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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Lin, Songzhu; Jia, Ruokun; He, Aimin; Gao, Xiaoli researched the compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole( cas:2208-59-5 ).Application of 2208-59-5.They published the article 《Glutaric acid-2-(pyridin-4-yl)-1H-benzimidazole (1/1)》 about this compound( cas:2208-59-5 ) in Acta Crystallographica, Section E: Structure Reports Online. Keywords: crystal structure glutaric acid pyridinylbenzimidazole; mol structure glutaric acid pyridinylbenzimidazole; hydrogen bond glutaric acid pyridinylbenzimidazole; pi stacking glutaric acid pyridinylbenzimidazole; benzimidazole pyridinyl glutaric acid crystal mol structure; imidazole pyridinylbenz glutaric acid crystal mol structure. We’ll tell you more about this compound (cas:2208-59-5).

The crystal structure of glutaric acid-2-(pyridin-4-yl)-1H-benzimidazole 1:1 complex, C12H9N3·C5H8O4, N-H···O and O-H···N H bonds link the components. There are also π-π stacking interactions between the imidazole rings, between the imidazole and pyridine rings and between the pyridine and benzene rings [centroid-centroid distances = 3.643(2), 3.573(2) and 3.740(1) Å, resp.]. Crystallog. data are given.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Quality Control of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Efficient propylphosphonic anhydride (T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles. Author is Wen, Xiaoan; Bakali, Jamal El; Deprez-Poulain, Rebecca; Deprez, Benoit.

Propylphosphonic anhydride (T3P) promotes cyclization of o-aminobenzenethiol, o-aminophenol, and o-phenylenediamine with carboxylic acids under microwave irradiation The one-pot procedure is efficient and allows short reaction times, easy workup, and good yields. Thus, we describe here a method for quick preparation of benzothiazoles, benzoxazoles and benzimidazoles.

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Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Rare 5-connected BN topology in homochiral Cd(II) camphorate with 2-(4-pyridyl)benzimidazole. Author is Li, Fei; Kang, Yao; Dai, Yu-Mei; Zhang, Jian.

A photoluminescent homochiral Cd(II) camphorate with auxiliary 2-(4-pyridyl)benzimidazole ligand metal-organic framework adopting the 5-connected BN topol. has been prepared, and its crystal structure was determined

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COA of Formula: C12H9N3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Syntheses, structures, and properties of transition metal complexes with 2-(n-pyridyl)benzimidazole (n = 2, 3, and 4). Author is Zhou, Ying-Xia; Li, Xia; Zhang, Hai-Yan; Fan, Cai-Ling; Zhang, Hong-Yun; Wu, Ben-Lai.

Three pyridylbenzimidazoles (2-PBIM, 3-PBIM, and 4-PBIM) were prepared (2-PBIM: 2-(2-pyridyl)-benzimidazole, 3-PBIM: 2-(3-pyridyl)-benzimidazole, 4-PBIM: 2-(4-pyridyl)-benzimidazole). Reactions of several transition metals (Cd2+, Cu2+, Fe2+) with the three ligands gave four new coordination complexes, [(Cd)2(2-PBIM)2(CH3COO)4] (1), [Cu(3-PBIM)2(CH3COO)2]·2H2O (2), [Cu(4-PBIM)2(CH3COO)2(H2O)]·H2O (3), and [Fe(4-PBIM)2(Cl)2(H2O)2] (4), resp. These four complexes were characterized by x-ray crystallog., IR spectroscopy, and UV absorption spectroscopy. Thermogravimetric properties of 2 and 4 were also measured. X-ray crystallog. studies reveal that these four complexes are very different, although the ligands are similar in structure. The role of hydrogen-bonding and π-π interactions in extending dimensionality of simple complexes is discussed.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Polyhedron called Pyridyl benzimidazole, benzoxazole, and benzothiazole platinum complexes, Author is He, Xiao-Feng; Vogels, Christopher M.; Decken, Andreas; Westcott, Stephen A., which mentions a compound: 2208-59-5, SMILESS is C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1, Molecular C12H9N3, Product Details of 2208-59-5.

Addition of 2-(pyrid-2(3,4)-yl)-benzimidazole, -benzoxazole, and -benzothiazole (LP) to [PtCl2(coe)]2 (coe = cis-cyclooctene) or K2PtCl4 gives bidentate cis-PtCl2(LP) or monodentate cis-PtCl2(LP)2 in moderate to high yields. Crystals of cis-dichloro(2-pyrid-2-ylbenzothiazole)platinum(II) as the CH2Cl2 solvate were triclinic, space group P1̅, a 7.8715(6), b 9.9873(7), c 10.5883(8) Å, α 104.149(1), β 103.754(1), γ 96.864(1)°, Z = 2. Cis-dichlorodi(2-pyrid-3-ylbenzoxazole)platinum(II) crystallized with a mol. of THF and H2O and were monoclinic, space group C2/c, a 18.698(10), b 16.325(10), c 8.853(6) Å, β 90.149(17)°, Z = 4.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2208-59-5, is researched, Molecular C12H9N3, about pH-Dependent Assembly of 1D to 3D Octamolybdate Hybrid Materials Based on a New Flexible Bis-[(pyridyl)-benzimidazole] Ligand, the main research direction is pH dependent preparation octamolybdate copper pyridylbenzimidazolebutane polymer; crystal structure octamolybdate copper pyridylbenzimidazolebutane polymer.Synthetic Route of C12H9N3.

Four octamolybdate hybrid materials based on a new flexible multidentate ligand, namely, H4L(γ-Mo8O26)·2H2O (1), [Cu(H2L)(β-Mo8O26)(H2O)2]·3H2O (2), [Cu(H2L)(γ-Mo8O26)]·3H2O (3), and Cu(HL)2(β-Mo8O26) (4), where L is 1,1′-(1,4-butanediyl)bis[2-(4-pyridyl)benzimidazole], were synthesized at different pH values under hydrothermal conditions. Compound 1, which is hydrothermally prepared at pH ≈ 1, exhibits a rare 1-dimensional (1D) Mo oxide chain. Compounds 2 and 3 are hydrothermally obtained at pH ≈ 2.5. In 2, CuII cations are bridged by H2L2+ ligands and (β-Mo8O26)4- anions to form an interesting two-dimensional (2D) layer. In 3, the H2L2+ ligands and (γ-Mo8O26)4- clusters bridge adjacent CuII cations to form a 3-dimensional framework. When the pH value is adjusted to 3.5, compound 4 was obtained. Because the HL+ cation acts as a monodentate ligand, 4 only exhibits a 1-dimensional chain structure. The structural diversities of 1-4 reveal that the pH value of the reaction system plays a crucial role in the assembly of POM-based metal-organic frameworks (MOFs). The electrochem. property of compound 4 also was studied in 1 M H2SO4 aqueous solution

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Structural and luminescent properties of a series of Cd(II) pyridyl benzimidazole complexes that exhibit extended three-dimensional hydrogen bonded networks, published in 2017, which mentions a compound: 2208-59-5, mainly applied to cadmium pyridylbenzimidazole complex preparation crystal structure; thermal stability photoluminescence cadmium pyridylbenzimidazole complex, Formula: C12H9N3.

Five new coordination complexes, [CdI2(3-PyBim)4](H2O)3 (1), [Cd(SO4)(3-PyBim)(H2O)4] (2), [CdCl2(4-PyBim)2(H2O)2] (3), [CdBr2(4-PyBim)2(H2O)2] (4) and [CdI2(4-PyBim)2(H2O)2] (3) [=2-Pyridin-3-yl-1H-benzoimidazole, =2-Pyridin-4-yl-1H-benzoimidazole], were obtained under hydrothermal conditions and characterized by single crystal x-ray diffraction, IR, elemental anal., and powder X-ray diffraction. All of the complexes have mononuclear structures. Among the crystal structures of these complexes, there exist a variety of intermol. hydrogen bonding interactions and π···π interactions, which further extend to a 3-D supramol. architecture. The solid state photoluminescent properties of – vary with the electronegativity of the coordination anion. Addnl., the thermogravimetric analyses of these complexes are discussed.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole(SMILESS: C1(C2=CC=NC=C2)=NC3=CC=CC=C3N1,cas:2208-59-5) is researched.Recommanded Product: 2-Chloropyridine 1-oxide. The article 《Effects of 2-arylbenzimidazoles on rat hepatic microsomal monooxygenase system》 in relation to this compound, is published in Comparative Biochemistry and Physiology, Part C: Pharmacology, Toxicology & Endocrinology. Let’s take a look at the latest research on this compound (cas:2208-59-5).

The effects of eight newly synthesized 2-aryl substituted benzimidazole derivatives on control and phenobarbital (PB)-treated rat liver microsomal aniline 4-hydroxylase and ethylmorphine N-demethylase activities, and their binding to control and PB-treated rat liver microsomal oxidized cytochrome P 450 are presented. All compounds inhibited ethylmorphine N-demethylase activity with IC50 values ranging from 8.50 × 10-4 M to 27.83 × 10-4 M in control and from 2.80 × 10-4 M to 15.79 × 10-4 M in PB-treated rats. Aniline 4-hydroxylase activity was inhibited by all of the compounds tested having IC50 values in the range of 7.04 × 10-4 M to 31.37 × 10-4 M in PB-treated rats, but only five of the compounds showed inhibitory activity in control rats. Only a few significant regression coefficients could be found between the parameters of the chems. studied and their inhibitory patterns. No correlation has been observed between the binding of the derivatives and their inhibitory pattern. The compound 2-benzylbenzimidazole was prepared by refluxing o-phenylenediamine with phenylacetic acid.

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HPLC of Formula: 2208-59-5. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Ground and excited state prototropism of 2-(4′-pyridyl)benzimidazole in micelles. Author is Khorwal, Vijaykant; Datta, Anindya.

The effect of micelles on ground and excited state prototropism of 2-(4′-pyridyl)benzimidazole (4PBI) has been studied by fluorescence spectroscopy. It has been observed that in sodium dodecyl sulfate (SDS) micelle, 4PBI is preferentially protonated at the pyridyl nitrogen atom, in contrast to the situation in neat aqueous solutions, in which imidazole and pyridyl nitrogen atoms have equal propensity for protonation. In SDS, the protonation of the benzimidazole nitrogen occurs only in the excited state. Such effects are not observed in cationic cetyl tri-Me ammonium bromide (CTAB) and neutral Triton X-100 (TX-100). Thus, 4PBI shows very good sensitivity for neg. charged interfaces between aqueous and apolar compartments in microheterogeneous media.

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Application In Synthesis of 2-(Pyridin-4-yl)-1H-benzo[d]imidazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-(Pyridin-4-yl)-1H-benzo[d]imidazole, is researched, Molecular C12H9N3, CAS is 2208-59-5, about Dependence of acute toxicity on structure in a series of 2-substituted benzimidazoles. Author is Lebedeva, M. N.; Kolosova, M. I.; Gladkikh, V. F.; Lychko, N. D..

A comparison of the acute toxicities of 52 benzimidazoles (I) in mice indicated that single substitution at position 2, especially with o-bromophenyl, o-, m-, or p-chlorophenyl, and o-aminophenyl, decreased toxicity ≥10-fold, whereas substitution also at position 5(6) or 1 increased toxicity. Of the 18 2-aryl substituted I, H-620 (I, R = o-aminophenyl, R1 = R2 = H) [5805-39-0] was the least toxic; H-728 (I, R = o-chlorophenyl, R1 = CO2Me, R2 = H) [34675-55-3] was most toxic. Of the 13 2-heteryl substituted I, H-725 (I, R = α-piperidyl, R1 = COMe, R2 = H) [34675-57-5] was least toxic; H-582 (I, R = γ-pyridyl, R1 = R2 = H) [2208-59-5] was most toxic. Of the 21 2-amino substituted I, H-738 (I, R = NHCOMe, R1 = R2 = H) [21202-05-1] was least toxic; H-658 (I, R = piperidyl, R1 = R2 = H) [2851-12-9] was most toxic.