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About m-Methoxyphenol, If you have any questions, you can contact Zhao, RN; Zhou, Z; Liu, JX; Wang, X; Zhang, Q; Li, D or concate me.. COA of Formula: C7H8O2

COA of Formula: C7H8O2. Authors Zhao, RN; Zhou, Z; Liu, JX; Wang, X; Zhang, Q; Li, D in AMER CHEMICAL SOC published article about in [Zhao, Ruinan; Zhou, Zhong; Liu, Jixiang; Wang, Xia; Zhang, Qian; Li, Dong] Hubei Univ Technol, Sch Mat & Chem Engn, Wuhan 430068, Peoples R China in 2020.0, Cited 77.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

An efficient silver-catalyzed para-selective amination and aminative dearomatization of phenols with azodicarboxylates was developed. It afforded the para-aminophenols or amino cyclohexadieneones from free phenols depending on whether it has a para-substituent. The reaction proceeded smoothly in water under simple and mild conditions, giving the highly selective products in good yields within a short reaction time. It also showed broad substrate scope and good functional group compatibility.

About m-Methoxyphenol, If you have any questions, you can contact Zhao, RN; Zhou, Z; Liu, JX; Wang, X; Zhang, Q; Li, D or concate me.. COA of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Fui, CJ; Ting, TX; Sarjadi, MS; Amin, Z; Sarkar, SM; Musta, B; Rahman, M or concate me.

COA of Formula: C7H8O2. Authors Fui, CJ; Ting, TX; Sarjadi, MS; Amin, Z; Sarkar, SM; Musta, B; Rahman, M in AMER CHEMICAL SOC published article about in [Fui, Choong Jian; Ting, Tang Xin; Sarjadi, Mohd Sani; Musta, Baba; Rahman, MdLutfor] Univ Malaysia Sabah, Fac Sci & Nat Resources, Kota Kinabalu 88400, Sabah, Malaysia; [Amin, Zarina] Univ Malaysia Sabah, Biotechnol Res Inst, Kota Kinabalu 88400, Sabah, Malaysia; [Sarkar, Shaheen M.] Univ Limerick, Bernal Inst, Dept Chem Sci, Limerick V94 T9PX, Ireland in 2021, Cited 80. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Highly active natural pandanus-extracted cellulose-supported poly(hydroxamic acid)-Cu(II) complex 4 was synthesized. The surface of pandanus cellulose was modified through graft copolymerization using purified methyl acrylate as a monomer. Then, copolymer methyl acrylate was converted into a bidentate chelating ligand poly(hydroxamic acid) via a Loosen rearrangement in the presence of an aqueous solution of hydroxylamine. Finally, copper species were incorporated into poly(hydroxamic acid) via the adsorption process. Cu(II) complex 4 was fully characterized by Fourier transform infrared (FTIR), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray (EDX), transmission electron microscopy (TEM), inductively coupled plasma optical emission spectrometry (ICP-OES), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) analyses. The cellulose-supported Cu(II) complex 4 was successfully applied (0.005 mol %) to the Ullmann etherification of aryl, benzyl halides, and phenacyl bromide with a number of aromatic phenols to provide the corresponding ethers with excellent yield [benzyl halide (70-99%); aryl halide (20-90%)]. Cu(II) complex 4 showed high stability and was easily recovered from the reaction mixture. It could be reused up to seven times without loss of its original catalytic activity. Therefore, Cu(II) complex 4 can be commercially utilized for the preparation of various ethers, and this synthetic technique could be a part in the synthesis of natural products and medicinal compounds.

COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Fui, CJ; Ting, TX; Sarjadi, MS; Amin, Z; Sarkar, SM; Musta, B; Rahman, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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About m-Methoxyphenol, If you have any questions, you can contact Maffei, LP; Faravelli, T; Cavallotti, C; Pelucchi, M or concate me.. Category: indole-building-block

Category: indole-building-block. Maffei, LP; Faravelli, T; Cavallotti, C; Pelucchi, M in [Maffei, Luna Pratali; Faravelli, Tiziano; Cavallotti, Carlo; Pelucchi, Matteo] Politecn Milan, CRECK Modelling Lab, Dept Chem Mat & Chem Engn G Natta, Pzza Leonardo da Vinci 32, I-20133 Milan, Italy published Electronic structure-based rate rules for ipso addition-elimination reactions on mono-aromatic hydrocarbons with single and double OH/CH3/OCH3/CHO/C2H5 substituents: a systematic theoretical investigation in 2020, Cited 91. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

The recent interest in bio-oils combustion and the key role of mono-aromatic hydrocarbons (MAHs) in existing kinetic frameworks, both in terms of poly-aromatic hydrocarbons growth and surrogate fuels formulation, motivates the current systematic theoretical investigation of one of the relevant reaction classes in MAHs pyrolysis and oxidation:ipsosubstitution by hydrogen. State-of-the-art theoretical methods and protocols implemented in automatized computational routines allowed to investigate 14 different potential energy surfaces involving MAHs with hydroxy and methyl single (phenol and toluene) and double (o-,m-,p-C6H4(OH)(2),o-,m-,p-CH3C6H4OH, ando-,m-,p-C6H4(CH3)(2)) substituents, providing rate constants for direct implementation in existing kinetic models. The accuracy of the adopted theoretical method was validated by comparison of the computed rate constants with the available literature data. Systematic trends in energy barriers, pre-exponential factors, and temperature dependence of the Arrhenius parameters were found, encouraging the formulation of rate rules for ipsosubstitutions on MAHs. The rules here proposed allow to extrapolate from a reference system the necessary activation energy and pre-exponential factor corrections for a large number of reactions from a limited set of electronic structure calculations. We were able to estimate rate constants for other 63 ipsoaddition-elimination reactions on di-substituted MAHs, reporting in total 75 rate constants for ipsosubstitution reactionso-,m-,p-R ‘ C6H4R + -> C6H5R + ‘, with R,R ‘ = OH/CH3/OCH3/CHO/C2H5, in the 300-2000 K range. Additional calculations performed for validation showed that the proposed rate rules are in excellent agreement with the rate constants calculated using the full computational protocol in the 500-2000 K range, generally with errors below 20%, increasing up to 40% in a few cases. The main results of this work are the successful application of automatized electronic structure calculations for the derivation of accurate rate constants for ipsosubstitution reactions on MAHs, and an efficient and innovative approach for rate rules formulation for this reaction class.

About m-Methoxyphenol, If you have any questions, you can contact Maffei, LP; Faravelli, T; Cavallotti, C; Pelucchi, M or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Sarma, D; Majumdar, B; Sarma, TK or concate me.

Recently I am researching about QUANTUM DOTS; PHOTOREDOX CATALYSIS; GRAPHENE OXIDE; NANODOTS, Saw an article supported by the IIT Indore; MHRD, New Delhi. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Sarma, D; Majumdar, B; Sarma, TK. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol. Quality Control of m-Methoxyphenol

The development of carbonaceous materials as metal-free catalysts integrating different types of catalysis in a single system represents a significant advance in cascade/tandem organic synthesis. Zero-dimensional carbon dots with tuneable optical properties and easily modifiable surface functionalities can be harnessed as a carbocatalyst for merging photooxidation and acid-catalyzed reactions in one pot. Herein, we explore carbon dots decorated with hydrogen sulfate groups as a photocatalyst for the dehydrogenative cross-coupling of xanthenes with ketones, arenes and 1,3-dicarbonyl compounds that showed high efficiency and selectivity under visible-light irradiation. The sulphated carbon dots demonstrate dual catalytic properties, wherein they induced the rapid photooxidation of xanthenes in the presence of molecular oxygen to form a hydroperoxy intermediate followed by coupling of nucleophiles catalysed by the acidic surface functional groups. The methodology represents an operationally simple pathway for the generation of C-C coupling products in a short reaction time with wide substrate scopes under mild conditions. The catalyst is easily separable and can be reused over multiple cycles with good efficiency.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Sarma, D; Majumdar, B; Sarma, TK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Get Up to Speed Quickly on Emerging Topics:150-19-6

HPLC of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Gendron, T; Pereira, R; Abdi, HY; Witney, TH; Arstad, E or concate me.

HPLC of Formula: C7H8O2. Recently I am researching about CONVERSION; MECHANISM; PHENOLS, Saw an article supported by the European Union’s Seventh Framework Programme (FP7/2007-2013) [602102]; Wellcome TrustWellcome TrustEuropean Commission [107610/Z/15/Z]; Royal Society Sir Henry Dale Fellowship [107610/Z/15/Z]; Engineering and Physical Sciences Research Council (EPSRC)UK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [C1519/A16463, C2536/A10337]; UCL MSci in Chemistry; Department of Health’s NIHR Biomedical Research Centres funding schemeNational Institute for Health Research (NIHR); CRUK Comprehensive Cancer Imaging Centre at KCL – Cancer Research UK; EPSRC Comprehensive Cancer Imaging Centre at KCL – Cancer Research UKUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC); CRUK Comprehensive Cancer Imaging Centre at UCL – Cancer Research UK; EPSRC Comprehensive Cancer Imaging Centre at UCL – Cancer Research UKUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC); CRUK Comprehensive Cancer Imaging Centre at Imperial – Cancer Research UK; EPSRC Comprehensive Cancer Imaging Centre at Imperial – Cancer Research UKUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC). Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gendron, T; Pereira, R; Abdi, HY; Witney, TH; Arstad, E. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Herein, we report that iron(II)/ammonium persulfate in aqueous acetonitrile mediates the Newman-Kwart rearrangement of O-aryl carbamothioates. Electron-rich substrates react rapidly under moderate heating to afford the rearranged products in excellent yields. The mild conditions, rapid reaction rates, and suitability for scale up offers immediate practical benefits to access functionalized thiophenols.

HPLC of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Gendron, T; Pereira, R; Abdi, HY; Witney, TH; Arstad, E or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Computed Properties of C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Reddy, DS; Kongot, M; Singh, V; Siddiquee, MA; Patel, R; Singhal, NK; Avecilla, F; Kumar, A or concate me.

An article Biscoumarin-pyrimidine conjugates as potent anticancer agents and binding mechanism of hit candidate with human serum albumin WOS:000570221000001 published article about DNA CLEAVAGE; APOPTOSIS-INDUCTION; IN-VITRO; COUMARIN; DERIVATIVES; CYTOTOXICITY; ANTITUMOR; HYBRIDS; DESIGN; HALOGENATION in [Reddy, Dinesh S.; Kongot, Manasa; Kumar, Amit] Jain Univ, Ctr Nano & Mat Sci, Jain Global Campus, Bangalore 562112, Karnataka, India; [Singh, Vishal; Singhal, Nitin K.] Natl Agri Food Biotechnol Inst, Mohali, India; [Siddiquee, Md. Abrar; Patel, Rajan] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, Biophys Chem Lab, New Delhi, India; [Avecilla, Fernando] Univ A Coruna, Fac Ciencias, Dept Quim, Ctr Invest Cient Avanzadas CICA,Grp Xenomar, La Coruna, Spain in 2021, Cited 56. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2

In our continuing efforts to develop therapeutically active coumarin-based compounds, a series of new C4-C4 ‘ biscoumarin-pyrimidine conjugates (1a-l) was synthesizedviaS(N)2 reaction of substituted 4-bromomethyl coumarin with thymine. All compounds were characterized using spectroscopic techniques, that is, attenuated total reflection infrared (ATR-IR), CHN elemental analysis, and(1)H and(13)C NMR (nuclear magnetic resonance). In addition, the structure of compound1d(1,3-bis[(7-chloro-2-oxo-2H-chromen-4-yl)methyl]-5-methylpyrimidine-2,4(1H,3H)-dione) was established through X-ray crystallography. Compounds1a-lwere screened for in vitro anticancer activity against C6 rat glioma cells. Among the screened compounds, 1,3-bis[(6-chloro-2-oxo-2H-chromen-4-yl)methyl]-5-methylpyrimidine-2,4(1H,3H)-dione (1c) was identified as the best antiproliferative candidate, exhibiting an IC(50)value of 4.85 mu M. All the compounds (1a-l) were found to be nontoxic toward healthy human embryonic kidney cells (HEK293), indicating their selective nature. In addition, the most active compound (1c) displayed strong binding interactions with the drug carrier protein, human serum albumin, and exhibited good solution stability at biological pH conditions. Fluorescence, UV-visible spectrophotometry and molecular modeling methodologies were employed for studying the interaction mechanism of compound1cwith protein.

Computed Properties of C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Reddy, DS; Kongot, M; Singh, V; Siddiquee, MA; Patel, R; Singhal, NK; Avecilla, F; Kumar, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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About m-Methoxyphenol, If you have any questions, you can contact Tabrizi, AK; Khademieslam, H; Hemmasi, AH; Bazyar, B; Atghia, SV or concate me.. Recommanded Product: 150-19-6

Recommanded Product: 150-19-6. Recently I am researching about ONE-POT SYNTHESIS; WATER-ABSORPTION BEHAVIOR; HETEROGENEOUS CATALYST; MECHANICAL-PROPERTIES; SULFONIC-ACID; IONIC LIQUID; SOLID ACID; EFFICIENT; NANOPARTICLES; IMMOBILIZATION, Saw an article supported by the Islamic Azad University of Tehran, Science and Research Branch. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Tabrizi, AK; Khademieslam, H; Hemmasi, AH; Bazyar, B; Atghia, SV. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

For the first time, chemical modification of raw Luffa with hydrogen sulfate moieties was investigated. For this purpose ammonium hydrogen sulfate moieties were immobilized on the surface of Luffa. This chemical modification performed by reaction of 3-aminopropyltriethoxy silane with raw Luffa and sulfonation of amine groups using sulfuric acid. The morphology of catalyst was investigated by Fourier transform spectroscopy, X-ray diffraction, thermogravimetric analysis, field emission scanning electron microscope, elemental-mapping, and energy dispersive X-Ray spectroscopy techniques. The catalytic performance of the synthesized catalyst was examined in the synthesis of coumarin and bis(indolyl)methane derivatives. Our method introduced a green protocol in using of a plant for the preparation of catalyst and one-pot solventless media for the synthesis of coumarins and bis(indolyl)methanes. Some of the advantages of our method are high yields of products, short reaction times, recyclability of catalyst, easy workup, and separation of catalyst and products.

About m-Methoxyphenol, If you have any questions, you can contact Tabrizi, AK; Khademieslam, H; Hemmasi, AH; Bazyar, B; Atghia, SV or concate me.. Recommanded Product: 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The important role of 150-19-6

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G or concate me.

An article URJC-1-MOF as New Heterogeneous Recyclable Catalyst for C-Heteroatom Coupling Reactions WOS:000480290100006 published article about METAL-ORGANIC FRAMEWORK; WATER-ADSORPTION; EFFICIENT; ACIDS; MOFS in [Munoz, Antonio; Orcajo, Gisela; Calleja, Guillermo] Rey Juan Carlos Univ, Dept Chem Energy & Mech Technol, C Tulipan S-N, Mostoles 28933, Spain; [Leo, Pedro; Martinez, Fernando] Rey Juan Carlos Univ, Dept Chem & Environm Technol, C Tulipan S-N, Mostoles 28933, Spain in 2019, Cited 41. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Formula: C7H8O2

Guillermo Calleja and co-workers from @urjc describe URJC-1-MOF as a new heterogeneous recyclable catalyst for c-heteroatom coupling reactions The capacity of copper-based URJC-1-MOF as a MOF catalyst in cross-coupling reactions has been evaluated, focusing on the Chan-Lam-Evans arylation-type reactions on amines and alcohols without extra additives or ligands. The extraordinary chemical and structural stability of URJC-1-MOF and its good specific surface, make this material a promising alternative to homogeneous Cu (II) catalysts for cross-coupling reactions. URJC-1-MOF showed a remarkable catalytic activity for cross-coupling C-N and C-O reactions, higher than other heterogeneous and homogeneous copper-based catalyst, such as CuO, HKUST-1, Cu-MOF-74, Cu(OAc)(2) and CuSO4.5H(2)O. Moreover, its easy recovery by simple filtration and reusability in successive runs without any loss of activity and stability, demonstrates the potential of URJC-1-MOF as an alternative catalyst for this kind of reactions in different chemical media of industrial interest.

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Munoz, A; Leo, P; Orcajo, G; Martinez, F; Calleja, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An overview of features, applications of compound:m-Methoxyphenol

HPLC of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Subhan, MA; Saha, PC; Sumon, SA; Alam, MM; Asiri, AM; Al-Mamun, M; Rahman, MM or concate me.

HPLC of Formula: C7H8O2. Authors Subhan, MA; Saha, PC; Sumon, SA; Alam, MM; Asiri, AM; Al-Mamun, M; Rahman, MM in WILEY-V C H VERLAG GMBH published article about in [Subhan, Md Abdus; Saha, Pallab C.; Sumon, Shamim A.] Shahjalal Univ Sci & Technol, Dept Chem, Sylhet 3114, Bangladesh; [Asiri, Abdullah M.; Rahman, Mohammed M.] King Abdulaziz Univ, Fac Sci, Chem Dept, POB 80203, Jeddah 21589, Saudi Arabia; [Asiri, Abdullah M.; Rahman, Mohammed M.] King Abdulaziz Univ, Ctr Excellence Adv Mat Res CEAMR, POB 80203, Jeddah 21589, Saudi Arabia; [Alam, M. M.] Shahjalal Univ Sci & Technol, Dept Chem Engn & Polymer Sci, Sylhet 3100, Bangladesh; [Al-Mamun, Mohammad] Griffith Univ, Griffith Sch Environm, Ctr Clean Environm & Energy, Gold Coast Campus, Southport, Qld 4222, Australia in 2021.0, Cited 53.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

The synthesized MgTi2O4.TiO2.Zn2TiO4 nanomaterial was characterized by XRD (X-Ray diffraction), SEM (Scanning electron microscopy), EDS (Energy dispersive x-ray spectroscopy), FTIR (Fourier transform infrared spectroscopy) and PL (Photoluminescence) study. Particles size of MgTi2O4.TiO2.Zn2TiO4 nanomaterial was found to be 37.3 nm. PL and PLE (Photoluminescence excitation) spectra are showed several peaks including one red PL at 723 nm, when excited at 320 nm. Nanomaterial was subject to electrochemical sensor study. Thin layer of synthesized MgTi2O4.TiO2.Zn2TiO4 nanomaterials was fabricated onto the glassy carbon electrode (GCE) with conducting binder to result the working electrode of 4-nitrophenylhydrazine (4-NPHyd) sensor, which was applied successively to selectively detect the 4-NPHyd in aqueous phase. The 4-NPHyd chemical sensor exhibited high sensitivity with lower detection limit, long-term stability in chemical environment and improved electrochemical responses during sensing performance. The linearity of calibration plot is obtained over the large linear dynamic range (LDR) from 0.1 nM to 0.1 mM of 4-NPHyd. The sensitivity calculated from the slop of calibration plot (ratio of current to concentration of 4-NPHyd) is 42.7215 mu AmM(-1)cm(-2) with detection limit (DL) of 0.02 +/- 0.001 nM at signal to noise ratio of 3(S/N). Therefore, the chemical sensor based on MgTi2O4.TiO2.Zn2TiO4 nanomaterials may be a promising highly sensitive sensor in electrochemical method for the effective detection of hazardous and carcinogenic chemicals in medical as well as biological sectors.

HPLC of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Subhan, MA; Saha, PC; Sumon, SA; Alam, MM; Asiri, AM; Al-Mamun, M; Rahman, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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About m-Methoxyphenol, If you have any questions, you can contact Francisco, CS; Javarini, CL; Barcelos, ID; Morais, PAB; de Paula, H; Borges, WD; Neto, AC; Lacerda, V or concate me.. Safety of m-Methoxyphenol

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis of Coumarin Derivatives as Versatile Scaffolds for GSK-3 beta Enzyme Inhibition published in 2020.0. Safety of m-Methoxyphenol, Reprint Addresses Lacerda, V (corresponding author), Univ Fed Espirito Santo, Ctr Ciencias Exatas, Dept Quim, Av Fernando Ferrari 514, BR-29075910 Vitoria, ES, Brazil.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Background: Glycogen synthase kinase-3 (GSK-3) is involved in the phosphorylation and inactivation of glycogen synthase. GSK-3 inhibitors have been associated with a variety of diseases, including Alzheimer’s disease (AD), diabetes type II, neurologic disorders, and cancer. The inhibition of GSK-3 beta isoforms is likely to represent an effective strategy against AD. Objective: The present work aimed to design and synthesize coumarin derivatives to explore their potential as GSK-3 beta kinase inhibitors. Methods: The through different synthetic methods were used to prepare coumarin derivatives. The GSK-3 beta activity was measured through the ADP-Glo (TM) Kinase Assay, which quantifies the kinase-dependent enzymatic production of ADP from ATP, using a coupled-luminescence-based reaction. A docking study was performed by using the crystallographic structure of the staurosporine/GSK-3 beta complex [Protein Data Bank (PDB) code: 1Q3D]. Results: The eleven coumarin derivatives were obtained and evaluated as potential GSK-3 beta inhibitors. Additionally, in silico studies were performed. The results revealed that the compounds 5c, 5d, and 6b inhibited GSK-3 beta enzymatic activity by 38.97-49.62% at 1 mM. The other coumarin derivatives were tested at 1 mM, 1 mu M, and 1 nM concentrations and were shown to be inhibitor candidates, with significant IC50 (1.224-6.875 mu M) values, except for compound 7c (IC50 – 10.809 mu M). Docking simulations showed polar interactions between compound 5b and Lys(85) and Ser(203), clarifying the mechanism of the most potent activity. Conclusion: The coumarin derivatives 3a and 5b, developed in this study, showed remarkable activity as GSK-3 beta inhibitors.

About m-Methoxyphenol, If you have any questions, you can contact Francisco, CS; Javarini, CL; Barcelos, ID; Morais, PAB; de Paula, H; Borges, WD; Neto, AC; Lacerda, V or concate me.. Safety of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles