What kind of challenge would you like to see in a future of compound:4′-Hydroxyacetophenone

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Recommanded Product: 99-93-4. In 2021.0 BIORESOURCE TECHNOL published article about EFFICIENT DEPOLYMERIZATION; ORGANOSOLV LIGNIN; KRAFT LIGNIN; HYDROGENOLYSIS; METAL; CONVERSION; ALCOHOL; SOLVENT; BIOMASS; NI in [Lin, Xiuhua; Chen, Lihui; Li, Heyu; Lv, Yuancai; Liu, Yifan; Liu, Minghua] Fuzhou Univ, Fujian Prov Engn Res Ctr Rural Waste Recycling Te, Coll Environm & Resources, Fuzhou 350116, Fujian, Peoples R China; [Lin, Xiuhua; Chen, Lihui; Li, Heyu; Lv, Yuancai; Liu, Yifan; Liu, Minghua] Fuzhou Univ, Fujian Prov Technol Exploitat Base Biomass Resour, Fuzhou 350116, Peoples R China; [Lu, Xuebin] Tianjin Univ, Sch Environm Sci & Engn, Tianjin 30072, Tianjin, Peoples R China in 2021.0, Cited 42.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

In this study, the sinocalamus oldhami alkali lignin was depolymerized into phenolic products in a combined system by using the composite alkali and Ni-W2C/activated carbon (AC) as catalysts. FT-IR, GPC, TG, 2D-HSQC and GC-MS were used to analyze the composition, structure and distribution of degradation products, and the synergistic effect of metal and alkali catalysts on the depolymerization of lignin was also studied. The results showed that Ni-W2C/AC and composite alkali could effectively improve the catalytic degradation efficiency of lignin under mild conditions, 94.4% of lignin was converted and 17.18% of phenolic monomers were obtained under 260 degrees C for 5 h. In this composite system, the synergism of the basic sites, the metal active sites and the Lewis acid sites could promote the cleavage of C-O bonds in the lignin molecule and lower the char formation during the base-catalyzed solvolysis. Phenolic monomers were mainly composed of phenol, 2-methyl-phenol and p-cresol etc.

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Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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SDS of cas: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Xie, PF; Ma, JH or send Email.

I found the field of Chemistry very interesting. Saw the article Insights into aqueous reduction of Cr(VI) by Fe3O4@NOM MNPs under irradiation: The role of carbonyl structures published in 2019.0. SDS of cas: 99-93-4, Reprint Addresses Ma, JH (corresponding author), Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100190, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

This study investigates the active sites in natural organic matter (NOM) that are important for the removal of Cr (VI), by using Fe3O4 magnetic nanoparticles (MNPs) modified by NOM (Fe3O4@NOM). NaBH4 is used to selectively reduce carbonyl groups in Fe3O4@NOM MNPs to demonstrate the role of carbonyl structures in the reduction of Cr(VI), especially under irradiation. Results observed using NOM and low molecular weight compounds further demonstrated that carbonyl structures in Fe3O4@NOM MNPs, especially aromatic ketones, can strongly promote Cr(VI) reduction. This phenomenon corresponds well to a model in which charge transfer interactions occur between donors and acceptors in NOM.

SDS of cas: 99-93-4. Welcome to talk about 99-93-4, If you have any questions, you can contact Xie, PF; Ma, JH or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Name: 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Zhang, YL; Li, BY; Yang, R; Xia, LY; Fan, AL; Chu, YC; Wang, LJ; Wang, ZC; Jiang, AQ; Zhu, HL or send Email.

An article A class of novel tubulin polymerization inhibitors exert effective anti-tumor activity via mitotic catastrophe WOS:000458597300065 published article about BIOLOGICAL EVALUATION; MICROTUBULE DYNAMICS; TUMOR-GROWTH; CELL-DEATH; CANCER; DERIVATIVES; COLCHICINE; RESISTANT; DISCOVERY; INSIGHT in [Zhang, Ya-Liang; Li, Bo-Yan; Yang, Rong; Xia, Lin-Ying; Chu, Yi-Chun; Wang, Lin-Jian; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Sch Med, Nanjing 210093, Jiangsu, Peoples R China; [Fan, A. -Li] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Clin Pharmacokinet Lab, Nanjing 211198, Jiangsu, Peoples R China in 2019.0, Cited 33.0. Name: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI(50) ranging 0.05-0.98 mu M) and tubulin polymerization inhibition (IC50 = 1.49 mu M) with reference drug CA-4(P) (GI(50) ranging 0.019-0.32 mu M, IC50 = 2.18 mu M). The following assays indicated that compound E24 disturbed the dynamics of tubulin catastrophe and rescue, which triggered G2/M arrest, leading to ROS accumulation, cleavage of PARP and apoptosis. Molecular dynamics simulation validated that compound E24 could tightly bind into tubulin heterodimers with beta Lys 254 and beta Cys 241 of tubulin in the docking pose. Metabolic stability and pharmacokinetics parameters were also determined. The half time (t(1/2)) displayed species differences in three microsomes. The plasma elimination half-life (t(1/2)), peak plasma concentration (C-max), mean retention time (MRT), the area under the curve (AUC(0-infinity),) and distribution volume (V-z) of E24 after intravenous administration were 0.90 +/- 0.22 h, 594.50 +/- 97.23 ng/mL, 1.09 +/- 0.22 h, 413.67 +/- 105.64 ng/mL*h and 5.03 +/- 1.82 L/kg, respectively. In HeLa-xenografts, compound E24 exhibited obvious antitumor efficacy via the suppression of tumor growth without weight loss of body or organ. In brief, compound E24 might be a hopeful candidate with excellent properties for oncotherapy as tubulin polymerization inhibitor. (C) 2018 Elsevier Masson SAS. All rights reserved.

Name: 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Zhang, YL; Li, BY; Yang, R; Xia, LY; Fan, AL; Chu, YC; Wang, LJ; Wang, ZC; Jiang, AQ; Zhu, HL or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Brief introduction of 4′-Hydroxyacetophenone

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Recommanded Product: 4′-Hydroxyacetophenone. In 2020.0 ORG LETT published article about VISIBLE-LIGHT PHOTOREDOX; O BOND-CLEAVAGE; ALCOHOL OXIDATION; ARYL HALIDES; BIOMASS; VALORIZATION; CHEMICALS; DEPOLYMERIZATION; REDUCTION; SYSTEMS in [Yang, Cheng; Karkas, Markus D.; Magallanes, Gabriel; Chan, Kimberly; Stephenson, Corey R. J.] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA; [Karkas, Markus D.] KTH Royal Inst Technol, Dept Chem, SE-10044 Stockholm, Sweden in 2020.0, Cited 31.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Herein, an organocatalytic method for photochemical C-O bond cleavage of lignin systems is reported. The use of photochemistry enabled fragmentation of the ss-O-4 linkage, the primary linkage in lignin, provides the fragmentation products in good to high yields. The approach was merged with reported oxidation conditions in a one-pot, two-step platform without any intermediary purification, suggesting its high fidelity. The future utility of the organocatalytic method was illustrated by applying the visible light-mediated protocol to continuous flow processing.

Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Let`s talk about compound :C8H8O2

Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article In silico studies, synthesis and anticancer activity of novel diphenyl ether-based pyridine derivatives published in 2019.0. Formula: C8H8O2, Reprint Addresses Shenoy, GG (corresponding author), Manipal Acad Higher Educ, Manipal Coll Pharmaceut Sci, Dept Pharmaceut Chem, Manipal 576104, Karnataka, India.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A series of novel 2-amino-4-(3-hydroxy-4-phenoxyphenyl)-6-(4-substituted phenyl) nicotinonitriles were synthesized and evaluated against HepG2, A-549 and Vero cell lines. Compounds 3b (IC50 16.740.45 mu M) and 3p (IC50 10.57 +/- 0.54 mu M) were found to be the most active compounds against A-549 cell line among the evaluated compounds. Further 3b- and 3p-induced apoptosis was characterized by AO/EB (acridine orange/ethidium bromide) nuclear staining method and also by DNA fragmentation study. A decrease in cell viability and initiation of apoptosis was clearly evident through the morphological changes in the A-549 cells treated with 3b and 3p when stained with this method. Fragmentation of DNA into nucleosomes was observed which further confirmed the cell apoptosis in cells treated with compound 3b. Flow cytometry studies confirmed the cell cycle arrest at G2/M phase in A549 cells treated with compound 3b. Further in silico studies performed supported the in vitro anticancer activity of these compounds as depicted by dock score and binding energy values. [GRAPHICS] .

Formula: C8H8O2. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Interesting scientific research on 99-93-4

Welcome to talk about 99-93-4, If you have any questions, you can contact Inaloo, ID; Majnooni, S or send Email.. Safety of 4′-Hydroxyacetophenone

In 2019.0 EUR J ORG CHEM published article about CATALYZED OXIDATIVE CARBONYLATION; AROMATIC NITRO-COMPOUNDS; PRIMARY O-ALKYL; CARBON-MONOXIDE; ORGANIC AZIDES; REDUCTIVE CARBONYLATION; MOLECULAR-OXYGEN; DIAZO-COMPOUNDS; ARYL HALIDES; N-ARYLATION in [Inaloo, Iman Dindarloo] Shiraz Univ, Coll Sci, Chem Dept, Shiraz 7194684795, Iran; [Majnooni, Sahar] Univ Isfahan, Chem Dept, Esfahan 8174673441, Iran in 2019.0, Cited 165.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

A palladium-catalyzed domino method for the direct synthesis of carbamates and ureas has been developed by using readily available and economical starting materials (aryl halide, carbon monoxide, sodium azide, amines and alcohols) in a one-pot approach. The domino process underwent carbonylation, Curtius rearrangement, and nucleophilic addition. This protocol provides a step-economical and highly efficient reaction to access the wide range of valuable carbamates, symmetrical and unsymmetrical ureas with high yields under remarkable mild reaction conditions that are important factors in pharmaceutical science, biochemistry and agricultural industries. Furthermore, the magnetically recoverable nanocatalyst (Fe3O4@SiO2/Pd(II)) can be conveniently and swiftly recycled using external magnet and reused at least for seven times without noticeable loss of its catalytic activity.

Welcome to talk about 99-93-4, If you have any questions, you can contact Inaloo, ID; Majnooni, S or send Email.. Safety of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Now Is The Time For You To Know The Truth About 4′-Hydroxyacetophenone

Quality Control of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Li, ZQ; Wu, Y; Yang, LY; Du, JZ; Deng, B; Zhang, J or send Email.

Quality Control of 4′-Hydroxyacetophenone. I found the field of Oceanography very interesting. Saw the article Carbon isotopes and lignin phenols for tracing the floods during the past 70 years in the middle reach of the Changjiang River published in 2020.0, Reprint Addresses Wu, Y (corresponding author), East China Normal Univ, State Key Lab Estuarine & Coastal Res, Shanghai 210012, Peoples R China.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone.

The Lake Tian E Zhou (TEZ, an oxbow lake) was formed during the rerouting of the Changjiang River in 1972, with strong influences from the main river channel and flood events. Herein, a sediment core was collected from the Lake TEZ for the measurements of carbon isotopes and biomarkers, including stable carbon isotopes (delta C-13), radiocarbon composition (Delta C-14), and lignin phenols, as well as lead-210 to reconstruct recent heavy flood events over the past 70 years. At the 24-26 cm interval, the sediment contained the highest OC%, TN%, and lignin phenols content, as well as significantly depleted C-13 but enriched C-14, corresponding to the extreme flood event in 1998. In addition, statistics from t-test showed that lignin phenols normalized to OC (?8), the concentration of 3, 5-dihydroxy benzoic acid (3, 5-BD), and the ratio of p-hydroxy benzophenone to total hydroxyl phenols (PHB/HP) were all significantly different between the layers containing flood deposits and the layers deposited under normal non-flood conditions (p<0.05). These results indicate that the later three parameters are highly related to flood events and can be used as compelling proxies, along with sediment chronology, for hydrological changes and storm/flood events in the river basin and coastal marine environments. Quality Control of 4′-Hydroxyacetophenone. Welcome to talk about 99-93-4, If you have any questions, you can contact Li, ZQ; Wu, Y; Yang, LY; Du, JZ; Deng, B; Zhang, J or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Welcome to talk about 99-93-4, If you have any questions, you can contact Chandrika, NT; Fosso, MY; Tsodikov, OV; LeVine, H; Garneau-Tsodikova, S or send Email.. Quality Control of 4′-Hydroxyacetophenone

Quality Control of 4′-Hydroxyacetophenone. In 2020.0 MOLECULES published article about POTENTIAL MULTIFUNCTIONAL AGENTS; ALZHEIMERS-DISEASE BRAIN; AMYLOID-BETA; BIOLOGICAL EVALUATION; BINDING-SITE; NEURODEGENERATIVE DISEASES; STRUCTURAL MODIFICATIONS; DESIGN; ACETYLCHOLINESTERASE; DERIVATIVES in [Chandrika, Nishad Thamban; Fosso, Marina Y.; Tsodikov, Oleg, V; Garneau-Tsodikova, Sylvie] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA; [LeVine, Harry, III] Univ Kentucky, Ctr Aging, Sch Med, Lexington, KY 40536 USA; [LeVine, Harry, III] Univ Kentucky, Sch Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA in 2020.0, Cited 78.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The fact that the number of people with Alzheimer’s disease is increasing, combined with the limited availability of drugs for its treatment, emphasize the need for the development of novel effective therapeutics for treating this brain disorder. Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (A beta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). We present the design, synthesis, and biochemical evaluation of these two series of novel 1,3-chalcone-donepezil (15a-15f) or 1,4-chalcone-donepezil (16a-16f) hybrids. We evaluate the relationship between their structures and their ability to inhibit AChE/BChE activity as well as their ability to bind A beta peptides. We show that several of these novel chalcone-donepezil hybrids can successfully inhibit AChE/BChE as well as the assembly of N-biotinylated A beta((1-42)) oligomers. We also demonstrate that the A beta binding site of these hybrids differs from that of Pittsburgh Compound B (PIB).

Welcome to talk about 99-93-4, If you have any questions, you can contact Chandrika, NT; Fosso, MY; Tsodikov, OV; LeVine, H; Garneau-Tsodikova, S or send Email.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

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Welcome to talk about 99-93-4, If you have any questions, you can contact Tian, XT; Liu, H; Qiao, SD; Yin, H; Chen, MC; Hu, P; Wang, YY; Peng, HG; Liu, F; Pan, GY; Huang, CG or send Email.. Product Details of 99-93-4

An article Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro WOS:000465049300019 published article about CHLOROGENIC ACID PROTECTS; GENIPIN PROTECTS; ALPHA-NAPHTHYLISOTHIOCYANATE; ISCHEMIA/REPERFUSION INJURY; RHUBARB ANTHRAQUINONES; D-GALACTOSAMINE; GENIPOSIDE; ANTIOXIDANT; HEPATOTOXICITY; INFLAMMATION in [Tian, Xiaoting; Liu, Huan; Qiao, Shida; Yin, Hao; Chen, Mingcang; Hu, Pei; Wang, Yangyang; Peng, Huige; Liu, Fang; Pan, Guoyu; Huang, Chenggang] Chinese Acad Sci, Shanghai Inst Materia Med, 501 Hai Ke Rd Zhangjiang, Shanghai 201203, Peoples R China; [Tian, Xiaoting; Liu, Huan; Qiao, Shida; Yin, Hao; Chen, Mingcang; Hu, Pei; Wang, Yangyang; Peng, Huige; Liu, Fang; Pan, Guoyu; Huang, Chenggang] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

Ethnopharmacological relevance: Yin-Chen-Hao Tang (YCHT) has been a very popular, hepatoprotective three-herb formula with an unclear chemical base. Aim of this study: To reveal the hepatoprotective chemical base of oral-dosed YCHT, we bridged the hepatic disposition of six compounds in vivo and their hepatoprotection in vitro. Materials and methods: In vivo, following the oral administration of YCHT in normal and CCl4-induced liver injury rats, the determinations of chlorogenic acid, 4-hydroxyacetophenone, geniposide, genipin, rhein and emodin were conducted in the portal vein plasma, the liver, and the systemic plasma. In vitro, the hepatoprotective activities of these compounds were determined in the CCl4-induced HepG2 cells. Results: Consistent with the highest content in YCHT, geniposide had the highest exposure in vivo. Inconsistent with the negligible content, rhein, 4-hydroxyacetophenone, emodin and genipin showed substantial hepatic accumulations. In contrast, chlorogenic acid, an ingredient that has a high content in YCHT, elicited no hepatic exposure. In normal rats, the hepatic disposition prevented the compounds entering into the systemic plasma from the portal vein plasma by 44.9-100%, except for rhein. CCl4-induced liver injury caused a decreased hepatic exposure of 4-hydroxyacetophenone, rhein and emodin by 50%. In vitro, all six compounds exerted the hepatoprotection by increasing cell viability, decreasing hepatic marker enzymes and inhibiting lipid peroxidation at varying levels. Conclusion Geniposide, rhein, emodin, 4-hydroxyacetophenone and genipin directly resisted liver injury in oral-dosed YCHT, while chlorogenic acid likely played an indirect role. This study proved that YCHT exerted hepatoprotection through multiple components and multiple actions. However, close attention should be paid to the possible side effects and oral dosage of YCHT in clinics.

Welcome to talk about 99-93-4, If you have any questions, you can contact Tian, XT; Liu, H; Qiao, SD; Yin, H; Chen, MC; Hu, P; Wang, YY; Peng, HG; Liu, F; Pan, GY; Huang, CG or send Email.. Product Details of 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Final Thoughts on Chemistry for 4′-Hydroxyacetophenone

Category: indole-building-block. Welcome to talk about 99-93-4, If you have any questions, you can contact Espinoza-Hicks, JC; Chacon-Vargas, KF; Hernandez-Rivera, JL; Nogueda-Torres, B; Tamariz, J; Sanchez-Torres, LE; Camacho-Davila, A or send Email.

An article Novel prenyloxy chalcones as potential leishmanicidal and trypanocidal agents: Design, synthesis and evaluation WOS:000461728400027 published article about DERIVATIVES; PREVENTION; DISEASE in [Espinoza-Hicks, Jose C.; Hernandez-Rivera, Jessica L.; Camacho-Davila, Alejandro] Univ Autonoma Chihuahua, Fac Ciencias Quim, Campus Univ,Apartado Postal 669, Chihuahua, Chih, Mexico; [Fabiola Chacon-Vargas, Karla; Enid Sanchez-Torres, Luvia] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Inmunol, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico; [Fabiola Chacon-Vargas, Karla; Nogueda-Torres, Benjamin] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Parasitol, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico; [Tamariz, Joaquin] Inst Politecn Nacl, Escuela Nacl Ciencias Biol, Dept Quim Organ, Prolongac Carpio & Plan de Ayala S-N, Mexico City 11340, DF, Mexico in 2019.0, Cited 43.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

The available drugs for treating Leishmaniasis and American trypanosomiasis have high toxicity and multiple side effects, among other problems. More effective and less toxic treatments are urgently needed. A series of chalcones that contained a prenyloxy or geranyloxy substituent was synthesized and characterized. Each substituent was attached to the A ring in some compounds and to the B ring in others, with additional substituents placed on the chalcone moiety. The present aim was to evaluate the effect of the substitution pattern on leishmanicidal and trypanocidal activity. When tested at a single concentration, the compounds exerting a metabolic inhibition close to or exceeding 50% for Leishmania mexicana were 11, 17 and 12, and for Trypanosoma cruzi were 11, 17, 15 and 26. Upon determining the selectivity index (SI =IC50/CC50), the values were 80.9, 1.24 and 55.12 for 11, 17 and 12 (respectively) versus L mexicana, and 75.1, 1.43, 27.36 and 33.52 for 11, 17, 15 and 26 (respectively) versus T. cruzi. Structural isomers 11 and 17 showed activity for both the L mexicana and T. cruzi strains, though the greater cytotoxic activity of 17 led to a lower SI. Compounds 12, 15 and 26 were species specific. For I cruzi, the SI was higher for 11, 15 and 26 than for the reference drugs nifurtimox and benznidazole. The examination of promastigote morphology after exposing L mexicana and T. cruzi to 11 revealed a decrease in cell density. The current findings suggest that 11 could be a useful lead compound for further SAR studies. (C) 2019 Elsevier Masson SAS. All rights reserved.

Category: indole-building-block. Welcome to talk about 99-93-4, If you have any questions, you can contact Espinoza-Hicks, JC; Chacon-Vargas, KF; Hernandez-Rivera, JL; Nogueda-Torres, B; Tamariz, J; Sanchez-Torres, LE; Camacho-Davila, A or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles