Category: 150-19-6

An article Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols WOS:000602666800001 published article about ORTHO-ARYLATION; ARENES; ALKENYLATION; SUBSTITUTION; ANNULATION; CONVERSION; ETHERS in [Yu, Jianjin; Zeng, Huiying] Lanzhou Univ, State Key Lab Appl Organ Chem, 222 Tianshui Rd, Lanzhou 730000, Peoples R China; [Li, Chao-Jun] McGill Univ, Dept Chem, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada; [Li, Chao-Jun] McGill Univ, FQRNT Ctr Green Chem & Catalysis, 801 Sherbrooke St West, Montreal, PQ H3A 0B8, Canada in 2021, Cited 63. Formula: C7H8O2. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Phenols are common precursors and core structures of a variety of industrial chemicals ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcohols by a dearomatization-rearomatization strategy, with water as the sole by-product. Various substituted phenols and primary alcohols were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

Formula: C7H8O2. About m-Methoxyphenol, If you have any questions, you can contact Yu, JJ; Li, CJ; Zeng, HY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery of Carboline Derivatives as Potent Antifungal Agents for the Treatment of Cryptococcal Meningitis WOS:000461537000012 published article about FLUCONAZOLE; COMBINATION in [Tu, Jie; Li, Zhuang; Jiang, Yanjuan; Ji, Changjin; Han, Guiyan; Wang, Yan; Liu, Na; Sheng, Chunquan] Second Mil Med Univ, Sch Pharm, Dept Med Chem, 325 Guohe Rd, Shanghai 200433, Peoples R China in 2019.0, Cited 40.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Formula: C7H8O2

Clinical treatment of cryptococcal meningitis (CM) remains a significant challenge because of the lack of effective and safe drug therapies. Developing novel CM therapeutic agents with novel chemical scaffolds and new modes of action is of great importance. Herein, new beta-hexahydrocarboline derivatives are shown to possess potent anticryptococcal activities. In particular, compound A4 showed potent in vitro and in vivo anticryptococcal activity with good metabolic stability and blood-brain barrier permeability. Compound A4 was orally active and could significantly reduce brain fungal burdens in a murine model of CM. Moreover, compound A4 could inhibit several virulence factors of Cryptococcus neoformans and might act by a new mode of action. Preliminary mechanistic studies revealed that compound A4 induced DNA double-stranded breaks and cell cycle arrest at the G2 phase by acting on the Cdc25c/CDK1/cyclin B pathway. Taken together, beta-hexahydrocarboline A4 represents a promising lead compound for the development of next-generation CM therapeutic agents.

About m-Methoxyphenol, If you have any questions, you can contact Tu, J; Li, Z; Jiang, YJ; Ji, CJ; Han, GY; Wang, Y; Liu, N; Sheng, CQ or concate me.. Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CATIONIC-POLYMERIZATION; EFFICIENT SYNTHESIS; CHEMISTRY; SILYLKETENES; POLYMERS, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [NSF 1807510]; NSFNational Science Foundation (NSF) [MRI-1334048]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mitchell, SM; Xiang, Y; Matthews, R; Arnburgey, AM; Pentzer, EB. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol. Product Details of 150-19-6

Silyl-substituted ketenes are attractive molecular building blocks due to their stability and ease of storage, as opposed to unstable alkyl and aryl ketenes. To better understand the reactivity of silyl ketenes and, in turn, their use in the preparation of highly functionalized small molecules, the reaction of silyl ketenes with different nucleophiles was studied. The addition of alcohol, amine, or thiol nucleophiles to the central carbon of silyl ketene, followed by proton transfer afforded alpha-silyl ester, amide, or thio-ester, respectively. Catalytic amounts of Lewis acid greatly increase the rate of the reaction, and the impact of nucleophile, Lewis acid, and silyl substituent are evaluated. The small molecules produced from these reactions give insight into the use of silyl ketenes as building blocks for complex molecular structures.

About m-Methoxyphenol, If you have any questions, you can contact Mitchell, SM; Xiang, Y; Matthews, R; Arnburgey, AM; Pentzer, EB or concate me.. Product Details of 150-19-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O2. Utsumi, T; Noda, K; Kawauchi, D; Ueda, H; Tokuyama, H in [Utsumi, Tatsuki; Noda, Kenta; Kawauchi, Daichi; Ueda, Hirofumi; Tokuyama, Hidetoshi] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Aoba 6-3 Aramaki, Sendai, Miyagi 9808578, Japan published Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst in 2020, Cited 64. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered beta,beta-disubstituted amines, allylamine, benzylamines, and alpha-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ.

About m-Methoxyphenol, If you have any questions, you can contact Utsumi, T; Noda, K; Kawauchi, D; Ueda, H; Tokuyama, H or concate me.. Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of m-Methoxyphenol. Recently I am researching about SPHINGOSINE 1-PHOSPHATE; FINGOLIMOD FTY720; ORAL FINGOLIMOD; BMS-986104; PREDICTION; ARTHRITIS; S1P1, Saw an article supported by the . Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Xiao, ZL; Yang, MG; Dhar, TGM; Xiao, HY; Gilmore, JL; Marcoux, D; McIntyre, KW; Taylor, TL; Shi, H; Levesque, PC; Marino, AM; Cornelius, G; Mathur, A; Shen, DR; Cvijic, ME; Lehman-McKeeman, LD; Sun, HD; Xie, JH; Carter, PH; Dyckman, AJ. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

Efforts aimed at increasing the in vivo potency and reducing the elimination half-life of 1 and 2 led to the identification of aryl ether and thioether-derived bicyclic S1P(1) differentiated modulators 3-6. The effects of analogs 3-6 on lymphocyte reduction in the rat (desired pharmacology) along with pulmonary- and cardiovascular-related effects (undesired pharmacology) are described. Optimization of the overall properties in the aryl ether series yielded 3d, and the predicted margin of safety against the cardiovascular effects of 3d would be large enough for human studies. Importantly, compared to 1 and 2, compound 3d had a better profile in both potency (ED50 < 0.05 mg/kg) and predicted human half-life (t(1/2) similar to 5 days). Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Xiao, ZL; Yang, MG; Dhar, TGM; Xiao, HY; Gilmore, JL; Marcoux, D; McIntyre, KW; Taylor, TL; Shi, H; Levesque, PC; Marino, AM; Cornelius, G; Mathur, A; Shen, DR; Cvijic, ME; Lehman-McKeeman, LD; Sun, HD; Xie, JH; Carter, PH; Dyckman, AJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021.0 J ASIAN NAT PROD RES published article about PHYTOPHTHORA-CAPSICI; BOTRYTIS-CINEREA; TREE PEONY; ANALOGS; RESISTANCE; SEED in [Tian, Yue-E; Sun, Di; Han, Xiao-Xiao; Yang, Jin-Ming; Zhang, Song; Feng, Nan-Nan; Zhu, Li-Na; Xu, Zhong-Yuan; Che, Zhi-Ping; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang] Henan Univ Sci & Technol, Coll Forestry, Dept Plant Protect, Lab Pharmaceut Design & Synth, Luoyang 471023, Peoples R China in 2021.0, Cited 25.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Name: m-Methoxyphenol

Three series of sulfonate derivatives of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, respectively. Among all the compounds, 4m displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 26.87 mg/L, respectively. The results show that acetyl and 4-OCH3 are two necessary groups. The existence of these two sites is closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group is well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased. [GRAPHICS] .

Name: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Tian, YE; Sun, D; Han, XX; Yang, JM; Zhang, S; Feng, NN; Zhu, LN; Xu, ZY; Che, ZP; Liu, SM; Lin, XM; Jiang, J; Chen, GQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 ACS OMEGA published article about SOLVENT-FREE SYNTHESIS; SOLID ACID CATALYST; ONE-POT SYNTHESIS; RECYCLABLE CATALYST; EFFICIENT; DERIVATIVES; NANOCOMPOSITES; KNOEVENAGEL; TRIFLATE; REAGENT in [Jadhav, Nirajkumar H.; Rasal, Nishant K.; Pawar, Ramdas A.] PDEAs Baburaoji Gholap Coll, Dept Chem, Pune 411027, Maharashtra, India; [Sakate, Sachin S.] PE Soc Modern Coll Arts Sci & Commerce, Pune 411005, Maharashtra, India; [Shinde, Dnyaneshwar R.; Pawar, Ramdas A.] PDEAs Prof Ramkrishna More Coll, Pune 411044, Maharashtra, India; [Jadhav, Nirajkumar H.] Dr DY Patil Sch Engn, Pune 412105, Maharashtra, India in 2019.0, Cited 59.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Application In Synthesis of m-Methoxyphenol

A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn0.925Ti0.075O having a high surface area and good Lewis acidity. The catalyst shows high activity toward a broad spectrum of the substituted phenols with beta-ketoesters such as ethyl acetoacetate, ethyl butyryl acetate, ethyl benzoyl acetate, and so forth in good yields over short reaction times during the synthesis of coumarins. The methodology was further extended for the synthesis of ayapin molecules. The catalyst also shows recycle activity up to seven cycles with very good stability.

About m-Methoxyphenol, If you have any questions, you can contact Jadhav, NH; Sakate, SS; Rasal, NK; Shinde, DR; Pawar, RA or concate me.. Application In Synthesis of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of m-Methoxyphenol. In 2020.0 CHEM COMMUN published article about TO-TAIL DIMERIZATION; DRUG DISCOVERY; BAYLIS-HILLMAN; IN-SITU; ACRYLONITRILE; SULFONAMIDES; INHIBITORS; FLUOROSULFONYLVINYLATION; CYCLOADDITION; DERIVATIVES in [Li, Chen; Zheng, Yujie; Rakesh, K. P.; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, State Key Lab Silicate Mat Architectures, 205 Luoshi Rd, Wuhan 430070, Peoples R China in 2020.0, Cited 65.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A versatile selectively addressable SuFEx click chemistry hub, but-3-ene-1,3-disulfonyl difluoride (BDF) was designed and synthesized through head-to-tail dimerization of ethenesulfonyl fluoride (ESF). BDF possesses three active sites to selectively participate in the construction of 4-membered, 5-membered and 6-membered cyclic sulfonamide (sultams) bearing aliphatic sulfonyl fluoride moieties for further manipulations in a fast, efficient and practical manner.

About m-Methoxyphenol, If you have any questions, you can contact Li, C; Zheng, YJ; Rakesh, KP; Qin, HL or concate me.. Application In Synthesis of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H8O2. Authors Kawamoto, Y; Kobayashi, T; Ito, H in AMER CHEMICAL SOC published article about in [Kawamoto, Yuichiro; Kobayashi, Toyoharu; Ito, Hisanaka] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 1920392, Japan in 2021.0, Cited 22.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Stachyodin A, possessing a unique spirotetrahydrofuran ring system, was isolated from the roots of Indigofera stachyodes in 2018. The first total synthesis of racemic stachyodin A was accomplished in 14 steps. The efficient stereoselective synthetic route involved one-pot Suzuki coupling and stereocontrolled epoxidation followed by reductive opening and spirocyclization.

About m-Methoxyphenol, If you have any questions, you can contact Kawamoto, Y; Kobayashi, T; Ito, H or concate me.. HPLC of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Novel 6-Aryloxy-4-chloro-2-phenylpyrimidines as Fungicides and Herbicide Safeners WOS:000575417400054 published article about ANTIFUNGAL ACTIVITY; DESIGN; PYRIMETHANIL; DERIVATIVES; INHIBITOR in [Deng, Xile; Zheng, Wenna; Jin, Can; Bai, Lianyang] Hunan Acad Agr Sci, Hunan Agr Biotechnol Res Inst, Key Lab Biol & Control Weeds, Changsha 410125, Peoples R China in 2020, Cited 68. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Quality Control of m-Methoxyphenol

Fenclorim is a commercial herbicide safener with fungicidal activity used for chloroacetanilide herbicides, which might be suitable as a lead compound for screening novel fungicides. However, little has been reported so far on the structure-activity relationship of fungicidal activities of fenclorim or its analogues. Here, a series of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was synthesized by a substructure splicing route using fenclorim as a lead compound. The structures of synthesized derivatives were characterized by H-1 NMR, C-13 NMR, and HRMS. Their fungicidal and herbicide safening activities were then evaluated. The results revealed that compound 11 had the best fungicidal activity against Sclerotinia sclerotiorum and Thanatephorus cucumeris, which was better than that of the control pyrimethanil. Moreover, compounds 3, 5, and 25 exhibited excellent safening activities against fresh weight, plant height, and root length, respectively. Such activities were significantly improved when compared to fenclorim. In summary, these findings look promising for the preparation of new fungicides and herbicide safeners based on the structure of fenclorim.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Deng, XL; Zheng, WN; Jin, C; Bai, LY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles