Category: 98-17-9

Song, ZH; Wang, GT; Li, W; Li, SK in [Song, Zehua; Wang, Guotong; Li, Wei; Li, Shengkun] Nanjing Agr Univ, Coll Plant Protect, Dept Pesticide Sci, Weigang 1, Nanjing 210095, Jiangsu, Peoples R China published Innate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides in 2019, Cited 39. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

The application of the pre-validated pharmacophore 2-(2-oxazolinyl) aniline as an innate directing group in the C-H etherification and amination of nicotinamides for the efficient synthesis of drug-and agrochemical- like molecules was determined. An operationally simple, and regioselective C-H functionalization of nicotinamides was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogues.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Song, ZH; Wang, GT; Li, W; Li, SK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 ORG LETT published article about 3-AMINOCHROMAN DERIVATIVES; INTERRUPTED PUMMERER; ARYL SULFOXIDES; INTRAMOLECULAR CAPTURE; OXIDATIVE BROMINATION; QUINONE METHIDES; SWERN OXIDATION; ALPHA-ARYLATION; LEWIS-ACIDS; PHENOLS in [Acosta-Guzman, Paola; Rodriguez-Lopez, Alvaro; Gamba-Sanchez, Diego] Univ Andes, Dept Chem, Lab Organ Synth Bio & Organocatalysis, Cra 1 18A-12 Q 305, Bogota 111711, Colombia in 2019, Cited 77. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Application In Synthesis of 3-(Trifluoromethyl)phenol

The competition between an unprecedented reductive chlorination and the Pummerer reaction was studied and applied to the synthesis of benzofused oxygen heterocycles including 3-aminochromanes and in the intramolecular chlorination of activated aromatic rings. The use of (COCl)(2) as a Pummerer activator showed substantial activity, producing alpha-chlorinated sulfides that can undergo Pummerer-Friedel-Crafts cyclization. If the aromatic ring has electron-donating groups in position three, then the reaction follows a different pathway, yielding the reductive chlorination products, where the chlorine atom comes from a sulfonium salt.

Application In Synthesis of 3-(Trifluoromethyl)phenol. Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H5F3O. In 2019 ACS CATAL published article about ACTIVATION; RHODIUM; AIR; FUNCTIONALIZATION; DERIVATIVES; BONDS in [Zhang, Luoqiang; Wang, Yanbing; Shi, Yang; Wu, Yimin; Lan, Jingbo; Ma, Weixin; You, Jingsong] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, 29 Wangjiang Rd, Chengdu 610064, Sichuan, Peoples R China in 2019, Cited 51. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

An urgent yet challenging task is to overcome the limitations in substrate scope and regio- and chemoselectivity in the oxidative couplings between two arenes for the construction of unsymmetrical 2,2′-difunctional biaryls with diverse application requirements. In this work, a co-oxidant-free Rh(I)/Zn(NTf2)(2)/air catalytic system has been developed for dual chelation-assisted oxidative C-H/C-H cross-couplings between two anilines, between two phenols, and between phenols and anilines, which enables rapid assembly of rich libraries of 2,2′-bianilines, 2,2′-biphenols, and 2′-aminobiphenyl-2-ols. This protocol features air as the sole oxidant, complete regioselectivity, high chemoselectivity, low molar ratio of substrates (even 1:1), convenient operation, and scale-up synthesis. The established catalytic system is tolerant of the substrates having both electron-donating and electron-withdrawing substituents at different positions of the aryl ring. This work further discloses that the chemoselectivity of cross-coupling over homocoupling mainly relies on a suitable combination of two directing groups (i.e., a pair of strongly and weakly coordinating directing groups) rather than the electronically distinct properties between two substrates, which provides an inspiration for designing the matching directing group pair for the dual chelation-assisted oxidative Ar-H/Ar-H cross-couplings. Thus, this strategy allows the highly chemoselective cross-coupling between electronically similar coupling partners, which represents a challenging task in the oxidative Ar-H/Ar-H cross-coupling reactions.

Bye, fridends, I hope you can learn more about C7H5F3O, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Manfrin, A; Hanggli, A; van den Wildenberg, J; McNeill, K in AMER CHEMICAL SOC published article about MECHANISTIC ORGANIC-PHOTOCHEMISTRY; TFM; PHARMACEUTICALS; FLUORINE; WATER; PHOTOHYDROLYSIS; ENVIRONMENT; REACTIVITY; DRUGS; ACID in [Manfrin, Alessandro; Haenggli, Aline; van den Wildenberg, Jeroen; McNeill, Kristopher] Swiss Fed Inst Technol, Inst Biogeochem & Pollutant Dynam, CH-8092 Zurich, Switzerland in 2020, Cited 45. Name: 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

The chemical class of benzotrifluoride derivatives is widely used in active ingredients of various commercial products, such as pharmaceuticals, pesticides, herbicides, and crop protection agents. Past studies have shown that some benzotrifluorides are not stable under UV irradiation in water and convert into benzoic acids due to C-F bond hydrolysis. It was also observed, but never systematically studied, that the ring substituents play an important role on the direct photochemical reactivity of the CF3 moiety. In the present work, we explore the structure-reactivity relationship between ring substituent and direct photodefluorination for 16 different substituents, by determining fluoride production rates, quantum yields, and half-lives, and found that strong electron-donating groups enhance the reactivity toward hydrolysis. In addition, flufenamic acid, travoprost, dutasteride, cyflumetofen, flutoanil, and teriflunomide were also examined, finding that their direct photochemical reactivity could be qualitatively predicted based on their ring substituents. We provide here a tool to evaluate the environmental persistence of benzotrifluoride contaminants, as well as to design more photodegradable new active ingredients.

Name: 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Manfrin, A; Hanggli, A; van den Wildenberg, J; McNeill, K or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors WOS:000540343900005 published article about POLIOVIRUS; REPLICATION; PROTEIN; ATPASE; CLASSICS; MOTIF in [Manganaro, Roberto; Zonsics, Birgit; Lopez, Moira Lorenzo; Saporito, Fabiana; Ferla, Salvatore; Brancale, Andrea] Cardiff Univ, Sch Pharm & Pharmaceut Sci, King Edward VII Ave, Cardiff CF10 3NB, Wales; [Bauer, Lisa; Donselaar, Tim; Zwaagstra, Marleen; Strating, Jeroen R. P. M.; Hurdiss, Daniel L.; van Kuppeveld, Frank J. M.] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Virol Div, NL-3584 CL Utrecht, Netherlands; [Coutard, Bruno] UVE Aix Marseille Univ, Inserm 1207, IHU Mediterranee Infect, Unite Virus Emergents,IRD 190, Marseille, France; [Coutard, Bruno] Aix Marseille Univ, CNRS, AFMB UMR 7257, Marseille, France in 2020, Cited 24. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Formula: C7H5F3O

Enteroviruses (EV) are a group of positive-strand RNA ( + RNA) viruses that include many important human pathogens (e.g. poliovirus, coxsackievirus, echovirus, numbered enteroviruses and rhinoviruses). Fluoxetine was identified in drug repurposing screens as potent inhibitor of enterovirus B and enterovirus D replication. In this paper we are reporting the synthesis and the antiviral effect of a series of fluoxetine analogues. The results obtained offer a preliminary insight into the structure-activity relationship of its chemical scaffold and confirm the importance of the chiral configuration. We identified a racemic fluoxetine analogue, 2b, which showed a similar antiviral activity compared to (S)-fluoxetine. Investigating the stereochemistry of 2b revealed that the Senantiomer exerts potent antiviral activity and increased the antiviral spectrum compared to the racemic mixture of 2b. In line with the observed antiviral effect, the Senantiomer displayed a dose-dependent shift in the melting temperature in thermal shift assays, indicative for direct binding to the recombinant 2C protein.

Formula: C7H5F3O. Welcome to talk about 98-17-9, If you have any questions, you can contact Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. Kaitoh, K; Nakatsu, A; Mori, S; Kagechika, H; Hashimoto, Y; Fujii, S in [Kaitoh, Kazuma; Hashimoto, Yuichi; Fujii, Shinya] Univ Tokyo, Inst Quantitat Biosci, Bunkyo Ku, 1-1-1 Yayoi, Tokyo 1130032, Japan; [Nakatsu, Aki; Mori, Shuichi; Kagechika, Hiroyuki; Fujii, Shinya] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, 2-3-10 Kanda Surugadai, Tokyo 1010062, Japan published Design, Synthesis and Biological Evaluation of Novel Nonsteroidal Progesterone Receptor Antagonists Based on Phenylamino-1,3,5-triazine Scaffold in 2019, Cited 33. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

We report here the development of phenylamino-1,3,5-triazine derivatives as novel nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiological systems, including the female reproductive system, and PR antagonists are promising candidates for clinical treatment of multiple diseases. By using the phenylamino-1,3,5-triazine scaffold as a template structure, we designed and synthesized a series of 4-cyanophenylamino-1,3,5-triazine derivatives. The synthesized compounds exhibited PR antagonistic activity, and among them, compound 12n was the most potent (IC50 = 0.30 mu M); it also showed significant binding affinity to the PR ligand-binding domain. Docking simulation supported the design rationale of the compounds. Our results suggest that the phenylamino-1,3,5-triazine scaffold is a versatile template for development of nonsteroidal PR antagonists and that the developed compounds are promising lead compounds for further structural development of nonsteroidal PR antagonists.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Kaitoh, K; Nakatsu, A; Mori, S; Kagechika, H; Hashimoto, Y; Fujii, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic O-H bond insertion reactions using surface modified sewage sludge as a catalyst WOS:000519903900026 published article about WET AIR OXIDATION; ARYL-ALPHA-DIAZOACETATES; FENTON-LIKE DEGRADATION; SI-H; CARBENE INSERTION; NATURAL-PRODUCTS; DIAZO-COMPOUNDS; N-H; HYDROGEN-ATOM; M-CRESOL in [Zhang, Zhipeng; Huang, Fei; Huang, He] Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China; [Zhang, Zhipeng] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou 510006, Peoples R China; [Yu, Yang; He, Yide] Nanjing Tech Univ, Sch Environm Sci & Engn, Nanjing 211816, Peoples R China; [Yi, Xiangyan; Baell, Jonathan B.; Huang, He] Nanjing Tech Univ, Sch Pharmaceut Sci, Nanjing 211816, Peoples R China; [Xu, Yao] Soochow Univ, Affiliated Hosp 1, Suzhou 215006, Peoples R China; Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville, Vic 3052, Australia in 2020, Cited 108. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Developing a greener, sustainable catalyst is a very important but challenging task in organic synthesis. Herein, for the first time, we choose more economical and greener surface modified sewage sludge-derived carbonaceous materials (SW) treated by perchloric acid as a new catalyst for carbene insertion of alpha-aryl alpha-diazoacetates into O-H bonds of phenols with good yields and high functional group tolerance. Significantly, we explored the scope of natural phenols with compelling biological activity, and successfully afforded the O-H insertion and meta C-H functionalization products. Their structures have been confirmed by single-crystal X-ray crystallography. Furthermore, the bioactivities (anti-tumor and anti-inflammatory) of the majority of O-H insertion products are better than those of the natural phenols themselves. The IC50 values indicated that the remarkable compounds 7a (IC50 = 16.80 mu M) and 7c (IC50 = 16.48 mu M) had better inhibition for tumor cell A-549 than positive control DDP (IC50 = 20.62 mu M). It should be noted that these transformations may provide a new strategy to derive natural products and discover new drugs.

Application In Synthesis of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Zhang, ZP; Yu, Y; Huang, F; Yi, XY; Xu, Y; He, YD; Baell, JB; Huang, H or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 3-(Trifluoromethyl)phenol. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and biological evaluation of quinazoline derivatives – A SAR study of novel inhibitors of ABCG2 published in 2019, Reprint Addresses Wiese, M (corresponding author), Univ Bonn, Inst Pharmaceut, Immenburg 4, D-53121 Bonn, Germany.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

Multidrug resistance (MDR) is a major obstacle for effective chemotherapeutic treatment of cancer frequently leading to failure of the therapy. MDR is often associated with the overexpression of ABC transport proteins like ABCB1 or ABCG2 which efflux harmful substances out of cells at the cost of ATP hydrolysis. One way to overcome MDR is to apply potent inhibitors of ABC transporters to restore the sensitivity of the cells toward cytostatic agents. This study focusses on the synthesis and evaluation of novel 2,4-disubstituted quinazoline derivatives regarding the structure-activity-relationship (SAR), their ability to reverse MDR and their mode of interaction with ABCG2. Hence, the inhibitory potency and selectivity toward ABCG2 was determined. Moreover, the intrinsic cytotoxicity and the reversal of MDR were investigated. Interaction type studies with the substrate Hoechst 33342 and conformational analyses of ABCG2 with 5D3 monoclonal antibody were performed for a better understanding of the underlying mechanisms. In our study we could further enhance the inhibitory effect against ABCG2 (compound 31, IC50: 55 nM) and identify the structural features that are crucial for inhibitory potency, the impact on transport activity and binding to the protein. (C) 2018 Elsevier Masson SAS. All rights reserved,

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Krapf, MK; Gallus, J; Spindler, A; Wiese, M or concate me.. Application In Synthesis of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Palladium-catalyzed cross-coupling of (hetero)aryl or alkenyl sulfonates with aryl titanium as the multi-functional reagent WOS:000527760500002 published article about SUZUKI-MIYAURA; ALKYL-HALIDES; ASYMMETRIC 1,4-ADDITION; ADDRESSING CHALLENGES; OXIDATIVE ADDITION; GRIGNARD-REAGENTS; CHLORIDES; TOSYLATES; BROMIDES; SECONDARY in [Lee, Hang Wai; So, Chau Ming; Yuen, On Ying; Wong, Wing Tak; Kwong, Fuk Yee] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China; [Lee, Hang Wai; So, Chau Ming; Wong, Wing Tak] Hong Kong Polytech Univ, Shenzhen Res Inst SZRI, Shenzhen, Peoples R China; [Yuen, On Ying; Kwong, Fuk Yee] Chinese Univ Hong Kong, Dept Chem, Shatin, Peoples R China in 2020, Cited 72. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Recommanded Product: 98-17-9

The first palladium-catalyzed cross-coupling reaction of aryl/heteroaryl and alkenyl mesylates and tosylates with aryl titanium as the multi-functional reagent is reported. Using the catalyst system of Pd(OAc)(2) associated with the new NMe2-CM-Phos (L14), a broad range of electron-rich, electron-neutral, electron-deficient, and sterically hindered aryl/heteroaryl and alkenyl mesylates and tosylates are well coupled with aryl titanium reagents to give the corresponding products in good to excellent yields. The catalyst loading down to 0.2 mol% Pd and the reaction time shortening to 10 min can be achieved. The reaction can be easily scaled up to the gram scale without diminishing the product yield.

Recommanded Product: 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Lee, HW; So, CM; Yuen, OY; Wong, WT; Kwong, FY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Concise, scalable and enantioselective total synthesis of prostaglandins WOS:000655716500001 published article about GENERAL STRATEGY; ACCESS in [Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Peoples R China; [Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China; [Zhang, Fuhao; Lu, Yixin] Natl Univ Singapore, Dept Chem, Singapore, Singapore; [Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Medi X, Shenzhen, Peoples R China in 2021, Cited 31. Application In Synthesis of 3-(Trifluoromethyl)phenol. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral centre on the scaffold of the prostaglandins was installed using the asymmetric hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-gram scale.

Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles