Category: 123-11-5

Safety of 4-Methoxybenzaldehyde. Authors Rej, S; Chatani, N in AMER CHEMICAL SOC published article about in [Rej, Supriya; Chatani, Naoto] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Organoboron reagents are important synthetic intermediates and have wide applications in synthetic organic chemistry. The selective borylation strategies that are currently in use largely rely on the use of transition-metal catalysts. Hence, identifying much milder conditions for transition-metal-free borylation would be highly desirable. We herein present a unified strategy for the selective C-H borylation of electron-deficient benzaldehyde derivatives using a simple metal-free approach, utilizing an imine transient directing group. The strategy covers a wide spectrum of reactions and (i) even highly sterically hindered C-H bonds can be borylated smoothly, (ii) despite the presence of other potential directing groups, the reaction selectively occurs at the o-C-H bond of the benzaldehyde moiety, and (iii) natural products appended to benzaldehyde derivatives can also give the appropriate borylated products. Moreover, the efficacy of the protocol was confirmed by the fact that the reaction proceeds even in the presence of a series of external impurities.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rej, S; Chatani, N or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N in [Milovic, Emilija; Petronijevic, Jelena; Joksimovic, Nenad] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12, Kragujevac 34000, Serbia; [Jankovic, Nenad] Univ Kragujevac, Inst Informat Technol Kragujevac, Dept Sci, Kragujevac 34000, Serbia; [Bogdanovic, Goran A.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, POB 522, Belgrade 11001, Serbia published On water synthesis of the novel 2-oxo-1,2,3,4-tetrahydropyrimidines in 2021, Cited 30. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A simple on water approach for the synthesis of novel tetrahydropyrimidine (THPM) derivatives has been developed under a green and sustainable fashion. For the first time, a deuterated Biginelli’s hybrid was synthesized. Novel THPMs are suitable for further derivatization and could be an excellent toolkit for lead-oriented synthesis and/or cross-coupling reactions. (C) 2020 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in subcritical EtOH WOS:000671550500009 published article about ONE-POT SYNTHESIS; HANTZSCH 1,4-DIHYDROPYRIDINES; OXIDATIVE DEALKYLATION; MICROWAVE IRRADIATION; SOLVENT; CATALYST; CHEMISTRY; ETHANOL; ABSENCE; SERIES in [Ersatir, Mehmet; Giray, Elife Sultan] Cukurova Univ, Arts & Sci Fac, Dept Chem, TR-01330 Adana, Turkey; [Turk, Murat] Cukurova Univ, Vocat Sch Ceyhan, Dept Property Protect & Secur, Adana, Turkey in 2021, Cited 41. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ersatir, M; Turk, M; Giray, ES or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Devi, P; Bishnoi, A; Singh, V in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Devi, P.; Bishnoi, A.] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India; [Singh, V.] Inst Engn & Technol, Dept Biotechnol, Lucknow 226021, Uttar Pradesh, India in 2021, Cited 37. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly efficient method for the multicomponent synthesis of substituted 4H-pyrido[1,2-a]pyrimidine-2-hydroxy-4-one derivatives, starting from 4H-pyrido[1,2-a]primidine-2-hydroxy-4-one, beta-naphthol, and substituted aromatic aldehydes, in moderate to good yields has been developed. The structure of the pyridopyrimidine derivatives was established by spectral methods. In vitro antibacterial activity of the newly synthesized compounds was evaluated against highly pathogenic Gram-positive [Staphylococcus aureus (MTCC 96)] and Gram-negative [Pseudomonas aeruginosa (MTCC 424), Salmonella typhi (MTCC 537), Klebsiella pneumoniae (MTCC 424), Escherichia coli (MTCC 64) and Chromobacterium violaceum] bacteria.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Devi, P; Bishnoi, A; Singh, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2021 J IRAN CHEM SOC published article about ANTIMICROBIAL ACTIVITY; ANALGESIC ACTIVITY; HETEROCYCLES in [Elkanzi, Nadia A. A.; Alruwaili, May M.; Alruwaili, Enas D.; Almamtrfi, Rahaf W.; Alsharary, Hadeel Kh.] Jouf Univ, Coll Sci, Chem Dept, POB 2014, Sakaka, Saudi Arabia; [Elkanzi, Nadia A. A.] Aswan Univ, Fac Sci, Chem Dept, POB 81528, Aswan, Egypt; [Hrichi, Hajer] Carthage Univ, Ctr Urbain Nord, Natl Inst Appl Sci & Technol, BPN 676, Tunis 1080, Tunisia; [Bakr, Rania B.; Hendawy, O.] Jouf Univ, Coll Pharm, Dept Pharmacol, Sakaka 2014, Aljouf, Saudi Arabia; [Bakr, Rania B.] Beni Suef Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Bani Suwayf 62514, Egypt; [Hendawy, O.] Beni Suef Univ, Fac Med, Dept Clin Pharmacol, Bani Suwayf, Egypt in 2021, Cited 34. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

In the current study, a new series of pyrazole derivatives4a-d,5a-dand6a-dpossessing 1,5,10,10a-tetrahydrobenzo[g]quinoline-3-carbonitrile moiety were synthesized by treating chalcones (3a-d) with hydrazine monohydrate/acetic anhydride, hydrazine monohydrate/formic acid and 4-chlorophenylhydrazine in ethanol, respectively. These reactions proceeded smoothly with satisfactory yields, and the obtained compounds were characterized using FTIR,H-1-NMR,C-13-NMR and elemental analyses. All the synthesized compounds were subjected to antibacterial activity againstBacillus subtilis,Staphylococcus aureus,Escherichia coli, andPseudomonas aeruginosabacteria and molecular docking studies. The antibacterial studies showed that all compounds exhibited good to excellent antibacterial activity against the tested bacterial strains. The structure-activity relationship studies revealed that the compounds3b,4b,5band6bbearing a chlorine atom at the para position of the phenyl group attached to pyrazole moiety in displayed the highest antibacterial activity against all the tested bacteria exceeding the standard drug ampicillin. Moreover, the molecular docking results showed that the highest scores docking have been obtained from the most active antibacterial compounds3b,3d,4b,4d,4c,5band6bwith good energy binding score within the active site of topoisomerase II DNA gyrase enzymes (PDB ID: 2XCS), suggesting that they can act by the inhibition of DNA replication. These compounds are auspicious candidates as antibacterial agents that would deserve further investigations.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elkanzi, NAA; Hrichi, H; Bakr, RB; Hendawy, O; Alruwaili, MM; Alruwaili, ED; Almamtrfi, RW; Alsharary, HK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 EUR J MED CHEM published article about PHASE-II TRIAL; CARBOXYLESTERASE ISOZYMES; DERIVATIVES; PROBE; IRINOTECAN; LOPERAMIDE; DISCOVERY; SUBSTRATE; PROGRESS in [Huo, Peng-Chao; Guan, Xiao-Qing; Song, Yun-Qing; Sun, Meng-Ru; He, Rong-Jing; Zou, Li-Wei; Xue, Li-Juan; Shi, Jin-Hui; Ge, Guang-Bo] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Shanghai, Peoples R China; [Huo, Peng-Chao; Zhang, Nan] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China; [Liu, Peng; Liu, Zhi-Guo] Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou, Zhejiang, Peoples R China in 2021, Cited 36. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Recommanded Product: 123-11-5

Human carboxylesterase 2 (hCES2A), one of the major serine hydrolases distributed in the small intestine, plays a crucial role in hydrolysis of ester-bearing drugs. Accumulating evidence has indicated that hCES2A inhibitor therapy can modulate the pharmacokinetic and toxicological profiles of some important hCES2A-substrate drugs, such as the anticancer agent CPT-11. Herein, a series of indanone-chalcone hybrids are designed and synthesized to find potent and highly selective hCES2A inhibitors. Inhibition assays demonstrated that most indanone-chalcone hybrids displayed strong to moderate hCES2A inhibition activities. Structure-hCES2A inhibition activity relationship studies showed that introduction of a hydroxyl at the C4′ site and introduction of an N-alkyl group at the C6 site were beneficial for hCES2A inhibition. Particularly, B7 (an N-alkylated 1-indanoneechalcone hybrid) exhibited the most potent inhibition on hCES2A and excellent specificity (this agent could not inhibit other human esterases including hCES1A and butyrylcholinesterase). Inhibition kinetic analyses demonstrated that B7 potently inhibited hCES2A-mediated FD hydrolysis in a mixed inhibition manner, with a calculated K-i value of 0.068 mu M. Furthermore, B7 was capable of inhibiting intracellular hCES2A in living cells and displayed good metabolic stability. Collectively, our findings show that indanone-chalcone hybrids are good choices for the development of hCES2A inhibitors, while B7 is a promising candidate for the development of novel anti-diarrhea agents to ameliorate irinotecan-induced intestinal toxicity. (c) 2020 Elsevier Masson SAS. All rights reserved.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Huo, PC; Guan, XQ; Liu, P; Song, YQ; Sun, MR; He, RJ; Zou, LW; Xue, LJ; Shi, JH; Zhang, N; Liu, ZG; Ge, GB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 CHEM BIOL DRUG DES published article about 3-COMPONENT SYNTHESIS; QUINOLINE; DESIGN; DISCOVERY; HYBRIDS; SULFIDE; JAK2 in [Nafie, Mohamed S.] Suez Canal Univ, Dept Chem, Fac Sci, Ismailia 41522, Egypt; [Mahgoub, Sebaey] Childrens Canc Hosp, Prote & Metabol Unit, Cairo, Egypt; [Amer, Atef M.] Zagazig Univ, Dept Chem, Fac Sci, Zagazig, Egypt in 2021, Cited 54. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. COA of Formula: C8H8O2

Quinoline derivatives are attracting considerable interest due to their biological importance. In this paper, several 2-amino-4-aryl-6-(quinolin-2-ylthio)pyridine-3,5-dicarbonitrile derivatives are synthesized by adopting a one-pot reaction of quinoline-2-thione, aromatic aldehydes, and malononitrile in the presence of sodium hydroxide in absolute ethanol. The structures of these newly synthesized compounds were determined using different spectroscopic techniques, including elemental analyses, IR,H-1 NMR, and MS. The synthesized derivatives were screened for their antimicrobial and cytotoxic activities. Compounds4a,4b,4d, and4eexhibited promising antimicrobial activity compared to antibacterial and antifungal standard drugs. Additionally,4f,4d, and4gshowed potent cytotoxic activity against both MCF-7 and A549 cells with IC(50)values (6.39-9.3 mu M). Our molecular docking results of compound4fprove good binding affinity toward the three tested proteins as Jak2/STATA3 inhibition and are in accordance with the RT-PCR mRNA expressions of the compound against MCF-7 cells which downregulated the Jak2 and STAT3 genes, and this may be the proposed mode of action for anti-breast cancer activity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nafie, MS; Mahgoub, S; Amer, AM or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Mansour, HS; Abd El-wahab, HAA; Ali, AM; Aboul-Fadl, T in ROYAL SOC CHEMISTRY published article about in [Mansour, Hany S.; Abd El-wahab, Hend A. A.; Ali, Ahmed M.; Aboul-Fadl, Tarek] Assiut Univ, Dept Med Chem, Fac Pharm, Assiut, Egypt in 2021.0, Cited 39.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The structure-based design of some CDK2 inhibitors with a 3-(benzylidene)indolin-2-one scaffold as potential anticancer agents was realized. Target compounds were obtained as E/Z mixtures and were resolved to corresponding E- and Z-diastereomers. In silico studies using MOE 2019.01 software revealed better docking on the targeted enzyme for the Z-diastereomer compared to the E-one. A time-dependent kinetic isomerization study was carried out for the inversion of E/Z diastereomers in DMSO-d(6) at room temperature, and were found to obey the first order kinetic reactions. Furthermore, a determination of the kinetic inter-conversion rate order by graphical analysis method and calculation of the rate constant and half-life of this kinetic process were carried out. For the prediction of the stability of the diastereomer(s), a good multiple regression equation was generated between the reaction rates of isomerization and some QM parameters with significant p value.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mansour, HS; Abd El-wahab, HAA; Ali, AM; Aboul-Fadl, T or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article PhIO-Mediated oxidative dethioacetalization/dethioketalization under waterfree conditions WOS:000659043800003 published article about 30-PERCENT HYDROGEN-PEROXIDE; CARBONYL-COMPOUNDS; EFFICIENT DEPROTECTION; REUSABLE CATALYST; CARBOXYLIC-ACIDS; MILD; DITHIOACETALS; 1,3-DITHIANES; PROTOCOL; THIOACETALIZATION in [Yu, Zhenyang; Ouyang, Yaxin; Wang, Xiaofan; Zhao, Bingyue; Wang, Xi; Du, Yunfei] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China; [Zhao, Kang] Shandong Univ, Inst Microbial Technol, State Key Lab Microbial Technol, Qingdao 266237, Peoples R China in 2021, Cited 54. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Treatment of thioacetals and thioketals with iodosobenzene in anhydrous DCM conveniently afforded the corresponding carbonyl compounds in high yields under water-free conditions. The mechanistic studies indicate that this dethioacetalization/dethioketalization process does not need water and the oxygen of the carbonyl products comes from the hypervalent iodine reagent. [GRAPHICS]

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yu, ZY; Ouyang, YX; Wang, XF; Zhao, BY; Wang, X; Du, YF; Zhao, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 4-Methoxybenzaldehyde. Authors Elfinger, M; Schonauer, T; Thoma, SLJ; Staglich, R; Drechsler, M; Zobel, M; Senker, J; Kempe, R in WILEY-V C H VERLAG GMBH published article about in [Elfinger, Matthias; Schoenauer, Timon; Kempe, Rhett] Univ Bayreuth, Inorgan Chem Catalyst Design 2, Sustainable Chem Ctr, D-95440 Bayreuth, Germany; [Thomae, Sabrina L. J.; Zobel, Mirijam] Univ Bayreuth, Solid State Chem Mesostruct Mat, D-95440 Bayreuth, Germany; [Staeglich, Robert; Senker, Juergen] Univ Bayreuth, Inorgan Chem 3, D-95440 Bayreuth, Germany; [Staeglich, Robert; Senker, Juergen] Univ Bayreuth, North Bavarian NMR Ctr, D-95440 Bayreuth, Germany; [Drechsler, Markus] Univ Bayreuth, Bavarian Polymer Inst BPI, Keylab Electron & Opt Microscopy, D-95440 Bayreuth, Germany in 2021.0, Cited 27.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Nanostructured and reusable 3d-metal catalysts that operate with high activity and selectivity in important chemical reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy-to-handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50 degrees C and 10 bar H-2 pressure) and outperforms commercially available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed. The key for the high activity seemed to be the used support: an N-doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores.

Recommanded Product: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elfinger, M; Schonauer, T; Thoma, SLJ; Staglich, R; Drechsler, M; Zobel, M; Senker, J; Kempe, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles