Category: 99-93-4

An article Cellulose as recyclable organocatalyst for ipso-hydroxylation of arylboronic acids WOS:000488141200007 published article about EFFICIENT HETEROGENEOUS CATALYST; OXIDATIVE HYDROXYLATION; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; GREEN; NANOPARTICLES; METAL; MILD; CONVERSION; SOLVENTS in [Laskar, Khairujjaman; Paul, Subham; Bora, Utpal] Tezpur Univ, Dept Chem Sci, Napaam 784028, Assam, India in 2019, Cited 43. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Category: indole-building-block

Cellulose catalyzed oxidative hydroxylation of aryl and hetero-arylboronic acids to the corresponding phenols under metal and base free strategy has been demonstrated. The sustainable ipso-hydroxylation takes place using hydrogen peroxide as an oxidant in water under mild condition in shorter period of time. Interestingly, easy recovery and reusability of heterogeneous catalyst without significant loss in catalytic yield makes the protocol environmentally benign. (C) 2019 Elsevier Ltd. All rights reserved.

Welcome to talk about 99-93-4, If you have any questions, you can contact Laskar, K; Paul, S; Bora, U or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. In 2020.0 CHINESE J CHEM published article about ELECTROPHILIC MONOFLUOROMETHYLATION; NUCLEOPHILES; FLUORINE; TRIFLUOROMETHYLATION; DIFLUOROMETHYLATION; CH2F in [Hong, Xin; Liu, Yafei; Shen, Qilong] Univ Chinese Acad Sci, Chinese Acad Sci, Ctr Excellence Mol Synth, Key Lab Organofluorine Chem,Shanghai Inst Organ C, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Lu, Long] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2020.0, Cited 39.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The Summary of main observation and conclusionStructure-reactivity study of a family of electrophilic monofluoromethylating reagents based on sulfonium ylide skeleton with different steric hindrance and electron-withdrawing properties was described. These studies led us to discover two highly reactive reagents 3 with a cyclic malonate backbone and 6 with an electron-poor 1,1,1,5,5,5-hexafluoropentane-2,4-dione backbone. The high reactivity of reagent 6 allowed to highly selectively access either C-monofluoromethylated or O-monofluoromethylated beta-ketoesters in high yields by the use of different bases. In addition, reactions of reagent 3 with a variety of nucleophiles including phenols, carboxylic acids, thiophenols or heteroaryl nucleophiles occurred in full conversion within 10 min at room temperature and the scopes for these reactions were reported in detail.

Welcome to talk about 99-93-4, If you have any questions, you can contact Hong, X; Liu, YF; Lu, L; Shen, QL or send Email.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Patil, PJ; Salunke, GD; Deshmukh, MB; Hangirgekar, SP; Chandam, DR; Sankpal, SA in [Patil, Pradeep J.; Salunke, Govind D.; Deshmukh, Madhukar B.; Hangirgekar, Shankar P.; Sankpal, Sandeep A.] Shivaji Univ, Dept Chem, Kolhapur 416004, Maharashtra, India; [Salunke, Govind D.] Raje Ramrao Mahavidyalaya, Dept Chem, Jath 416404, India; [Chandam, Dattatray R.] Bhogawati Mahavidyalaya, Dept Chem, Kolhapur 416001, Maharashtra, India published Thiamine Hydrochloride Catalyzed Synthesis of 1,2,4-Triazolidine-3-thiones in Aqueous Medium in 2019.0, Cited 53.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In the present work, the catalytic potential of natural organo-catalyst thiamine hydrochloride is explored for the synthesis of 1,2,4-triazolidine-3-thiones in aqueous medium. The reaction of thiosemicarbazides with various substrates viz aryl/ heteroaryl aldehydes, isatins, cyclic and aromatic ketones to obtain corresponding 1,2,4-triazolidine-3-thiones have been successfully demonstrated for the first time. The method proposed in this work addresses the green chemistry principles such as biodegradable catalyst, ambient reaction condition, shorter reaction time, high yield of the products, recyclability of catalyst and high atom economy.

Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Patil, PJ; Salunke, GD; Deshmukh, MB; Hangirgekar, SP; Chandam, DR; Sankpal, SA or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, Biological Evaluation, Structure-Activity Relationship, and Mechanism of Action Studies of Quinoline-Metronidazole Derivatives Against Experimental Visceral Leishmaniasis WOS:000471834500027 published article about POTENTIAL ORAL TREATMENT; PROGRAMMED CELL-DEATH; REACTIVE OXYGEN; NITRIC-OXIDE; ANTILEISHMANIAL ACTIVITY; DRUG-RESISTANCE; OXIDATIVE STRESS; DONOVANI; THERAPY; ACTIVATION in [Upadhyay, Akanksha; Gupta, Sampa; Kushwaha, Pragati; Sashidhara, Koneni V.] CSIR Cent Drug Res Inst, Med & Proc Chem Div, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Chandrakar, Pragya; Parmar, Naveen; Kar, Susanta] CSIR Cent Drug Res Inst, Div Parasitol, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Singh, Sandeep Kumar; Rashid, Mamunur; Wahajuddin, Muhammad] CSIR Cent Drug Res Inst, Pharmacokinet & Metab Div, BS-10-1,Sect 10,Jankipuram Extens,Sitapur Rd, Lucknow 226031, Uttar Pradesh, India; [Upadhyay, Akanksha; Chandrakar, Pragya; Gupta, Sampa; Parmar, Naveen; Singh, Sandeep Kumar; Rashid, Mamunur; Kushwaha, Pragati; Wahajuddin, Muhammad; Sashidhara, Koneni V.; Kar, Susanta] Acad Sci & Innovat Res AcSIR, Anusandhan Bhawan, New Delhi 110025, India in 2019.0, Cited 69.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

In our efforts to identify novel chemical scaffolds for the development of antileishmanial agents, a series of quinoline metronidazole hybrid compounds was synthesized and tested against the murine model of visceral leishmaniasis. Among all synthesized derivatives, 15b and 15i showed significant antileishmanial efficacy against both extracellular promastigote (IC50 9.54 and 5.42 mu M, respectively) and intracellular amastigote (IC50 9.81 and 3.75 mu M, respectively) forms of Leishmania donovani with negligible cytotoxicity toward the host 0774 macrophages, Vero cells). However, compound 15i effectively inhibited the parasite burden in the liver and spleen (>80%) of infected BALB/c mice. Mechanistic studies revealed that 15i triggers oxidative stress which induces bioenergetic collapse and apoptosis of the parasite by decreasing ATP production and mitochondrial membrane potential. Structure activity analyses and pharmacokinetic studies suggest 15i as a promising antileishmanial lead and emphasize the importance of quinoline metronidazole series as a suitable platform for the future development of antileishmanial agents.

Welcome to talk about 99-93-4, If you have any questions, you can contact Upadhyay, A; Chandrakar, P; Gupta, S; Parmar, N; Singh, SK; Rashid, M; Kushwaha, P; Wahajuddin, M; Sashidhara, KV; Kar, S or send Email.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A new method for the synthesis of chalcone derivatives promoted by PPh3/I(2)under non-alkaline conditions WOS:000590637100001 published article about SOLVENT-FREE CONDITIONS; EFFICIENT SYNTHESIS; HETEROGENEOUS CATALYST; BIOLOGICAL EVALUATION; ALDOL CONDENSATIONS; DESIGN; AGENTS; FLAVONOIDS; INHIBITORS; AMIDATION in [Xue, Kangsheng] Changchun Univ Chinese Med, Coll Pharm, Changchun, Peoples R China; [Sun, Guoxiang] Yancheng Inst Technol, Sch Chem & Chem Engn, Yancheng, Jiangsu, Peoples R China; [Zhang, Yanzhi; Chen, Xubing] Dali Univ, Coll Pharm, Dali, Peoples R China; [Zhou, Yang; Hou, Jinjun; Long, Huali; Zhang, Zijia; Lei, Min; Wu, Wanying] Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Natl Engn Lab TCM Standardizat Technol, Shanghai, Peoples R China; [Zhou, Yang; Hou, Jinjun; Long, Huali; Zhang, Zijia; Lei, Min; Wu, Wanying] Univ Chinese Acad Sci, Beijing, Peoples R China in 2021, Cited 61. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

A straightforward and general method has been developed for the synthesis of chalcone derivatives by a Claisen-Schmidt reaction in the presence of PPh3/I-2 in 1,4-dioxane under reflux temperatures. With the condensation of the aromatic ketone and aldehyde occurring at non-strongly alkaline conditions, our proposed method significantly expands the range of applicable substrates, especially for groups that are unstable under alkaline conditions.

SDS of cas: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article DABCO Catalyzed Synthesis of beta-Hydroxy Ketones Derived from alpha-Methyl Ketones and Ninhydrin under Microwave Irradiations published in 2019.0. SDS of cas: 99-93-4, Reprint Addresses Srivastava, V (corresponding author), Banaras Hindu Univ, Dept Chem, Indian Inst Technol, Varanasi 221005, Uttar Pradesh, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Microwave induced an efficient, green and rapid protocol for the synthesis of 2-substituted-2-hydroxyindan-1,3-dione derivatives from the reaction of ninhydrin and ketone by using inexpensive 1,4-diazabicyclo[2.2.2]octane (DABCO) organocatalyst in water has been developed. Mild reaction conditions, shorter reaction time, metal-free approach, water as a green solvent, scalability and broad substrate scope are the salient features of this protocol.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, P; Mishra, A; Chauhan, S; Singh, S; Srivastava, V or concate me.. SDS of cas: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 99-93-4. Moudache, M; Silva, F; Nerin, C; Zaidi, F in [Moudache, Messaad; Zaidi, Farid] Univ Bejaia, Fac Sci Nat & Vie, Dept Sci Alimentaires, Route Targa Ouzemour, Bejaia 06000, Algeria; [Moudache, Messaad] Univ Bouira, Faculte Sci Nat & Vie & Sci La Terre, Bouira 10000, Algeria; [Silva, Filomena] ARAID Agencia Aragonesa Invest & Desarrollo, Av Ranillas 1-D,Planta 2a,Oficina B, Zaragoza 50018, Spain; [Silva, Filomena] Univ Zaragoza, Fac Vet Med, Calle Miguel Servet 177, Zaragoza 50013, Spain; [Silva, Filomena] Univ Beira Interior, CICS UBI Hlth Sci Res Ctr, Ave Infante D Henrique, Covilha 6200506, Portugal; [Nerin, Cristina] I3A Aragon Inst Engn Res, Calle Mariano Esquillor S-N, Zaragoza 50018, Spain published Olive cake and leaf extracts as valuable sources of antioxidant and antimicrobial compounds: a comparative study in 2021.0, Cited 56.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Purpose Aiming to exploit the remediation of olive cake and leaves, a comparative study between these extracts from the same trees has been carried out to explore them as a source of bioactive compounds with added value. Methods Olive cake (OCE) and leaf (OLE) methanolic extracts were chemically characterized by UPLC-QTOF-MS, and tested for their in vitro antimicrobial activity using a broth microdilution method. The antioxidant activity was evaluated using the DPPH scavenging, ferric reducing-antioxidant power and iron chelation assays. Results Our results demonstrated that Gram-positive bacteria were more sensitive to the extracts tested than Gram-negative bacteria, with the exception of Yersinia enterocolitica and Campylobacter jejuni. OLE have higher amounts of ash, carbohydrates, total phenolic content and flavonoids than OCE. UPLC-ESI-TOF-MS allowed the putative identification of 48 and 45 compounds in OLE and OCE, respectively, with three newly identified compounds in OLE. OLE had the highest antioxidant activity based on DPPH, ferrozin and FRP. Conclusion This study provides novel information on the presence of bioactive compounds, antioxidant and antibacterial capacity of Olea europaea L. leaf and cake extracts, which can lead to the use of these by-products as sources of natural-based bioactive compounds suitable for numerous applications. Graphic

SDS of cas: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Moudache, M; Silva, F; Nerin, C; Zaidi, F or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about C-H ACTIVATION; ESTERIFICATION; FORMAMIDES; ALDEHYDES; CHEMISTRY; GRAPHENE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21671068]; Dengfeng Plan High-level Hospital Construction Opening Project of Foshan Fourth People’s Hospital [FSSYKF-2020012]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Wang, FH; Liu, ZY; Yang, S; Shi, L; Lin, DZ; Liu, HY; Yuan, GQ. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Quality Control of 4′-Hydroxyacetophenone

The push-pull electronic and steric effect of copper porphyrin catalysts on the cross-dehydrogenative coupling (CDC) reaction between the hydroxyl group of phenol substrates and C(sp(3))-H bond have been investigated. Results showed that copper porphyrin bearing electron-withdrawing, bulky steric hindrance or heteroatom of pyridyl groups could increase the catalytic activity in the reaction. 5,10,15,20-(tetrakis(4-pyridyl)porphyrin)copper (CuTPyP) was found the best among all tested catalysts. Phenol substrates bearing various functional groups afforded moderate to excellent yields (99%). Significantly, as compared to other tested copper porphyrins, CuTPyP not only exhibited remarkable higher activity but also could shorten the reaction time from 12 to 6 h.

Quality Control of 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Kaur, H; Singh, J; Narasimhan, B in BMC published article about STRUCTURE-BASED DESIGN; GLUTAMATE LIGASE; AZO DYES; CANCER; DERIVATIVES; ANTIBACTERIAL; RESISTANCE; INHIBITORS; PROTEIN; ASSAY in [Kaur, Harmeet; Narasimhan, Balasubramanian] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Singh, Jasdir] Postgrad Inst Med Sci, Coll Pharm, Rohtak 124001, Haryana, India in 2019.0, Cited 45.0. SDS of cas: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Background: In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (A-E) by base catalyzed Claisen-Schmidt condensation with different substituted aromatic/heteroaromatic aldehydes. Methodology: The synthesized chalcones were assessed for their in vitro antimicrobial potential towards several pathogenic microbial strains by tube dilution method and further evaluated for antioxidant potential by DPPH assay. These derivatives were also assessed for the cytotoxicity towards the human lung cancer cell line (A549) and normal cell line (HEK) by MTT assay. The most active antimicrobial compounds were docked using Schrodinger v18.1 software with the various potential bacterial receptors to explore the mechanism of interaction. Results: The derivative C-22 exhibited high antibacterial activity with very low MIC (1.95-3.90 mu g ml(-1)) and MBC (3.90-7.81 mu g ml(-1)) values. The derivatives C-23, C-24 and C-27 have demonstrated good antioxidant potential (IC50 = 7-18 mu g ml(-1)) correlated to the ascorbic acid (IC50 = 4.45 mu g ml(-1)). The derivative C-25 had shown comparable cytotoxicity to camptothecin against A549 cell line. The docking studies predicted the bacterial dihydrofolate reductase (PDB ID: 3SRW) and bacterial DNA gyrase (PDB ID: 4ZVI) as the possible targets for most of the active antimicrobial compounds. These derivatives affirmed their safety by presenting less cytotoxicity towards HEK cells. Further the ADME prediction by qikprop module of the Schrodinger proved that these compounds exhibited drug-like attributes. Conclusion: Hence, these compounds have shown their potential as lead for future expansion of novel antimicrobial and cytotoxic drugs.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 J COLLOID INTERF SCI published article about ADVANCED OXIDATION; ORGANIC POLLUTANTS; COEXISTING CHEMICALS; PROTOCATECHUIC ACID; FENTON OXIDATION; WATER-TREATMENT; PHOTO-FENTON; WASTE-WATER; REMOVAL; CONTAMINANTS in [Cheng, Feng; Zhou, Peng; Huo, Xiaowei; Liu, Yang; Liu, Yunxin; Zhang, Yongli] Sichuan Univ, Coll Architecture & Environm, Chengdu 610065, Peoples R China in 2020.0, Cited 49.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

The photocatalytic behavior of the graphene oxide (GO) modified Fe(III)/peroxymonosulfate (Fe/PMS) system for bisphenol A (BPA) degradation was investigated. With the addition of GO, a dramatic enhancement of BPA degradation was obtained at pH 3.0 under visible light irradiation. According to ESR analysis and quenching tests, both SO4 center dot- and center dot OH are responsible for BPA degradation. The characterization analysis demonstrates that Fe(III) can chelate with the oxygenic functional groups on the surface of GO forming a stable GO-Fe(III) complex. The detections of different kinds of Fe species reveal that Fe(III) can be reduced to Fe(II) by GO via intramolecular electron transfer in the GO-Fe(III) complex, and visible light could enhance this process. The Fe(III)/Fe(II) cycle not only occurs on the surface of GO, but also in aqueous solution via homogeneous reactions. In addition, the degradation pathway of BPA was proposed based on the identification of the intermediates using GC-MS and LC-MS techniques. (C) 2020 Elsevier Inc. All rights reserved.

Recommanded Product: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles