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The Tet1 and histone methylation expression pattern in dairy goat testis

DNA methylation and histone methylation are critical for mammalian development. Ten-eleven translocation (Tet1), a key regulator of DNA methylation, has been identified as a key enzyme for the activation of DNA demethylation; histone H3 lysine 9 (H3K9) and 27 (H3K27) methylation repress gene expression. Significant progress on the biological functions of Tet proteins has been made in mice and humans. However, their expression pattern and function in the male germ cells in the dairy goat testis are still unclear. The present study described the expression pattern of Tet1, H3K9, and H3K27 in the dairy goat testis and cultured goat spermatogonia stem cells (gSSCs). The results showed that Tet1 was weakly expressed in the dairy goat’s testis compared to other organ tissues. Tet1, 5-hydroxymethylcytosine, H3K9, and H3K27 expressions were positive and dynamically changing during spermatogenesis; however, they showed weak expression in neonate stage invivo. Tet1 and 5-hydroxymethylcytosine showed low expression in gSSCs invitro in differentiated cultures. These will provide new perspectives for DNA methylation/demethylation and better regulation of epigenetic modifications in gSSCs.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 16096-33-6, help many people in the next few years.Computed Properties of C14H11N

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Green synthesis of predominant (1 1 1) facet CuO nanoparticles: Heterogeneous and recyclable catalyst for N-arylation of indoles

Well faceted CuO nanoparticles were synthesized by thermal-assisted green strategy at reflux temperature in a short period of time. A possible growth mechanism of such highly faceted nanostructures based on typical biomolecule-crystal interactions in aqueous solution is tentatively proposed. The large surface area (223.36 m2/g) and rich exposed active sites are expected to endow such nanostructures with excellent performances in catalysis as demonstrated here for remarkable catalytic activity with respect to the N-arylation of indoles. Nanoparticles were characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. Both the activity and selectivity of the N-arylation reactions could be tuned by varying the concentration of CuO nanoparticles. Nanoparticles catalyst were recycled and reused for further catalytic reactions with minimal loss in activity. A variety of indole derivatives afforded corresponding N-arylation product with excellent yields (up to 98%).

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Cu(OAc)2¡¤H2O-catalyzed N-arylation of nitrogen-containing heterocycles

In the absence of any additional ligands, the efficient N-arylation of nitrogen-containing heterocycles with aryl iodides catalyzed by relative low catalyst amount of Cu(OAc)2¡¤H2O was developed. This simple catalytic system is involved in the C-N cross-coupling reaction and works for a variety of pyrazole, pyrrole, imidazole, triazole, indole, benzoimidazole, benzotriazole, carbazole, and anilines as well as aryl iodides with different electronic properties. Highly efficient copper(II)-catalyzed N-arylation protocol was established.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Iodide-mediated or iodide-catalyzed demethylation and friedel-crafts C-H borylative cyclization leading to thiophene-fused 1,2-oxaborine derivatives

The first synthesis of dithieno-1,2-oxaborine derivatives was achieved via iodide-mediated or iodide-catalyzed demethylation of 3-methoxy-2,2?-bithiophene and subsequent C-H borylation. A wide variety of thiophene-fused oxaborines could be synthesized by the procedure.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Palladium-catalyzed c(sp2)-n bond cross-coupling with triaryl phosphates

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(-cinnamyl)Cl]2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Highly reusable support-free copper(II) complex of para-hydroxy-substituted salen: Novel, efficient and versatile catalyst for C?N bond forming reactions

An air-stable, highly active and versatile method for C?N bond forming reactions is reported. Under mild conditions using a highly reusable support-free Cu(II)?salen complex, structurally diverse N-aryl-substituted compounds were obtained via direct C?N bond forming reaction of HN-heterocycles with aryl iodides or three-component C?N bond forming reaction of 2-bromobenzaldehyde, aniline derivatives and sodium azide in good to excellent yields. C?N bond forming reaction for benzimidazole derivatives was also performed in the presence of the catalyst under ambient conditions. A series of hybrid benzimidazoles bearing morpholine, tetrazole and quinoxaline backbones were produced using this method. All reactions were performed in short times under air. The Cu(II) catalyst could be reused up to eight times in the direct cross-coupling reaction of 9H?carbazole with iodobenzene without any decrease in its catalytic activity.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Electric Literature of 16096-33-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.16096-33-6, Name is 1-Phenyl-1H-indole, molecular formula is C14H11N. In a Article£¬once mentioned of 16096-33-6

Highly reusable support-free copper(II) complex of para-hydroxy-substituted salen: Novel, efficient and versatile catalyst for C?N bond forming reactions

An air-stable, highly active and versatile method for C?N bond forming reactions is reported. Under mild conditions using a highly reusable support-free Cu(II)?salen complex, structurally diverse N-aryl-substituted compounds were obtained via direct C?N bond forming reaction of HN-heterocycles with aryl iodides or three-component C?N bond forming reaction of 2-bromobenzaldehyde, aniline derivatives and sodium azide in good to excellent yields. C?N bond forming reaction for benzimidazole derivatives was also performed in the presence of the catalyst under ambient conditions. A series of hybrid benzimidazoles bearing morpholine, tetrazole and quinoxaline backbones were produced using this method. All reactions were performed in short times under air. The Cu(II) catalyst could be reused up to eight times in the direct cross-coupling reaction of 9H?carbazole with iodobenzene without any decrease in its catalytic activity.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Analysis of photofading of phenylazo-indole and phenylazo-N-ethanolaniline disperse dyes on poly(ethylene terephthalate) fabric using the PM5 method

The photofading behaviors of phenylazo-N-(ethanol)aniline and phenylazo-indole, nitrohetarylazo-N-substituted aniline disperse dyes on poly(ethylene terephthalate) (PET) substrate were analyzed using the Kubelka-Munk (K/S) parameters of the dyed fabrics exposed to a carbon arc in air. The initial experimental slopes (KPET) of fading on PET were estimated from the time profiles of the K/S values at the lambdamax. The rates (k0,i) of reaction of these dyes with 1O2 were estimated by frontier orbital theory using the PM5 method. The photosensitivities (fi) of the dyes were estimated from the KPET assuming that the KPET values are proportional to the product of k0,i and fi. Dyes with small fi values, irrespective of their k0,i values, possess excellent lightfastness (LF), while dyes with larger fi values possess poorer LF. The validity of estimating k0,i values by the MO method was confirmed experimentally by analyzing the mutually photosensitized fading behaviors of combination dyeings.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Photoredox Catalysis Induced Bisindolylation of Ethers/Alcohols via Sequential C-H and C-O Bond Cleavage

A visible-light-engaged 2-fold site-selective alkylation of indole derivatives with aliphatic ethers or alcohols has been accomplished for easy access to symmetric 3,3?-bisindolylmethane derivatives. The experimental data suggest a sequential photoredox catalysis induced radical addition and proton-mediated Friedel-Crafts alkylation mechanism.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Ligand complex of copper (II) supported on superparamagnetic Fe3O4aSiO2 nanoparticles: an efficient and magnetically separable catalyst for N-arylation of nitrogen-containing heterocycles with aryl halides

In this study, we introduce the ligand complex of copper (II) supported on superparamagnetic Fe3O4aSiO2 nanoparticles as a highly intriguing magnetic catalyst in N-arylation of nitrogen heterocycles with aryl halides. The present methodology offers several advantages such as; low catalyst loading, the use of magnetically recoverable and reusable catalyst, high to excellent yields without using any external ligands or additives, short reaction times and simplicity of operation. Also, the magnetic catalyst could be easily separated from the final product by an external magnet and reused up to seven times without any significant loss of activity. Therefore, this separation strategy with negligible leaching makes Fe3O4aSiO2/ligand/Cu(II) an economical catalyst to perform this transformation.

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Reference£º
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles