Category: 123-11-5

SDS of cas: 123-11-5. Authors Masaret, GS in WILEY published article about in [Masaret, Ghada S.] Umm Al Qura Univ, Coll Appl Sci, Chem Dept, Mecca 21955, Saudi Arabia in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The newly synthesized 3-(3-amino-5-(phenylamino)-4-(phenylcarbamoyl)thiophen-2-yl)-3-oxopropanoate was utilized as a precursor for the synthesis of pyrazolyl-thiophene derivative, which undergoes cyclization upon treatment with benzaldehyde derivatives to provide pyrazolo[3,4-d]thieno[3,2-b]pyridines. Basic treatment of pyrazolyl-thiophene derivative with phenyl isothiocyanate followed by subsequent addition of chloroacetone and/or ethyl bromoacetate yielded the thiazolylidene-pyrazolyl thiophenes. In addition, the building block 3-(3-amino-5-(phenylamino)-4-(phenylcarbamoyl)thiophen-2-yl)-3-oxopropanoate was converted into the corresponding thieno[3,2-b]pyridine compounds through its reactions with (DMF-DMA) and/or heating in sodium ethoxide. Moreover, the reaction of 7-hydroxy-5-oxo-N-phenyl-2-(phenylamino)-4,5-dihydrothieno[3,2-b]pyridine-3-carboxamide with 2-arylidenemalononitrile produced the new annulated pyrano[2,3-d]thieno[3,2-b]pyridines. The prepared thiophene-based compounds were evaluated against HepG2, PC3, and MCF-7 cancer cells, and normal fibroblast cell (WI38). The pyrazolo[3,4-d]thieno[3,2-b]pyridine and pyrano[2,3-d]thieno[3,2-b]pyridine compounds substituted with chlorophenyl group presented promising cytotoxic activities against HepG2 cancer cell line without any human toxicity. Docking study for the synthesized thiophene compounds delivered valuable insights about the binding interactions with the crystal structure of NS5B enzyme with PDB ID (4TLR).

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Masaret, GS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 J AM CHEM SOC published article about POVAROV REACTION; CATALYSIS; CHEMISTRY; DESIGN in [Feng, Xuanyu; Song, Yang; Lin, Wenbin] Univ Chicago, Dept Chem, Chicago, IL 60637 USA in 2021, Cited 70. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Product Details of 123-11-5

Owing to hindered diffusions, the application of porous catalytic materials has been limited to relatively simple organic transformations with small substrates. Herein we report a dimensional reduction strategy to construct a two-dimensional metal-organic framework (MOF), Zr6OTf-BTB, with 96% accessible Lewis acidic sites as probed by the bulky Lewis base pivalonitrile. With nearly free substrate accessibility, Zr6OTf-BTB outperformed two three-dimensional MOF counterparts of similar Lewis acidity (Zr6OTf-BPDC and Zr6OTf-BTC) in catalyzing sterically hindered multicomponent reactions (MCRs) for the construction of tetrahydroquinoline and aziridine carboxylate derivatives with high turnover numbers (TONs). Zr6OTf-BTB was also superior to the homogeneous benchmark Sc(OTf)(3) with nearly 14 times higher TON and 9 times longer catalyst lifetime. Furthermore, the topology-activity relationships in these Zr-based Lewis acidic MOFs were rationalized by comparing their Lewis acidity, numbers of Lewis acidic sites, and sterically accessible Lewis acidic sites. Zr6OTf-BTB was successfully used to construct several bioactive molecules via MCRs with excellent efficiency. This dimensional reduction strategy should allow the development of other MOF catalysts for synthetically useful and complicated organic transformations.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Feng, XY; Song, Y; Lin, WB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4+2] Cyclization of 2-Benzothiazolimines and Aldehydes WOS:000643595200031 published article about MESOIONIC XANTHINE ANALOGS; MANNICH REACTION; CYCLOADDITION; ISOTHIOUREAS; CATALYSIS; ACCESS; ACID in [Chen, Xue-Ping; Hou, Ke-Qiang; Zhou, Feng; Chan, Albert S. C.; Xiong, Xiao-Feng] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Chiral Mol & Drug Discover, Guangzhou 510006, Peoples R China in 2021.0, Cited 41.0. Recommanded Product: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

We report the direct asymmetric synthesis of pyrimido[2,1-b]benzothiazoles using a commercially available chiral amine catalyst. A variety of 2-benzothiazolimines and aldehydes were well tolerated under the reaction conditions and generated the corresponding products in 81-99% yields with excellent diastereoselectivities and enantioselectivities (up to >20:1 dr, 99% ee). Furthermore, the products could be easily converted to other useful chiral building blocks.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chen, XP; Hou, KQ; Zhou, F; Chan, ASC; Xiong, XF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Effect of supramolecular polymeric aggregation in room temperature ionic liquids (RTILs) on catalytic activity in the synthesis of 4H-chromene derivatives and Knoevenagel condensation WOS:000610834000025 published article about ONE-POT SYNTHESIS; AMBIENT-TEMPERATURE; ESI-MS; EXTRACTION; SOLVENTS; FLUIDS in [Muhammad, Shoaib; Ali, Firdous Imran; Javed, Muhammad Naveed; Wasim, Agha Arsalan; Riaz, Kashif; Hashmi, Imran Ali] Univ Karachi, Dept Chem, Main Univ Rd, Karachi 75270, Sindh, Pakistan; [Bari, Ahmed] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia; [Rafique, Faisal; Ilyas, Muhammad Amjad; Riaz, Kashif] Univ Karachi, Dept Appl Phys, Main Univ Rd, Karachi 75270, Sindh, Pakistan; [Mahmood, Syed Junaid; Ahmed, Amir] PCSIR Labs Complex, Karachi 75280, Pakistan in 2021, Cited 52. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

RTILs exhibit supramolecular self-assembled polymeric aggregation due to noncovalent interactions. The influence of the aggregation behaviour of RTILs on catalytic activity is evident but still poorly understood. The present work focuses on establishing a relationship between the role of supramolecular self-assembly of RTILs on catalysis in organic reactions. Herein, we report four unreported, air and water stable, halide free, C-2-symmetrical, third generation, hydrophobic imidazolium-based room temperature ionic liquids (RTILs 1-4), their synthesis and function as catalysts for the synthesis of 4H-chromene derivatives (terahydrobenzo[b]pyran) and Knoevenagel condensation. The RTILs showed unprecedented solubility/miscibility behaviour. The RilLs showed that 1,3-dihexyhmidazolium 2-aminobenzoate [hhim] [OAB] (RTIL-3) performed better in terms of yield and reaction time. Supramolecular polymeric aggregation was explored by employing ESIMS, while the critical aggregation concentration (CAC) was calculated via recording electrical conductivity of RTILs in absolute ethanol. We have also used rheometry experiments to explore forces governing the occurrence of aggregates in the liquid phase of RTILs. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Muhammad, S; Ali, FI; Javed, MN; Wasim, AA; Bari, A; Rafique, F; Ilyas, MA; Riaz, K; Mahmood, SJ; Ahmed, A; Hashmi, IA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and antitumor activity of sacroflavonoside WOS:000479490300001 published article about CELL; RESVERATROL; APOPTOSIS; AUTOPHAGY; CASPASE-3; PROGNOSIS in [Wang, Qinghu; Xin, Ying; Pa, Biligetu; He, Xiang; Bao, Wenqiang] Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China in 2021, Cited 19. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2

Sacroflavonoside, a new derivative of diphenylethene, was isolated from Artemisia sacrorum, which have been found to possess the inhibitory effect on the proliferation of gastric carcinoma cells (MKN-45) in vitro in our previous studies. With anisaldehyde (SM-A) as starting material, the sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization. The structure of sacroflavonoside was established by 1 D (H-1 NMR and C-13 NMR) and 2 D-NMR (HSQC and HMBC) spectral analysis. The antitumor activity and potential mechanism against MKN-45 cells of sacroflavonoside were evaluated in vitro. The results showed that sacroflavonoside could significantly induce MKN-45 cells apoptosis and autophagy by increasing the expression of Bax, Caspase-3, Beclin1 and LC3-II proteins and decreasing the expression of Bcl-2 protein at low micromole level. This investigation provided a valuable lead structure for the development of antitumor drugs. [GRAPHICS] .

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wang, QH; Xin, Y; Pa, B; He, X; Bao, WQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ataie, F; Davoodnia, A; Khojastehnezhad, A in TAYLOR & FRANCIS LTD published article about ONE-POT SYNTHESIS; CONVENIENT SYNTHESIS; PYRAN DERIVATIVES; HETEROPOLY ACIDS; NIFE2O4; LIQUID in [Ataie, Farideh; Davoodnia, Abolghasem] Islamic Azad Univ, Mashhad Branch, Dept Chem, Mashhad 9175687119, Razavi Khorasan, Iran; [Khojastehnezhad, Amir] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 917751436, Razavi Khorasan, Iran in 2021, Cited 46. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In this study, a graphene oxide (GO) functionalized organic-inorganic hybrid was prepared by covalently immobilization of organic (3-aminopropyltrimethoxysilane) and inorganic (H3PMo12O40) groups on the basal plane of GO. Structure of catalyst was characterized with different analysis such as FT-IR, SEM, TEM, EDS, WDX, XRD, and TGA. All analyses approve the successful covalently immobilization of organic and inorganic parts on the GO. The activity of catalyst has been tested for the synthesis of tetrahydrobenzo[b]pyran derivatives under solvent-free condition in short reaction time and good to excellent yields. [GRAPHICS] .

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ataie, F; Davoodnia, A; Khojastehnezhad, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, in vitro evaluation and molecular docking of new pyrazole derivatives bearing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety as potent antibacterial agents WOS:000580977100002 published article about ANTIMICROBIAL ACTIVITY; ANALGESIC ACTIVITY; HETEROCYCLES in [Elkanzi, Nadia A. A.; Alruwaili, May M.; Alruwaili, Enas D.; Almamtrfi, Rahaf W.; Alsharary, Hadeel Kh.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia; [Elkanzi, Nadia A. A.] Aswan Univ, Fac Sci, Chem Dept, POB 81528, Aswan, Egypt; [Hrichi, Hajer] Carthage Univ, Ctr Urbain Nord, Natl Inst Appl Sci & Technol, BPN 676, Tunis 1080, Tunisia; [Bakr, Rania B.; Hendawy, O.] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka 2014, Aljouf, Saudi Arabia; [Bakr, Rania B.] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt; [Hendawy, O.] Beni Suef Univ, Fac Med, Dept Clin Pharmacol, Bani Suwayf, Egypt in 2021, Cited 34. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In the current study, a new series of pyrazole derivatives4a-d,5a-dand6a-dpossessing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety were synthesized by treating chalcones (3a-d) with hydrazine monohydrate/acetic anhydride, hydrazine monohydrate/formic acid and 4-chlorophenylhydrazine in ethanol, respectively. These reactions proceeded smoothly with satisfactory yields, and the obtained compounds were characterized using FTIR,H-1-NMR,C-13-NMR and elemental analyses. All the synthesized compounds were subjected to antibacterial activity againstBacillus subtilis,Staphylococcus aureus,Escherichia coli, andPseudomonas aeruginosabacteria and molecular docking studies. The antibacterial studies showed that all compounds exhibited good to excellent antibacterial activity against the tested bacterial strains. The structure-activity relationship studies revealed that the compounds3b,4b,5band6bbearing a chlorine atom at the para position of the phenyl group attached to pyrazole moiety in displayed the highest antibacterial activity against all the tested bacteria exceeding the standard drug ampicillin. Moreover, the molecular docking results showed that the highest scores docking have been obtained from the most active antibacterial compounds3b,3d,4b,4d,4c,5band6bwith good energy binding score within the active site of topoisomerase II DNA gyrase enzymes (PDB ID: 2XCS), suggesting that they can act by the inhibition of DNA replication. These compounds are auspicious candidates as antibacterial agents that would deserve further investigations.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elkanzi, NAA; Hrichi, H; Bakr, RB; Hendawy, O; Alruwaili, MM; Alruwaili, ED; Almamtrfi, RW; Alsharary, HK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gein, VL; Pastukhova, EV in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Gein, V. L.; Pastukhova, E. V.] Perm State Pharmaceut Acad, Perm 614990, Russia in 2021, Cited 5. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A series of new 1-aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones has been synthesized through a three-component reaction of aroylpyruvic acid methyl ester with a mixture of aromatic aldehyde and glycinamide hydrochloride in glacial acetic acid in the presence of anhydrous sodium bicarbonate.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Pastukhova, EV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sun, YY; Gao, PP; Zhu, L; Li, ZX; Zhao, RY; Li, CY; Shan, LH in ELSEVIER SCIENCE INC published article about ABIRATERONE ACETATE; NECROPTOSIS; PYRIDINES; INHIBITOR; CHEMISTRY; DESIGN in [Sun, Yingying; Gao, Peipei; Li, Zhaoxiang; Zhao, Ruiyun; Shan, Lihong] Zhengzhou Univ, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China; [Sun, Yingying; Gao, Peipei; Li, Zhaoxiang; Zhao, Ruiyun; Shan, Lihong] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou, Henan, Peoples R China; [Zhu, Li] Shanxi Med Univ, Taiyuan Cent Hosp, 5 Dong San Dao Xiang, Taiyuan 030009, Peoples R China; [Li, Congyu] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Zhengzhou, Peoples R China in 2021.0, Cited 34.0. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A series of new 17-cyanopyridine derivatives of pregnenolone have been synthesized, and their anti-proliferative activities against different human cancer cell lines were tested. The extensive structure-activity relationship (SAR) data suggested that the introduction of 2-amino-4-aryl-3-cyanopyridine to the D ring of pregnenolone may increase the anti-cancer activity. Among the products, the most potent compound 4j exhibited good growth inhibition against all the tested cells especially for PC- 3 cells with an IC50 value of 2.0 mu M. Further mechanistic studies showed that 4j inhibited the formation of cell colonies and migration, increased the level of reactive oxygen species (ROS) in PC-3 cells in a concentration-dependent manner, and induced necroptosis through the phosphorylation of receptor interacting protein 1/3 (P-RIP1/3) and phosphorylation of mixed lineage kinase domain-like protein (P-MLKL) pathway. The 17-pregnenolone cyanopyridine derivatives hold promising potential as anti-proliferative agents, and the most potent compound could be used as a starting point for the development of new steroidal heterocycles with improved anticancer potency and selectivity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sun, YY; Gao, PP; Zhu, L; Li, ZX; Zhao, RY; Li, CY; Shan, LH or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Authors Potapov, AY; Polikarchuk, VA; Paponov, BV; Ledeneva, IV; Stolpovskaya, NV; Kryl’skii, DV; Shikhaliev, KS in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Potapov, A. Yu.; Polikarchuk, V. A.; Ledeneva, I. V.; Stolpovskaya, N. V.; Shikhaliev, Kh. S.] Voronezh State Univ, Voronezh 394006, Russia; [Paponov, B. V.] Belgorod Natl Res Univ, Belgorod 308015, Russia; [Kryl’skii, D. V.] Res Inst Appl Acoust, Dubna 141981, Russia in 2021, Cited 16. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A convenient synthetic approach to polysubstituted dihydrogenated or heteroaromatic 1,2,4-triazolo[1,5-a]pyrimidines derivatives containing at position 5 a 4-methylpyrimidine moiety bearing a cycloamino substituent at position 2 and linked to the triazolopyrimidine bicycle through its position 5 was developed. The approach involves unusual three-component condensations of 3-amino-1,2,4-triazoles, methyl 3-(2-R-4-methylpyrimidin-5-yl)-3-oxopropionates, and a series of C-1 synthons whose synthetic equivalents are a series of aromatic aldehydes, triethyl orthoformate, or DMFDMA were used as of C-1 synthons.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Potapov, AY; Polikarchuk, VA; Paponov, BV; Ledeneva, IV; Stolpovskaya, NV; Kryl’skii, DV; Shikhaliev, KS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles