Category: 79815-20-6

On July 4, 2007, Hartikka, Antti; Slosarczyk, Adam T.; Arvidsson, Per I. published an article.Recommanded Product: H-Idc-OH The title of the article was Application of novel sulfonamides in enantioselective organocatalyzed cyclopropanation. And the article contained the following:

Three novel aryl sulfonamides derived from (2S)-indoline-2-carboxylic acid have been obtained and used as organocatalysts. The catalysts incorporate diverse functionality on the Ph ring, enabling steric, and electronic fine tuning of the catalysts. The catalysts facilitate the reaction between a range of α,β-unsaturated aldehydes and sulfur ylides, thus providing cyclopropane products in enantiomeric excesses of up to 99%. E.g., reaction of (E)-MeCH:CHCHO and Me2S+C-HCOPh gave 45% cyclopropane I (88% ee). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: H-Idc-OH

The Article related to enantioselective cyclopropanation unsaturated aldehyde sulfur ylide arylsulfonamide catalyst, Alicyclic Compounds: Cyclopropanes and other aspects.Recommanded Product: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 8, 2015, Cleghorn, Laura A. T.; Albrecht, Sebastien; Stojanovski, Laste; Simeons, Frederick R. J.; Norval, Suzanne; Kime, Robert; Collie, Iain T.; De Rycker, Manu; Campbell, Lorna; Hallyburton, Irene; Frearson, Julie A.; Wyatt, Paul G.; Read, Kevin D.; Gilbert, Ian H. published an article.Safety of H-Idc-OH The title of the article was Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei. And the article contained the following:

There is an urgent need for new, brain penetrant small mols. that target the central nervous system second stage of human African trypanosomiasis (HAT). We report that a series of novel indoline-2-carboxamides have been identified as inhibitors of Trypanosoma brucei from screening of a focused protease library against Trypanosoma brucei brucei in culture. We describe the optimization and characterization of this series. Potent antiproliferative activity was observed The series demonstrated excellent pharmacokinetic properties, full cures in a stage 1 mouse model of HAT, and a partial cure in a stage 2 mouse model of HAT. Lack of tolerability prevented delivery of a fully curative regimen in the stage 2 mouse model and thus further progress of this series. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to trypanosomicide indolinecarboxamide preparation structure activity brain penetrant trypanosomiasis, Pharmacology: Structure-Activity and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 10, 2016, Pelz, Nicholas F.; Bian, Zhiguo; Zhao, Bin; Shaw, Subrata; Tarr, James C.; Belmar, Johannes; Gregg, Claire; Camper, DeMarco V.; Goodwin, Craig M.; Arnold, Allison L.; Sensintaffar, John L.; Friberg, Anders; Rossanese, Olivia W.; Lee, Taekyu; Olejniczak, Edward T.; Fesik, Stephen W. published an article.Recommanded Product: 79815-20-6 The title of the article was Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods. And the article contained the following:

Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family of proteins responsible for the regulation of programmed cell death. Amplification of Mcl-1 is a common genetic aberration in human cancer whose overexpression contributes to the evasion of apoptosis and is one of the major resistance mechanisms for many chemotherapies. Mcl-1 mediates its effects primarily through interactions with pro-apoptotic BH3 containing proteins that achieve high affinity for the target by utilizing four hydrophobic pockets in its binding groove. Here we describe the discovery of Mcl-1 inhibitors using fragment-based methods and structure-based design. These novel inhibitors exhibit low nanomolar binding affinities to Mcl-1 and >500-fold selectivity over Bcl-xL. X-ray structures of lead Mcl-1 inhibitors when complexed to Mcl-1 provided detailed information on how these small-mols. bind to the target and were used extensively to guide compound optimization. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to preparation indoleacylsulfonamide antitumor myeloid leukemia, crystal structure, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wang, Meng; Chen, Jun; Chen, Zongjia; Zhong, Changxu; Lu, Ping published an article in 2018, the title of the article was Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis.Safety of H-Idc-OH And the article contains the following content:

The enantioselective intramol. α-arylation of cyclobutanones was established by combining palladium and enamine catalyst systems. Two different enantioselective control strategies were developed for cyclobutanone substrates bearing O- or N-tethered aryl bromides. Further synthetic applications are also reported. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to cyclobutanone enantioselective desymmetrization palladium enamine catalyst, arylation, cyclobutanones, desymmetrization, palladium, synergistic catalysis, General Organic Chemistry: Synthetic Methods and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 14, 2020, Ouyang, Lu; Xia, YanPing; Wei, YiFei; Liao, Jianhua; Luo, Renshi published an article.Product Details of 79815-20-6 The title of the article was Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand. And the article contained the following:

A highly Me2Zn-mediated catalytic enantioselective Reformatsky reaction of aldehydes and ketones with Et iodoacetate using a readily available prolinol ligand is reported. This reaction provides an efficient method for the construction of β-hydroxy esters in up to 98% yield and 95% enantiomeric excess (ee) value. A wide range of functional groups are tolerated and the practicality of this protocol is demonstrated by performing the reaction on a gram scale. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Product Details of 79815-20-6

The Article related to enantioselective reformatsky reaction aldehyde ketone iodoacetate prolinol ligand, hydroxy ester enantioselective synthesis, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 8, 2004, Blanc, Catherine; Agbossou-Niedercorn, Francine published an article.HPLC of Formula: 79815-20-6 The title of the article was Chiral aminophosphine-oxazoline auxiliaries applied to copper-catalyzed enantioselective 1,4-additions to enones. And the article contained the following:

A series of chiral aminophosphine-oxazoline auxiliaries has been prepared and applied in the copper-catalyzed 1,4-addition of diethylzinc to enones. The addition products are obtained quant. in up to 67% ee. The most efficient ligand of the series is based on L-indoline carboxylic acid and L-valinol. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).HPLC of Formula: 79815-20-6

The Article related to chiral aminophosphine oxazoline auxiliary preparation, copper catalyst enantioselective addition diethylzinc enone, General Organic Chemistry: Synthetic Methods and other aspects.HPLC of Formula: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On December 8, 2010, Lin, Ning; Chen, Miao-Miao; Luo, Ren-Shi; Deng, Yan-Qiu; Lu, Gui published an article.Safety of H-Idc-OH The title of the article was Indolinylmethanol catalyzed enantioselective Reformatsky reaction with ketones. And the article contained the following:

A series of chiral indolinylmethanol ligands have been applied for the first time in the asym. Reformatsky reaction of an α-bromoester with ketones. In the presence of NiBr2 and zinc powder, up to 75% yield and 87% ee were obtained for a variety of aromatic and aliphatic ketones. The use of Ni(acac)2 resulted in 96% ee although the corresponding yield was low. This process provided a convenient method to access synthetically useful chiral β-hydroxyesters. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to hydroxy ester asym synthesis, asym reformatsky reaction bromo ester ketone nickel indolinylmethanol catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Candeias, Nuno R.; Carias, Carolina; Gomes, Luis F. R.; Andre, Vania; Duarte, M. Teresa; Gois, Pedro M. P.; Afonso, Carlos A. M. published an article in 2012, the title of the article was Asymmetric intramolecular C-H insertion of α-diazoacetamides in water by dirhodium(II) catalysts derived from natural amino acids.Product Details of 79815-20-6 And the article contains the following content:

The asym. dirhodium(II)-catalyzed intramol. C-H insertion of α-diazo acetamides in water is described for the first time. The use of natural α-amino acids as chiral ligands allowed the preparation of novel dirhodium(II) homochiral complexes by a simple procedure consisting of the in situ ligand exchange starting from dirhodium tetraacetate. The catalytic system was further reused up to 7 cycles and β-lactams were obtained in good yields and enantiomeric excess. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Product Details of 79815-20-6

The Article related to lactam enantioselective preparation, diazoacetamide enantioselective cyclization rhodium catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 27, 2020, Luo, Renshi; Chen, Miao-Miao; Ouyang, Lu; Chan, Albert S. C.; Lu, Gui published an article.SDS of cas: 79815-20-6 The title of the article was Enantioselective Reformatsky Reaction of Ketones Catalyzed by Chiral Indolinylmethanol. And the article contained the following:

A reliable and practical Reformatsky reaction of Et iodidoacetate with ketones for the synthesis of chiral β-hydroxyl carbonyl compounds in good yields and excellent enantioselectivities is presented. A readily available dihydroindole derivative was used as chiral catalyst, Et iodidoacetate was the nucleophile, and Me2Zn was the zinc source. The presence of air was found to be essential for the efficient construction of new carbon-carbon bonds through a radical pathway. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).SDS of cas: 79815-20-6

The Article related to enantioselective reformatsky ketone iodoacetate chiral indolinylmethanol catalyst, General Organic Chemistry: Synthetic Methods and other aspects.SDS of cas: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 31, 2010, Gandia-Herrero, Fernando; Escribano, Josefa; Garcia-Carmona, Francisco published an article.Application In Synthesis of H-Idc-OH The title of the article was Structural implications on color, fluorescence, and antiradical activity in betalains. And the article contained the following:

Betalains are water-soluble pigments with high anti-radical capacity which bestow bright colors on flowers and fruits of most plants of the order Caryophyllales. They are classified as betacyanins, exhibiting a violet coloration, and betaxanthins, which exhibit yellow coloration. Traditionally, betalains have been defined as condensation products of betalamic acid with different amines and amino acids, but the implication of the pigment structure for their properties has not been investigated. This paper explores different structural features of the betalains, revealing the clues for the switch from yellow to violet color, and the loss of fluorescence. A relevant series of 15 betalain-related compounds (both natural and novel semisynthetic ones) is obtained and characterized by chromatog., UV-vis spectrophotometry, fluorescence, and electrospray ionization mass spectroscopy. Anti-radical properties of individual pure compounds in a broad pH range are studied under the ABTS·+ radical assay. Relevance of specific bonds is studied, and differences between betaxanthins and betacyanins are used to explore in depth the structure-antiradical activity relationships in betalains. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to flower color fluorescence antiradical antioxidant betalain betaxanthin betacyanin, Plant Biochemistry: Composition and Products and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles