Category: 2208-59-5

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Solvothermal Synthesis and Diverse Coordinate Structures of a Series of Luminescent Copper(I) Thiocyanate Coordination Polymers Based on N-Heterocyclic Ligands.Category: indole-building-block.

Solvothermal reactions of CuSCN with 4-amino-3,5-bis(3-pyridyl)-1,2,4-triazole (3-Abpt), 5-(4-pyridyl)tetrazole (4-Ptz), and 2-(n-pyridyl)benzimidazole (n-PyHBIm, n = 4, 3, 2) in MeCN afford six novel coordination polymers: [Cu5(SCN)5(3-Abpt)2]n (1), [Cu(SCN)(3-Abpt)]n (2), [Cu(SCN)(4-Ptz)]n (3), [Cu2(SCN)2(4-PyHBIm)]n (4), [Cu2(SCN)2(3-PyHBIm)]n (5), and [Cu2(SCN)2(2-PyBIm)(2-PyHBIm)]n (6). All these complexes were structurally characterized by x-ray diffraction anal. 1 Is the 1st example of a 1,1,1,3-μ4-tetradentate thiocyanate complex which displays a three-dimensional (3D) polymeric framework constructed from thiocyanate and tetradentate 3-Abpt. 2 Exhibits a two-dimensional (2D) 4.82 network constructed from unidentate thiocyanate and tridentate 3-Abpt. 3 Is a 1-dimensional (1D) ladder-like double-chain polymer assembled by bidentate thiocyanate and 4-Ptz ligands. 4 Shows a 2-dimensional 1,1,3-μ3-thiocyanate Cu 4.82 network where bidentate 4-PyHBIm locates at both sides of the 2-dimensional layer. 5 Displays a 2-dimensional 63 network constructing from 1,1,3-μ3-thiocyanate and bidentate 3-PyHBIm. 6 Is a 1-dimensional 21 helical chain polymer constructing from 1,3-μ2-thiocyanate and 2-PyBIm anion. Bond valence sum (BVS) anal. and magnetic susceptibility indicate that 6 is a mixed-valence compound The coordinate diversity of thiocyanate is discussed. 1-6 Are all thermally stable up to 230-290°. They exhibit yellow or blue luminescence originating from ligand-to-metal charge transfer or ligand-centered emission.

Different reactions of this compound(2-(Pyridin-4-yl)-1H-benzo[d]imidazole)Category: indole-building-block require different conditions, so the reaction conditions are very important.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Journal of Physical Chemistry called Photophysics of three pyridylbenzimidazoles in solution, Author is Brown, Robert G.; Entwistle, Neil; Hepworth, John D.; Hodgson, Kevin W.; May, Bernadette, the main research direction is fluorescence decay pyridylbenzimidazole; benzimidazole pyridyl hydrogen transfer alc.Computed Properties of C12H9N3.

Fluorescence decay time data are presented for the three benzimidazoles with pyridine substituted at the 2 position. The anomalous behavior of 2-(2′-pyridyl)benzimidazole in alcs. is explained in terms of the alc. facilitating H transfer from the imidazole ring to the pyridine N atom. The rate constants for this process are determined by studying the quenching of the fluorescence of 2-(2′-pyridyl)benzimidazole in cyclohexane by EtOH.

The article 《Photophysics of three pyridylbenzimidazoles in solution》 also mentions many details about this compound(2208-59-5)Computed Properties of C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides. Author is Moorthy, Jarugu Narasimha; Neogi, Ishita.

A variety of primary (mostly benzylic) alcs. react with o-phenylenediamine to give benzimidazoles in one pot using IBX in DMSO as the oxidant at room temperature Arylmethyl bromides also undergo oxidative cyclocondensation with o-phenylenediamine under similar conditions to give benzimidazoles in moderate yields, albeit at slightly elevated temperatures

The article 《IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides》 also mentions many details about this compound(2208-59-5)Product Details of 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins. Author is Khorwal, Vijaykant; Sadhu, Biswajit; Dey, Arghya; Sundararajan, Mahesh; Datta, Anindya.

2-(4′-Pyridyl)benzimidazole (4PBI) can exist in several states of protonation, having three basic nitrogen atoms. The equilibrium involving these states, in ground as well as in excited states, are found to be affected significantly by cyclodextrins (CDs). The formation of inclusion complexes of this compound with all three varieties of cyclodextrins is observed to be more favorable at pH 9 than at pH 4, due to the predominance of the neutral form of dye at pH 9. The binding affinity of 4PBI to CDs is found to be governed by two factors: (i) the size of the host and (ii) the mode of insertion of 4PBI. We find that, for the host with a smaller cavity (α-CD), insertion of the dye with a pyridyl face is favored, whereas, for γ-CD, the preference is shifted toward the benzimidazole face of the dye. For β-CD, the binding affinity of the dye is maximum due to perfect cavity matching with the guest. A combination of steric factor and hydrogen bonding interaction is found to be responsible for modulation of the protonation-deprotonation equilibrium of the guest mol. in the inclusion complex. Surprisingly, a protonated form is found to be promoted upon inclusion in cyclodextrins, under certain conditions. This is an unusual behavior and has been rationalized by prototropism involving the hydroxyl protons of cyclodextrin mols.

The article 《Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins》 also mentions many details about this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Journal of Physical Chemistry called Photophysics of three pyridylbenzimidazoles in solution, Author is Brown, Robert G.; Entwistle, Neil; Hepworth, John D.; Hodgson, Kevin W.; May, Bernadette, the main research direction is fluorescence decay pyridylbenzimidazole; benzimidazole pyridyl hydrogen transfer alc.Computed Properties of C12H9N3.

Fluorescence decay time data are presented for the three benzimidazoles with pyridine substituted at the 2 position. The anomalous behavior of 2-(2′-pyridyl)benzimidazole in alcs. is explained in terms of the alc. facilitating H transfer from the imidazole ring to the pyridine N atom. The rate constants for this process are determined by studying the quenching of the fluorescence of 2-(2′-pyridyl)benzimidazole in cyclohexane by EtOH.

The article 《Photophysics of three pyridylbenzimidazoles in solution》 also mentions many details about this compound(2208-59-5)Computed Properties of C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides. Author is Moorthy, Jarugu Narasimha; Neogi, Ishita.

A variety of primary (mostly benzylic) alcs. react with o-phenylenediamine to give benzimidazoles in one pot using IBX in DMSO as the oxidant at room temperature Arylmethyl bromides also undergo oxidative cyclocondensation with o-phenylenediamine under similar conditions to give benzimidazoles in moderate yields, albeit at slightly elevated temperatures

The article 《IBX-mediated one-pot synthesis of benzimidazoles from primary alcohols and arylmethyl bromides》 also mentions many details about this compound(2208-59-5)Product Details of 2208-59-5, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins. Author is Khorwal, Vijaykant; Sadhu, Biswajit; Dey, Arghya; Sundararajan, Mahesh; Datta, Anindya.

2-(4′-Pyridyl)benzimidazole (4PBI) can exist in several states of protonation, having three basic nitrogen atoms. The equilibrium involving these states, in ground as well as in excited states, are found to be affected significantly by cyclodextrins (CDs). The formation of inclusion complexes of this compound with all three varieties of cyclodextrins is observed to be more favorable at pH 9 than at pH 4, due to the predominance of the neutral form of dye at pH 9. The binding affinity of 4PBI to CDs is found to be governed by two factors: (i) the size of the host and (ii) the mode of insertion of 4PBI. We find that, for the host with a smaller cavity (α-CD), insertion of the dye with a pyridyl face is favored, whereas, for γ-CD, the preference is shifted toward the benzimidazole face of the dye. For β-CD, the binding affinity of the dye is maximum due to perfect cavity matching with the guest. A combination of steric factor and hydrogen bonding interaction is found to be responsible for modulation of the protonation-deprotonation equilibrium of the guest mol. in the inclusion complex. Surprisingly, a protonated form is found to be promoted upon inclusion in cyclodextrins, under certain conditions. This is an unusual behavior and has been rationalized by prototropism involving the hydroxyl protons of cyclodextrin mols.

The article 《Modulation of Protonation-Deprotonation Processes of 2-(4′-Pyridyl)benzimidazole in Its Inclusion Complexes with Cyclodextrins》 also mentions many details about this compound(2208-59-5)Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C12H9N3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Synthesis and structure of a binuclear zinc complex [(ZnCl2)(PyBIm)]2. Author is Zhang, Quan-Zheng; Nie, Jiang-Hui; Zhou, Xu; Lu, Hong-Dian; Tian, Chang-An; Zhao, Di-Fang.

A new binuclear zinc complex [(ZnCl2)(PyBIm)]2 (PyBIm = 2-(4-pyridyl)benzimidazole) was synthesized by hydrothermal reaction. The complex crystallizes in triclinic space group P21/n with crystal cell parameters of a 0.77451(4)nm, b = 1.25249( 5) nm, c 1.31596(7) nm, β 100.294(3)° and Z = 2. The crystal x-ray anal. shows that Zn atom is coordinated by two Cl atoms and two N atoms from two PyBIm ligands in a distorted tetrahedral geometry. The Zn···Zn separation is 0.7094(5) nm, and the hydrogen bonding and π···π interactions also exist in the structure.

The article 《Synthesis and structure of a binuclear zinc complex [(ZnCl2)(PyBIm)]2》 also mentions many details about this compound(2208-59-5)Formula: C12H9N3, you can pay attention to it, because details determine success or failure

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 2208-59-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Four new compounds based on terephthalate and 2-(4-pyridyl)benzimidazole ligands. Author is Xia, Chang-Kun; Wu, Yun-Long; Xie, Ji-Min.

Four compounds based on H2BDC and PyBIm [H2BDC = 1,4-benzenedicarboxylic acid, PyBIm = 2-(4-pyridyl)benzimidazole], (PyBIm)(H2BDC)0.5 (1), Co(PyBIm)2(HBDC)(BDC)0.5 (2), Ni(PyBIm)2(HBDC)(BDC)0.5 (3), and Zn(BDC)(PyBIm).H2O (4), were synthesized by hydrothermal methods and characterized by x-ray diffraction. Compound 1 contains 2 types of H-bonding N-H···N and O-H···N, which connect the mols. into a 2D layer. Complex 2 crystallizes isostructural to 3 in triclinic space group P1̅, in 1D chains. The H-bonding interactions between uncoordinated N, N-H, and COOH groups in 2 connect the 1D chains into a 2D layer. Complex 4 displays a 1D structure, which is finally extended to a 3D supramol. framework by H-bonding and π-π packing interactions. The magnetic properties of 2 and 3 were studied as well.

After consulting a lot of data, we found that this compound(2208-59-5)Product Details of 2208-59-5 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2208-59-5, is researched, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Sequence-specific fluorometric recognition of HIV-1 ds-DNA with zwitterionic zinc(II)-carboxylate polymers, Author is Sun, Bin; Zhao, Hai-Qing; Xie, Bao-Ping; Bai, Li-Ping; Jiang, Zhi-Hong; Chen, Jin-Xiang, the main research direction is HIV1 DNA fluorescent probe zwitterionic zinc carboxylate polymer; organic metal framework zwitterionic zinc carboxylate polymer synthesis; Crystal structure; Fluorescence detection; HIV-1 ds-DNA recognition; Water-stable MOF.Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole.

Four water-stable zwitterionic zinc-carboxylate polymers are prepared by reacting N-carboxymethyl-(3,5-dicarboxy)-pyridinium bromide (H3CmdcpBr) with zinc(II) nitrate in the presence of NaOH, through adjusting the solvents and ancillary ligands. With H2O as the solvent and the absence of an ancillary ligand, a two-dimensional (2D) polymer network [Zn(Cmdcp)(H2O)]n (1) is formed. In a mixed H2O/DMF solvent and with the presence of chelating ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen) and 2-(4-pyridyl)benzimidazole (pbz), a one-dimensional (1D) polymer of {[Zn2(Cmdcp)(bipy)2(H2O)5](NO3)2·3H2O}n (2), a mononuclear ionic species of [Zn(phen)(H2O)4][Cmdcp] (3), and a 2D polymer of {[Zn(Cmdcp)(pbz)][pbz]·7H2O}n (4) are accordingly formed. Compounds 1-4 are characterized by IR, elemental analyses and single crystal X-ray crystallog. Compound 2 strongly adsorbs single-stranded DNA (ss-DNA) probe (denoted as P-DNA) labeled with carboxyfluorescein (FAM) and quenches its fluorescence via a photo-induced electron transfer process. If, however, a double-stranded DNA (ds-DNA) of the human immunodeficiency virus 1 (HIV-1 ds-DNA) is further present, the P-DNA interacts with the major groove in HIV-1 ds-DNA via Hoogsteen hydrogen bonding to form a rigid triplex structure. This results in partial or complete fluorescence recovery depending on the concentration of HIV-1 ds-DNA. The findings are applied in fluorometric sensing of HIV-1 ds-DNA. The calibration plot is linear in the 0-60 nM target DNA concentration range, with a 7.4 nM detection limit (at a signal-to-noise ratio of 3). The assay is highly specific and not interfered by one base pair mutated for complementary target HIV-1 ds-DNA, complementary ss-DNA, single-base pair mutated for complementary ss-DNA, non-specific ss-DNA sequences, and higher-order dimeric G-quadruplexes.

After consulting a lot of data, we found that this compound(2208-59-5)Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles