Category: 80-59-1

An article Second-Generation meta-Phenolsulfonic Acid-Formaldehyde Resin as a Catalyst for Continuous-Flow Esterification WOS:000506088700033 published article about DIRECT ESTER CONDENSATION; CARBOXYLIC-ACIDS; SULFONIC-ACID; WATER-TOLERANT; NONCATALYTIC TRANSESTERIFICATION; DEHYDRATIVE ESTERIFICATION; EQUIMOLAR AMOUNTS; ALCOHOLS; POLYMER; BIODIESEL in [Hu, Hao; Ota, Hajime; Baek, Heeyoel; Shinohara, Kenta; Uozumi, Yasuhiro; Yamada, Yoichi M. A.] RIKEN, Ctr Sustainable Resource Sci, Wako, Saitama 3510198, Japan; [Mase, Toshiaki; Uozumi, Yasuhiro] Inst Mol Sci, Okazaki, Aichi 4448787, Japan in 2020, Cited 38. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Computed Properties of C5H8O2

A second-generation m-phenolsulfonic acid-formaldehyde resin (PAFR II) catalyst was prepared by condensation polymerization of sodium m-phenolsulfonate and paraformaldehyde in an aqueous H2SO4 solution. This reusable, robust acid resin catalyst was improved in both catalytic activity and stability, maintaining the characteristics of the previous generation catalyst (p-phenolsulfonic acid-formaldehyde resin). PAFR II was applied in the batchwise and continuous-flow direct esterification without water removal and provided higher product yields in continuous-flow esterification than any other commercial ion-exchanged acid catalyst tested.

Computed Properties of C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Hu, H; Ota, H; Baek, H; Shinohara, K; Mase, T; Uozumi, Y; Yamada, YMA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Traceless selenocarboxylates for the one-pot synthesis of amides and derivatives WOS:000604923900010 published article about BOND FORMATION; CARBOXYLIC-ACIDS; EFFICIENT AMIDATION; STAUDINGER LIGATION; PRACTICAL SYNTHESIS; SECONDARY AMIDES; AMINO-ACIDS; THIO ACIDS; AZIDES; PEPTIDE in [Silva, Luana; Rosario, Alisson R.; Machado, Bianca M.; Ludtke, Diogo S.] Univ Fed Rio Grande do Sul, Inst Quim, Av Bento Goncalves 9500, BR-91501970 Porto Alegre, RS, Brazil in 2021, Cited 75. Application In Synthesis of (E)-2-Methylbut-2-enoic acid. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We have recently reported a one-pot procedure for glycosyl amides synthesis using selenocarboxylate as traceless reagent. Herein, we present a further application of selenocarboxylate-azide reaction for amide bond formation on a broader range of substrates, including heterocyclic systems and fatty acid. This method proved to be highly efficient for the synthesis of primary and secondary amides, sulfonamides, imides, phosphoramide and also carbamate. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Silva, L; Rosario, AR; Machado, BM; Ludtke, DS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: (E)-2-Methylbut-2-enoic acid. In 2020 FOOD ADDIT CONTAM A published article about MASS-SPECTROMETRY; ECHIUM-VULGARE; N-OXIDES; CYNOGLOSSUM-OFFICINALE; VENOOCCLUSIVE DISEASE; METABOLIC-ACTIVATION; MEDICINAL-PLANTS; RISK-ASSESSMENT; IDENTIFICATION; BIOSYNTHESIS in [Maedge, Inga; Gehling, Matthias; Schoene, Cindy; These, Anja] German Fed Inst Risk Assessment, Dept Safety Food Chain, Max Dohrn Str 8-10, D-10589 Berlin, Germany; [Maedge, Inga; Winterhalter, Peter] Tech Univ Carolo Wilhelmina Braunschweig, Inst Food Chem, Braunschweig, Germany in 2020, Cited 64. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Pyrrolizidine alkaloids (PAs) and their corresponding N-oxides (PANOs) have been determined in food and feed at levels relevant for consumer health. More than 660 different PAs have been detected, but few are available as reference substances for analytical demands. In the context of the European legislation on maximum levels of PAs in food products, a defined analytical scope of 21 PAs for determination has been suggested. An expansion of the scope from 21 to 35 PAs, including 14 structural isomers, is currently under discussion. In the present study, a target screening method was established for a comprehensive characterisation of PA profiles of the species Echium vulgare, Heliotropium europaeum, Cynoglossum officinale and Symphytum spp. to assess whether an expansion of the analytical scope is required to quantitatively cover the total PA contents of Boraginaceae species. The scope of the method comprised known and unknown PAs previously screened and confirmed in the respective plant extracts. A total of 176 PAs and PANOs were detected. The toxic 1,2-unsaturated PAs represent the predominant PA type with about 98% of the mean total content. This PA profiling demonstrates that an expansion of the scope from 21 to 35 PAs is required to adequately cover the mean total PA contents of Cynoglossum officinale and H. europaeum, whereas in the case of Symphytum spp. and Echium vulgare an expansion would not be necessary.

Name: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Madge, I; Gehling, M; Schone, C; Winterhalter, P; These, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 80-59-1. Authors Korff, M; Imberg, L; Will, JM; Buckreiss, N; Kalinina, SA; Wenzel, BM; Kastner, GA; Daniliuc, CG; Barth, M; Ovsepyan, RA; Butov, KR; Humpf, HU; Lehr, M; Panteleev, MA; Poso, A; Karst, U; Steinmetzer, T; Bendas, G; Kalinin, DV in AMER CHEMICAL SOC published article about in [Korff, Marvin; Imberg, Lukas; Kastner, Gregor A.; Barth, Maximilian; Lehr, Matthias; Kalinin, Dmitrii, V] Univ Munster, Inst Pharmaceut & Med Chem, D-48149 Munster, Germany; [Will, Jonas M.; Karst, Uwe] Univ Munster, Inst Inorgan & Analyt Chem, D-48149 Munster, Germany; [Bueckreiss, Nico; Bendas, Gerd] Univ Bonn, Pharmaceut Inst, D-53121 Bonn, Germany; [Kalinina, Svetlana A.; Humpf, Hans-Ulrich] Univ Munster, Inst Food Chem, D-48149 Munster, Germany; [Wenzel, Benjamin M.; Steinmetzer, Torsten] Philipps Univ Marburg, Inst Pharmaceut Chem, Dept Pharm, D-35032 Marburg, Germany; [Daniliuc, Constantin G.] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany; [Ovsepyan, Ruzanna A.; Butov, Kirill R.; Panteleev, Mikhail A.] Dmitriy Rogachev Natl Med Res Ctr Pediat Hematol, Lab Translat Med, Moscow 117997, Russia; [Ovsepyan, Ruzanna A.; Butov, Kirill R.; Panteleev, Mikhail A.] Russian Acad Sci, Ctr Theoret Problems Physicochem Pharmacol, Moscow 119991, Russia; [Panteleev, Mikhail A.] Lomonosov Moscow State Univ, Fac Phys, Moscow 119991, Russia; [Panteleev, Mikhail A.] Moscow Inst Phys & Technol, Fac Biol & Med Phys, Dolgoprudnyi 141700, Russia; [Poso, Antti] Univ Eastern Finland, Fac Hlth Sci, Sch Pharm, Kuopio 70211, Finland; [Poso, Antti] Univ Hosp Tubingen, Dept Internal Med 8, D-72076 Tubingen, Germany in 2020, Cited 75. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We herein report the conventional and microscale parallel synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a 1,2,4-triazol-5-amine scaffold. Structural variations of this scaffold allowed identifying derivative 21i, a potent 29 nM inhibitor of FXIIa, with improved selectivity over other tested serine proteases and also finding compound 21m with 27 nM inhibitory activity toward thrombin. For the first time, acylated 1,2,4-triazol-5-amines were proved to have anticoagulant properties and the ability to affect thrombin- and cancer-cell-induced platelet aggregation. Performed mass spectrometric analysis and molecular modeling allowed us to discover previously unknown interactions between the synthesized inhibitors and the active site of FXIIa, which uncovered the mechanistic details of FXIIa inhibition. Synthesized compounds represent a promising starting point for the development of novel antithrombotic drugs or chemical tools for studying the role of FXIIa and thrombin in physiological and pathological processes.

Recommanded Product: 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Korff, M; Imberg, L; Will, JM; Buckreiss, N; Kalinina, SA; Wenzel, BM; Kastner, GA; Daniliuc, CG; Barth, M; Ovsepyan, RA; Butov, KR; Humpf, HU; Lehr, M; Panteleev, MA; Poso, A; Karst, U; Steinmetzer, T; Bendas, G; Kalinin, DV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium catalyzed carbonylations of alkenyl halides with formic acid to get corresponding alpha,beta-unsaturated carboxylic acids and esters WOS:000461410800017 published article about ACETIC-ANHYDRIDE; ORGANIC HALIDES; ARYL BROMIDES; OLEFINS; CO; HYDROCARBOXYLATION; HYDROXYCARBONYLATION; ALKYNES; HYDROESTERIFICATION in [Pongracz, Peter] Univ Pecs, Dept Inorgan Chem, H-7624 Pecs, Hungary; Janos Szentagothai Sci Ctr, MTA TKI Res Grp Select Chem Syntheses, H-7624 Pecs, Hungary in 2019, Cited 30. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1. Quality Control of (E)-2-Methylbut-2-enoic acid

Palladium-catalysed carbonylation reactions have been developed in the presence of formic acid as carbon monoxide source. alpha,beta-Unsaturated carboxylic acids and esters were synthesized by the transformation of alkenyl halides in moderate to good yields. The selection of the base proved to be crucial regarding the reaction outcome. A set of various substrates were proven under optimised reaction conditions. Compared to aliphatic alcohols, phenols showed excellent reactivity as O-nucleophiles.

Quality Control of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Bartal, B; Mikle, G; Kollar, L; Pongracz, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 80-59-1. In 2019 INT J MOL SCI published article about SYRIAN CIVIL-WAR; IN-VITRO; CUTANEOUS LEISHMANIASIS; ANTILEISHMANIAL ACTIVITY; ANTIBACTERIAL ACTIVITY; MEDICINAL-PLANTS; NATURAL-PRODUCTS; CHENOPODIUM-AMBROSIOIDES; TRADITIONAL MEDICINE; MAIN COMPONENTS in [Delgado-Altamirano, Ronna] Univ Autonoma Queretaro, Fac Quim, Posgrad Ciencias Quim Biol, Cerro Campanas S-N, Queretaro 76010, Mexico; [Delgado-Altamirano, Ronna; Rojas-Molina, Alejandra] Univ Autonoma Queretaro, Fac Quim, Lab Invest Quim & Farmacol Prod Nat, Cerro Campanas S-N, Queretaro 76010, Mexico; [Isela Lopez-Palma, Rosa; Delgado-Dominguez, Jose; Becker, Ingeborg] Univ Nacl Autonoma Mexico, Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Invest Med Expt, Lab Inmunoparasitol,Fac Med, Dr Balmis 148, Mexico City 06720, DF, Mexico; [Monzote, Lianet] Inst Med Trop Pedro Kouri, Dept Parasitol, Apdo Postal 601, Havana 10400, Cuba; [Fausto Rivero-Cruz, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico; [Esturau-Escofet, Nuria] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico; [Vazquez-Landaverde, Pedro A.] Inst Politecn Nacl, Ctr Invest Ciencia Aplicada & Tecnol Avanzada, Unidad Queretaro, Cerro Blanco 141 Colonia Cimatario, Queretaro 76090, Mexico in 2019, Cited 79. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), -ionone (3), caryophyllene oxide (4), -caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 +/- 0.36 M). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

SDS of cas: 80-59-1. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: (E)-2-Methylbut-2-enoic acid. In 2020 ORG LETT published article about RADICAL AMINOFLUORINATION; MEDICINAL CHEMISTRY; FLUORINATION; ALKENES; STRATEGIES; HALOFUNCTIONALIZATION; GENERATION; ALKALOIDS; CENTERS; ESTERS in [Xu, Zheyuan; Fu, Yao] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Urban Pollutant Convers, Anhui Prov Key Lab Biomass Clean Energy,iChEM, Hefei 230026, Anhui, Peoples R China; [Fei, Haiyang; Wu, Hongmiao; Zhu, Lin; Lu, Hongjian] Nanjing Univ, Inst Chem & BioMed Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn, Nanjing 210093, Peoples R China; [Jalani, Hitesh B.] Yonsei Univ, Dept Pharm, Incheon 21983, South Korea; [Jalani, Hitesh B.] Yonsei Univ, Yonsei Inst Pharmaceut Sci, Incheon 21983, South Korea; [Li, Guigen] Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA in 2020, Cited 55. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

An efficient fluorocyclization of alpha,beta-unsaturated amides through a formal halocyclization process is developed. The reaction proceeds under transition-metal-free conditions and leads to the formation of fluorinated oxazolidine-2,4-diones with excellent regio- and diastereoselectivity. The evaluation of the reaction mechanism based on preliminary experiments and density functional theory calculations suggests that a synergetic syn-oxo-fluorination occurs and is followed by an anti-oxo substitution reaction. The reaction opens a new window in the field of stereospecific fluorofunctionalization.

Name: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Fei, HY; Xu, ZY; Wu, HM; Zhu, L; Jalani, HB; Li, GG; Fu, Y; Lu, HJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article C-2-Symmetric Cinchona Alkaloid Derivatives: Versatile Catalysts for the Enantioselective C-C Bond Forming Conjugate Addition of Nucleophiles to Simple alpha,beta-Unsaturated Acyl Pyrazoles WOS:000603432100011 published article about CHIRAL LEWIS-ACID; MICHAEL ADDITION; ASYMMETRIC REACTION; DIELS-ALDER; CYCLOADDITIONS; NITROMETHANE; PROPIOLOYLPYRAZOLES; BENZYLHYDROXYLAMINE; MALONONITRILE; ACTIVATION in [Curran, Simon P.; Fallon, Brendan J.; Connon, Stephen J.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Chem, 152-160 Pearse St, Dublin 2, Ireland in 2020, Cited 57. HPLC of Formula: C5H8O2. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

A single C-2-symmetric squaramide catalyst system allows the facile addition of either malononitrile or benzyl nitroacetate to simple pyrazole-based Michael acceptors with excellent enantiocontrol and at lower catalyst loadings than previously possible. The latter reactions are not diastereoselective, however facile hydrogenolysis leads to decarboxylation and formation of the formal adduct from the addition of nitromethane (a very recalcitrant nucleophile in this chemistry) with excellent yield and enantiocontrol.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Curran, SP; Fallon, BJ; Connon, SJ or concate me.. HPLC of Formula: C5H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. Authors Ouyang, J; Kennemur, JL; Kanta, D; Fares, C; List, B in AMER CHEMICAL SOC published article about in [Ouyang, Jie; Kennemur, Jennifer L.; Kanta, De Chandra; Fares, Christophe; List, Benjamin] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany in 2019, Cited 43. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1

We report a catalytic asymmetric Nazarov cyclization of simple, acylic, alkyl-substituted divinyl ketones using our recently disclosed strong and confined imidodiphosphorimidate Bronsted acids. The corresponding monocyclic cyclopentenones are formed in good yields and excellent regio-, diastereo-, and enantioselectivities. Further, the chemical utility of the obtained enantiopure cyclopentenones is demonstrated.

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Ouyang, J; Kennemur, JL; Kanta, D; Fares, C; List, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A in [Delgado-Altamirano, Ronna] Univ Autonoma Queretaro, Fac Quim, Posgrad Ciencias Quim Biol, Cerro Campanas S-N, Queretaro 76010, Mexico; [Delgado-Altamirano, Ronna; Rojas-Molina, Alejandra] Univ Autonoma Queretaro, Fac Quim, Lab Invest Quim & Farmacol Prod Nat, Cerro Campanas S-N, Queretaro 76010, Mexico; [Isela Lopez-Palma, Rosa; Delgado-Dominguez, Jose; Becker, Ingeborg] Univ Nacl Autonoma Mexico, Hosp Gen Mexico Dr Eduardo Liceaga, Unidad Invest Med Expt, Lab Inmunoparasitol,Fac Med, Dr Balmis 148, Mexico City 06720, DF, Mexico; [Monzote, Lianet] Inst Med Trop Pedro Kouri, Dept Parasitol, Apdo Postal 601, Havana 10400, Cuba; [Fausto Rivero-Cruz, Jose] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico; [Esturau-Escofet, Nuria] Univ Nacl Autonoma Mexico, Inst Quim, Mexico City 04510, DF, Mexico; [Vazquez-Landaverde, Pedro A.] Inst Politecn Nacl, Ctr Invest Ciencia Aplicada & Tecnol Avanzada, Unidad Queretaro, Cerro Blanco 141 Colonia Cimatario, Queretaro 76090, Mexico published Chemical Constituents with Leishmanicidal Activity from a Pink-Yellow Cultivar of Lantana camara var. aculeata (L.) Collected in Central Mexico in 2019, Cited 79. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Lantana camara (L.) is employed by several ethnical groups to treat numerous diseases. Although there are no ethnomedical reports on its use against leishmaniasis, organic extracts prepared from L. camara were shown to display leishmanicidal activity. In the present study, we carried out a bioassay-guided fractionation of the dichloromethane extract from Mexican L. camara in order to identify the compounds responsible for the leishmanicidal activity. Eighteen chromatographic fractions (FI-FXVIII) were evaluated in vitro against Leishmania mexicana and L. amazonensis. FII, FX, FXI, FXV, and FXVI showed significant activity against both Leishmania strains, the most potent of which was FXV. Eicosane (1), squalene (2), -ionone (3), caryophyllene oxide (4), -caryophyllene (5), hexanoic acid (6), tiglic acid (7), a mixture of lantanilic (8) and camaric (9) acids, and lantadene B (10) were identified and obtained from the active fractions and evaluated for their leishmanicidal activity. The mixture of lantanilic (8) and camaric (9) acids (79%/21%) was the most potent one (half maximal inhibitory concentration (IC50) = 12.02 +/- 0.36 M). This study indicates that this cultivar of L. camara has high potential for the development of phytomedicines or as a source of natural products, which might represent lead compounds for the design of new drugs against leishmaniasis.

Category: indole-building-block. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Delgado-Altamirano, R; Lopez-Palma, RI; Monzote, L; Delgado-Dominguez, J; Becker, I; Rivero-Cruz, JF; Esturau-Escofet, N; Vazquez-Landaverde, PA; Rojas-Molina, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles