Category: 65417-22-3

On July 31, 2018, Bodunov, Vladimir A.; Galenko, Ekaterina E.; Galenko, Alexey V.; Novikov, Mikhail S.; Khlebnikov, Alexander F. published an article.Formula: C11H11NO2 The title of the article was Synthesis of substituted indole-3-carboxylates by iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-aryl-5-methoxyisoxazoles. And the article contained the following:

The iron(II)-catalyzed domino isomerization of 3-alkyl/aryl-4-arylisoxazoles provided a selective access to a wide range of structurally diverse highly substituted indole-3-carboxylates such as I [R = H, 6-Me, 4-MeO, etc.; R1 = Me, 4-ClC6H4, 2-naphthyl, etc.; R2 = Me, pyrrolidin-1-yl]. The operational simplicity, high atom efficiency and the use of stable starting materials and an inexpensive and low-toxicity catalyst were some of the attractive features of this tandem double ring-opening-ring-closure strategy. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Formula: C11H11NO2

The Article related to indole carboxylate green preparation, isoxazole tandem isomerization iron catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 1986, Pindur, Ulf; Flo, Camran published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Reactions of electron-rich heterocycles with derivatives of carboxylic ortho acids. VII. Regioselective, mild acylation of 2-methylindole with di- and trialkoxycarbenium tetrafluoroborates. A simple procedure for deriving 3-acyl-2-methylindoles and 3-methoxycarbonyl-2-methylindole. And the article contained the following:

The regioselective acylation of 2-methylindole with RC+(OR1)2BF4- (R = H, Me, R1 = Et; R = Ph, R1 = Me; R = OMe, R1 = Me) gave indoles I [R2 = MeCOPhCO,CO2Me). The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to methylindole acylation alkoxycarbenium tetrafluoroborate regiochem, indole acyl carboxy, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 4, 2016, Liu, Xiao-Guang; Li, Zi-Hao; Xie, Jian-Wei; Liu, Ping; Zhang, Jie; Dai, Bin published an article.Product Details of 65417-22-3 The title of the article was Copper-catalyzed synthesis of 2,3-disubstituted indoles from ortho-haloanilines and β-keto esters/β-diketone. And the article contained the following:

Tetrazole-1-acetic acid was identified as an efficient ligand to promote copper-catalyzed domino reaction of ortho-iodo/bromo-anilines RNH2 (R = 2-IC6H4, 2-I-5-H3CC6H3, 3-iodopyridin-2-yl, 2,4-Br2C6H3, etc.) with β-keto esters/β-diketone R1C(O)CH2C(O)R2 (R1 = CH3, (CH3)CH, C6H5, etc.; R2 = CH3, CH2CH3, OCH3, OCH2CH3) for 2,3-disubstituted indoles’ synthesis, e.g., I, with high yields under mild conditions. The protocol, with an easily-available catalytic system, shows good substrate tolerance towards various functional groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Product Details of 65417-22-3

The Article related to indole preparation, ortho haloaniline dicarbonyl compound domino reaction copper catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 1990, Sakamoto, Takao; Nagano, Tatsuo; Kondo, Yoshinori; Yamanaka, Hiroshi published an article.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Condensed heteroaromatic ring systems. XVII. Palladium-catalyzed cyclization of β-(2-halophenyl)amino substituted α,β-unsaturated ketones and esters to 2,3-disubstituted indoles. And the article contained the following:

Palladium-catalyzed cyclization of β-(2-halophenyl)amino substituted α,β-unsaturated ketones and esters, prepared from 2-haloanilines by three different methods, gave 2,3-disubstituted indoles. Thus, conductivity of 2-IC6H4NH2 with AcCH2Ac in C6H6 containing catalyst 4-MeC6H4SO3H gave 72% 2-IC6H4NHCMe:CHCOMe which on cyclization with Pd(OAc)2 in Et3N-DMF in a sealed tube (120°, 6 h) gave 49% 3-acetyl-2-methylindole. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to halophenylaminoalkenone preparation palladium catalyzed cyclization, acylindole, indole acyl, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 1, 2020, Thombal, Raju S.; Lee, Yong Rok published an article.COA of Formula: C11H11NO2 The title of the article was Palladium-Catalyzed Direct Oxidative C-H Activation/Annulation for Regioselective Construction of N-Acylindoles. And the article contained the following:

A Pd(II)-catalyzed C(sp3)-H/C(sp2)-H coupling/annulation of anilides and α-dicarbonyl compounds for the synthesis of diverse N-acyl indoles was described. The reaction was achieved by cascade C-H activation, coupling, and intramol. cyclization. This protocol provided a variety of indoles with high functional group tolerance and excellent regioselectivity. The utility of this protocol was demonstrated by transforming the synthesized compound into diversely functionalized analogs. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).COA of Formula: C11H11NO2

The Article related to acylindole regioselective preparation, anilide dicarbonyl compound coupling intramol cyclizn, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 10, 2020, Vu, Cuong M.; Le, Khoa B.; Vo, Uyen N.; Van, Vy D. T.; Nguyen, Anh T.; Phan, Nam T. S.; Le, Nhan T. H.; Nguyen, Tung T. published an article.COA of Formula: C11H11NO2 The title of the article was Recyclable CuFe2O4 for the synthesis of 2,3-disubstituted indoles. And the article contained the following:

A method for the CuFe2O4-catalyzed coupling of 2-iodo- or 2-bromoanilines 2-X-RC6H3NH2 (R = H, 4-trifluoromethoxy, 5-trifluoromethyl, etc.; X = I or Br) and acetylacetone or isosteric 1,3-diketones R1C(O)CH2C(O)R2 (R1 = Me, ethyl; R2 = ethoxy, methoxy) to afford 2,3-disubstituted indoles I (R3 = H, 5-bromo, 6-Me, etc.) has been developed. The superparamagnetic material showed superior activity in comparison to other ferrites or copper-based metal-organic frameworks. Functionalities including ester, cyano, and halogen groups were compatible with the reaction conditions. The CuFe2O4 catalyst was easily recoverable and reusable and offers a convenient pathway to afford synthetically useful heterocycles. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).COA of Formula: C11H11NO2

The Article related to indole preparation, haloaniline diketone heterocyclization copper ferrite nanocatalyst recycling, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C11H11NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Zechao; Yin, Zhiping; Wu, Xiao-Feng published an article in 2018, the title of the article was Copper-catalyzed carbonylative transformations of indoles with hexaketocyclohexane.Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate And the article contains the following content:

With hexaketocyclohexane octahydrate as the carbon monoxide source, a novel procedure for copper-catalyzed direct double carbonylation of indoles was established. Using alcs. as reaction partners, moderate to good yields of the desired double carbonylation products were obtained. Wide functional group tolerance and substrate scope was observed The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole hexaketocyclohexane alc copper catalyst alkoxycarbonylation, indolyl oxoacetate preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 8, 2008, Tanimori, Shinji; Kirihata, Mitsunori published a patent.Name: Methyl 2-methyl-1H-indole-3-carboxylate The title of the patent was Preparation of indole compounds by cyclocondensation of haloanilines. And the patent contained the following:

Title compounds I [R1 = (un)substituted alkyl, cycloalkyl, heterocyclyl, alkynyl, alkoxy, aryl ether group, cyano, carboxyl, carbamoyl, etc.; R2 electron-withdrawing group; R3 = H, any group given for R2; n = 0-4], useful as intermediates for drugs, agrochems., electronic materials, etc., are prepared by reacting haloanilines II (R3, n = same as above; Hr = halo) with R1COCH2R2 (R1, R2 = same as above) in the presence of catalysts. Thus, Me 3-oxo-4-chlorobutanoate was added dropwise to a mixture of NaH and DMSO and the reaction mixture was treated with 2-IC6H4NH2, CuI, and L-proline at room temperature for 5 h to give 23% Me 2-chloromethyl-1H-indole-3-carboxylate. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Name: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole compound preparation, haloaniline cyclocondensation oxochlorobutanoate cuprous iodide catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Name: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 18, 2013, Nguyen, Huy H.; Kurth, Mark J. published an article.Reference of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Microwave-assisted synthesis of 3-nitroindoles from N-aryl enamines via intramolecular arene-alkene coupling. And the article contained the following:

A variety of N-aryl β-nitroenamines were effectively transformed into 3-nitroindoles in good yields and with complete regioselectivity via a rapid microwave (μW) assisted intramol. arene-alkene coupling reaction. This report further demonstrates the versatility of this method by constructing 3-carboalkoxy- and 3-cyanoindoles. Optimization data, substrate scope, and applications are discussed. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Reference of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to indole derivative preparation, aryl enamine preparation intramol coupling reaction palladium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lv, Honggui; Shi, Jingjing; Wu, Bo; Guo, Yujuan; Huang, Junjun; Yi, Wei published an article in 2017, the title of the article was One-pot synthesis of 2,3-difunctionalized indoles via Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization.Recommanded Product: 65417-22-3 And the article contains the following content:

The first Rh(III)-catalyzed carbenoid insertion C-H activation/cyclization of N-arylureas R1NHC(O)R (R = N(CH3)2, NHCH3; R1 = naphth-1-yl, 2-CH3C6H4, 3-ClC6H4, 4-CH3(O)CC6H4, etc.) and α-diazo β-keto esters R2C(O)C(=N2)C(O)R3 [R2 = H, Me, Ph, CH2OCH3, CH2CH3; R3 = C(O)OCH2CH3, C(O)OCH2C6H5, ((OCH3)2)P(O), etc.] was reported. The redox-neutral reaction has the following features: good to excellent yields, broad substrate/functional group tolerance, exclusive regioselectivity, and no need for addnl. oxidants or additives, which render this methodol. as a more efficient and versatile alternative to the existing methods for the synthesis of 2,3-difunctionalized indoles e.g., I. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: 65417-22-3

The Article related to indole preparation green chem regioselective, arylurea diazo keto ester bond activation cyclization rhodium catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles