Category: 99-93-4

In 2019.0 REC NAT PROD published article about IDENTIFICATION; GENUS in [Bao, Wugedunqiqige; Wang, Qinghu; Hao, Junsheng] Inner Mongolia Univ Nationalities, Coll Tradit Mongolian Med, Tongliao 028000, Inner Mongolia, Peoples R China in 2019.0, Cited 14.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

A new coumarin, named as arteordocoumarin A (1), together with eight known compounds (2-9) were isolated from the CHCl3 extract of Artemisia ordosica (A. ordosica). The structures of 1 was elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1D and 2D NMR techniques.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4′-Hydroxyacetophenone. I found the field of Chemistry very interesting. Saw the article Construction of C-O bond via cross-dehydrogenative coupling of sp [3] C-H bond with phenols catalyzed by copper porphyrin published in 2020, Reprint Addresses Liu, HY (corresponding author), South China Univ Technol, Dept Chem, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510641, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.

Copper porphyrin-catalyzed construction of ether bond by cross-dehydrogenative coupling of sp [3] C-H bond with phenols bearing electron-withdrawing groups (EWG) was described for the first time. A broad range of substrates afforded different acetals in moderate to excellent yields with good functional group tolerance. The developed method is not only suitable for phenol substrates with ortho-directing groups, but also suitable for those phenol without ortho-directing groups. Significantly, a high turnover number (TON) up to 7300 was achieved in gram-level test. (C) 2020 Elsevier Ltd. All rights reserved.

Safety of 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Authors Ding, YX; Ma, RC; Xiao, XQ; Wang, L; Wang, ZM; Ma, YM in AMER CHEMICAL SOC published article about in [Ding, Yuxin; Ma, Renchao; Wang, Lei; Wang, Zhiming; Ma, Yongmin] Taizhou Univ, Inst Adv Studies, Taizhou 318000, Peoples R China; [Ding, Yuxin; Ma, Renchao; Wang, Lei; Wang, Zhiming; Ma, Yongmin] Taizhou Univ, Sch Pharmaceut & Chem Engn, Taizhou 318000, Peoples R China; [Ding, Yuxin; Ma, Yongmin] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China; [Xiao, Xu-Qiong] Hangzhou Normal Univ, Key Lab Organosilicon Chem & Mat Technol, Minist Educ, Hangzhou 311121, Peoples R China in 2021.0, Cited 68.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A one-pot, four-component annulation of 2,3,4,6-tetraarylpyridines from aromatic aldehydes, methyl ketones, diaryl ethanones, and ammonium acetate is described. The reaction features high functional group compatibility in air under solvent-free conditions without any additive and only water as the nontoxic byproduct, providing a strategy for the facile, economical, and ecofriendly construction of multiaryl-substituted pyridines from simple and readily available reactants.

Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nizamuddin, ND; Ahad, HA; Devanna, N in [Nizamuddin, N. D.] Jawaharlal Nehru Technol Univ Anantapur JNTUA, Ananthapuramu 515001, Andhra Pradesh, India; [Ahad, Hindustan Abdul] Raghavendra Inst Pharmaceut Educ & Res RIPER, Dept Ind Pharm, Ananthapuramu 515721, Andhra Pradesh, India; [Devanna, Nayakanti] Jawaharlal Nehru Technol Univ Anantapu Oil Techno, Ananthapuramu 51500, Andhra Pradesh, India published Molecular Docking studies of N-Methyl- 2, 3 -Disubstituted Quinazolin-4-Ones Scaffold in 2020.0, Cited 22.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In recent days, synthesis of anticancer molecules having both low adverse effects and specific protein targeting are seldom. Synthesis of anticancer molecules having both low adverse effects and specific protein targeting is challenging. The main objective of our study was to develop molecules that can target activated protein kinase P38 alpha and activin receptor (ALK2) kinase for treating carcinoma. P38 alpha is involved in cell differentiation, apoptosis, and autophagy.Activin receptor (ALK2) kinase is responsible for mutations of cancerous cells. The synthesis of N-Methyl – 2, 3 -Disubstituted Quinazolin-4-Ones was carried out by refluxing of 1-methyl-2-(pyridinyl)-1,2-dihydro-4H-3,1-benzoxazin-4-one with 4-substituted phenyl-1,3-thiazol-2-amines. The molecular docking of 1-methyl-3-(4-substituted phenyl-1,3-thiazol-2-yl)2-(pyridin-3-yl)-2,3-dihydroquinazolin-4(1H)-one (5Da1-5Dk11) and 1-methyl-3-(4-substituted phenyl- 1,3-thiazol-2-yl)-2-(pyridin-4-yl)-2,3dihydroquinazolin-4(1H)-one (5Ea1-5Ek11) derivatives were carried out using Schrodinger Glide (version 2020_1) software. Twenty-two quinazoline-4-one derivatives were docked into selective P38 alpha and ACVR1 (ALK2) kinase with PDB code 3GC7, 6GI6. Based on the docking score, comparison between quinazolin-4-one derivatives, co-crystallized Ligands interaction was evaluated using 5-Fluorouracil as standard. Best activity was found in compounds 5Df6, 5Dd4, 5Ed4 and 5Ef6 with ACVR1 (ALK2) kinase with score of -8.223, -7.936, -8.123, 7.907 and 5Df6, 5Dh8, 5Eb2 and 5Ee5 with P38alpha with score of -7.19, -7.027, -6.698, -6.789 Kcal/mol against enzymes responsible for treatment for cancer compare with reference drug score -5.765 and -6.195. This study will help in the design and development of a drug that gives room for the synthesis of a new selective ACVR1 (ALK2) kinase and P38alpha enzyme inhibitor with predetermined affinity and activity of the compound.

Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Nizamuddin, ND; Ahad, HA; Devanna, N or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Li, H; Hung, A; Yang, AWH in NATURE RESEARCH published article about in [Li, Hong; Yang, Angela Wei Hong] RMIT Univ, Sch Hlth & Biomed Sci, Discipline Chinese Med, POB 71, Bundoora, Vic 3083, Australia; [Hung, Andrew] RMIT Univ, Sch Sci, Melbourne, Vic 3000, Australia in 2021.0, Cited 69.0. Computed Properties of C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Prostate cancer (PCa) is a cancer that occurs in the prostate with high morbidity and mortality. Danggui Beimu Kushen Wan (DBKW) is a classic formula for patients with difficult urination including PCa. This study aimed to investigate the molecular mechanisms of DBKW for PCa. We obtained DBKW compounds from our previous reviews. We identified potential targets for PCa from literature search, currently approved drugs and Open Targets database and filtered them by protein-protein interaction network analysis. We selected 26 targets to predict three cancer-related pathways. A total of 621 compounds were screened via molecular docking using PyRx and AutoDock Vina against 21 targets for PCa, producing 13041 docking results. The binding patterns and positions showed that a relatively small number of tight-binding compounds from DBKW were predicted to interact strongly and selectively with three targets. The top five high-binding-affinity compounds were selected to generate a network, indicating that compounds from all three herbs had high binding affinity against the 21 targets and may have potential biological activities with the targets. DBKW contains multi-targeting agents that could act on more than one pathway of PCa simultaneously. Further studies could focus on validating the computational results via experimental studies.

Welcome to talk about 99-93-4, If you have any questions, you can contact Li, H; Hung, A; Yang, AWH or send Email.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Aerobic oxidation of alkyl chain in alkylphenols over combination of Pt and Pd catalysts WOS:000451493400018 published article about LIQUID-PHASE OXIDATION; CO-N-C; SELECTIVE OXIDATION; BIO-OIL; EFFICIENT CATALYST; CRESOL; MANGANESE; LIGNIN; HYDROXYBENZALDEHYDE; FRACTIONATION in [Nakagawa, Yoshinao; Tokuma, Kensuke; Nakaji, Yosuke; Miyagawa, Akari; Tamura, Masazumi; Tomishige, Keiichi] Tohoku Univ, Dept Appl Chem, Sch Engn, Aoba Ku, 6-6-07 Aoba, Sendai, Miyagi 9808579, Japan; [Nakagawa, Yoshinao; Tamura, Masazumi; Tomishige, Keiichi] Tohoku Univ, Res Ctr Rare Met & Green Innovat, Aoba Ku, 468-1 Aoba, Sendai, Miyagi 9800845, Japan in 2019.0, Cited 45.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Oxidation of benzylic position in alkylphenols with molecular oxygen in acidic conditions, which is very difficult because of the intense dimerization or polymerization, was investigated with various combinations of noble metal catalysts. The combination of Pt/C and Pd(CH3COO)(2) catalysts showed activity in the formation of p-hydroxybenzaldehyde formation from p-cresol. The best p-hydroxybenzaldehyde yield was 35%, which was obtained in 50 wt% aqueous acetic acid, Pt on carbon : Pd(CH3COO)(2) weight ratio = 1 : 2, at 353 K. From XRD, TEM-EDX and XAFS characterizations, the Pt and Pd species were totally reduced to Pt and Pd metal particles, respectively, in spite of the oxidative reaction conditions. Polymerized products (tar) of p-cresol formed with Pt/C catalyst and air can be the reductants for Pd(CH3COO)(2) into Pd metal. The catalysts or catalyst combinations without Pd degrees metal showed no activity in the formation of p-hydroxybenzaldehyde, suggesting that Pd is the active species. The effects of the air pressure and presence of radical scavenger were very small, suggesting that non-free-radical mechanism was involved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Nakagawa, Y; Tokuma, K; Nakaji, Y; Miyagawa, A; Tamura, M; Tomishige, K or concate me.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Evaluation of inhibition of lignocellulose-derived by-products on bioethanol production by using the QSAR method and mechanism study WOS:000475995000018 published article about SACCHAROMYCES-CEREVISIAE; ETHANOL FERMENTATION; PHENOLIC-COMPOUNDS; JOINT TOXICITY; DETOXIFICATION; PRETREATMENT; DEGRADATION; HYDROLYSATE; DERIVATIVES; GROWTH in [Hou, Jinju; Tang, Jiawen; Chen, Jinhuan; Deng, Jie; Wang, Juan; Zhang, Qiuzhuo] East China Normal Univ, Sch Ecol & Environm Sci, Shanghai Key Lab Urban Ecol Proc & Ecorestorat, Shanghai 200241, Peoples R China; [Zhang, Qiuzhuo] Inst Ecochongming IEC, 3663 N Zhongshan Rd, Shanghai 200062, Peoples R China in 2019.0, Cited 41.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

To evaluate the inhibition of by-products that exist in pretreated lignocellulose hydrolysate on bioethanol fermentation, quantitative structure-activity relationship (QSAR) models were established in the present study. These models have the potential to predict the fermentation inhibition to minimize the experimental effort. They also provided an innovative methodology for removing fermentation inhibitors purposefully and for optimizing pretreatment parameters and thus could enhance the bioethanol yield. The results indicated that the fermentation inhibition of phenolic aldehyde were stronger than that of phenolic acid followed by phenolic alcohol in which the fermentation inhibition was weakened by the existence of the methoxy group in the benzene ring. Meanwhile, the formation of the intramolecular hydrogen bonds of fermentation inhibitors also played an important role in weakening their fermentation inhibition. The individual fermentation inhibition of fermentation inhibitors was found strongly related to their molecular descriptors. Furthermore, ferulic acid was chosen as the representative inhibitor for the primary investigation on the combined fermentation inhibition of the various complex binary fermentation inhibitor mixtures, which co-existed in the lignocellulose hydrolysate. As indicated by the results, antagonism occurred mainly under the higher ferulic acid concentrations in the binary mixtures, while a simple additive effect was generated.

Safety of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Hou, JJ; Tang, JW; Chen, JH; Deng, J; Wang, J; Zhang, QZ or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article D35-TiO2 nano-crystalline film as a high performance visible-light photocatalyst towards the degradation of bis-phenol A WOS:000445416900094 published article about BISPHENOL-A; DOPED TIO2; ORGANIC POLLUTANTS; ANATASE TIO2; PHOTODEGRADATION; OXIDATION; MECHANISM; PHOTOELECTROCATALYSIS; HETEROJUNCTION; NANOCOMPOSITE in [Bai, Xue; Yang, Lei; Jin, Pengkang] Xian Univ Architecture & Technol, Sch Environm & Municipal Engn, Xian 710055, Shaanxi, Peoples R China; [Hagfeldt, Anders] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, Lab Photomol Sci, CH-1015 Lausanne, Switzerland; [Johansson, Erik M. J.] Uppsala Univ, Dept Chem, Angstrom Lab, Box 538, S-75121 Uppsala, Sweden in 2019.0, Cited 62.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

Dye-sensitized photocatalytic suspension system for wastewater treatment is still limited in practice due to particle aggregation, fast charge carrier recombination, poor stability and recycling issue. In this study, we combine TiO2 nano-crystalline film with D35 organic dye to fabricate a new visible-light photocatalyst D35-TiO2, which exhibits excellent visible light absorption. Its transient photocurrent is almost 10 times higher than pure TiO2 under visible light illumination (lambda > 420 nm). Besides the well characterizations of the D35-TiO2 film, e.g., SEM, EDS, TEM, XRD, UV-Vis DRS, XPS, PL and I-T, degradation of bis-phenol A (BPA) is performed as the model reaction to test its photocatalytic activity. Meanwhile, we employ external bias in the reaction system to further enhance the photogenerated charge carrier separation, and improve the photocatalytic efficiency. Under the better experimental conditions of initial BPA concentration (5 mg/L), initial pH (pH 7), external bias (0.25 V) and sensitizer concentration (0.1 mM), BPA is almost completely degraded in 300 min, and the four intermediates are gradually mineralized. The ecotoxicity of BPA also decreases significantly after the photo-degradation. During the reaction, center dot O-2(-) plays a dominant role, meanwhile center dot OH and h(D35)(+) also contribute to the BPA degradation. After five cycles, the D35-TiO2 film still maintain the normal photocatalytic activity. Due to the high stability and recyclability, the D35-TiO2 nano-crystalline film provides a sustainable way for degrading micropollutants in wastewater.

Recommanded Product: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Nanoporous AlSBA-15 catalysed Claisen-Schmidt condensation for the synthesis of novel and biologically active chalcones WOS:000540213400017 published article about HUMAN SERUM-ALBUMIN; MICROWAVE IRRADIATION; DERIVATIVES; ANTIOXIDANT; CURCUMIN; ANTICANCER; DESIGN in [Chandrasekar, Govindasamy] Imam Abdhulrahman Bin Faisal Univ, Coll Sci, Basic & Appl Sci Res Ctr, POB 31441, Dammam, Saudi Arabia; [Elamathi, Palani; Balamurali, M. M.] Vellore Inst Technol, Sch Adv Sci, Chem Div, Chennai, Tamil Nadu, India in 2020.0, Cited 35.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 4′-Hydroxyacetophenone

Mesoporous AlSBA-15 catalysts (n(Si)/n(Al)ratios of 41, 129 and 210) were synthesized by sol-gel method. These materials were characterized by XRD, N(2)sorption, FTIR, TPD-NH3, FESEM, EDX, and TEM analysis. XRD analysis of AlSBA-15 catalysts confirmed the existence of well-ordered crystalline structure havingp6mmsymmetry. N(2)sorption isotherm of AlSBA-15 catalysts showed a type IV adsorption isotherm with H1 hysteresis loops. SEM analysis of AlSBA-15 (41) indicated worm-like particle morphology with a size range of 3 mu m with co-occurrence of smaller particles of size ca. 1 mu m. TEM analysis of AlSBA-15 (41) showed existence of uniform array of tubular nano-channels. The catalytic application of AlSBA-15 catalysts was tested on industrially important chalcones synthesis via Claisen-Schmidt condensation reaction in environment friendly approach. The reaction parameters such as time, temperature,n(Si)/n(Al)ratio, catalyst amount, and catalyst stability were investigated. AlSBA-15 (41) catalyst showed an excellent catalytic performance with 98% 1-tetralone conversion with 100% selectivity of compound 1c (91% yield) within 120 min AlSBA-15 (129) and AlSBA-15 (210) catalysts. The anti-oxidant activity of the synthesised chalcones were investigated by various in-vitro procedures, including radical scavenging potentials-1, 1-diphenyl-2-picryl-hydrazil, hydrogen peroxide scavenging, and ferric reducing potential assay. The new chalcone derivatives synthesised in this work showed a very good antioxidant activity and some were found to be more active than the parent chalcones, (E)-3-(4-hydroxy-3-methoxyphenyl)-1-phenylprop-2-en-1-one (compound 8c), and standard antioxidant (curcumin).

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and biological effects of naphthalene-chalcone derivatives WOS:000526454100005 published article about ANTIDEPRESSANT-LIKE ACTIVITY; BEHAVIORAL DESPAIR; MOLECULAR DOCKING; MICE; ANTICONVULSANT; ANTIOXIDANT; INHIBITION; EXTRACTS in [Jin, Qing-Hao] Zhejiang Ocean Univ, Donghai Sci & Technol Coll, Zhoushan 316000, Zhejiang, Peoples R China; [Chen, Hong-Hai; Chen, Wen-Bo] Hailisheng Pharmaceut Co Ltd, Zhoushan 316000, Zhejiang, Peoples R China; [Fu, Zhi-Yang; Guan, Li-Ping] Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316022, Zhejiang, Peoples R China; [Jiang, Hai-Ying] Jiaxing Univ, Coll Med, Jiaxing 314001, Zhejiang, Peoples R China in 2020.0, Cited 30.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 4′-Hydroxyacetophenone

In this paper, 21 naphthalene-chalcone derivatives were synthesized and their biological effects were evaluated. The results showed that compounds 2a-2u displayed clear antidepressant activity at 30 mg/kg in the forced swimming test. Compounds 2h, 2o, 2t, and 2u exhibited a good antidepressant effect in the forced swimming test and tail suspension test at 30 mg/kg. Compounds 2h, 2o, 2t, and 2u but had no effect on locomotor activity in the open-field test in mice. In addition, the most antidepressant activity of compound 2o is likely mediated by increased serotonin and norepinephrine levels in central nervous system. Compounds 2a-2u also showed the analgesic and anti-inflammatory effects at 30 mg/kg.

Recommanded Product: 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles