displayed by each compound. Due to the bulk of the isoproproxy unit and the consequent steric hindrance in forming aggregates in the solid state, compounds 1 and 2 exhibit larger interplanar angles than do corresponding chalcones with methoxy units. The total stabilization energies of the crystal packing, E-tot distributed as Coulombic (E-coul), polarization (E-pol), dispersion (E-disp), and repulsion (E-rep) have been computed by PIXEL. For compound 1, six motifs (molecule pairs) and for compound 2, with two independent molecules in the asymmetric unit, thirteen motifs are identified by the PIXEL calculations to have energies, -E-tot, above the cut-offvalue of 10 kJ.mol(-1). For each of these motifs, the largest contributor to the E-tot value is the E-disp term, irrespective of the type(s) of interaction(s) connecting the two molecules, if any, in the motifs. (C) 2021 Elsevier B.V. All rights reserved.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gomes, LR; Low, JN; Wardell, JL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Direct and efficient electrocatalytic multicomponent assembling of arylaldehydes, malononitrile, and pyrazolin-5-ones into spirocyclopropyl pyrazolone scaffold WOS:000660333100001 published article about REVERSE-TRANSCRIPTASE INHIBITORS; ONE-POT SYNTHESIS; N,N’-DIALKYLBARBITURIC ACIDS; BIOLOGICAL EVALUATIONS; CASCADE; CYCLIZATION; MALONATE; DESIGN; DERIVATIVES; MOLECULES in [Elinson, Michail N.; Ryzhkova, Yuliya E.; Vereshchagin, Anatoly N.; Ryzhkov, Fedor V.; Kalashnikova, Varvara M.; Egorov, Mikhail P.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow, Russia; [Kalashnikova, Varvara M.] DI Mendeleev Univ Chem Technol Russia, Moscow, Russia in 2021, Cited 49. SDS of cas: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The new electrochemical multicomponent assembling has been found: the electrolysis of arylaldehydes, malononitrile, and pyrazolin-5-ones in alcohols in an undivided cell in the presence of sodium bromide as mediator results in the formation of substituted 4-methyl-7-oxo-2-phenyl-5,6-diazaspiro[2.4]hept-4-ene-1,1-dicarbonitriles in 60-80% yields. The optimized reaction conditions and a mechanistic rationale for this electrocatalytic multicomponent assembling are presented. [GRAPHICS] .

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elinson, MN; Ryzhkova, YE; Vereshchagin, AN; Ryzhkov, FV; Kalashnikova, VM; Egorov, MP or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Morita, S; Yoshimura, T; Matsuo, J in ROYAL SOC CHEMISTRY published article about in [Morita, Shunya; Yoshimura, Tomoyuki; Matsuo, Jun-ichi] Kanazawa Univ, Div Pharmaceut Sci, Grad Sch Med Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan in 2021.0, Cited 40.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Three-component reactions of nitroalkanes, acrylamides, and aldehydes by using a catalytic amount of KOH in DMSO gave beta ‘-hydroxy-gamma-nitro amides. Mechanistic studies suggested that the reactions proceeded by domino Michael/aldol reactions. The highly nucleophilic nature of transient amide enolates that were formed by Michael addition of nitronate anions to acrylamides in DMSO enabled the realization of catalytic intermolecular aldol reactions of amide enolates in the presence of acidic nitroalkanes.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Morita, S; Yoshimura, T; Matsuo, J or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. Authors Zhang, L; Hu, YY; Wang, Y; Kong, BH; Chen, Q in ELSEVIER published article about in [Zhang, Lang; Hu, Yingying; Kong, Baohua; Chen, Qian] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China; [Wang, Yan] Shimadzu CO LTD China, Shenyang 110016, Peoples R China in 2021.0, Cited 40.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

This study evaluated the effect of different sugar smoking times on the flavour profiles of chicken drumsticks using an electronic nose (E-nose), electronic tongue (E-tongue), and headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME/GC-MS). The moisture content, water activity, pH, and L*-value decreased from 71.26% to 65.23%, 0.987 to 0.979, 6.66 to 5.36, and 61.84 to 52.34, respectively (P < 0.05). The a*-value and b*-value increased from 4.96 to 9.65 and 16.61 to 26.45, respectively (P < 0.05) with the increase in smoking times. Seventy-five volatile compounds were identified, and 18 volatile compounds were identified as key odour compounds and among them seven key volatile compounds with variable importance in projection (VIP) > 1 were detected. Principal component analysis of E-nose, E-tongue, and HS-SPME/GC-MS indicated that 3-, 4-, and 5-min smoking samples had similar odour and taste profiles. Sensory analysis indicated that the 4-min sample had increased overall acceptability. The correlation analysis of E-nose and key volatile compounds with odour activity value > 1 and VIP >1 confirmed that W1C, W3C, and W5C sensors were sensitive to aromatic compounds, and W2S sensor was sensitive to ketones. These results may provide guidance for smoked chicken producers to reasonably control flavour formation.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, L; Hu, YY; Wang, Y; Kong, BH; Chen, Q or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of 4,4 ‘-(arylmethylene)bis(3-methyl-1-phenyl-1H-pyrazol-5-ols) and evaluation of their antioxidant and anticancer activities WOS:000657746900001 published article about SOLID ACID CATALYST; EFFICIENT; DERIVATIVES; APOPTOSIS; EDARAVONE; REGULATORS; AUTOPHAGY; PYRAZOLE; DFT in [Cadena-Cruz, Jose Eduardo] Univ Cent Ecuador, Fac Ciencias Quim, Quito, Ecuador; [Guaman-Ortiz, Luis M.; Bailon-Moscoso, Natalia; Murillo-Sotomayor, Kevin E.; Ortiz-Guaman, Nadia V.] Univ Tecn Particular Loja, Dept Ciencias Salud, San Cayetano Alto S-N, Loja 1101608, Ecuador; [Romero-Benavides, Juan Carlos] Univ Tecn Particular Loja, Dept Quim & Ciencias Exactas, San Cayetano Alto S-N, Loja 1101608, Ecuador; [Heredia-Moya, Jorge] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Biomed CENBIO, Quito 170527, Ecuador in 2021, Cited 51. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Background Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, and some have been approved for the treatment of different types of cancer. Results 4,4MODIFIER LETTER PRIME-(Arylmethylene)bis(1H-pyrazol-5-ols) derivatives 3a-q were synthetized by a three components reaction of 3-methyl-1-phenyl-5-pyrazolone (1) with various benzaldehydes 2 catalyzed by sodium acetate at room temperature. The structures of all synthesized compounds were characterized by physicochemical properties and spectral means (IR and NMR) and were evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4MODIFIER LETTER PRIME-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives 3a-q were synthetized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard. Conclusion Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound 3i proved to be a very potent scavenger with an IC50 of 6.2 +/- 0.6 mu M and exhibited an IC50 of 9.9 +/- 1.1 mu M against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Cadena-Cruz, JE; Guaman-Ortiz, LM; Romero-Benavides, JC; Bailon-Moscoso, N; Murillo-Sotomayor, KE; Ortiz-Guaman, NV; Heredia-Moya, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles