Category: 150-19-6

In 2019.0 ARCH PHARM published article about COUMARIN DERIVATIVES; BIOLOGICAL EVALUATION; OXIDATIVE STRESS; TARGETING ACETYLCHOLINESTERASE; ANTICHOLINESTERASE ACTIVITY; DESIGN; DISEASE; PHTHALIMIDE in [Kara, Jiraporn; Suwanhom, Paptawan; Lomlim, Luelak] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, 15 Karnjanavanich Rd, Hat Yai 90112, Songkhla, Thailand; [Wattanapiromsakul, Chatchai; Puripattanavong, Jindaporn] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai, Thailand; [Nualnoi, Teerapat] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Hat Yai, Songkhla, Thailand; [Khongkow, Pasarat] Prince Songkla Univ, Inst Biomed Engn, Fac Med, Hat Yai, Thailand; [Lee, Vannajan Sanghiran] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur, Malaysia; [Gaurav, Anand] UCSI Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Kuala Lumpur, Malaysia in 2019.0, Cited 38.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. SDS of cas: 150-19-6

Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04 +/- 0.01 mu M), noncompetitively inhibited AChE with a higher potency than tacrine and galantamine. Compounds 5d, 5j, and 5m showed a moderate antilipid peroxidation activity. The compounds showed cytotoxicity in the same range as the standard drugs in HEK-293 cells. Molecular docking demonstrated that 5a acted as a dual binding site inhibitor. The coumarin moiety occupied the peripheral anionic site and showed p-p interaction with Trp278. The tertiary amino group displayed significant cation-p interaction with Phe329. The aromatic group showed p-p interaction with Trp83 at the catalytic anionic site. The long chain of methylene lay along the gorge interacting with Phe330 via hydrophobic interaction. Molecular docking was applied to postulate the selectivity toward AChE of 5a in comparison with donepezil and tacrine. Structural insights into the selectivity of the coumarin derivatives toward huAChE were explored by molecular docking and 3D QSAR and molecular dynamics simulation for 20 ns. ADMET analysis suggested that the 2-(2-oxo-2H-chromen-4-yl)acetamides showed a good pharmacokinetic profile and no hepatotoxicity. These coumarin derivatives showed high potential for further development as anti-Alzheimer agents.

About m-Methoxyphenol, If you have any questions, you can contact Kara, J; Suwanhom, P; Wattanapiromsakul, C; Nualnoi, T; Puripattanavong, J; Khongkow, P; Lee, VS; Gaurav, A; Lomlim, L or concate me.. SDS of cas: 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An approach for the calculation of vaporization enthalpies of aromatic and heteroaromatic compounds at 298.15 K applicable to supercooled liquids WOS:000583948500144 published article about STANDARD MOLAR ENTHALPIES; NORMAL BOILING TEMPERATURE; VAPOR-PRESSURES; THERMODYNAMIC PROPERTIES; HEAT-CAPACITIES; THERMOCHEMICAL PROPERTIES; SUBLIMATION ENTHALPIES; PHASE-TRANSITIONS; ORGANIC-COMPOUNDS; SUBSTITUTED BENZENES in [Solomonov, Boris N.; Yagofarov, Mikhail, I] Kazan Fed Univ, Dept Phys Chem, Kremlevskaya Str 18, Kazan 420008, Russia in 2020, Cited 186. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Quality Control of m-Methoxyphenol

An approach for the calculation of the vaporization enthalpies of aromatic and heteroaromatic compounds at T = 298.15 K with accuracy competitive with experiment was proposed. The vaporization enthalpies may be calculated from the solution enthalpies of liquid and solvation enthalpies in benzene. The solution enthalpies of liquids were shown to be constant within a given type of aromatic compounds. For a set of 67 liquid and 41 solid aromatic and heteroaromatic compounds not capable of intermolecular hydrogen bonding, it was experimentally demonstrated that the solution enthalpies of liquids or supercooled liquids in benzene were equal to 1 +/- 1 kJ . mol(-1). The way to consider intermolecular hydrogen bonding, e.g., in phenol, aniline, pyrrole derivatives, was also proposed. The methods for solvation enthalpy calculation were proposed previously. The calculated and literature vaporization enthalpies values of 415 aromatic and heteroaromatic compounds were compared. Average absolute deviation amounted to 1.3 kJ . mol(-1). The proposed approach is especially valuable for calculation of the vaporization enthalpies of low-volatile compounds, including those solid at T = 298.15 K. (C) 2020 Elsevier B.V. All rights reserved.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Solomonov, BN; Yagofarov, MI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of m-Methoxyphenol. Recently I am researching about HOMOPROPARGYLIC ALCOHOLS; ENOL-ETHERS; CYCLOISOMERIZATION; HYDROAMINATION; BOND; HYDROALKOXYLATION; CYCLIZATION; INDOLES; ACETALS; ROUTE, Saw an article supported by the National Institutes of Health (NIGMS)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM110560]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [S10RR028859]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R01GM110560] Funding Source: NIH RePORTER. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Costello, JP; Ferreira, EM. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

The steric and electronic drivers of regioselectivity in platinum -catalyzed intramolecular hydroalkoxylation are elucidated. A branch point is found that divides the process between 5-exo and 6-endo selective processes, and enol ethers can be accessed in good yields for both oxygen heterocycles. The main influence arises from an electronic effect, where the alkyne substituent induces a polarization of the alkyne that leads to preferential heteroatom attack at the more electron -deficient carbon. The electronic effects are studied in other contexts, including hydroacyloxylation and hydroamination, and similar trends in directionality are predominant although not uniformly observed.

About m-Methoxyphenol, If you have any questions, you can contact Costello, JP; Ferreira, EM or concate me.. Safety of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Facile synthesis of 3-aryl benzofurans, 3-aryl benzothiophenes, 2-aryl indoles and their dimers WOS:000482268300003 published article about PALLADIUM-CATALYZED REACTION; SOLID-PHASE SYNTHESIS; PHENOLIC CONSTITUENTS; DERIVATIVES; INHIBITORS; HETEROCYCLES; CHEMISTRY; MECHANISM; RECEPTOR; FURANS in [Umareddy, Pailla; Arava, Veera Reddy] Suven Life Sci Ltd, R&D Ctr, Hyderabad, Telangana, India in 2019.0, Cited 66.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Recommanded Product: 150-19-6

The preparation of 3-aryl benzofuran and benzothiophenes and their dimers at 2-position and, 2-aryl indoles and their 3-position dimers preparation is described. [GRAPHICS] .

Recommanded Product: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Umareddy, P; Arava, VR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-19-6. In 2020.0 CHEMISTRYSELECT published article about ONE-POT SYNTHESIS; ANTIMYCOBACTERIAL ACTIVITY; SELECTIVE HALOGENATION; CARBONYL-COMPOUNDS; METHYL KETONES; VISIBLE-LIGHT; EFFICIENT; DERIVATIVES; CHLORINATION; COUMARINS in [Vanammoole, Lakshmireddy; Kommera, Rajkumar; Kurma, Siva Hariprasad; Bhimapaka, China Raju] CSIR, Dept Organ Synth & Proc Chem, Indian Inst Chem Technol, Hyderabad 500007, India; [Vaidya, Jayathirtha Rao] CSIR, Fluoro Agrochem, Indian Inst Chem Technol, Hyderabad 500007, India; [Vanammoole, Lakshmireddy; Kommera, Rajkumar; Kurma, Siva Hariprasad; Vaidya, Jayathirtha Rao; Bhimapaka, China Raju] AcSIR Postal Staff Coll Area, Sect 19, Ghaziabad 201002, Uttar Pradesh, India in 2020.0, Cited 77.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A systematic study has been conducted for the regioselective halogenation of 2H-chromenones to prepare 3-halo-2H-chromenones, 4-substituted 3-halo-2H-chromenones and 3-(2-haloacetyl)-2H-chromenones. Commercially available NaCl/NaBr has been used as halogen source and oxone as an oxidant to produce the compounds. Further, the method has been successfully applied for the preparation of pharmaceutically important halogenated 2H-chromenone natural products. The present approach is simple, economically viable and provided the target compounds with good yields.

About m-Methoxyphenol, If you have any questions, you can contact Vanammoole, L; Kommera, R; Kurma, SH; Vaidya, JR; Bhimapaka, CR or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective D-3 Dopamine Receptor Agonist WOS:000585210700031 published article about IMPULSE CONTROL DISORDERS; D3 RECEPTOR; IN-VIVO; HIGH-AFFINITY; CRYSTAL-STRUCTURE; BIVALENT LIGANDS; MPTP TOXICITY; FORCE-FIELD; POTENT; PRAMIPEXOLE in [Moritz, Amy E.; Free, R. Benjamin; Akano, Emmanuel O.; Sibley, David R.] NINDS, Mol Neuropharmacol Sect, Intramural Res Program, NIH, Bethesda, MD 20892 USA; [Weiner, Warren S.; Aube, Jeffrey; Frankowski, Kevin J.] Univ Kansas, Specialized Chem Ctr, Lawrence, KS 66047 USA; [Gandhi, Disha; Aube, Jeffrey; Frankowski, Kevin J.] UNC Eshelman Sch Pharm, Ctr Integrat Chem Biol & Drug Discovery, Chapel Hill, NC 27599 USA; [Abramyan, Ara; Shi, Lei] NIDA, Computat Chem & Mol Biophys Unit, Mol Targets & Medicat Discovery Branch, Intramural Res Program,NIH, Baltimore, MD 21224 USA; [Keck, Thomas M.] Rowan Univ, Coll Sci & Math, Dept Chem & Biochem, Dept Mol & Cellular Biosci, Glassboro, NJ 08028 USA; [Ferrer, Marc; Hu, Xin; Southall, Noel] NIH, NIH Chem Genom Ctr, Div Preclin Innovat, Natl Ctr Adv Translat Sci, Rockville, MD 20850 USA; [Steiner, Joseph] NINDS, NeuroTherapeut Dev Unit, Intramural Res Program, NIH, Bethesda, MD 20892 USA in 2020.0, Cited 101.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2

To identify novel D-3 dopamine receptor (D3R) agonists, we conducted a high-throughput screen using a beta-arrestin recruitment assay. Counterscreening of the hit compounds provided an assessment of their selectivity, efficacy, and potency. The most promising scaffold was optimized through medicinal chemistry resulting in enhanced potency and selectivity. The optimized compound, ML417 (20), potently promotes D3R-mediated beta-arrestin translocation, G protein activation, and ERK1/2 phosphorylation (pERK) while lacking activity at other dopamine receptors. Screening of ML417 against multiple G protein-coupled receptors revealed exceptional global selectivity. Molecular modeling suggests that ML417 interacts with the D3R in a unique manner, possibly explaining its remarkable selectivity. ML417 was also found to protect against neurodegeneration of dopaminergic neurons derived from iPSCs. Together with promising pharmacokinetics and toxicology profiles, these results suggest that ML417 is a novel and uniquely selective D3R agonist that may serve as both a research tool and a therapeutic lead for the treatment of neuropsychiatric disorders.

About m-Methoxyphenol, If you have any questions, you can contact Moritz, AE; Free, RB; Weiner, WS; Akano, EO; Gandhi, D; Abramyan, A; Keck, TM; Ferrer, M; Hu, X; Southall, N; Steiner, J; Aube, J; Shi, L; Frankowski, KJ; Sibley, DR or concate me.. Computed Properties of C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O2. I found the field of Chemistry very interesting. Saw the article Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp(3))-H activation published in 2021.0, Reprint Addresses Zhang, YH (corresponding author), Tongji Univ, Shanghai Key Lab Chem Assessment & Sustainabil, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol.

Transition-metal-catalyzed cross-electrophile C(sp(2))-(sp(3)) coupling and C-H alkylation reactions represent two efficient methods for the incorporation of an alkyl group into aromatic rings. Herein, we report a Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides. Methoxy and benzyloxy groups, which are ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp(3))-H activation. The reaction provides an innovative and convenient access for the synthesis of alkylated phenol derivatives, which are widely found in bioactive compounds and organic functional materials.

About m-Methoxyphenol, If you have any questions, you can contact Wu, Z; Jiang, H; Zhang, YH or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols WOS:000584726200008 published article about PRELIMINARY PHARMACOLOGICAL EVALUATION; HECK-OXYARYLATION; DERIVATIVES; OXYPHENYLATION; EFFICIENT; RING in [Gaspar, Francisco V.; Barcellos, Julio C. F.; Civicos, Jose F.; Costa, Paulo R. R.] Univ Fed Rio de Janeiro, Inst Pesquisas Prod Nat, Lab Quim Bioorgan, Ctr Ciencias Saude, Bloco H,Ilha Cidade Univ, BR-21941590 Rio De Janeiro, RJ, Brazil; [Merino, Pedro] Univ Zaragoza, Inst Biocomp & Fis Sistemas Complejos BIFI, Fac Ciencias, Campus San Francisco, E-50009 Zaragoza, Spain; [Najera, Carmen] Univ Alicante, Ctr Innovac Quim Avanzada ORFEO CINQA, Apdo 99, Alicante 03080, Spain in 2020.0, Cited 33.0. Name: m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

The oxyarylation of alkoxy-2H-chromenes (1a-e) with o-iodophenols substituted by electron-withdrawing (CHO) and electron-donating (OMe) groups is studied under two experimental conditions: a) Pd(OAc)(2), Ag2CO3 in PEG-400 at 140 degrees C, 10 min and b) oxime-based palladacycle, DIPEA, in PEG-400 at 150 degrees C, 3-4 h. Pterocarpans are obtained in moderate to good chemical yields. (C) 2020 Published by Elsevier Ltd.

Name: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Gaspar, FV; Barcellos, JCF; Civicos, JF; Merino, P; Najera, C; Costa, PRR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: m-Methoxyphenol. I found the field of Chemistry very interesting. Saw the article A total synthesis of (+)-brazilin published in 2020.0, Reprint Addresses Yang, XH (corresponding author), Shanxi Canc Inst, Lab Anim Ctr, Taiyuan 030013, Peoples R China.; Wang, XJ; Wang, LP (corresponding author), Jiangxi Sci & Technol Normal Univ, Sch Pharm, Nanchang 330013, Jiangxi, Peoples R China.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol.

Described herein is a concise total synthesis of (+)-brazilin from readily available 4-bromo-1,2dimethoxybenzene. In this synthetic route, a Sharpless asymmetric dihydroxylation was employed to introduce the chiral hydroxyl group, and trifluoroacetic acid (TFA) catalyzed one-pot intramolecular tandem Prins/Friedel-Crafts reaction was also involved as the key transformation in the construction of the hybrid chromane and indane framework. (C) 2020 Elsevier Ltd. All rights reserved.

Name: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Huang, SP; Ou, WT; Li, W; Xiao, HS; Pang, YY; Zhou, Y; Wang, XJ; Yang, XH; Wang, LP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhang, W; Yang, W; Zhao, WX in [Zhang, Wu; Yang, Wen; Zhao, Wanxiang] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometries, Changsha 410082, Hunan, Peoples R China published Lewis acid-promoted site-selective cyanation of phenols in 2020.0, Cited 66.0. COA of Formula: C7H8O2. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

An efficient Lewis acid-promoted site-selective electrophilic cyanation of 3-substituted and 3,4-disubstituted phenols has been developed. The cyanation reactions using MeSCN as the cyanating reagent proceeded efficiently to afford a wide range of 2-hydroxybenzonitriles with high efficiency and excellent regioselectivity. This protocol could provide a practical method for the synthesis and modification of biologically active molecules.

COA of Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Zhang, W; Yang, W; Zhao, WX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles