Category: 123-11-5

Authors Barhdadi, S; Mertens, B; Van Bossuyt, M; Van de Maele, J; Anthonissen, R; Canfyn, M; Courselle, P; Rogiers, V; Deconinck, E; Vanhaecke, T in PERGAMON-ELSEVIER SCIENCE LTD published article about MUTAGENICITY; CONSTITUENTS; CHEMICALS; FRAGRANCE; TOXICITY in [Barhdadi, Sophia; Mertens, Birgit; Van Bossuyt, Melissa; Van de Maele, Jolien; Anthonissen, Roel; Canfyn, Michael; Courselle, Patricia; Deconinck, Eric] Sciensano, Sci Direct Chem & Phys Hlth Risks, Brussels, Belgium; [Barhdadi, Sophia; Van Bossuyt, Melissa; Rogiers, Vera; Vanhaecke, Tamara] Vrije Univ Brussel VUB, Fac Med & Pharm, Dept In Vitro Toxicol & Dermatocosmetol IVTD, Brussels, Belgium; [Mertens, Birgit] Univ Antwerp, Dept Biomed Sci, Antwerp, Belgium in 2021, Cited 44. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

E-cigarettes have become very popular, a trend that has been stimulated by the wide variety of available e-liquid flavours. Considering the large number of e-liquid flavours (>7000), there is an urgent need to establish a screening strategy to prioritize the flavouring substances of highest concern for human health. In the present study, a prioritization strategy combining analytical screening, in silico tools and literature data was developed to identify potentially genotoxic e-liquid flavourings. Based on the analysis of 129 e-liquids collected on the Belgian market, 60 flavourings with positive in silico predictions for genotoxicity were identified. By using literature data, genotoxicity was excluded for 33 of them whereas for 5, i.e. estragole, safrole, 2-furylmethylketon, 2,5-dimethyl-4-hydroxyl-3(2H)-furanone and transhexanal, there was a clear concern for in vivo genotoxicity. A selection of 4 out of the remaining 22 flavourings was tested in two in vitro genotoxicity assays. Three out of the four tested flavourings induced gene mutations and chromosome damage in vitro, whereas equivocal results were obtained for the fourth compound. Thus, although there is a legislative framework which excludes the use of CMR compounds in e-liquids, flavourings of genotoxic concern are present and might pose a health risk for e-cigarette users.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Barhdadi, S; Mertens, B; Van Bossuyt, M; Van de Maele, J; Anthonissen, R; Canfyn, M; Courselle, P; Rogiers, V; Deconinck, E; Vanhaecke, T or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jia, WL; Ces, SV; Fernandez-Ibanez, MA in [Jia, Wen-Liang; Ces, Sabela Vega; Fernandez-Ibanez, M. Angeles] Univ Amsterdam, Vant Hoff Inst Mol Sci, NL-1098 XH Amsterdam, Netherlands published Divergent Total Syntheses of Yaequinolone-Related Natural Products by Late-Stage C-H Olefination in 2021.0, Cited 41.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Divergent total syntheses of 10 yaequinolone-related natural products have been achieved for the first time by latestage C-H olefination of 3,4-dioxygenated 4-aryl-5-hydroxyquinolin-2(1H)-ones, core structures of this family of natural products. A robust synthetic methodology to construct the core structures has been established, and the C-H olefination reaction has been carried out with synthetically useful yields and high levels of site-selectivity under mild reaction conditions in the presence of a Pd/S,O-ligand catalyst.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jia, WL; Ces, SV; Fernandez-Ibanez, MA or concate me.. Name: 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Suresh, P; Thamotharan, S; Ganesan, SS in WILEY-V C H VERLAG GMBH published article about in [Suresh, Pavithira; Selva Ganesan, Subramaniapillai] SASTRA Deemed Univ, Dept Chem, Sch Chem & Biotechnol, Thanjavur 613401, Tamil Nadu, India; [Thamotharan, Subbiah] SASTRA Deemed Univ, Sch Chem & Biotechnol, Biomol Crystallog Lab, Dept Bioinformat, Thanjavur 613401, Tamil Nadu, India in 2021.0, Cited 26.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Metal-free N-heterocyclic carbene (NHC) organocatalysis in D2O medium was elegantly utilised for the synthesis of highly diastereoselective deuterated spiropyran derivatives. Selective deuteration was exclusively achieved on the C5 carbon atom of the pyran ring. Quantum chemical calculations were performed to prove the preferential formation of a single diastereomer from the possible four diastereomers. The scope of NHC organocatalysis in D2O was also extended for the synthesis of deuterated spirooxindole derivative.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Suresh, P; Thamotharan, S; Ganesan, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and characterization of a novel organic-inorganic hybrid salt and its application as a highly effectual Bronsted-Lewis acidic catalyst for the production of N,N ‘-alkylidene bisamides WOS:000576690800001 published article about DICATIONIC IONIC LIQUID; EFFICIENT CATALYST; SYMMETRICAL BISAMIDES; THERMAL-ANALYSIS; PERFORMANCE; LIGANDS; AMIDES in [Zare, Abdolkarim; Monfared, Fatemeh; Sajadikhah, Seyed Sajad] Payame Noor Univ, Dept Chem, POB 19395-3697, Tehran, Iran in 2021, Cited 54. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In this research, a novel organic-inorganic hybrid salt, namely,N-1,N-1,N-2,N-2-tetramethyl-N-1,N-2-bis(sulfo)ethane-1,2-diaminium tetrachloroferrate ([TMBSED][FeCl4](2)) was prepared and characterized by Fourier-transform infrared spectroscopy (FT-IR), energy-dispersive X-ray spectroscopy (EDX), elemental mapping, field emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), thermal gravimetric (TG), differential thermal gravimetric (DTG), and vibrating-sample magnetometry (VSM) analyses. Catalytic activity of the hybrid salt was tested for the synthesis ofN,N ‘-alkylidene bisamides through the reaction of benzamide (2 eq.) and aromatic aldehydes (1 eq.) under solvent-free conditions in which the products were obtained in high yields and short reaction times. The catalyst was superior to many of the reported catalysts in terms of two or more of these factors: the reaction medium and temperature, yield, time, and turnover frequency (TOF). [TMBSED][FeCl4](2)is a Bronsted-Lewis acidic catalyst; there are two SO3H groups (as Bronsted acidic sites) and two tetrachloroferrate anions (as Lewis acidic sites) in its structure. Highly effectiveness of the catalyst for the synthesis ofN,N ‘-alkylidene bisamides can be attributed to synergy of the Bronsted and Lewis acids and also possessing two sites of each acid.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zare, A; Monfared, F; Sajadikhah, SS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 ACS CATAL published article about RESONANCE RAMAN; CATALYSIS; AMINATIONS; COMPLEXES; CHEMISTRY; AMIDES; AZIDES in [Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Weyhermueller, Thomas; Werle, Christophe] Max Planck Inst Chem Energy Convers, D-45470 Mulheim, Germany; [Chatterjee, Basujit; Jena, Soumyashree; Chugh, Vishal; Werle, Christophe] Ruhr Univ Bochum, D-44801 Bochum, Germany in 2021, Cited 130. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Formula: C8H8O2

The direct synthesis of amides and nitriles from readily available aldehyde precursors provides access to functional groups of major synthetic utility. To date, most reliable catalytic methods have typically been optimized to supply one product exclusively. Herein, we describe an approach centered on an operationally simple iron-based system that, depending on the reaction conditions, selectively addresses either the C=O or C-H bond of aldehydes. This way, two divergent reaction pathways can be opened to furnish both products in high yields and selectivities under mild reaction conditions. The catalyst system takes advantage of iron’s dual reactivity capable of acting as (1) a Lewis acid and (2) a nitrene transfer platform to govern the aldehyde building block. The present transformation offers a rare control over the selectivity on the basis of the iron system’s ionic nature. This approach expands the repertoire of protocols for amide and nitrile synthesis and shows that fine adjustments of the catalyst system’s molecular environment can supply control over bond activation processes, thus providing easy access to various products from primary building blocks.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chatterjee, B; Jena, S; Chugh, V; Weyhermuller, T; Werle, C or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Phytochemical components and biological activities of essential oils from three selected medicinal plants WOS:000613173400003 published article about IN-VITRO; MYRISTICA-FRAGRANS; ANGELICA-DAHURICA; PATCHOULI ALCOHOL; INFLAMMATION; INHIBITION in [Zhang, Lanyue; Ye, Mao; Shi, Yaohui; Zhu, Haiping; Chi, Lejing; Pan, Chunxing; Xu, Yani; Li, Chunlian] Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China; [Xiang, Hongping] Guangdong Univ Technol, Sch Mat & Energy, Guangzhou 510006, Peoples R China; [Zheng, Xi] Rutgers State Univ, Susan Lehman Cullman Lab Canc Res, Ernest Mario Sch Pharm, Dept Chem Biol, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA in 2021, Cited 42. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Essential oils extracted from herbs have been utilized in food and medicine on the account of their increasing physicochemical characteristics. This present study aimed to investigate the phytochemical components, antiinflammatory, cytotoxic, anti-microbial and anti-oxidant activities of essential oils from Pogostemon cablin (P. cablin), Angelica dahurica (A. dahurica) and Myristica fragrans (M. fragrans), all belong to medicine food homology herbs. Approximately 107 components were identified by gas chromatography mass spectrometry (GC-MS) from these essential oils. The main compounds of P. cablin essential oils (PCEOs) were patchouli alcohol (27.72%), alpha-buaiacene (17.94%) and alpha-guaiene (14.15%); in A. dahurica essential oils (ADEOs) were anethole (24.91%) and cinnamaldehyde (18.35%); and in M. fragrans essential oils (MFEOs) were (1S)-(-)-alpha-pinene (23.39%), alpha-terpineol (18.60%) and caryophyllene (10.34%). These essential oils were found to have strong antiinflammatory activities through decreasing the production of cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), nuclear factor-kappa B p65 (P65) and tumor necrosis factor-alpha (TNF-alpha). These essential oils also had significant anti-bacterial activities against both Gram-negative and Gram-positive strains and anti-fungal activities. Moreover, effective anti-oxidant properties of three essential oils were estimated (0.001962%-0.19%). The study also explored the effect of these essential oils on the survival of Brain microglia (BV2) microglial cells (IC50 = 145.50-281.52 mu g/mL). Based on these bioactivities, these essential oils could be used as food additives, fragrances, cosmetics and health products.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, LY; Ye, M; Shi, YH; Zhu, HP; Chi, LJ; Pan, CX; Xu, YN; Zheng, X; Xiang, HP; Li, CL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mitra, S; Mukherjee, S in [Mitra, Sankash; Mukherjee, Santanu] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India published Iridium-Catalyzed Asymmetric Allylic Alkylation of Deconjugated Butyrolactams in 2021.0, Cited 59.0. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Compared with the ever-growing list of nonprochiral nucleophiles in Ir-catalyzed asymmetric allylic substitution reactions, prochiral nucleophiles are less studied. We present a new prochiral nucleophile, namely, deconjugated butyrolactam, for Ir-catalyzed asymmetric allylic alkylation (AAA). This reaction provides access to a-allyl deconjugated butyrolactams with a moderate to good dr and an excellent er. This is the first AAA reaction of deconjugated butyrolactams. Allyl transposition through Cope rearrangement appears to proceed stereospecifically to form.-allyl conjugated butyrolactams.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mitra, S; Mukherjee, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. In 2021 DALTON T published article about CATALYZED OXIDATIVE SYNTHESIS; ONE-POT SYNTHESIS; 4(3H)-QUINAZOLINONE DERIVATIVES; CASCADE SYNTHESIS; BENZYL ALCOHOLS; QUINAZOLINONES; METAL; EFFICIENT; SILICA; OXIDE in [Gupta, Radhika; Arora, Gunjan; Yadav, Priya; Dixit, Ranjana; Sharma, Rakesh Kumar] Univ Delhi, Green Chem Network Ctr, Dept Chem, Delhi 110007, India; [Yadav, Priya; Srivastava, Anju] Univ Delhi, Hindu Coll, Dept Chem, Delhi 110007, India in 2021, Cited 74. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

In the present work, we report the design and fabrication of a copper-containing ionic liquid supported magnetic nanocatalyst via a convenient and straightforward synthetic approach for the formation of 2-phenylquinazolin-4(3H)-ones using o-aminobenzamide and benzaldehydes as the reaction partners. The successful formation and properties of the as-prepared catalyst have been thoroughly investigated using diverse physico-chemical techniques including FT-IR, XRD, FE-SEM, TEM, ICP, VSM, BET and TGA. Using this nanocatalytic system, a variety of 2-phenylquinazolin-4(3H)-ones are synthesized in excellent yields with operational ease and short reaction times in an environmentally preferable solvent under open air and without using any external oxidizing agent. Besides, the catalyst possessed facile magnetic recoverability and remarkable reusability for six consecutive runs without any appreciable decrease in the catalytic efficiency.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gupta, R; Arora, G; Yadav, P; Dixit, R; Srivastava, A; Sharma, RK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2021 BIOORG MED CHEM LETT published article about CATALYZED N-ALKYLATION; BIOLOGICAL-ACTIVITIES; ANTIOXIDANT ACTIVITY; DERIVATIVES; ANTICONVULSANT; FILMS; ALCOHOLS; DESIGN; AMINES in [Kumar, C. B. Pradeep] Malnad Coll Engn, Dept Chem, Hassan 573202, India; [Raghu, M. S.; Parashuram, L.] New Horizon Coll Engn, Dept Chem, Bengaluru 560103, India; [Prathibha, B. S.; Prashanth, M. K.] BNM Inst Technol, Dept Chem, Bengaluru 560070, India; [Kanthimathi, G.] Ramco Inst Technol, Dept Chem, Rajapalayam 626117, Tamil Nadu, India; [Kumar, K. Yogesh] Jain Univ, Sch Engn & Technol, Dept Chem, Ramanagara 562112, India; [Alharthi, Fahad A.] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia in 2021, Cited 50. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A Ta2O5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been synthesized and characterized. It was then used as a highly effective nanocatalyst for the synthesis of quinolin-2(1H)-one derivatives through C-O bond functionalization. The special advantage of this heterogeneous solid catalyst is the reusability of the catalyst for up to five cycles without any noticeable reduction in product yields. In comparison, healthy reaction profiles, wide substrate scope, excellent yields and easy workup conditions are the notable highlights of this approach. All the compounds were tested for their anticancer activity against MCF-7 (human breast), HepG2 (human liver), HCT116 (human colorectal), and PC-3 (human prostate) cancer cell lines with the MTT assay. All the compounds were shown to have moderate to good inhibitory effects on tested cancer cell lines. Besides, compounds 5b, 5c and 5d showed good selectivity against epidermal growth factor receptor-tyrosine kinase (EGFR-TK). Molecular docking results showed that active compounds showed a good affinity towards EGFR kinase (PDB ID: 6V6O) by forming two hydrogen bonds with Cys-797 and Tyr-801. All the compounds were screened for computational ADMET and Lipinski analysis.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kumar, CBP; Raghu, MS; Prathibha, BS; Prashanth, MK; Kanthimathi, G; Kumar, KY; Parashuram, L; Alharthi, FA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about METAL-ORGANIC FRAMEWORKS; COORDINATION POLYMERS; GAS-ADSORPTION; LIGAND; CONDENSATION; ZN(II); NANOPARTICLES; LUMINESCENCE; COMBINATION; SELECTIVITY, Saw an article supported by the CSIR, New Delhi, IndiaCouncil of Scientific & Industrial Research (CSIR) – India [09/239(0506)2014-EMR-l]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Tom, L; Kurup, MRP. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Recommanded Product: 123-11-5

A Cd(II) coordination polymer based on a polytopic compartmental ligand was synthesized, and used as an efficient heterogeneous catalyst for the Knoevenagel reaction between benzaldehyde and malononitrile under mild reaction conditions. The solid catalyst was characterized using single crystal XRD, X-ray powder diffraction, SEM, TGA, UV diffuse reflectance, infrared spectroscopy and elemental analysis. The compound is a two-dimensional (2D) MOF with a grid structure. Topological analysis of the framework revealed that it is a 2,4-connected binodal net. The catalytic activity was tested between various benzaldehydes containing different substituents with malononitrile. The effect of reaction parameters such as solvent, time, reactant ratio and catalyst amount was investigated. Furthermore, the catalyst stability was examined through reusability experiments and it is observed that the catalyst can be recycled at least five times without significant drop in its activity.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Tom, L; Kurup, MRP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles