Category: 79815-20-6

Lakhdar, Sami; Appel, Roland; Mayr, Herbert published an article in 2009, the title of the article was How Does Electrostatic Activation Control Iminium-Catalyzed Cyclopropanations?.Related Products of 79815-20-6 And the article contains the following content:

Prediction of lg k=s(N+E) verified: In contrast to previous statements, ordinary α,β-unsaturated iminium ions do react with sulfur ylides. Electrostatic interactions accelerate the reactions by a factor of more than 105 and are responsible for the high stereoselectivity. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6

The Article related to electrostatic activation iminium catalyzed cyclopropanation stereoselectivity, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.Related Products of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ibrahem, Ismail; Zhao, Gui-Ling; Rios, Ramon; Vesely, Jan; Sunden, Henrik; Dziedzic, Pawel; Cordova, Armando published an article in 2008, the title of the article was One-pot organocatalytic domino Michael/α-alkylation reactions: direct catalytic enantioselective cyclopropanation and cyclopentanation reactions.Electric Literature of 79815-20-6 And the article contains the following content:

The development of one-pot organocatalytic domino Michael/α-alkylation reactions between bromomalonates or bromoacetoacetate esters and α,β-unsaturated aldehydes is presented. The chiral-amine-catalyzed reactions with bromomalonates as substrates give access to the corresponding 2-formylcyclopropane derivatives in high yields with excellent diastereoselectivity and up to 99% ee. The catalytic domino Michael/α-alkylation reactions between 4-bromo-acetoacetate and enals provide a route for the synthesis of functionalized cyclopentanones in good to high yields with 93-99% ee. The products from the organocatalytic reactions were also reduced with high diastereoselectivity to the corresponding cyclopropanols and cyclopentanols, resp. Moreover, one-pot combinations of amine and heterocyclic carbene catalysis (AHCC) enabled the highly enantioselective synthesis of β-malonate esters (91-97% ee) from the reaction between bromomalonates and enals. The tandem catalysis included the catalytic domino reaction followed by catalytic in situ chemoselective ring-opening of the 2-formylcyclopropane intermediates. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to catalytic enantioselective cyclopropanation cyclopentanation, Physical Organic Chemistry: Ring Formation, Cleavage, Enlargement, and Contraction and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 6, 2003, Toda, Narihiro; Ori, Mayuko; Takami, Kazuko; Tago, Keiko; Kogen, Hiroshi published an article.SDS of cas: 79815-20-6 The title of the article was Total Synthesis of (+)-Benzastatin E via Diastereoselective Grignard Addition to 2-Acylindoline. And the article contained the following:

A stereoselective total synthesis of (+)-benzastatin E is described. The synthesis involves a diastereoselective Grignard addition to 2-acylindoline I, which is derived from com. available (S)-2-indolinecarboxylic acid. The unknown absolute configuration of (+)-1 is determined as (9S,10R). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).SDS of cas: 79815-20-6

The Article related to benzastatin e asym synthesis, grignard addition diastereoselective benzastatin e preparation, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.SDS of cas: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 30, 2006, Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi published an article.Reference of H-Idc-OH The title of the article was Study on the synthesis of S-(-)-2-Carboxyindoline. And the article contained the following:

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH

The Article related to carboxyindoline preparation nitrotoluene chiral resolution carnitine oxalate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Reference of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Basolo, Luca; Bernasconi, Alice; Borsini, Elena; Broggini, Gianluigi; Beccalli, Egle M. published an article in 2011, the title of the article was Solvent-Free, Microwave-Assisted N-Arylation of Indolines by using Low Palladium Catalyst Loadings.Recommanded Product: 79815-20-6 And the article contains the following content:

A series of substituted N-arylindolines is prepared by a solvent-free, palladium-catalyzed procedure. The procedure requires only low loadings of catalyst, uses microwave irradiation, and starts from com. available substrates. The method proceeds in good yields and in short reaction times with aryl bromides, chlorides, and iodides, also on 2-substituted indolines. The combination of solvent-free methods with microwave heating will further increase in importance in the search for more environmentally acceptable synthesis methods. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to indoline aryl preparation aryl halide palladium phosphine catalyst microwave, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 28, 2011, de Lange, Ben; Hyett, David J.; Maas, Peter J. D.; Mink, Daniel; van Assema, Friso B. J.; Sereinig, Natascha; de Vries, Andre H. M.; de Vries, Johannes G. published an article.Synthetic Route of 79815-20-6 The title of the article was Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis. And the article contained the following:

The use of a combination of biocatalysis and homogeneous catalysis led to a very short synthesis route to enantiopure (S)-2-indolinecarboxylic acid. Thus, reacting 2-ClC6H4CHO with Ac2O/NaOAc gave 2-ClC6H4CH:CHCO2H in 55% yield. The latter compound was treated with phenylalanine ammonia lyase to give (S)-2-ClC6H4CH2CH(NH2)CO2H (I), that, upon addition of CuCl/H2O, produced 77% of the title compound Alternatively, treating 2-ClC6H4CH:CH(NHCOMe)CO2H with [Rh(cod)2]BF4/MonoPhos/H2CH2Cl2 gave the reduced compound which was then converted into I and taken on to the final compound as stated above. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

The Article related to indolinecarboxylic acid asym synthesis biocatalysis homogeneous catalysis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 30, 2006, Qian, Chao; Zhang, Jia-sen; Liu, Jian-qing; Li, Lu-zhen; Chen, Xin-zhi published an article.Reference of H-Idc-OH The title of the article was Study on the synthesis of S-(-)-2-Carboxyindoline. And the article contained the following:

A general synthetic route of S-(-)-2-carboxyindoline was proposed which started from o-nitrotoluene and di-Et oxalate, via condensation, nitro-group reduction, heterocyclic reduction and hydrolysis, 2-carboxyindoline was achieved with total yield of 40.6%. Especially, using 10% Pd-C as catalysts, the heterocycle is reduced easily with hydrogen at 160° and 6.2 MPa, the catalysts also can be reclaimed. Through steps of chlorination, esterification, fractional crystallization, and hydrolysis, the S-(-)-2-carboxyindoline was resolved with L-carnitine oxalate as the chiral resolution reagent. The titled product can be achieved with 32% yield and [α20589 = -27.5] (c = 1.0, DMSO). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH

The Article related to carboxyindoline preparation nitrotoluene chiral resolution carnitine oxalate, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Reference of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Basolo, Luca; Bernasconi, Alice; Borsini, Elena; Broggini, Gianluigi; Beccalli, Egle M. published an article in 2011, the title of the article was Solvent-Free, Microwave-Assisted N-Arylation of Indolines by using Low Palladium Catalyst Loadings.Recommanded Product: 79815-20-6 And the article contains the following content:

A series of substituted N-arylindolines is prepared by a solvent-free, palladium-catalyzed procedure. The procedure requires only low loadings of catalyst, uses microwave irradiation, and starts from com. available substrates. The method proceeds in good yields and in short reaction times with aryl bromides, chlorides, and iodides, also on 2-substituted indolines. The combination of solvent-free methods with microwave heating will further increase in importance in the search for more environmentally acceptable synthesis methods. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to indoline aryl preparation aryl halide palladium phosphine catalyst microwave, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 28, 2011, de Lange, Ben; Hyett, David J.; Maas, Peter J. D.; Mink, Daniel; van Assema, Friso B. J.; Sereinig, Natascha; de Vries, Andre H. M.; de Vries, Johannes G. published an article.Synthetic Route of 79815-20-6 The title of the article was Asymmetric Synthesis of (S)-2-Indolinecarboxylic Acid by Combining Biocatalysis and Homogeneous Catalysis. And the article contained the following:

The use of a combination of biocatalysis and homogeneous catalysis led to a very short synthesis route to enantiopure (S)-2-indolinecarboxylic acid. Thus, reacting 2-ClC6H4CHO with Ac2O/NaOAc gave 2-ClC6H4CH:CHCO2H in 55% yield. The latter compound was treated with phenylalanine ammonia lyase to give (S)-2-ClC6H4CH2CH(NH2)CO2H (I), that, upon addition of CuCl/H2O, produced 77% of the title compound Alternatively, treating 2-ClC6H4CH:CH(NHCOMe)CO2H with [Rh(cod)2]BF4/MonoPhos/H2CH2Cl2 gave the reduced compound which was then converted into I and taken on to the final compound as stated above. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

The Article related to indolinecarboxylic acid asym synthesis biocatalysis homogeneous catalysis, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 2013, Liu, Jin-Qiang; Chen, Xin-Zhi; Ji, Baoming; Zhao, Bang-Tun published an article.Application of 79815-20-6 The title of the article was Transformation of L-phenylalanine to (S)-indoline-2-carboxylic acid without group-protection. And the article contained the following:

(S)-Indoline-2-carboxylic acid was synthesized by use of a nitro amination approach with L-phenylalanine as chiral pool. The first step of the synthesis was nitration of L-phenylalanine, with urea nitrate (UN)/H2SO4 as nitrating reagent, to give 2,4-dinitro-L-phenylalanine in 75.7 % yield in one-pot synthesis and 69.1 % yield by step-wise nitration. Intramol. nitro amination of 2,4-dinitro-L-phenylalanine gave (S)-6-nitro-indoline-2-carboxylic acid in 65.7 % yield and more than 99.5 % enantiomeric excess (ee). The title compound, (S)-indoline-2-carboxylic acid, was obtained in 85.9 % yield and high ee by one-pot transformation of (S)-6-nitroindoline-2-carboxylic acid. The total synthesis consisted of three operations and gave the title compound in 42 % yield and more than 99.5 % ee. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to phenylalanine transformation indoline carboxylic acid preparation protection group free, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles