Category: 79815-20-6

On June 16, 2011, Xiao, Jian; Xu, Feng-Xia; Lu, Yun-Peng; Liu, Yan-Ling; Loh, Teck-Peng published an article.Related Products of 79815-20-6 The title of the article was Highly efficient and modularly tuned bicyclic organocatalyst for the enantioselective Michael addition of aldehydes to nitroalkenes. And the article contained the following:

A new type of bicyclic catalyst has been successfully applied to the asym. Michael addition of aldehydes R1CH2CHO [R1 = Me, Et, n-Pr] to nitrostyrenes R2CH:CHNO2 [R2 = Ph, 4-BrC6H4, 2-furyl, etc.] to produce OHCCH(R1)CH(R2)CH2NO2 in good yields and good enantioselectivities by using a self-assembly strategy. The success of this reaction is attributed to good control of the geometry of the enamine and efficient face shielding. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6

The Article related to bicyclic catalyst enantioselective michael aldehyde nitroalkene, General Organic Chemistry: Synthetic Methods and other aspects.Related Products of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 3, 2000, Sato, S.; Watanabe, H.; Asami, M. published an article.Formula: C9H9NO2 The title of the article was Catalytic asymmetric borane reduction of prochiral ketones by the use of diazaborolidine catalysts prepared from chiral β-diamines. And the article contained the following:

The catalytic asym. borane reduction of prochiral ketones was examined in the presence of chiral diazaborolidine catalysts prepared in situ from chiral β-diamines and borane. Chiral secondary alcs. were obtained with modest to high enantiomeric excesses (up to 92% ee) using (S)-2-[[4-(trifluoromethyl)anilino]methyl]indoline. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Formula: C9H9NO2

The Article related to asym reduction ketone diazaborolidine, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C9H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Huo, Li-chun; Liu, Sheng-li; Li, Chun-xin published an article in 2015, the title of the article was Synthesis process of (S)-indoline-2-carboxylic acid.Recommanded Product: H-Idc-OH And the article contains the following content:

Synthesis process of (S)-indoline-2-carboxylic acid was investigated, where di-Et oxalate and o-nitrotoluene were taken as raw material to generate an intermediate the Et o-nitrophenylpyruvate under the action of potassium ethoxide. The target product (S)-indoline-2-carboxylic acid was obtained from Et o-nitrophenylpyruvate by nickel-catalytic hydrogenation, magnesium powder reduction and chiral separation The overall yield is 38%(based on o-nitrotoluene). This synthesis process is low in cost and environmental pollution. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: H-Idc-OH

The Article related to indoline carboxylic acid synthesis chiral separation nickel catalytic hydrogenation, Placeholder for records without volume info and other aspects.Recommanded Product: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On April 30, 2006, Sun, Suya; Jia, Youzhi; Zeng, Ning; Li, Famei published an article.Electric Literature of 79815-20-6 The title of the article was Chiral ligand-exchange chromatography for separation of three stereoisomers of octahydroindole-2-carboxylic acid. And the article contained the following:

A novel HPLC method is described for separation of the three stereoisomers of octahydroindole-2-carboxylic acid (Oic), an intermediate in the synthesis of perindopril. The chiral mobile phase contained the complex of Cu(II) with the optically active selector L-phenylalaninamide (L-PheA), and an ion-pair reagent, sodium 1-octanesulfonate. The effects of the concentrations of the Cu(II)-L-PheA complex and the ion-pair reagent, mobile phase pH, ionic strength, acetonitrile content, and column temperature were studied. Satisfactory resolution was achieved for three stereoisomers, RRR-, SSS-, and SRR-Oic. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to octahydroindolecarboxylic acid stereoisomer chiral ligand exchange chromatog, Organic Analytical Chemistry: Separations and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 30, 2007, Zhang, Yingru; Dai, Jun; Wang-Iverson, David B.; Tymiak, Adrienne A. published an article.Name: H-Idc-OH The title of the article was Simulated moving columns technique for enantioselective supercritical fluid Chromatography. And the article contained the following:

This article describes a very useful extension of an unique column switching technique called Simulated Moving Columns (SMC) that was previously reported for chiral HPLC. SMC uses two or three short chiral columns connected in series, and enables the unresolved enantiomers to sep. repeatedly and exclusively through each of the columns until sufficient resolution is attained. The technique is significantly enhanced through the use of supercritical fluid chromatog. (SFC). The supercritical or near critical carbon dioxide (CO2) used in the mobile phase of SFC possesses the properties of a liquid as well as a gas, and usually results in much sharper peaks compared to HPLC. Consequently, by combining SMC with SFC (SMC-SFC), the authors were able to dramatically increase the number of SMC cycles with significantly less band broadening compared to HPLC. For the 1st time, an enantioselective SFC separation was demonstrated by increasing the column from the actual 20 cm length to reach a half meter virtual length with remarkably enhanced efficiency. Off-column band broadening resulting from a two-column SMC system was measured, and its impact on the enantioselectivity of SMC-SFC is much less than in SMC-HPLC. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH

The Article related to enantioselective supercritical fluid chromatog simulated moving column, Organic Analytical Chemistry: Separations and other aspects.Name: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 31, 2018, Kumar, Nadavala Siva; Sreenivasulu, Vudagandla; Ramachandra, Bondigalla; Asif, Mohammad; Ibrahim, Ahmed A. published an article.Application of 79815-20-6 The title of the article was A stability-indicating LC-MS method for determination of perindopril and its process related impurities. And the article contained the following:

Perindopril erbumine belongs to the member of angiotensin-converting enzyme inhibitors group used in the treatment of heart failure and hypertension. Asimple and highly sensitive LC-MS method has been developed for the simultaneous determination of three process-related impurities (L-norvaline, L-norvaline Et ester HCl, and (S)-indoline-2-carboxylic acid) in perindopril. Samples were separated using 5 mM ammonium formate (A) and acetonitrile/methanol (B) as the mobile phase on a Symmetry C18 column (75 mm × 4.6 mm, 3.5 μm) using gradient elution mode at a flow rate of 0.6 mL/min. The proposed method was validated as per ICH guidelines and can be used for quality testing of perindopril and determining its process-related impurities in pharmaceuticals. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to perindopril impurity analysis lc ms stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Le, Truong-Giang; Pham, Hoai-Thu; Martin, James P.; Chataigner, Isabelle; Renaud, Jean-Luc published an article in 2020, the title of the article was Organocatalyzed regioselective and enantioselective synthesis of 1,4- and 1,2-dihydropyridines.Electric Literature of 79815-20-6 And the article contains the following content:

Herein, the first examples of asym. organocatalyzed synthesis of 1,2-dihydropyridines, affording enantioselective access to and partially solving regioselectivity challenges in the synthesis of dihydropyridines is reported. It has been demonstrated that through modification of organocatalysts both 1,2- and 1,4-dihydropyridines (1,2- and 1,4-DHPs) can be obtained with high regioselectivity (ratio of 1,2-DHP/1,4-DHP from 95/5 to 0/100) and enantioselectivity (33% ee for 1,2-DHPs and up to 98% ee for 1,4-DHPs) in good yields (up to 87%). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to dihydropyridine preparation green chem regioselective enantioselective organocatalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On July 31, 2018, Kumar, Nadavala Siva; Sreenivasulu, Vudagandla; Ramachandra, Bondigalla; Asif, Mohammad; Ibrahim, Ahmed A. published an article.Application of 79815-20-6 The title of the article was A stability-indicating LC-MS method for determination of perindopril and its process related impurities. And the article contained the following:

Perindopril erbumine belongs to the member of angiotensin-converting enzyme inhibitors group used in the treatment of heart failure and hypertension. Asimple and highly sensitive LC-MS method has been developed for the simultaneous determination of three process-related impurities (L-norvaline, L-norvaline Et ester HCl, and (S)-indoline-2-carboxylic acid) in perindopril. Samples were separated using 5 mM ammonium formate (A) and acetonitrile/methanol (B) as the mobile phase on a Symmetry C18 column (75 mm × 4.6 mm, 3.5 μm) using gradient elution mode at a flow rate of 0.6 mL/min. The proposed method was validated as per ICH guidelines and can be used for quality testing of perindopril and determining its process-related impurities in pharmaceuticals. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to perindopril impurity analysis lc ms stability, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Le, Truong-Giang; Pham, Hoai-Thu; Martin, James P.; Chataigner, Isabelle; Renaud, Jean-Luc published an article in 2020, the title of the article was Organocatalyzed regioselective and enantioselective synthesis of 1,4- and 1,2-dihydropyridines.Electric Literature of 79815-20-6 And the article contains the following content:

Herein, the first examples of asym. organocatalyzed synthesis of 1,2-dihydropyridines, affording enantioselective access to and partially solving regioselectivity challenges in the synthesis of dihydropyridines is reported. It has been demonstrated that through modification of organocatalysts both 1,2- and 1,4-dihydropyridines (1,2- and 1,4-DHPs) can be obtained with high regioselectivity (ratio of 1,2-DHP/1,4-DHP from 95/5 to 0/100) and enantioselectivity (33% ee for 1,2-DHPs and up to 98% ee for 1,4-DHPs) in good yields (up to 87%). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to dihydropyridine preparation green chem regioselective enantioselective organocatalyst, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Hsu, Shih-Fan; Ko, Chih-Wei; Wu, Yao-Ting published an article in 2011, the title of the article was Cobalt-Catalyzed Carbon-Carbon Bond Formation: Synthesis and Applications of Enantiopure Pyrrolidine Derivatives[1].Computed Properties of 79815-20-6 And the article contains the following content:

In the presence of cobalt catalysts and tetramethylethylenediamine (TMEDA), the iodine atom in (S)-2-(iodomethyl)pyrrolidines was replaced by an aryl or an alkynyl group from the corresponding Grignard reagent, and the coupling products were obtained in good to excellent yields (16 examples; 75-94% yields). The scope and limitations of this protocol were examined The stereochem. of the pyrrolidines was unaffected by the reaction conditions. The coupling products are important building blocks of phenanthroindolizidine alkaloids. Palladium-catalyzed formal [4+2] cycloaddition of 2,2′-diiodobiphenyl with the thus-generated (S)-2-(3-trimethylsilyl-2-propynyl)pyrrolidine gave a good yield of the desilylated phenanthrene, which was then converted into unnatural (+)-(S)-tylophorine by the Pictet-Spengler cyclization. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Computed Properties of 79815-20-6

The Article related to pyrrolidine enantiopure preparation cross coupling cobalt catalyzed, tylophorine synthesis cross coupling cobalt catalyzed, Alkaloids: Alkaloids Containing One Nitrogen Atom In A Ring and other aspects.Computed Properties of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles