Category: 99-93-4

Authors Chen, J; Yang, HL; Fu, HQ; He, HY; Zeng, Q; Li, XH in ROYAL SOC CHEMISTRY published article about BOND-CLEAVAGE; PHOTOCATALYTIC OXIDATION; CATALYTIC-OXIDATION; AEROBIC OXIDATION; VISIBLE-LIGHT; PB/PBO2 ANODE; DEGRADATION; DEPOLYMERIZATION; HYDROGENOLYSIS; COPPER in [Chen, Jing; Yang, Hanling; Fu, Hongquan; Zeng, Qiang; Li, Xuehui] South China Univ Technol, Sch Chem & Chem Engn, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Peoples R China; [He, Hongyan] Chinese Acad Sci, CAS Key Lab Green Proc & Engn, Inst Proc Engn, Beijing 100190, Peoples R China in 2020.0, Cited 67.0. Product Details of 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Electrochemical oxidation is a promising and effective method for lignin depolymerization owing to its selective oxidation capacity and environmental friendliness. Herein, the electrooxidation of non-phenolic alkyl aryl ether monomers and beta-O-4 dimers was experimentally (by cyclic voltammetry, in situ spectroelectrochemistry, and gas chromatography-mass spectroscopy) and theoretically (by DFT calculations) explored in detail. Compared to the reported literature (T. Shiraishi, T. Takano, H. Kamitakahara and F. Nakatsubo, Holzforschung, 2012, 66(3), 303-309), 1-(4-ethoxyphenyl)ethanol showed a distinguishable oxidation pathway, where the resulting carbonyl product surprisingly underwent a bond cleavage on alkyl-aryl ether to ultimately produce a quinoid like compound. In contrast, beta-O-4 dimers, like 2-phenoxy-1-phenethanol and 2-phenoxyacetophenone also demonstrated electrochemical oxidation induced by C-beta-O and C-alpha-C-beta bond cleavages. For the oxidation products, the presence of the C-alpha-hydroxyl group in dimers was the key to selectively generate aldehyde-containing species under mild electrochemical conditions, otherwise it produces alcohol-containing products following a different mechanism compared to the C-alpha = O containing dimers.

Product Details of 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Chen, J; Yang, HL; Fu, HQ; He, HY; Zeng, Q; Li, XH or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about IMIDAZOLATE-BRIDGED DICOPPER(II); CHEMOSELECTIVE AEROBIC OXIDATION; SELECTIVE OXIDATION; CRYSTAL-STRUCTURE; HETEROBIMETALLIC COMPLEX; P-HYDROXYBENZALDEHYDE; DINUCLEAR COMPLEXES; MACROCYCLIC LIGAND; BENZYLIC ALCOHOLS; AQUEOUS-MEDIUM, Saw an article supported by the . Published in ELSEVIER SCIENCE SA in LAUSANNE ,Authors: Asthana, M; Syiemlieh, I; Kumar, A; Lal, RA. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Recommanded Product: 99-93-4

We report herein a ligand and additive- free [CuNi(bz)(3)(bpy)(2)]ClO4 catalyst system that efficiently and selectively catalyses the oxidation of a range of primary and secondary benzylic alcohols, 1 – heteroaryl alcohols, cinnamyl alcohol, and aliphatic alcohols mediated by hydrogen peroxide to the corresponding aldehydes and ketones, respectively.

Recommanded Product: 99-93-4. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nakagawa, Y; Tokuma, K; Nakaji, Y; Miyagawa, A; Tamura, M; Tomishige, K in [Nakagawa, Yoshinao; Tokuma, Kensuke; Nakaji, Yosuke; Miyagawa, Akari; Tamura, Masazumi; Tomishige, Keiichi] Tohoku Univ, Dept Appl Chem, Sch Engn, Aoba Ku, 6-6-07 Aoba, Sendai, Miyagi 9808579, Japan; [Nakagawa, Yoshinao; Tamura, Masazumi; Tomishige, Keiichi] Tohoku Univ, Res Ctr Rare Met & Green Innovat, Aoba Ku, 468-1 Aoba, Sendai, Miyagi 9800845, Japan published Aerobic oxidation of alkyl chain in alkylphenols over combination of Pt and Pd catalysts in 2019.0, Cited 45.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Oxidation of benzylic position in alkylphenols with molecular oxygen in acidic conditions, which is very difficult because of the intense dimerization or polymerization, was investigated with various combinations of noble metal catalysts. The combination of Pt/C and Pd(CH3COO)(2) catalysts showed activity in the formation of p-hydroxybenzaldehyde formation from p-cresol. The best p-hydroxybenzaldehyde yield was 35%, which was obtained in 50 wt% aqueous acetic acid, Pt on carbon : Pd(CH3COO)(2) weight ratio = 1 : 2, at 353 K. From XRD, TEM-EDX and XAFS characterizations, the Pt and Pd species were totally reduced to Pt and Pd metal particles, respectively, in spite of the oxidative reaction conditions. Polymerized products (tar) of p-cresol formed with Pt/C catalyst and air can be the reductants for Pd(CH3COO)(2) into Pd metal. The catalysts or catalyst combinations without Pd degrees metal showed no activity in the formation of p-hydroxybenzaldehyde, suggesting that Pd is the active species. The effects of the air pressure and presence of radical scavenger were very small, suggesting that non-free-radical mechanism was involved.

Recommanded Product: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Nakagawa, Y; Tokuma, K; Nakaji, Y; Miyagawa, A; Tamura, M; Tomishige, K or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2021.0 MOL CATAL published article about METAL-ORGANIC FRAMEWORKS; HETEROGENEOUS CATALYST; BRONSTED ACIDITY; BENZOXAZOLES; EFFICIENT; ZR; CHEMISTRY; SCAFFOLD; CASCADE in [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Minh-Huy Dinh Dang; Tan Le Hoang Doan] VNU HCM, Ctr Innovat Mat & Architectures INOMAR, Ho Chi Minh City 721337, Vietnam; [Linh Ho Thuy Nguyen; Phuong Hoang Tran] VNU HCM, Fac Chem, Univ Sci, Ho Chi Minh City 721337, Vietnam; [Linh Ho Thuy Nguyen; Trang Thi Thu Nguyen; Minh-Huy Dinh Dang; Phuong Hoang Tran; Tan Le Hoang Doan] Ho Chi Minh City VNU HCM, Vietnam Natl Univ, Ho Chi Minh City 721337, Vietnam in 2021.0, Cited 58.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Use of green chemistry and alternative strategies has been explored to prepare diverse organic derivatives. The combination between heterogeneous catalyst, environmentally benign reaction and high-yielding methods is gaining momentum. Herein, a defective 6-connected Hf-MOF, named Hf-BTC, was efficiently synthesized and characterized for the heterogeneous catalysis under microwave irradiation. The MOF features including structural defect, porosity, acidity, and stability was analyzed by powder X-ray diffraction, N-2 sorption isotherms, acid-base titration, and thermal gravimetric analysis. In the catalytic studies, the Brunsted-Lewis dual acidic HfBTC was efficiently applied for the synthesis of the heterocyclic compounds via the microwave-assisted cycloaddition and condensation reactions. The reactions proceeded smoothly in the presence of the Hf-MOF with a broad scope of substrates provided the expected products in high to excellent yields (up to 99 %) for few minutes and the catalyst could be easily recycle over many consecutive reactions without loss of its reactivity and structure.

Welcome to talk about 99-93-4, If you have any questions, you can contact Nguyen, LHT; Nguyen, TTT; Dang, MHD; Tran, PH; Doan, TLH or send Email.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MOLECULAR CHAPERONE; ANTICANCER AGENTS; FORCE-FIELD; CANCER; DYNAMICS; DOCKING; DESIGN; OPTIMIZATION; PERFORMANCE; GENERATION, Saw an article supported by the Center for Drug Research and Development (CDRD), Faculty of Pharmacy, The British University in Egypt; Natural Sciences and Engineering Research Council (NSERC) of CanadaNatural Sciences and Engineering Research Council of Canada (NSERC) [RGPIN-2017-04233]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. HPLC of Formula: C8H8O2

Although hepatocellular carcinoma (HCC)-related mortality has increased over the past decades, treatment options are still very limited, underlining the need for developing new therapeutic strategies. The molecular chaperone heat shock protein 90 (Hsp90) plays a key role in post-translational maturation of many oncogenic client proteins that are important for survival and proliferation of cancer cells. Thus, inhibitors of Hsp90 are promising targets for many cancer types. In this study, 15 diarylpyrazole compounds were screened against MCF7 and HepG2 cell lines. Compound 8, which contained a thiophene group, demonstrated the highest antiproliferative activity against HepG2 cells having an IC50, of 0.083 mu M. Four additional diarylpyrazoles, each containing a thiophene group, were prepared and screened for antiproliferative activity. None of these four compounds exhibited superior activity to compound 8 on HepG2 cells. Therefore, compound 8 was selected for further in vitro assays. Cell cycle arrest was observed at the G2 phase in compound 8-treated cells. Compound 8 also caused a 7.7-fold increase in caspase-3. These results confirm the apoptotic effect of compound 8 on HepG2 cells. Moreover, compound 8 inhibited Hsp90 (IC50, = 2.67 +/- 0.18 mu M) in an in vitro assay and caused a 70.8% reduction in Hsp90 levels in a HepG2 cell-based assay. Additionally, compound 8 caused significant reduction in the levels of Hsp90 client proteins (Akt, c-Met, c-Raf, and EGFR) and a 1.57-fold increase in Hsp70. Molecular docking studies were also performed to predict the binding mode of compound 8 and followed by molecular dynamics simulations to give further insights into the binding mode of 8.

HPLC of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Mohamady, S; Ismail, MI; Mogheith, SM; Attia, YM; Taylor, SD or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4′-Hydroxyacetophenone. Authors Abdel-Rahman, IM; Mustafa, M; Mohamed, SA; Yahia, R; Abdel-Aziz, M; Abuo-Rahma, GEA; Hayallah, AM in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Abdel-Rahman, Islam M.; Mustafa, Muhamad; Abuo-Rahma, Gamal El-Din A.; Hayallah, Alaa M.] Deraya Univ, Fac Pharm, Dept Pharmaceut Chem, New Minia 61519, Minia, Egypt; [Mohamed, Soad A.] Deraya Univ, Fac Pharm, Dept Pharmaceut, New Minia 61519, Minia, Egypt; [Yahia, Ramadan] Deraya Univ, Fac Pharm, Dept Microbiol, New Minia 61519, Minia, Egypt; [Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A.] Menia Univ, Fac Pharm, Dept Med Chem, Al Minya 61519, Egypt; [Hayallah, Alaa M.] Assiut Univ, Fac Pharm, Pharmaceut Organ Chem, Assiut, Egypt; [Hayallah, Alaa M.] Sphinx Univ, Fac Pharm, Dept Pharmaceut Chem, New Assiut, Egypt in 2021, Cited 45. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The design, synthesis and identification of a novel series of Mannich bases of ciprofloxacin was reported. Naphthol derivatives 2a and 2b showed highly potent cytotoxic activity among the tested compounds. Compound 2a showed broad spectrum antiproliferative activity with GI(50) of 2.5-6.79 mu M with remarkable selectivity towards renal and prostate cancers with selectivity ratios ranging from 0.17 to 6.79. Independently, 2a showed outstanding activity against colon cancer HOP-92 cell lines with IC50 of 6.66 mu M while 2b showed highly potent activity against ovarian cancer cell lines with IC50 of 0.97 mu M. Results showed that 2b induced cell cycle arrest at G2/M phase and apoptosis; compound 2b showed over-expression of caspase-3 protein level (449.2 +/- 7.95) compared to doxorubicin (578.7 +/- 14.4 pg/mL). Meanwhile, compounds 2a and 2b experienced outstanding activity against both Gram-positive and Gram-negative microorganisms. Interestingly, compound 2j experienced high activity against Escherichia coli and Pseudomonas aeruginosa with MIC of 0.036 and 0.043, respectively. Compound 2d revealed 27 folds and 22 folds, respectively increasing of activity over ciprofloxacin against Staphylococcus aureus and MRSA(reference strain). Compound 2d showed high activity against Staphylococcus aureus, MRSA (reference strain) and MRSA (clinical strain) with MIC of 0.57, 0.52, 0.082 mu g/mL, respectively. Interestingly, the most active tested compounds were found to have promising physicochemical and drug likeness properties. The Mannich bases 2j, 2d and 2g showed promising antibacterial activities, while naphthols 2a and 2b showed promising antiproliferative and antibacterial activities that require further optimization.

Safety of 4′-Hydroxyacetophenone. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gupta, S; Ameta, C; Punjabi, PB in WILEY published article about GRAPHENE OXIDE; ORGANIC-DYES; IONIC LIQUID; LEAF EXTRACT; EFFICIENT; REDUCTION; NANOPARTICLES; DERIVATIVES; SOLVENT; CAFE2O4 in [Gupta, Sharoni; Ameta, Chetna; Punjabi, Pinki Bala] Mohanlal Sukhadia Univ, Univ Coll Sci, Dept Chem, Microwave Synth Lab, Udaipur 313001, Rajasthan, India in 2020.0, Cited 61.0. Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

In the present paper, a novel and benign protocol for microwave enhanced one pot syntheses of 2,3-dihydro-1,5 benzodiazepine derivatives from substituted acetophenones, aryl-aldehydes and o-phenylene diamine using heterogeneous calcium ferrite/graphene oxide (CF/GO) nanocomposite has been reported. The catalyst was prepared by ultrasonication method and characterized by spectral and analytical techniques. The CF/GO nanocomposite was employed for environmentally benign synthesis of 2,3-dihydro-1,5 benzodiazepines. The synthesized benzodiazepine derivatives were screened for their antimicrobial activities against various bacteria and fungi. The present synthetic strategy offered several advantages such as excellent yields in short span of time, simple modus operandi, ease of isolation and purification of products, simple recovery and reusability of the catalyst. A tentative mechanism for synthesis of 2,3-dihydro-1,5 benzodiazepine using CF/GO nanocatalyst has also been proposed.

Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gupta, S; Ameta, C; Punjabi, PB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 99-93-4. Recently I am researching about BIOLOGICAL EVALUATION; DRUG-RESISTANCE; POTENTIAL EGFR; TK INHIBITORS; IN-VITRO; DERIVATIVES; DESIGN, Saw an article supported by the Department of Science and Technology, New Delhi, IndiaDepartment of Science & Technology (India) [IF-131173]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Nawaz, F; Alam, O; Perwez, A; Rizvi, MA; Naim, MJ; Siddiqui, N; Pottoo, FH; Jha, M. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Pyrazoline-linked carboxamide derivatives were designed, synthesized, and evaluated for potential epidermal growth factor receptor (EGFR) kinase inhibition, anticancer activity, and apoptotic and cardiomyopathy toxicity. Compounds 6m and 6n inhibit EGFR kinase at a concentration of 6.5 +/- 2.91 and 3.65 +/- 0.54 mu M, respectively. Some of these compounds showed effects on proliferation, which were also then evaluated against four different human cancer cell lines, that is, MCF-7 (breast cancer), A549 (non-small-cell lung tumor), HCT-116 (colon cancer), and SiHa cells (cancerous tissues of the cervix uteri). The results showed that certain synthetic compounds showed significant inhibitor activity; compounds 6m and 6n were more cytotoxic than doxorubicin against A549 cancer cells, with IC50 values of 10.3 +/- 1.07 and 4.6 +/- 0.57 mu M, respectively. Additionally, compounds 6m and 6n induced apoptosis in A549 cancer cells, as evidenced by 4 ‘,6-diamidino-2-phenylindole (DAPI) staining and phase-contrast microscopy. Potency to induce apoptosis by compound 6n was further confirmed by fluorescence-activated cell sorting using Annexin V-FITC and propidium iodide labeling. Compound 6n showed normal cardiomyocytes with no marked sign of pyknotic nuclei in cardiomyopathy and also normal histological appearance of the renal cortex when compared with that of control. Results of molecular docking studies suggested that compounds 6m and 6n can bind to the hinge region of the adenosine triphosphate-binding site of EGFR kinase, like the standard drug erlotinib. Therefore, the present study suggests that compounds 6m and 6n have potent in vitro antitumor activities against the human non-small-cell lung tumor cell line A549, which can be further explored in other cancer cell lines and in animal studies.

SDS of cas: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Nawaz, F; Alam, O; Perwez, A; Rizvi, MA; Naim, MJ; Siddiqui, N; Pottoo, FH; Jha, M or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Bisphenol A attenuation in natural microcosm: Contribution of ecological components and identification of transformation pathways through stable isotope tracing WOS:000509618300061 published article about PHOTOCATALYTIC DEGRADATION; HUMAN EXPOSURE; SURFACE-WATER; RIVER ESTUARY; ANALOGS; PHOTODEGRADATION; BIODEGRADATION; TOXICITY; PRODUCTS; REMOVAL in [Li, Yan; Zhang, Han; Rashid, Azhar; Hu, Anyi; Adyari, Bob; Wang, Yuwen; Yu, Chang-Ping; Sun, Qian] Chinese Acad Sci, Inst Urban Environm, CAS Key Lab Urban Pollutant Convers, Xiamen 361021, Fujian, Peoples R China; [Li, Yan; Adyari, Bob; Wang, Yuwen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Rashid, Azhar] Nucl Inst Food & Agr, Peshawar 25000, Pakistan; [Yu, Chang-Ping] Natl Taiwan Univ, Grad Inst Environm Engn, Taipei 106, Taiwan; [Xin, Kuikui; Li, Haoran] Xiamen Univ, Coll Environm & Ecol, Xiamen 361005, Fujian, Peoples R China in 2020.0, Cited 51.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Category: indole-building-block

Residues of bisphenol A (BPA) are ubiquitously detected in the surface water due to its widespread usage. This study systematically investigated the dissipation and kinetics of BPA under simulated hydrolysis, direct and indirect photolysis, bacterial degradation, microbial degradation and natural attenuation in microcosm. Structural equation modeling (SEM) by using partial least square method in path coefficient analysis suggested that the microbial degradation was the major factor involved in the natural attenuation of BPA. The potential transformation products were identified by using liquid chromatography high-resolution mass spectrometry (LC-HRMS) and stable isotope tracing technique by simultaneous performing gas chromatography combustion isotope ratio mass spectrometry (GC-C-IRMS) and gas chromatography mass spectrometry (GC-MS). A total of fourteen including three novel transformation products of BPA were identified to indicate five possible pathways. An increased yield of labeled (delta C-13) CO2 and detection of C-13-labeled phospholipid fatty acids (PLFAs) indicated the mineralization of BPA and possible utilization of BPA or its transformation products by microbes for cellular membrane synthesis, respectively.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article 4,6-Diphenylpyrimidine Derivatives as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease WOS:000456351300032 published article about BIOLOGICAL EVALUATION; FUTURE TREATMENTS; DIRECTED LIGANDS; CELL MODEL; DONEPEZIL; MAO; CHOLINESTERASE; SYMPTOMS; HYBRIDS; DESIGN in [Kumar, Bhupinder; Dwivedi, Ashish Ranjan; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Lab Organ & Med Chem, Bathinda 151001, Punjab, India; [Sarkar, Bibekananda; Mantha, Anil K.; Parkash, Jyoti] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Anim Sci, Bathinda 151001, Punjab, India; [Gupta, Sukesh Kumar; Krishnamurthy, Sairam] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India in 2019.0, Cited 46.0. Quality Control of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Alzheimer’s disease (AD) is a neurodegenerative disorder with multifactorial pathogenesis. Monoamine oxidase (MAO) and acetylcholinesterase enzymes (AChE) are potential targets for the treatment of AD. A total of 15 new propargyl containing 4,6-diphenylpyrimidine derivatives were synthesized and screened for the MAO and AChE inhibition activities along with ROS production inhibition and metal-chelation potential. All the synthesized compounds were found to be selective and potent inhibitors of MAO-A and AChE enzymes at nanomolar concentrations. VB1 was found to be the most potent MAO-A and BuChE inhibitor with IC50 values of 18.34 +/- 0.38 nM and 0.666 +/- 0.03 mu M, respectively. It also showed potent AChE inhibition with an IC50 value of 30.46 +/- 0.23 nM. Compound VB8 was found to be the most potent AChE inhibitor with an IC50 value of 9.54 +/- 0.07 nM and displayed an IC50 value of 1010 +/- 70.42 nM against the MAO-A isoform. In the cytotoxic studies, these compounds were found to be nontoxic to the human neuroblastoma SH-SYSY cells even at 25 mu M concentration. All the compounds were found to be reversible inhibitors of MAO-A and AChE enzymes. In addition, these compounds also showed good neuroprotective properties against 6-OHDA- and H2O2-induced neurotoxicity in SH-SYSY cells. All the compounds accommodate nicely to the hydrophobic cavity of MAO-A and AChE enzymes. In the molecular dynamics simulation studies, both VB1 and VB8 were found to be stable in the respective cavities for 30 ns. Thus, 4,6-diphenylpyrimidine derivatives can act as promising leads in the development of dual-acting inhibitors targeting MAO-A and AChE enzymes for the treatment of Alzheimer’s disease.

Welcome to talk about 99-93-4, If you have any questions, you can contact Kumar, B; Dwivedi, AR; Sarkar, B; Gupta, SK; Krishnamurthy, S; Mantha, AK; Parkash, J; Kumar, V or send Email.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles