Category: 79815-20-6

On March 15, 2014, Luo, Ren-shi; Xie, Ling; Liao, Jian-hua; Zhang, Jian published an article.Product Details of 79815-20-6 The title of the article was Synthesis and characterization of novel indole chiral amino alcohols. And the article contained the following:

With (S)-indole-2-carboxylic acid and (S)-octahydroindole-2-carboxylic acid as raw material, processed by esterification, protection, Grignard reaction and reduction by Pd/C, two new chiral indole derivative (S)-(2-octahydroindole) di-Ph methanol and (S)-(2-indolinyl)-diphenyl methanol were synthesized in high yield. The total yields were resp. 88.3% and 83.7%, the structure of the products were characterized by 1HNMR, 13CNMR and HRMS spectra. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Product Details of 79815-20-6

The Article related to synthesis characterization indole chiral amino alc esterification grignard reduction, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 1, 2008, Sayago, Francisco J.; Isabel Calaza, M.; Jimenez, Ana I.; Cativiela, Carlos published an article.Application In Synthesis of H-Idc-OH The title of the article was Versatile methodology for the synthesis and α-functionalization of (2R,3aS,7aS)-octahydroindole-2-carboxylic acid. And the article contained the following:

An improved strategy for the effective synthesis of enantiomerically pure (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, based on the formation of a trichloromethyloxazolidinone derivative, has been developed. Addnl., the completely diastereoselective α-alkylation of such oxazolidinone provides a very convenient and concise route to enantiopure α-tetrasubstituted derivatives of this stereoisomer of octahydroindole-2-carboxylic acid. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to indolecarboxylic octahydro alkylated asym synthesis, indolooxazolidinone preparation stereoselective alkylation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Lafzi, Ferruh; Kilic, Haydar; Tanriver, Gamze; Avci, Oykum Naz; Catak, Saron; Saracoglu, Nurullah published an article in 2019, the title of the article was Design and synthesis of novel indoline-(thio)urea hybrids.Recommanded Product: H-Idc-OH And the article contains the following content:

A series of novel indoline-(thio)ureas e.g., (S)-2-(aminomethyl)-N-((S)-1-phenylethyl)indoline-1-carbothioamide was designed and prepared using indoline(s) e.g., (S)-2-(azidomethyl)indoline as a new platform and tested as organocatalysts in the Michael and Morita-Baylis-Hillman reactions. Most of the compounds were found to be very active catalysts although they did not promote the enantioselectivity. As agents for the conversion of thiocarbonyl compounds into carbonyl compounds, potentials of PIFA and DDQ were also displayed. Furthermore, DFT calculations rationalized the exptl. observed non-enantioselectivity of the catalysts. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: H-Idc-OH

The Article related to thiourea indoline preparation enantioselective dft, indoline michael morita baylis hillman organocatalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 15, 2012, Lin, Ning; Luo, Ren-shi; Chen, Miao-miao; Lu, Gui published an article.COA of Formula: C9H9NO2 The title of the article was Synthesis and characterization of two chiral indoline derivatives. And the article contained the following:

Two indoline carboxylic acid derivatives (S)-(1-methylindolin-2-yl)diphenylmethanol and (S)-2-(1-methylindolin-2-yl)-1,3-diphenylpropan-2-ol were synthesized from (S)-indoline-2-carboxylic acid, through the N-methylation, esterification and Grignard addition The total yields of the two products were 86.5% and 89.7% resp. The structures of product were confirmed by 1HNMR, 13CNMR and HRMS. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).COA of Formula: C9H9NO2

The Article related to chiral indolinecarboxylic acid methylation esterification addition, methylindolinyl diphenylmethanol diphenylpropanol preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C9H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 24, 2011, Roca-Lopez, David; Merino, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Herrera, Raquel P. published an article.Electric Literature of 79815-20-6 The title of the article was Organocatalyzed Michael addition reaction by novel (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, a new fused proline. And the article contained the following:

The authors present their results on the organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst. Computational calculations support the results obtained with (R,S,S)-Oic vs. its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to acetone nitroolefin michael addition, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Georgieva, Miglena K.; Duarte, Filipe J. S.; Santos, A. Gil published an article in 2016, the title of the article was Directed electrostatic activation in enantioselective organocatalytic cyclopropanation reactions: a computational study.COA of Formula: C9H9NO2 And the article contains the following content:

Cyclopropane rings are versatile building blocks in organic chem. Their synthesis, by the reaction of sulfur ylides with α,β-unsaturated carbonyl compounds, has recently aroused renewed interest after the discovery of efficient catalysis by using (S)-indoline-2-carboxylic acid. In order to rationalize the behavior of this catalyst, MacMillan proposed a directed electrostatic activation (DEA) mechanism, in which the neg. carboxylate group interacts with the pos. thionium moiety, thus reducing the activation energy and increasing the reaction rate. More recently, Mayr refuted some of MacMillan conclusions, but accepted the DEA mechanism as a justification for the exptl. high reaction rates. In contrast, our results indicate that the selectivity obtained in the process seems to result from several strong hydrogen bond interactions between the two reacting species, while no strong evidence for a DEA mechanism was found. We also concluded that the hydrogen bonds don’t improve the reaction rate by lowering the activation energy of the rate-determining step, but can do it by promoting efficient reaction trajectories due to long-range complexation of the reagents. Finally, our results confirm that the cyclopropanation reaction occurs by a two-step mechanism, and that the overall enantioselectivity depends on the relative energies of the two steps, averaged by the relative populations of the iminium intermediates that are initially formed in the reaction. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).COA of Formula: C9H9NO2

The Article related to enantioselective cyclopropanation catalyst mechanism kinetics activation energy, Physical Organic Chemistry: Theoretical Organic Chemical Concepts, Including Quantum and Molecular Mechanical Studies and other aspects.COA of Formula: C9H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On October 31, 2009, Luo, Ren-Shi; Weng, Jiang; Ai, Hui-Bing; Lu, Gui; Chan, Albert S. C. published an article.Application In Synthesis of H-Idc-OH The title of the article was Highly efficient asymmetric Michael reaction of aldehydes to nitroalkenes with diphenylperhydroindolinol silyl ethers as organocatalysts. And the article contained the following:

New dihydroindole and perhydroindole derivatives were synthesized in good yields and evaluated as chiral catalysts in the asym. Michael reaction of aldehydes to nitroalkenes. (2S,3aS,7aS)-Diphenylperhydroindolinol silyl ether facilitated the reaction of a wide range of aldehyde and nitroalkene substrates, providing Michael adducts in nearly optically pure form (99% ee), good yields and high diastereoselectivities (syn/anti up to 99:1). These results show that perhydroindole derivatives can be highly efficient organocatalysts for the asym. Michael reaction, exhibiting comparable or even better enantioselectivities than proline derivatives The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to michael stereoselective aldehyde nitroalkene silyloxydiphenylmethylindole catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Aldehydes and Derivatives, Including Sulfur Analogs and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 30, 2008, Jainta, Manuel; Nieger, Martin; Brase, Stefan published an article.Application In Synthesis of H-Idc-OH The title of the article was Microwave-assisted stereoselective one-pot synthesis of symmetrical and unsymmetrical 2,5-diketopiperazines from unprotected amino acids. And the article contained the following:

The facile condensation of unprotected amino acids by phosphite-promoted one-step coupling reaction is a highly efficient synthesis to generate stereoselective and optically pure sym. and unsym. functionalized diketopiperazines. The use of microwaves enhanced by small amounts of ionic liquid is accompanied by significant improvement in reaction times and yields. Simple filtration through a pad of silica provides the pure compounds in very good to excellent yields. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application In Synthesis of H-Idc-OH

The Article related to diketopiperazine derivative preparation, amino acid cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Das, Krishna Kanta; Ghosh, Asim Kumar; Hajra, Alakananda published an article in 2022, the title of the article was Late-stage ortho-C-H alkenylation of 2-arylindazoles in aqueous medium by Manganese(I)-catalysis.Synthetic Route of 79815-20-6 And the article contains the following content:

Earth-abundant and water-tolerant manganese(I) catalyzed alkenylation of 2-arylindazoles I (R = H, F, Cl; R1 = H, 4-Me, 3-Cl, etc.) with alkyl and aryl alkynes R2CCR3 (R2 = H, Ph, Me; R3 = hexyl, Ph, thiophen-3-yl, etc.) through C-H bond activation is described with a unique level of E-selectivity. The reaction proceeds through the control of C3 nucleophilicity of 2-aryl indazoles. This method is applied to the late-stage functionalization of complex mols. including ethinylestradiol, norethisterone, and N-protected amino acid derivatives, e.g., prop-2-yn-1-yl (tert-butoxycarbonyl)-L-phenylalaninate. The kinetic isotope studies suggest that the C-H bond activation step may not be the rate-determining step. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Synthetic Route of 79815-20-6

The Article related to aryl indazole alkenyl preparation diastereoselective regioselective, alkyne aryl indazole alkenylation manganese catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Synthetic Route of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 24, 2011, Roca-Lopez, David; Merino, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Herrera, Raquel P. published an article.Electric Literature of 79815-20-6 The title of the article was Organocatalyzed Michael addition reaction by novel (2R,3aS,7aS)-octahydroindole-2-carboxylic acid, a new fused proline. And the article contained the following:

The authors present their results on the organocatalytic enantioselective Michael addition reaction of acetone to different nitroolefines using (2R,3aS,7aS)-octahydroindole-2-carboxylic acid [(R,S,S)-Oic] as a new and suitable catalyst. Computational calculations support the results obtained with (R,S,S)-Oic vs. its diastereomeric form (S,S,S)-Oic. The final products are obtained in good yields and moderate enantioselectivities (up to 58% ee). The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to acetone nitroolefin michael addition, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ketones and Derivatives, Including Quinones and Sulfur Analogs and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles