Category: 98-17-9

Recently I am researching about POLIOVIRUS; REPLICATION; PROTEIN; ATPASE; CLASSICS; MOTIF, Saw an article supported by the Netherlands Organisation for Scientific ResearchNetherlands Organization for Scientific Research (NWO) [NWO-ECHO-711.017.002, NWO-VICI-91812628]; European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant [842333]; EMBO non-stipendiary long-term Fellowship [ALTF 1172-2018]; Ser Cymru II programme – Cardiff University; European Regional Development Fund through the Welsh Government; European Union (Horizon 2020 Marie Sklodowska-Curie ETN ‘ANTIVIRALS’) [642434]. Recommanded Product: 3-(Trifluoromethyl)phenol. Published in ELSEVIER in AMSTERDAM ,Authors: Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Enteroviruses (EV) are a group of positive-strand RNA ( + RNA) viruses that include many important human pathogens (e.g. poliovirus, coxsackievirus, echovirus, numbered enteroviruses and rhinoviruses). Fluoxetine was identified in drug repurposing screens as potent inhibitor of enterovirus B and enterovirus D replication. In this paper we are reporting the synthesis and the antiviral effect of a series of fluoxetine analogues. The results obtained offer a preliminary insight into the structure-activity relationship of its chemical scaffold and confirm the importance of the chiral configuration. We identified a racemic fluoxetine analogue, 2b, which showed a similar antiviral activity compared to (S)-fluoxetine. Investigating the stereochemistry of 2b revealed that the Senantiomer exerts potent antiviral activity and increased the antiviral spectrum compared to the racemic mixture of 2b. In line with the observed antiviral effect, the Senantiomer displayed a dose-dependent shift in the melting temperature in thermal shift assays, indicative for direct binding to the recombinant 2C protein.

Recommanded Product: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C7H5F3O. In 2020 PEST MANAG SCI published article about ACETOLACTATE SYNTHASE; COMPUTATIONAL DESIGN; RESISTANCE; HERBICIDES; MUTATIONS; EVOLUTION; WEEDS in [Qu, Ren-Yu; Yang, Jing-Fang; Chen, Qiong; Yang, Wen-Chao; Yang, Guang-Fu] Cent China Normal Univ, Int Joint Res Ctr Intelligent Biosensor Technol &, Key Lab Pesticide & Chem Biol, Coll Chem,Chem Biol Ctr,Minist Educ, Wuhan, Peoples R China; [Niu, Cong-Wei; Xi, Zhen] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin, Peoples R China; [Yang, Guang-Fu] Collaborat Innovat Ctr Chem Sci & Engn, Tianjin, Peoples R China in 2020, Cited 40. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

BACKGROUND Intensifying weed resistance has challenged the use of existing acetohydroxyacid synthase (AHAS)-inhibiting herbicides. Hence, there is currently an urgent requirement for the discovery of a new AHAS inhibitor to effectively control AHAS herbicide-resistant weed species produced by target mutation. RESULTS To combat weed resistance caused by AHAS with P197L mutation, we built a structure library consisting of pyrimidinyl-salicylic acid derivatives. Using the pharmacophore-linked fragment virtual screening (PFVS) approach, hit compound 8 bearing 6-phenoxymethyl substituent was identified as a potential AHAS inhibitor with antiresistance effect. Subsequently, derivatives of compound 8 were synthesized and evaluated for their inhibitory activities. The study of the enzyme-based structure-activity relationship and structure-resistance relationship studies led to the discovery of a qualified candidate, 28. This compound not only significantly inhibited the activity of wild-type Arabidopsis thaliana (At) AHAS and P197L mutant, but also exhibited good antiresistance properties (RF = 0.79). Notably, compared with bispyribac at 37.5-150 g of active ingredient per hectare (g a.i. ha(-1)), compound 27 exhibited higher growth inhibition against both sensitive and resistant Descurainia sophia, CONCLUSION The title compounds have great potential to be developed as new leads to effectively control herbicide-resistant weeds comprising AHAS with P197L mutation. Also, our study provided a positive case for discovering novel, potent and antiresistance inhibitors using a fragment-based drug design approach. (c) 2020 Society of Chemical Industry

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Qu, RY; Yang, JF; Chen, Q; Niu, CW; Xi, Z; Yang, WC; Yang, GF or concate me.. Computed Properties of C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 3-(Trifluoromethyl)phenol. In 2021 ACS APPL MATER INTER published article about IRIDIUM(III) COMPLEXES; EN-ROUTE; DESIGN; PHOTOPHYSICS; FUNDAMENTALS; TUNABILITY in [Tai, Wun-Shan; Gnanasekaran, Premkumar; Chi, Yun] Natl Tsing Hua Univ, Dept Chem, Hsinchu 30013, Taiwan; [Tai, Wun-Shan; Gnanasekaran, Premkumar; Chi, Yun] Natl Tsing Hua Univ, Frontier Res Ctr Fundamental & Appl Sci Matters, Hsinchu 30013, Taiwan; [Chen, Yi-Yang; Hung, Wen-Yi] Natl Taiwan Ocean Univ, Dept Optoelect & Mat Technol, Keelung 20224, Taiwan; [Zhou, Xiuwen] Univ Queensland, Sch Math & Phys, Brisbane, Qld 4072, Australia; [Chou, Tai-Che; Lee, Gene-Hsiang; Chou, Pi-Tai] Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan; [You, Caifa; Chi, Yun] City Univ Hong Kong, Dept Mat Sci & Engn, Dept Chem, Kowloon, Kowloon 999077, Peoples R China; [You, Caifa; Chi, Yun] City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, Kowloon 999077, Peoples R China in 2021, Cited 57. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A new class of bis-tridentate Ir(III) complexes (Dap-1-4) was synthesized using carbene pincer pro-chelates PC1 center dot H-3(PF6)(2) or PC2 center dot H-3(PF6)(2) with either imidazolylidene or imidazo[4,5-b]pyridin-2-ylidene appendages, together with a second cyclometalating 2,6-diaryoxypyridine chelate, L1H(2) and L2H(2), differed by a NMe2 donor at the central pyridinyl fragment. The respective emission tuning between the ultraviolet and blue region was rationalized using time-dependent density functional theory (TD-DFT) approaches. Next, a highly efficient blue emitter (Dap-5) was synthesized by concomitant addition of two methyl groups and a single CF3 substituent at the central phenyl and peripheral imidazo[4,5-b]pyridin-2-ylidene entities of the carbene pincer chelate, respectively. The organic light-emitting diode (OLED) device with 15 wt % Dap-5 in DPEPO shows electroluminescence at 468 nm and with CIE (0.14, 0.15) and a max external quantum efficiency (max EQE) of 16.8% with low efficiency roll-off (EQE of 14.4% at 1000 cd m(-2)); the latter is attributed to the relatively shortened triplet excited-state radiative lifetime. These results highlight the adequateness of bis-tridentate Ir(III) phosphors in fabrication of practical blue-emitting OLEDs.

Quality Control of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Tai, WS; Gnanasekaran, P; Chen, YY; Hung, WY; Zhou, XW; Chou, TC; Lee, GH; Chou, PT; You, CF; Chi, Y or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Gold-Catalyzed Hydrophenoxylation of Propargylic Alcohols and Amines: Synthesis of Phenyl Enol Ethers published in 2019. Quality Control of 3-(Trifluoromethyl)phenol, Reprint Addresses Sheppard, TD (corresponding author), UCL, Dept Chem, 20 Gordon St, London WC1H 0AJ, England.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

A practical method for the synthesis of phenyl enol ethers is reported. The combination of a gold(I) catalyst and potassium carbonate selectively mediates the addition of phenols to propargylic alcohols/amines in a chemo-, regio-, and stereoselective fashion in high yield. The resulting enol ethers are formed exclusively with a Z-configuration and can be obtained from a wide array of phenols and propargylic alcohols or amines with the reaction showing excellent functional group tolerance.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Laserna, V; Rojas, CJ; Sheppard, TD or concate me.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-(Trifluoromethyl)phenol. In 2019 EUR J MED CHEM published article about ANDROGEN-RECEPTOR; TRIFLUOROMETHYL GROUP; BIOLOGICAL-ACTIVITY; FLUORINE; INHIBITORS; ANALOGS; PHARMACOKINETICS; CHEMISTRY; LIGANDS; BINDING in [Pertusati, Fabrizio; Ferla, Salvatore; Bassetto, Marcella; Brancale, Andrea; Khandil, Sahar; Westwell, Andrew D.; McGuigan, Christopher] Sch Pharm & Pharmaceut Sci, Redwood Bldg,King Edwards 7 Ave, Cardiff CF10 3NB, S Glam, Wales in 2019, Cited 76. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

SAR studies on bicalutamide, enobosarm and enzalutamide analogues, functionalised with polyfluorinated groups, is presented. Among the novel bicalutamide and enobosarm derivatives synthesised, several displayed significantly improved in vitro anticancer activity, with IC50 values in the low micromolar range against four different prostate cancer cell lines (LNCaP, VCaP, DU-145 and 22Rv1), showing up to 48-fold increase in comparison with the parent structures. In particular, SF5 enobosarm analogues were found to be most potent compounds, full AR antagonists and with favourable ADME properties. The most promising compound (48a) was evaluated for its in vivo efficacy in PC xenograft mouse model (22Rv1) with results comparable to the standard-of-care docetaxel. (C) 2019 Published by Elsevier Masson SAS.

Safety of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pertusati, F; Ferla, S; Bassetto, M; Brancale, A; Khandil, S; Westwell, AD; McGuigan, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Electrochemical Reductive Smiles Rearrangement for C-N Bond Formation published in 2019. COA of Formula: C7H5F3O, Reprint Addresses Guo, C (corresponding author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Anhui, Peoples R China.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

A conceptually new and synthetically valuable radical Smiles rearrangement reaction is reported under undivided electrolytic conditions. This protocol employs an entirely new strategy for the electrochemical radical Smiles rearrangement. Remarkably, an amidyl radical generated from the cleavage of the N-O bond under reductive electrolytic conditions plays a crucial role in this transformation. Various hydroxylamine derivatives bearing different substituents are suitable in this electrochemical transformation, furnishing the corresponding amides in up to 86% yield.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Chang, XH; Zhang, QL; Guo, C or concate me.. COA of Formula: C7H5F3O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Visible-Light-Induced Radical Carbo-Cyclization/gem-Diborylation through Triplet Energy Transfer between a Gold Catalyst and Aryl Iodides published in 2020. Safety of 3-(Trifluoromethyl)phenol, Reprint Addresses Hashmi, ASK (corresponding author), Heidelberg Univ, Organ Chem Inst, D-69120 Heidelberg, Germany.; Hashmi, ASK (corresponding author), King Abdulaziz Univ KAU, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Geminal diboronates have attracted significant attention because of their unique structures and reactivity. However, benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, building blocks for biologically relevant compounds, are unknown. A promising protocol using visible light and aryl iodides for constructing valuable building blocks, including benzofuran-, indole-, and benzothiophene-based benzylic gem-diboronates, via radical carbo-cyclization/gem-diborylation of alkynes with a high functional group tolerance is presented. The utility of these gem-diboronates has been demonstrated by a 10 g scale conversion, by versatile transformations, by including the synthesis of approved drug scaffolds and two approved drugs, and even by polymer synthesis. The mechanistic investigation indicates that the merging of the dinuclear gold catalyst (photoexcitation by 315-400 nm UVA light) with Na2CO3 is directly responsible for photosensitization of aryl iodides (photoexcitation by 254 nm UV light) with blue LED light (410-490 nm, lambda(max) = 465 nm) through an energy transfer (EnT) process, followed by homolytic cleavage of the C-I bond in the aryl iodide substrates.

Safety of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, LM; Si, XJ; Rominger, F; Hashmi, ASK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 ORG LETT published article about INSERTION in [Empel, Claire; Jana, Sripati; Pei, Chao; Koenigs, Rene M.] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany; [Empel, Claire; Thanh Vinh Nguyen; Koenigs, Rene M.] Univ New South Waley, Sch Chem, Sydney, NSW 2052, Australia in 2020, Cited 44. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Product Details of 98-17-9

In this work, we report a thorough investigation of the reaction of phenols with aryldiazoacetates. Mechanistic studies using different spectroscopic methods and theoretical calculations suggest a hydrogen bond between phenol and aryldiazoacetates, which can be modulated by the phenol acidity. The pK(A) of phenol and therefore the hydrogen bond plays an important role in a subsequent photoinduced proton transfer reaction to give the formal O-H functionalization product of phenols.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Empel, C; Jana, S; Pei, C; Nguyen, TV; Koenigs, RM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. I found the field of Chemistry very interesting. Saw the article Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides published in 2020, Reprint Addresses Geetharani, K (corresponding author), Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

A cobalt-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B(2)pin(2) or B(2 )neop(2)) has been developed under mild reaction conditions, demonstrating the first cobalt-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this cobalt-mediated catalytic cycle.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Verma, PK; Prasad, KS; Varghese, D; Geetharani, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019 J AM CHEM SOC published article about COPPER-MEDIATED DIFLUOROMETHYLATION; BOND-CLEAVAGE; FLUORINE; ARYL; PHARMACEUTICALS; GENERATION; REDUCTION; IODIDES; REAGENT in [Jui, Nathan T.] Emory Univ, Dept Chem, 1515 Pierce Dr, Atlanta, GA 30322 USA; Emory Univ, Winship Canc Inst, Atlanta, GA 30322 USA in 2019, Cited 43. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Category: indole-building-block

Fluorinated organic molecules are pervasive within the pharmaceutical and agrochemical industries due to the range of structural and physicochemical properties that fluorine imparts. Currently, the most abundant methods for the synthesis of the aryl-CF2 functionality have relied on the deoxyfluorination of ketones and aldehydes using expensive and poorly atom economical reagents. Here, we report a general method for the synthesis of aryl-CF2R and aryl-CF2H compounds through activation of corresponding trifluoromethyl arene precursors. This strategy is enabled by an endergonic electron transfer event that provides access to arene radical anions that lie outside of the catalyst reduction potential. Fragmentation of these reactive intermediates delivers difluorobenzylic radicals that can be intercepted by abundant alkene feedstocks or a hydrogen atom to provide a diverse array of difluoalkylaromatics.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Vogt, DB; Seath, CP; Wang, HB; Jui, NT or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles