Category: 29046-78-4

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.Formula: C4H10Cl2NiO2.Pieber, Bartholomaeus; Malik, Jamal A.; Cavedon, Cristian; Gisbertz, Sebastian; Savateev, Aleksandr; Cruz, Daniel; Heil, Tobias; Zhang, Guigang; Seeberger, Peter H. published the article 《Semi-heterogeneous Dual Nickel/Photocatalysis using Carbon Nitrides: Esterification of Carboxylic Acids with Aryl Halides》 about this compound( cas:29046-78-4 ) in Angewandte Chemie, International Edition. Keywords: graphitic carbon nitride nickel photocatalytic esterification catalyst; carboxylic acid aryl halide graphitic carbon nitride nickel esterification; aryl carboxylic ester preparation; dual catalysis; graphitic carbon nitride; heterogeneous catalysis; metallaphotoredox; photocatalysis. Let’s learn more about this compound (cas:29046-78-4).

Cross-coupling reactions mediated by dual nickel/photocatalysis are synthetically attractive but rely mainly on expensive, non-recyclable noble-metal complexes as photocatalysts. Heterogeneous semiconductors, which are commonly used for artificial photosynthesis and wastewater treatment, are a sustainable alternative. Graphitic carbon nitrides, a class of metal-free polymers that can be easily prepared from bulk chems., are heterogeneous semiconductors with high potential for photocatalytic organic transformations. Here, we demonstrate that graphitic carbon nitrides in combination with nickel catalysis can induce selective C-O cross-couplings of carboxylic acids with aryl halides, yielding the resp. aryl esters in excellent yield and selectivity. The heterogeneous organic photocatalyst exhibits a broad substrate scope, is able to harvest green light, and can be recycled multiple times. In situ FTIR was used to track the reaction progress to study this transformation at different irradiation wavelengths and reaction scales.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Mazaud, Louis; Tricoire, Maxime; Bourcier, Sophie; Cordier, Marie; Gandon, Vincent; Auffrant, Audrey published an article about the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4,SMILESS:COCCOC.Cl[Ni]Cl ).Related Products of 29046-78-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:29046-78-4) through the article.

The synthesis of a tridentate NNN ligand incorporating an amidoquinoline and an iminophosphorane (LRH, R = Ph, Cy) was carried out. Coordination to Pd(II) and Ni(II) precursors gave as expected square planar complexes [LRMCl]. The most surprising result came from the reaction of LPhH with [Ni(COD)2] which gave a Ni(II)-Ph complex bearing a tridentate amidoquinoline-aminophosphine ligand. This rearrangement would result from a proton transfer assisted by the Ni0 when stabilized by a Ph substituent at the P, as suggested by DFT calculations and complementary experiments This Ni-Ph complex formed the corresponding benzoyl complex under a CO atm.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov’t, Organic Letters called Deaminative Reductive Cross-Electrophile Couplings of Alkylpyridinium Salts and Aryl Bromides, Author is Liao, Jennie; Basch, Corey H.; Hoerrner, Megan E.; Talley, Michael R.; Boscoe, Brian P.; Tucker, Joseph W.; Garnsey, Michelle R.; Watson, Mary P., which mentions a compound: 29046-78-4, SMILESS is COCCOC.Cl[Ni]Cl, Molecular C4H10Cl2NiO2, Safety of Nickel(II) chloride ethylene glycol dimethyl ether complex.

A nickel-catalyzed reductive cross-coupling of alkylpyridinium salts and aryl bromides has been developed using Mn as the reductant. Both primary and secondary alkylpyridinium salts can be used, and high functional group and heterocycle tolerance is observed, including for protic groups. Mechanistic studies indicate the formation of an alkyl radical, and controlling its fate was key to the success of this reaction.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Sequential C-O decarboxylative vinylation/C-H arylation of cyclic oxalates via a nickel-catalyzed multicomponent radical cascade, published in 2020, which mentions a compound: 29046-78-4, mainly applied to aryl methylcyclohexyl allyl carboxylate selective diastereoselective preparation; cyclic oxalate alkyne aryl bromide sequential decarboxylative vinylation arylation, Product Details of 29046-78-4.

A selective, sequential C-O decarboxylative vinylation/C-H arylation of cyclic oxalate derivatives enabled by visible-light photoredox/nickel dual catalysis was described. This protocol utilizes a multicomponent radical cascade process, i.e. decarboxylative vinylation/1,5-HAT/aryl cross-coupling, to achieve efficient, site-selective dual-functionalization of saturated cyclic hydrocarbons in one single operation. This synergistic protocol provided straightforward access to sp3-enriched scaffolds such as I [R = OPh, OAc, OBz, etc.; R1 = 4-CNC6H4, 4-MeC6H4, 2-pyridyl, etc.; X = CH2, O; Y = CH2, O, S, N-Boc, etc.] and an alternative retrosynthetic disconnection to diversely functionalized saturated ring systems from the simple starting materials.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.Related Products of 29046-78-4.Xiao, Jian; Wang, Ya-Wen; Qiu, Zhong-Ping; Peng, Yu published the article 《Ni-Catalyzed Intramolecular Reductive 1,2-Dicarbofunctionalization of Alkene: Facile Access to Podophyllum Lignans Core》 about this compound( cas:29046-78-4 ) in Synlett. Keywords: tetracyclic podophyllum lignan preparation diastereoselective; alkene reductive coupling heterocyclization nickel catalyst. Let’s learn more about this compound (cas:29046-78-4).

The facile access to the tetracyclic skeleton of podophyllotoxin (5R,5aS,6R,8aR)/(5R,5aS,6S,8aS)-I, a medicinally important lignan natural product, was efficiently achieved via a unique intramol. alkylarylation of the tethered alkene II in dihalide under mild conditions using reductive nickel catalysis.

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Borates as a Traceless Activation Group for Intermolecular Alkylarylation of Ethylene through Photoredox/Nickel Dual Catalysis, the main research direction is ethylene dicarbofunctionalization borate traceless activation group; vinyl borate aryl halide alkyl oxalate three component alkylarylation; synergistic photoredox nickel dual catalysis.Electric Literature of C4H10Cl2NiO2.

A formal ethylene alkylarylation reaction with aryl halides and alkyl oxalates enabled by synergistic photoredox/nickel catalysis is reported. This protocol takes advantage of borates as a traceless activation group, achieving the formal ethylene difunctionalized products via a catalytic three-component 1,2-alkylarylation of vinyl borate followed by a base-assisted deborylation process. The mild conditions allow for excellent functional groups compatibility and broad substrate scope.

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dauncey, Elizabeth M.; Dighe, Shashikant U.; Douglas, James J.; Leonori, Daniele published an article about the compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4,SMILESS:COCCOC.Cl[Ni]Cl ).Synthetic Route of C4H10Cl2NiO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:29046-78-4) through the article.

A divergent strategy for the remote arylation, vinylation and alkylation of nitriles e.g., I is described. These processes proceed through the photoredox generation of a cyclic iminyl radical and its following ring-opening reaction. The distal nitrile radical is then engaged in nickel-based catalytic cycles to form C-C bonds with aryl bromides ArBr [Ar = 4-(acetyl)phenyl, 2-methylpyridin-4-yl, 1H-1,3-benzodiazol-2-yl, etc.], alkynes RCCH [R = (CH2)4CH3, cyclohexyl, 3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propyl, etc.] and alkyl bromides R1Br [R1 = 3-phenylpropyl, 4-(1,3-dioxolan-2-yl)butyl, 2-chloroethyl, etc.].

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: Nickel(II) chloride ethylene glycol dimethyl ether complex. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex, is researched, Molecular C4H10Cl2NiO2, CAS is 29046-78-4, about Ligand-based H2 transfer with dihydrazonopyrrole complexes of nickel. Author is McNeece, Andrew J.; Jesse, Kate A.; Filatov, Alexander S.; Schneider, Joseph E.; Anderson, John S..

Biol. uses precise control over proton, electron, H-atom, or H2 transfer to mediate challenging reactivity. While synthetic complexes have made incredible strides in replicating secondary coordination electron or proton donors, there are comparatively fewer examples of ligands that can mediate both proton and electron storage. Rarer still are ligands that can store full H2 equivalent Here we report a dihydrazonopyrrole Ni complex where an H2 equiv can be stored on the ligand periphery without any redox change at the metal center. This ligand-based storage of H2 can be leveraged for catalytic hydrogenations. Kinetic and computational anal. suggests a rate determining H2 binding step followed by comparatively facile H-H scission to hydrogenate the ligand. This system is an unusual example where a synthetic system can mimic biol.’s ability to mediate H2 transfer via secondary coordination sphere-based processes.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex( cas:29046-78-4 ) is researched.Recommanded Product: 29046-78-4.Zhang, Shou-Kun; Struwe, Julia; Hu, Lianrui; Ackermann, Lutz published the article 《Nickela-electrocatalyzed C-H Alkoxylation with Secondary Alcohols: Oxidation-Induced Reductive Elimination at Nickel(III)》 about this compound( cas:29046-78-4 ) in Angewandte Chemie, International Edition. Keywords: benzamide secondary alc nickel electrocatalyst alkoxylation DFT directing group; C−H alkoxylation; electrocatalysis; electrochemistry; nickel; oxygenation. Let’s learn more about this compound (cas:29046-78-4).

Nickela-electrooxidative C-H alkoxylations with challenging secondary alcs. were accomplished in a fully dehydrogenative fashion, thereby avoiding stoichiometric chem. oxidants, with H2 as the only stoichiometric byproduct. The nickel-electrocatalyzed oxygenation proved viable with various (hetero)arenes, including naturally occurring secondary alcs., without racemization. Detailed mechanistic investigation, including DFT calculations and cyclovoltammetric studies of a well-defined C-H activated nickel(III) intermediate, suggest an oxidation-induced reductive elimination at nickel(III).

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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Nickel(II) chloride ethylene glycol dimethyl ether complex(SMILESS: COCCOC.Cl[Ni]Cl,cas:29046-78-4) is researched.COA of Formula: C4H10Cl2NiO2. The article 《Synergistic Activation of Amides and Hydrocarbons for Direct C(sp3)-H Acylation Enabled by Metallaphotoredox Catalysis》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:29046-78-4).

The uses of omnipresent, thermodynamically stable amides and aliphatic C(sp3)-H bonds for various functionalizations are ongoing challenges in catalysis. In particular, the direct coupling between the two functional groups was not realized. Here, the authors report the synergistic activation of the two challenging bonds, the amide C-N and unactivated aliphatic C(sp3)-H, via metallaphotoredox catalysis to directly acylate aliphatic C-H bonds using amides as stable and readily accessible acyl surrogates. N-acylsuccinimides served as efficient acyl reagents for the streamlined synthesis of synthetically useful ketones from simple C(sp3)-H substrates. Detailed mechanistic studies using both computational and exptl. mechanistic studies were performed to construct a detailed and complete catalytic cycle. The origin of the superior reactivity of the N-acylsuccinimides over other more reactive acyl sources such as acyl chlorides is an uncommon reaction pathway which commences with C-H activation prior to oxidative addition of the acyl substrate.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles