Category: 79815-20-6

On May 31, 2008, Baumann, Thomas; Baechle, Michael; Hartmann, Caroline; Brase, Stefan published an article.Electric Literature of 79815-20-6 The title of the article was Thermal effects in the organocatalytic asymmetric α-amination of disubstituted aldehydes with azodicarboxylates: a high-temperature organocatalysis. And the article contained the following:

This article describes the thermally accelerated organocatalytic α-amination of disubstituted aldehydes with azodicarboxylates under microwave conditions. Compared to the results previously obtained at room temperature, both yield and enantioselectivity could be significantly increased. Employing microwave irradiation resulted in a considerably reduced reaction time. Therefore, this improved protocol allows the fast and efficient synthesis of α,α-disubstituted amino aldehydes and provided the best results for the α-amination of disubstituted aldehydes to date. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Electric Literature of 79815-20-6

The Article related to thermal organocatalysis asym amination disubstituted aldehyde azodicarboxylate temperature, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Electric Literature of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 19, 2010, Xiao, Jian; Xu, Feng-Xia; Lu, Yun-Peng; Loh, Teck-Peng published an article.Safety of H-Idc-OH The title of the article was Chemzymes: A New Class of Structurally Rigid Tricyclic Ambiphilic Organocatalyst Inspired by Natural Product. And the article contained the following:

A new class of structurally rigid tricyclic ambiphilic chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asym. induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Safety of H-Idc-OH

The Article related to chemzyme rigid tricyclic amphibian organocatalyst inspired natural crystallog, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Safety of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On November 30, 2004, Jung, Doo Young; Park, Doo Han; Kim, Sung Han; Kim, Yong Hae published an article.Computed Properties of 79815-20-6 The title of the article was Dual enantioselective Diels-Alder process in the cyclization of chiral acrylamide with dienes. And the article contained the following:

Diels-Alder cycloadditions of chiral acrylamides with cyclopentadiene or 2, 3-dimethyl butadiene proceed with high diastereofacial selectivity. Either endo-R or endo-S products have been obtained depending upon the structures of acrylamides and Lewis acids used. The endo form was exclusively obtained over the exo form. The dependence of the mechanism of formation of opposite configurations of endo-R or endo-S products on the Lewis acids is discussed. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Computed Properties of 79815-20-6

The Article related to dual enantioselective diels alder cyclization chiral acrylamide diene, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On February 21, 2005, Ori, Mayuko; Toda, Narihiro; Takami, Kazuko; Tago, Keiko; Kogen, Hiroshi published an article.Recommanded Product: 79815-20-6 The title of the article was Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: application to the total syntheses of benzastatin E and natural virantmycin. And the article contained the following:

An efficient methodol. for the synthesis of 2,2,3-trisubstituted tetrahydroquinolines has been developed, which involves the triphenylphosphine-CCl4-mediated stereospecific rearrangement of α,α-disubstituted indoline-2-methanols (I) to 2,2,3-trisubstituted tetrahydroquinolines. The rearrangement precursors I are readily prepared by the diastereoselective Grignard addition to 2-acylindolines. The total syntheses of (+)-benzastatin E (II) and natural virantmycin (III) were accomplished utilizing this methodol. This rearrangement reaction might afford some chem. precedent for the biogenetic pathway of the benzastatin family. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Recommanded Product: 79815-20-6

The Article related to benzastatin e preparation, virantmycin preparation, tetrahydroquinoline preparation rearrangement indolinemethanol, indoline methanol preparation grignard addition acylindoline and other aspects.Recommanded Product: 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 1, 2020, Sakamuri, Sukumar; Liu, Dingguo; Eltepu, Laxman; Liu, Bin; Reboton, Lisa Jo; Preston, Ryan; Bradshaw, Curt W. published an article.Product Details of 79815-20-6 The title of the article was Identification of a Tricyclic PIII Chiral Auxiliary for Solid-Supported Synthesis of Stereopure Phosphorothioate-Containing Oligonucleotides. And the article contained the following:

Since the recognition of oligonucleotides as a therapeutic modality, significant work has been devoted to improving therapeutic properties, including nuclease stability. Phosphorothioate (PS) modifications of phosphodiesters are one of the most explored chem. modification and integral to currently approved oligonucleotide therapeutics, including antisense oligonucleotides (ASOs) and short interfering RNAs (siRNAs). Insertion of sulfur into the phosphate bridge in an n-mer leads to 2n isomeric mixtures of PSs, with different nuclease stability and protein-binding properties. Efforts to create stereopure PS-containing oligonucleotides has spurred interest in identifying new synthetic methods. Herein, work on a novel and practical tricyclic PIII chiral auxiliary and its application in solid-supported synthesis of stereopure PS-containing oligonucleotides is reported. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Product Details of 79815-20-6

The Article related to phosphodiester phosphorothioate antisense oligonucleotide chiral auxiliary nuclease stability, chiral auxiliaries, oligonucleotides, phosphorothioates, solid-supported synthesis, synthesis design and other aspects.Product Details of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 31, 2006, Metzner, L.; Neubert, K.; Brandsch, M. published an article.Reference of H-Idc-OH The title of the article was Substrate specificity of the amino acid transporter PAT1. And the article contained the following:

The proton coupled amino acid transporter PAT1 expressed in intestine, brain, and other organs accepts L- and D-proline, glycine, and L-alanine but also pharmaceutically active amino acid derivatives such as 3-amino-1-propanesulfonic acid, L-azetidine-2-carboxylic acid, and cis-4-hydroxy-D-proline as substrates. We systematically analyzed the structural requirements for PAT1 substrates by testing 87 amino acids, proline homologs, indoles, and derivatives Affinity data and effects on membrane potential were determined using Caco-2 cells. For aliphatic amino acids, a blocked carboxyl group, the distance between amino and carboxyl group, and the position of the hydroxyl group are affinity limiting factors. Methylation of the amino group enhances substrate affinity. Hetero atoms in the proline template are well tolerated. Aromatic α-amino acids display low affinity. PAT1 interacts strongly with heterocyclic aromatic acids containing an indole scaffold. The structural requirements of PAT1 substrates elucidated in this study will be useful for the development of prodrugs. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Reference of H-Idc-OH

The Article related to amino acid transport pat1 transporter intestine epithelium, carboxyl hydroxyl amino imino group amino acid structure transport, prodrug drug transport metabolism amino group methylation pat1 and other aspects.Reference of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nonappa; Ahonen, Kari; Lahtinen, Manu; Kolehmainen, Erkki published an article in 2011, the title of the article was Cyclic dipeptides: catalyst/promoter-free, rapid and environmentally benign cyclization of free amino acids.Quality Control of H-Idc-OH And the article contains the following content:

With growing public concern over global warming and the amount of greenhouse gases, it is important to reduce the amount of chems. and eliminate waste, to obtain better results in a simple, selective, safe, and environmentally benign fashion compared to conventional tedious chem. synthesis. Herein, the authors disclose an environmentally benign, rapid, catalyst/promoter/coupling reagent-free cyclization procedure of free amino acids to furnish exclusively cyclic dipeptides (2,5-diketopiperazines, DKPs) in excellent or even quant. yields, along with their solid state self-assembling properties. This process is extremely simple and highly efficient with little or no traditional synthetic skills and without any chromatog. purification Synthesis of structurally diverse DKPs has been achieved with a dramatic decrease in the reaction time, the amount/number of solvents used, a significant increase in the yield and nearly complete elimination of waste. As a result, this is an excellent example for the environmentally benign, clean and green chem. concept. The most exciting outcome of this investigation is an unusual case of chiral self-recognition encountered upon the cyclization of rac-pipecolic acid, which resulted in the formation of the meso-product exclusively. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Quality Control of H-Idc-OH

The Article related to cyclic dipeptide diketopiperazine preparation amino acid catalyst free cyclization, crystal structure diketopiperazine cyclic dipeptide, pipecolic acid cyclization chiral self recognition and other aspects.Quality Control of H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 31, 2007, Rios, Ramon; Sunden, Henrik; Vesely, Jan; Zhao, Gui-Ling; Dziedzic, Pawel; Cordova, Armando published an article.Application of 79815-20-6 The title of the article was A simple organocatalytic enantioselective cyclopropanation of α,β-unsaturated aldehydes. And the article contained the following:

A highly chemo- and enantioselective organocatalytic cyclopropanation of α,β-unsaturated aldehydes with bromomalonate and 2-bromoacetoacetate esters is presented. The reaction is catalyzed by chiral amines and gives access to 2-formylcyclopropanes in high yields and up to 99% ee. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Application of 79815-20-6

The Article related to chiral amine catalyzed enantioselective cyclopropanation alpha beta unsaturated aldehyde, alpha beta unsaturated aldehyde cyclopropanation bromomalonate bromoacetoacetate ester catalyst and other aspects.Application of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On January 17, 2011, Chisholm, Cora D.; Wenzel, Thomas J. published an article.Related Products of 79815-20-6 The title of the article was Enantiomeric discrimination of aromatic-containing anionic substrates using cationic cyclodextrins. And the article contained the following:

Cationic α-, β-, and γ-cyclodextrins were prepared by reacting the corresponding native cyclodextrin (CD) with glycidyltrimethylammonium chloride (GTAC). The reaction conditions were varied to alter the degree of substitution of GTAC units on the cyclodextrin. The CD-GTAC derivatives, which retain a pos. charge independent of pH, were evaluated as water-soluble chiral NMR solvating agents for anionic substrates. The CD-GTAC derivatives are considerably more effective at causing enantiomeric discrimination in the 1H NMR spectra of aromatic-containing anionic substrates than the neutral native cyclodextrins. Derivatives with a degree of substitution of ∼1.5 were more effective than those with lower or higher degree of substitution. Not one of the α-, β-, and γ-CD-GTAC derivatives was consistently the most effective at causing enantiomeric discrimination for all of the substrates examined herein. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Related Products of 79815-20-6

The Article related to aromatic containing anion enantiomeric discrimination trimethylammonium modified cyclodextrin nmr, chiral nmr solvating agent trimethylammonium modified cyclodextrin anion substrate and other aspects.Related Products of 79815-20-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On March 31, 2022, Zhang, Hongjun; Cheng, Zeguang; Wei, Litian; Yu, Xinjun; Wang, Zhao; Zhang, Yinjun published an article.Formula: C9H9NO2 The title of the article was Semi-rational protein engineering of a novel esterase from Bacillus aryabhattai (BaCE) for resolution of (R,S)-ethyl indoline-2-carboxylate to prepare (S)-indoline-2-carboxylic acid. And the article contained the following:

A gene encoding an esterase from Bacillus aryabhattai (BaCE) was identified, synthesized and efficiently expressed in the Escherichia coli system. A semi-rational protein engineering was applied to further improve the enzymes enantioselectivity. Under the guidance of the mol. docking result, a single mutant BaCE-L86Q and a double mutant BaCE-L86Q/G284E were obtained, with its Emax value 6.4 times and 13.9 times of the wild-type BaCE, resp. The recombinant BaCEs were purified and characterized. The overwhelming E value demonstrated that BaCE-L86Q/G284E was a promising biocatalyst for the biol. resolution to prepare (S)-indoline-2-carboxylic acid. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Formula: C9H9NO2

The Article related to bacillus escherichia esterase protein engineering enantioselectivity, (s)-indoline-2-carboxylic acid, biocatalysis, enantioselective, esterase, overexpression, protein engineering and other aspects.Formula: C9H9NO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles