Category: 98-17-9

Formula: C7H5F3O. Zhang, LQ; Wang, YB; Shi, Y; Wu, YM; Lan, JB; Ma, WX; You, JS in [Zhang, Luoqiang; Wang, Yanbing; Shi, Yang; Wu, Yimin; Lan, Jingbo; Ma, Weixin; You, Jingsong] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, 29 Wangjiang Rd, Chengdu 610064, Sichuan, Peoples R China published Highly Regio- and Chemoselective Oxidative C-H/C-H Cross-Couplings of Anilines and Phenols Enabled by a Co-Oxidant-Free Rh(I)/Zn(NTf2)(2)/Air Catalytic System in 2019, Cited 51. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

An urgent yet challenging task is to overcome the limitations in substrate scope and regio- and chemoselectivity in the oxidative couplings between two arenes for the construction of unsymmetrical 2,2′-difunctional biaryls with diverse application requirements. In this work, a co-oxidant-free Rh(I)/Zn(NTf2)(2)/air catalytic system has been developed for dual chelation-assisted oxidative C-H/C-H cross-couplings between two anilines, between two phenols, and between phenols and anilines, which enables rapid assembly of rich libraries of 2,2′-bianilines, 2,2′-biphenols, and 2′-aminobiphenyl-2-ols. This protocol features air as the sole oxidant, complete regioselectivity, high chemoselectivity, low molar ratio of substrates (even 1:1), convenient operation, and scale-up synthesis. The established catalytic system is tolerant of the substrates having both electron-donating and electron-withdrawing substituents at different positions of the aryl ring. This work further discloses that the chemoselectivity of cross-coupling over homocoupling mainly relies on a suitable combination of two directing groups (i.e., a pair of strongly and weakly coordinating directing groups) rather than the electronically distinct properties between two substrates, which provides an inspiration for designing the matching directing group pair for the dual chelation-assisted oxidative Ar-H/Ar-H cross-couplings. Thus, this strategy allows the highly chemoselective cross-coupling between electronically similar coupling partners, which represents a challenging task in the oxidative Ar-H/Ar-H cross-coupling reactions.

Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, LQ; Wang, YB; Shi, Y; Wu, YM; Lan, JB; Ma, WX; You, JS or send Email.. Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK in [Zhang, Tian-Yi; Bai, Xue-Qian; Chen, Jiang-Hui; Song, Ze-Wen; Feng, Bo] Jilin Med Univ, Jilin 132013, Jilin, Peoples R China; [Li, Chun-Shi; Cui, Ming-Yue] Third Peoples Hosp Dalian, Dalian 116000, Peoples R China; [Chen, Jiang-Hui; Song, Ze-Wen] Yanbian Univ, Dept Pharm, Yanji 133002, Peoples R China; [Liu, Xue-Kun] Tonghua Normal Univ, Sch Pharm Med, Tonghua 134002, Jilin, Peoples R China published Design, synthesis and evaluation of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties as antibacterial agents in 2021, Cited 21. Computed Properties of C7H5F3O. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

In the present investigation, a series of dihydrotriazine derivatives-bearing 5-aryloxypyrazole moieties were synthesized and their structures were confirmed by different spectral tools. The biological evaluation in vitro revealed that some of the target compounds exerted good antibacterial and antifungal activity in comparison with the reference drugs. Among these novel hybrids, compound 10d showed the most potent activity with minimum inhibitory concentration values (MIC) of 0.5 mu g/mL againstS. aureus4220, MRSA 3506 and E. coli 1924 strain. The cytotoxic activity of the compounds 6d, 6m,10d and 10g was assessed in MCF-7 and HeLa cells. Growth kinetics study showed significant inhibition of bacterial growth when treated with different conc. of 10d. In vitro enzyme study implied that compound 10d exerted its antibacterial activity through DHFR inhibition. Moreover, significant inhibition of biofilm formation was observed in bacterial cells treated with MIC conc. of 10d as visualized by SEM micrographs. [GRAPHICS] .

Computed Properties of C7H5F3O. Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, TY; Li, CS; Cui, MY; Bai, XQ; Chen, JH; Song, ZW; Feng, B; Liu, XK or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-(Trifluoromethyl)phenol. I found the field of Chemistry very interesting. Saw the article Pummerer Synthesis of Chromanes Reveals a Competition between Cyclization and Reductive Chlorination published in 2019, Reprint Addresses Gamba-Sanchez, D (corresponding author), Univ Andes, Dept Chem, Lab Organ Synth Bio & Organocatalysis, Cra 1 18A-12 Q 305, Bogota 111711, Colombia.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

The competition between an unprecedented reductive chlorination and the Pummerer reaction was studied and applied to the synthesis of benzofused oxygen heterocycles including 3-aminochromanes and in the intramolecular chlorination of activated aromatic rings. The use of (COCl)(2) as a Pummerer activator showed substantial activity, producing alpha-chlorinated sulfides that can undergo Pummerer-Friedel-Crafts cyclization. If the aromatic ring has electron-donating groups in position three, then the reaction follows a different pathway, yielding the reductive chlorination products, where the chlorine atom comes from a sulfonium salt.

Recommanded Product: 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Acosta-Guzman, P; Rodriguez-Lopez, A; Gamba-Sanchez, D or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H5F3O. Recently I am researching about GENERAL STRATEGY; ACCESS, Saw an article supported by the Shenzhen Science and Technology Innovation Committee [KQTD20150717103157174]; Shenzhen Nobel Prize Scientists Laboratory Project [C17783101]; Key-Area Research and Development Program of Guangdong Province [2020B010188001]; Innovative Team of Universities in Guangdong Province [2020KCXTD016]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21991113, 21901107]; Southern University of Science and Technology (start-up fund). Published in NATURE RESEARCH in BERLIN ,Authors: Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral centre on the scaffold of the prostaglandins was installed using the asymmetric hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-gram scale.

Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM or send Email.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. In 2020 J AGR FOOD CHEM published article about 6 LEAF VEGETABLES; PROTOPORPHYRINOGEN; RESIDUE in [Zhao, Li-Xia; Jiang, Mao-Jun; Hu, Jia-Jun; Zou, Yue-Li; Cheng, Yuan; Ren, Tao; Gao, Shuang; Fu, Ying; Ye, Fei] Northeast Agr Univ, Coll Sci, Dept Appl Chem, Harbin 150030, Peoples R China in 2020, Cited 42. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

To seek new protoporphyrinogen oxidase (PPO) inhibitors with better biological activity, a series of novel diphenyl ether derivatives containing tetrahydrophthalimide were designed based on the principle of substructure splicing and bioisomerization. PPO inhibition experiments exhibited that 6c is the most potential compound, with the half-maximal inhibitory concentration (IC50) value of 0.00667 mg/L, showing 7 times higher activity than Oxyfluorfen (IC50 = 0.0426 mg/L) against maize PPO and similar herbicidal activities to Oxyfluorfen in weeding experiments in greenhouses and field weeding experiments. In view of the inspected bioactivities, the structure-activity relationship (SAR) of this series of compounds was also discussed. Crop selection experiments demonstrate that compound 6c is safe for soybeans, maize, rice, peanuts, and cotton at a dose of 300 g ai/ha. Accumulation analysis experiments showed that the accumulation of 6c in some crops (soybeans, peanuts, and cotton) was significantly lower than Oxyfluorfen. Current work suggests that compound 6c may be developed as a new herbicide candidate in fields.

Quality Control of 3-(Trifluoromethyl)phenol. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Regioselective Monobromination of Phenols with KBr and ZnAl-BrO3–Layered Double Hydroxides WOS:000522454500150 published article about N-BROMOSUCCINIMIDE NBS; AROMATIC-COMPOUNDS; OXIDATIVE BROMINATION; SELECTIVE MONOBROMINATION; SUBSTITUTED PHENOLS; EFFICIENT SYNTHESIS; MILD; BROMIDE; ACID; ANILINES in [Wang, Ligeng; Feng, Chun; Zhang, Yan; Hu, Jun] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310004, Peoples R China in 2020, Cited 69. Product Details of 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The regioselective mono-bromination of phenols has been successfully developed with KBr and ZnAl-BrO3–layered double hydroxides (abbreviated as ZnAl-BrO3–LDHs) as brominating reagents. The para site is much favorable and the ortho site takes the priority if para site is occupied. This reaction featured with excellent regioselectivity, cheap brominating reagents, mild reaction condition, high atom economy, broad substrate scope, and provided an efficient method to synthesize bromophenols.

Product Details of 98-17-9. Welcome to talk about 98-17-9, If you have any questions, you can contact Wang, LG; Feng, C; Zhang, Y; Hu, J or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 J AM CHEM SOC published article about BOND FORMATION; ALKYL-HALIDES; PHOTOREDOX; BORYLATION; COBALT; SIZE; DIBORYLMETHANE; NANOPARTICLES; CONSTRUCTION; CARBANIONS in [Zhang, Lumin; Si, Xiaojia; Rominger, Frank; Hashmi, A. Stephen K.] Heidelberg Univ, Organ Chem Inst, D-69120 Heidelberg, Germany; [Hashmi, A. Stephen K.] King Abdulaziz Univ KAU, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia in 2020, Cited 67. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Computed Properties of C7H5F3O

Geminal diboronates have attracted significant attention because of their unique structures and reactivity. However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown. A promising protocol using visible light and aryl iodides for constructing valuable building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presented. The utility of these gem-diboronates has been demonstrated by a 10 g scale conversion, by versatile transformations, by including the synthesis of approved drug scaffolds and two approved drugs, and even by polymer synthesis. The mechanistic investigation indicates that the merging of the dinuclear gold catalyst (photoexcitation by 315-400 nm UVA light) with Na2CO3 is directly responsible for photosensitization of aryl iodides (photoexcitation by 254 nm UV light) with blue LED light (410-490 nm, lambda(max) = 465 nm) through an energy transfer (EnT) process, followed by homolytic cleavage of the C-I bond in the aryl iodide substrates.

Computed Properties of C7H5F3O. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about ANTIFUNGAL ACTIVITY; DESIGN; PYRIMETHANIL; DERIVATIVES; INHIBITOR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772182]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deng, XL; Zheng, WN; Jin, C; Bai, LY. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Fenclorim is a commercial herbicide safener with fungicidal activity used for chloroacetanilide herbicides, which might be suitable as a lead compound for screening novel fungicides. However, little has been reported so far on the structure-activity relationship of fungicidal activities of fenclorim or its analogues. Here, a series of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was synthesized by a substructure splicing route using fenclorim as a lead compound. The structures of synthesized derivatives were characterized by H-1 NMR, C-13 NMR, and HRMS. Their fungicidal and herbicide safening activities were then evaluated. The results revealed that compound 11 had the best fungicidal activity against Sclerotinia sclerotiorum and Thanatephorus cucumeris, which was better than that of the control pyrimethanil. Moreover, compounds 3, 5, and 25 exhibited excellent safening activities against fresh weight, plant height, and root length, respectively. Such activities were significantly improved when compared to fenclorim. In summary, these findings look promising for the preparation of new fungicides and herbicide safeners based on the structure of fenclorim.

Category: indole-building-block. Welcome to talk about 98-17-9, If you have any questions, you can contact Deng, XL; Zheng, WN; Jin, C; Bai, LY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Recently I am researching about ANTIFUNGAL ACTIVITY; DESIGN; PYRIMETHANIL; DERIVATIVES; INHIBITOR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31772182]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Deng, XL; Zheng, WN; Jin, C; Bai, LY. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Fenclorim is a commercial herbicide safener with fungicidal activity used for chloroacetanilide herbicides, which might be suitable as a lead compound for screening novel fungicides. However, little has been reported so far on the structure-activity relationship of fungicidal activities of fenclorim or its analogues. Here, a series of 4-chloro-6-substituted phenoxy-2-phenylpyrimidine derivatives was synthesized by a substructure splicing route using fenclorim as a lead compound. The structures of synthesized derivatives were characterized by H-1 NMR, C-13 NMR, and HRMS. Their fungicidal and herbicide safening activities were then evaluated. The results revealed that compound 11 had the best fungicidal activity against Sclerotinia sclerotiorum and Thanatephorus cucumeris, which was better than that of the control pyrimethanil. Moreover, compounds 3, 5, and 25 exhibited excellent safening activities against fresh weight, plant height, and root length, respectively. Such activities were significantly improved when compared to fenclorim. In summary, these findings look promising for the preparation of new fungicides and herbicide safeners based on the structure of fenclorim.

Category: indole-building-block. Welcome to talk about 98-17-9, If you have any questions, you can contact Deng, XL; Zheng, WN; Jin, C; Bai, LY or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Discovery of Novel pERK1/2-or beta-Arrestin-Preferring 5-HT1A Receptor-Biased Agonists: Diversified Therapeutic-like versus Side Effect Profile WOS:000580558700018 published article about FUNCTIONAL SELECTIVITY; DRUG DISCOVERY; SEROTONIN; ANTAGONIST; METABOLISM; AGENTS; POTENT; RATS; HIPPOCAMPUS; ANXIOLYTICS in [Sniecikowska, Joanna; Gluch-Lutwin, Monika; Bucki, Adam; Wieckowska, Anna; Siwek, Agata; Jastrzebska-Wiesek, Magdalena; Partyka, Anna; Wilczynska, Daria; Pytka, Karolina; Latacz, Gniewomir; Przejczowska-Pomierny, Katarzyna; Wyska, Elzbieta; Wesolowska, Anna; Pawlowski, Maciej; Kolaczkowski, Marcin] Jagiellonian Univ, Med Coll, Fac Pharm, PL-30688 Krakow, Poland; [Newman-Tancredi, Adrian] Neurolixis, Castres, France in 2020, Cited 67. Recommanded Product: 98-17-9. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Novel 1-(1-benzoylpiperidin-4-yl)methanamine derivatives with high affinity and selectivity for serotonin 5-HT1A receptors were obtained and tested in four functional assays: ERK1/2 phosphorylation, adenylyl cyclase inhibition, calcium mobilization, and beta-arrestin recruitment. Compounds 44 and 56 (2-methylaminophenoxyethyl and 2-(1H-indol-4-yloxy)ethyl derivatives, respectively) were selected as biased agonists with highly differential signaling fingerprints that translated into distinct in vivo profiles. In vitro, 44 showed biased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-like effect in the Porsolt forced swimming test in rats. In contrast, compound 56 exhibited a first-in-class profile: it preferentially and potently activated beta-arrestin recruitment in vitro and potently elicited lower lip retraction in vivo, a component of serotonergic syndrome. Both compounds showed promising developability properties. The presented 5-HT1A receptor-biased agonists, preferentially targeting various signaling pathways, have the potential to become drug candidates for distinct central nervous system pathologies and possessing accentuated therapeutic activity and reduced side effects.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Sniecikowska, J; Gluch-Lutwin, M; Bucki, A; Wieckowska, A; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wilczynska, D; Pytka, K; Latacz, G; Przejczowska-Pomierny, K; Wyska, E; Wesolowska, A; Pawlowski, M; Newman-Tancredi, A; Kolaczkowski, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles