Category: 98-17-9

Quality Control of 3-(Trifluoromethyl)phenol. In 2020 ANTIVIR RES published article about POLIOVIRUS; REPLICATION; PROTEIN; ATPASE; CLASSICS; MOTIF in [Manganaro, Roberto; Zonsics, Birgit; Lopez, Moira Lorenzo; Saporito, Fabiana; Ferla, Salvatore; Brancale, Andrea] Cardiff Univ, Sch Pharm & Pharmaceut Sci, King Edward VII Ave, Cardiff CF10 3NB, Wales; [Bauer, Lisa; Donselaar, Tim; Zwaagstra, Marleen; Strating, Jeroen R. P. M.; Hurdiss, Daniel L.; van Kuppeveld, Frank J. M.] Univ Utrecht, Fac Vet Med, Dept Infect Dis & Immunol, Virol Div, NL-3584 CL Utrecht, Netherlands; [Coutard, Bruno] UVE Aix Marseille Univ, Inserm 1207, IHU Mediterranee Infect, Unite Virus Emergents,IRD 190, Marseille, France; [Coutard, Bruno] Aix Marseille Univ, CNRS, AFMB UMR 7257, Marseille, France in 2020, Cited 24. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

Enteroviruses (EV) are a group of positive-strand RNA ( + RNA) viruses that include many important human pathogens (e.g. poliovirus, coxsackievirus, echovirus, numbered enteroviruses and rhinoviruses). Fluoxetine was identified in drug repurposing screens as potent inhibitor of enterovirus B and enterovirus D replication. In this paper we are reporting the synthesis and the antiviral effect of a series of fluoxetine analogues. The results obtained offer a preliminary insight into the structure-activity relationship of its chemical scaffold and confirm the importance of the chiral configuration. We identified a racemic fluoxetine analogue, 2b, which showed a similar antiviral activity compared to (S)-fluoxetine. Investigating the stereochemistry of 2b revealed that the Senantiomer exerts potent antiviral activity and increased the antiviral spectrum compared to the racemic mixture of 2b. In line with the observed antiviral effect, the Senantiomer displayed a dose-dependent shift in the melting temperature in thermal shift assays, indicative for direct binding to the recombinant 2C protein.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Manganaro, R; Zonsics, B; Bauer, L; Lopez, ML; Donselaar, T; Zwaagstra, M; Saporito, F; Ferla, S; Strating, JRPM; Coutard, B; Hurdiss, DL; van Kuppeveld, FJM; Brancale, A or concate me.. Quality Control of 3-(Trifluoromethyl)phenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies published in 2019. Product Details of 98-17-9, Reprint Addresses Lolli, ML (corresponding author), Univ Turin, Dept Sci & Drug Technol, Via Pietro Giuria 9, I-10125 Turin, Italy.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol

Plasmodium falciparum dihydroorotate dehydrogenase (PJDHODH) has been clinically validated as a target for antimalarial drug discovery, as a triazolopyrimidine class inhibitor (DSM265) is currently undergoing clinical development. Here, we have identified new hydroxyazole scaffold-based PJDHODH inhibitors belonging to two different chemical series. The first series was designed by a scaffold hopping strategy that exploits the use of hydroxylated azoles. Within this series, the hydroxythiadiazole 3 was identified as the best selective PJDHODH inhibitor (IC50 12.0 mu M). The second series was designed by modulating four different positions of the hydroxypyrazole scaffold. In particular, hydroxypyrazoles 7e and 7f were shown to be active in the low mu M range (IC50 2.8 and 5.3 mu M, respectively). All three compounds, 3, 7e and 7f showed clear selectivity over human DHODH (IC50> 200 mu M), low cytotoxicity, and retained micromolar activity in P. falciparum-infected erythrocytes. The crystallographic structures of PJDHODH in complex with compounds 3 and 7e proved their binding mode, supplying essential data for future optimization of these scaffolds. (C) 2018 Elsevier Masson SAS. All rights reserved.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pippione, AC; Sainas, S; Goyal, P; Fritzson, I; Cassiano, GC; Giraudo, A; Giorgis, M; Tavella, TA; Bagnati, R; Rolando, B; Caing-Carlsson, R; Costa, FTM; Andrade, CH; Al-Karadaghi, S; Boschi, D; Friemann, R; Lolli, ML or concate me.. Product Details of 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. I found the field of Pharmacology & Pharmacy very interesting. Saw the article A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer published in 2019, Reprint Addresses Pertusati, F (corresponding author), Sch Pharm & Pharmaceut Sci, Redwood Bldg,King Edwards 7 Ave, Cardiff CF10 3NB, S Glam, Wales.. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol.

SAR studies on bicalutamide, enobosarm and enzalutamide analogues, functionalised with polyfluorinated groups, is presented. Among the novel bicalutamide and enobosarm derivatives synthesised, several displayed significantly improved in vitro anticancer activity, with IC50 values in the low micromolar range against four different prostate cancer cell lines (LNCaP, VCaP, DU-145 and 22Rv1), showing up to 48-fold increase in comparison with the parent structures. In particular, SF5 enobosarm analogues were found to be most potent compounds, full AR antagonists and with favourable ADME properties. The most promising compound (48a) was evaluated for its in vivo efficacy in PC xenograft mouse model (22Rv1) with results comparable to the standard-of-care docetaxel. (C) 2019 Published by Elsevier Masson SAS.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Pertusati, F; Ferla, S; Bassetto, M; Brancale, A; Khandil, S; Westwell, AD; McGuigan, C or concate me.. Product Details of 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about SUPEROLEOPHILIC NANOFIBROUS MEMBRANES; CYCLOTRIPHOSPHAZENE SYNTHESIS; FLUORINATED BENZOXAZINES; POLYBENZOXAZINE; POLYMERIZATION; DESIGN; FABRICATION; STABILITY; CARDANOL; DIAMINES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21274049]. Published in BUDAPEST UNIV TECHNOL & ECON in BUDAPEST ,Authors: Ma, HX; Qiu, JJ; Liu, CM. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Name: 3-(Trifluoromethyl)phenol

Six fluorine-containing, mix-substituted phosphazene-based branched benzoxazine monomers with a low melting point were successfully prepared and their chemical structures were verified by H-1, C-13, P-31 and F-19 nuclear magnetic resonance (NMR). These branched benzoxazine resins underwent thermal ring-opening polymerization to form cured polymers with high thermal stability both in N-2 atmosphere and in air. The co-substituents, both m-CF3PhOH andp-CF3PhOH, imposed significant effects on processing, thermal, and surface properties of corresponding polybenzoxazines. Non-isothermal differential scanning calorimetry (DSC) under diverse heating rates was adopted to investigate the curing kinetics and determine the activation energy of polymerization. DSC results indicate that the m-CF3PhO-/p-CF3PhO- groups have the potential to lower ring-opening polymerization temperature. Glass transition temperatures (T(g)s) of polybenzoxazines derived from p-CF3PhOH are higher than that of polymers derived from m-CF3PhOH due to different steric hindrance and crosslinking density. More interesting, all polybenzoxazines show relatively high dielectric constant but exhibit low dielectric loss at ambient temperature.

Name: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ma, HX; Qiu, JJ; Liu, CM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 ORG LETT published article about NICKEL-CATALYZED BORYLATION; C-H BORYLATION; ALPHA,BETA-UNSATURATED CARBONYL; ALKYLBORONIC ESTERS; COUPLING REACTIONS; SECONDARY; HALIDES; FUNCTIONALIZATION; HYDROBORATION; REACTIVITY in [Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K.] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India in 2020, Cited 61. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. COA of Formula: C7H5F3O

A cobalt-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B(2)pin(2) or B(2 )neop(2)) has been developed under mild reaction conditions, demonstrating the first cobalt-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this cobalt-mediated catalytic cycle.

COA of Formula: C7H5F3O. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Verma, PK; Prasad, KS; Varghese, D; Geetharani, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MULTIKINASE INHIBITOR; DISCOVERY; RESISTANCE; SORAFENIB; MUTATIONS; PATHWAY, Saw an article supported by the National Science FoundationNational Science Foundation (NSF) [CHE-1455306]; Canadian Cancer Society Research InstituteCanadian Cancer Society (CCS) [704116]; Canada Research Chair ProgramCanada Research Chairs; Canadian Institutes for Health ResearchCanadian Institutes of Health Research (CIHR) [FDN143277]; Stauffer Endowed Fellowship, USC Graduate School; USC Dornsife Chemical Biology Training Program; TD Bank postdoctoral fellowship; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P30GM124165] Funding Source: NIH RePORTER. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Assadieskandar, A; Yu, CQ; Maisonneuve, P; Kunnov, I; Sicheri, F; Zhang, C. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Category: indole-building-block

One effective means to achieve inhibitor specificity for RAF kinases, an important family of cancer drug targets, has been to target the monomeric inactive state conformation of the kinase domain, which, unlike most other kinases, can accommodate sulfonamide-containing drugs such as vemurafenib and dabrafenib because of the presence of a unique pocket specific to inactive RAF kinases. We previously reported an alternate strategy whereby rigidification of a nonselective pyrazolo[3,4-d]pyrimidine-based inhibitor through ring closure afforded moderate but appreciable increases in selectivity for RAF kinases. Here, we show that a further application of the rigidification strategy to a different pyrazolopyrimidine-based scaffold dramatically improved selectivity for RAF kinases. Crystal structure analysis confirmed our inhibitor design hypothesis revealing that 21 engages an active-like state conformation of BRAF normally associated with poorly discriminating inhibitors. When screened against a panel of distinct cancer cell lines, the optimized inhibitor 21 primarily inhibited the proliferation of the expected BRAF(V600E)-harboring cell lines consistent with its kinome selectivity profile. These results suggest that rigidification could be a general and powerful strategy for enhancing inhibitor selectivity against protein kinases, which may open up therapeutic opportunities not afforded by other approaches.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Assadieskandar, A; Yu, CQ; Maisonneuve, P; Kunnov, I; Sicheri, F; Zhang, C or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Regio- and Stereoselective Synthesis of Enynyl-Aryl Ethers Enabled by Copper/Iodide Tandem Catalysis WOS:000481018100001 published article about C-H BOND; TERMINAL ALKYNES; COPPER; PALLADIUM; HALIDES; ALKENES; ESTERS; IODINATION; COMPLEXES; PHENOLS in [Wu, Yun-Bin; Xiao, Lin; Mao, Chun-Li; Zang, Zhong-Lin; Zhou, Cheng-He; Cai, Gui-Xin] Southwest Univ, Key Lab Luminescent & Real Time Analyt Chem, Minist Educ,Sch Chem & Chem Engn, Key Lab Appl Chem Chongqing Municipal,Inst Bioorg, Chongqing 400715, Peoples R China; [Cai, Gui-Xin] Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China in 2019, Cited 82. Category: indole-building-block. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9

An approach to preparing enynyl-aryl ethers from phenols and phenylacetylenes is described. This method without extra ligands, overcoming the favored Glaser-Hay dimerization of alkyne, features a wide substrate scope (38 examples including endofolliculina and indole) and the merits of high atom and step economy, good regio- and stereoselectivity (Z-isomers major) in moderate to good isolated yields. Mechanistic studies show that the reaction is enabled by distinctive copper/iodide tandem catalysis.

Category: indole-building-block. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Wu, YB; Xiao, L; Mao, CL; Zang, ZL; Zhou, CH; Cai, GX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHOSPHORYLATION CASCADE; HYPERTENSION; COTRANSPORTER; MUTATIONS, Saw an article supported by the JSPS Core-to-Core Program, A. Advanced Research Networks; Japan Agency for Medical Research and Development (AMED)Japan Agency for Medical Research and Development (AMED) [JP20am0101098]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H. The CAS is 98-17-9. Through research, I have a further understanding and discovery of 3-(Trifluoromethyl)phenol. Recommanded Product: 3-(Trifluoromethyl)phenol

We report here structural development of N-(4-phenoxyphenyl)benzamide derivatives as novel SPAK (STE20/ SPS1-related proline/alanine-rich kinase) inhibitors. Abnormal activation of the signal cascade of with-no-lysine kinase (WNK) with OSR1 (oxidative stress-responsive kinase 1)/SPAK and NCC (NaCl cotransporter) results in characteristic salt-sensitive hypertension, and therefore inhibitors of the WNK-OSR1/SPAK-NCC cascade are candidates for antihypertensive drugs. Based on the structure of lead compound 2, we examined the SAR of N-(4-phenoxyphenyl)benzamide derivatives, and developed compound 20l as a potent SPAK inhibitor. Compounds 20l is a promising candidate for a new class of antihypertensive drugs.

Recommanded Product: 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Fujii, S; Kikuchi, E; Watanabe, Y; Suzuyama, H; Ishigami-Yuasa, M; Mori, T; Isobe, K; Uchida, S; Kagechika, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 98-17-9. Gilles, P; Veryser, C; Vangrunderbeeck, S; Ceusters, S; Van Meervelt, L; De Borggraeve, WM in [Gilles, Philippe; Veryser, Cedrick; Vangrunderbeeck, Sarah; Ceusters, Sam; De Borggraeve, Wim M.] Katholieke Univ Leuven, Dept Chem, Mol Design & Synth, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium; [Van Meervelt, Luc] Katholieke Univ Leuven, Dept Chem, Biochem Mol & Struct Biol, Celestijnenlaan 200F,Box 2404, B-3001 Leuven, Belgium published Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides in 2019, Cited 34. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A novel synthetic strategy toward N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.

About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Gilles, P; Veryser, C; Vangrunderbeeck, S; Ceusters, S; Van Meervelt, L; De Borggraeve, WM or concate me.. SDS of cas: 98-17-9

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 98-17-9. Ye, LB; Han, C; Shi, PQ; Gao, W; Mei, WJ in [Ye, Lianbao; Han, Chao; Shi, Peiqi; Gao, Wei] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Guangdong, Peoples R China; [Mei, Wenjie] Guangdong Pharmaceut Univ, Guangdong Prov Engn Technol Ctr Mol Probes & Biom, Guangzhou 510006, Guangdong, Peoples R China published Copper-catalyzed synthesis of phenol and diaryl ether derivatives via hydroxylation of diaryliodoniums in 2019, Cited 53. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9.

A copper-catalysed hydroxylation of diaryliodoniums to generate phenols and diaryl ethers is reported. This method allows the synthesis of diversely functionalized phenols under mild reaction conditions without the need for a strong inorganic base or an expensive noble-metal catalyst. Significantly, convenient application of diaryliodoniums is demonstrated in the preparation of diaryl ethers in a one-pot operation.

Product Details of 98-17-9. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Ye, LB; Han, C; Shi, PQ; Gao, W; Mei, WJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles